Milk fat globule-EGF factor 8/lactadherin plays a crucial role in maintenance and repair of murine intestinal epithelium

Journal of Clinical Investigation

Volumn 117, Issue 12, 2007, Pages 3673-3683

  Bu, Heng Fu ^a   Zuo, Xiu Li ^a,b   Wang, Xiao ^a   Ensslin, Michael A ^c   Koti, Vjola ^a   Hsueh, Wei ^a   Raymond, Adam S ^c   Shur, Barry D ^c   Tan, Xiao Di ^a,d  

^a NORTHWESTERN UNIVERSITY   (United States)

^b SHANDONG UNIVERSITY   (China)

^c EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d CHILDREN'S MEMORIAL HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LACTADHERIN; PHOSPHATIDYLSERINE;

ARTICLE; CELL MIGRATION; CELL REGENERATION; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; GENE DELETION; INTESTINE EPITHELIUM CELL; INTESTINE INJURY; MACROPHAGE; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; SEPSIS; WOUND HEALING;

ACTINS; ANIMALS; ANTIBODIES; ANTIGENS, SURFACE; CELL MOVEMENT; CYTOSKELETON; DISEASE MODELS, ANIMAL; ENTEROCYTES; HOMEOSTASIS; MACROPHAGES; MICE; MICE, KNOCKOUT; MILK PROTEINS; PHOSPHATIDYLSERINES; PROTEIN KINASE C-EPSILON; RATS; RECOMBINANT PROTEINS; RNA, MESSENGER; SEPSIS; WOUND HEALING;

EID: 36849003113     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI31841     Document Type: Article

References (38)

1. Radtke, F., Clevers, H., and Riccio, O. 2006. From gut homeostasis to cancer. Curr. Mol. Med. 6:275-289.
2. Yang, Q., Bermingham, N.A., Finegold, M.J., and Zoghbi, H.Y. 2001. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science. 294:2155-2158.
3. Hall, P.A., Coates, P.J., Ansari, B., and Hopwood, D. 1994. Regulation of cell number in the mammalian gastrointestinal tract: the importance of apoptosis. J. Cell Sci. 107:3569-3577.
4. van Es, J.H., et al. 2005. Wnt signalling induces maturation of Paneth cells in intestinal crypts. Nat. Cell Biol. 7:381-386.
5. Blikslager, A.T., Moeser, A.J., Gookin, J.L., Jones, S.L., and Odle, J. 2007. Restoration of barrier function in injured intestinal mucosa. Physiol. Rev. 87:545-564.
6. Stubbs, J.D., et al. 1990. cDNA cloning of a mouse mammary epithelial cell surface protein reveals the existence of epidermal growth factor-like domains linked to factor VIII-like sequences. Proc. Natl. Acad. Sci. U. S. A. 87:8417-8421.
7. Yolken, R.H., et al. 1992. Human milk mucin inhibits rotavirus replication and prevents experimental gastroenteritis. J. Clin. Invest. 90:1984-1991.
8. Thery, C., et al. 1999. Molecular characterization of dendritic cell-derived exosomes. Selective accumulation of the heat shock protein hsc73. J. Cell Biol. 147:599-610.
9. Hanayama, R., et al. 2002. Identification of a factor that links apoptotic cells to phagocytes. Nature. 417:182-187.
10. Ensslin, M.A., and Shur, B.D. 2003. Identification of mouse sperm SED1, a bimotif EGF repeat and discoidin-domain protein involved in sperm-egg binding. Cell. 114:405-417.
11. Taylor, M.R., Couto, J.R., Scallan, C.D., Ceriani, R.L., and Peterson, J.A. 1997. Lactadherin (formerly BA46), a membrane-associated glycoprotein expressed in human milk and breast carcinomas, promotes Arg-Gly-Asp (RGD)-dependent cell adhesion. DNA Cell Biol. 16:861-869.
12. Andersen, M.H., Berglund, L., Rasmussen, J.T., and Petersen, T.E. 1997. Bovine PAS-6/7 binds alpha v beta 5 integrins and anionic phospholipids through two domains. Biochemistry. 36:5441-5446.
13. Silvestre, J.S., et al. 2005. Lactadherin promotes VEGF-dependent neovascularization. Nat. Med. 11:499-506.
14. Oshima, K., et al. 1999. Lactation-dependent expression of an mRNA splice variant with an exon for a multiply O-glycosylated domain of mouse milk fat globule glycoprotein MFG-E8. Biochem. Biophys. Res. Commun. 254:522-528.
15. Li, Y., Urban, J.M., Cayer, M.L., Plummer, H.K., 3rd, and Heckman, C.A. 2006. Actin-based features negatively regulated by protein kinase C-epsilon. Am. J. Physiol. Cell Physiol. 291:C1002-C1013.
16. Nusrat, A., Delp, C., and Madara, J.L. 1992. Intestinal epithelial restitution. Characterization of a cell culture model and mapping of cytoskeletal elements in migrating cells. J. Clin. Invest. 89:1501-1511.
17. Lotz, M.M., Rabinovitz, I., and Mercurio, A.M. 2000. Intestinal restitution: progression of actin cytoskeleton rearrangements and integrin function in a model of epithelial wound healing. Am. J. Pathol. 156:985-996.
18. Bu, H.F., et al. 2006. Lysozyme-modified probiotic components protect rats against polymicrobial sepsis: role of macrophages and cathelicidin-related innate immunity. J. Immunol. 177:8767-8776.
19. Dignass, A., Lynch-Devaney, K., Kindon, H., Thim, L., and Podolsky, D.K. 1994. Trefoil peptides promote epithelial migration through a transforming growth factor beta-independent pathway. J. Clin. Invest. 94:376-383.
20. Tan, X.D., Chen, Y., Liu, Q., Gonzalez-Crussi, F., and Liu, X. 2000. Prostanoids mediate the protective effect of trefoil factor 3 in oxidant-induced intestinal epithelial cell injury: role of cyclooxygenase-2. J. Cell Sci. 113:2149-2155.
21. Chen, Y.H., Lu, Y., De Plaen, I.G., Wang, L.Y., and Tan, X.D. 2000. Transcription factor NF-kappaB signals antianoikic function of trefoil factor 3 on intestinal epithelial cells. Biochem. Biophys. Res. Commun. 274:576-582.
22. Martin, S.J., et al. 1995. Early redistribution of plasma membrane phosphatidylserine is a general feature of apoptosis regardless of the initiating stimulus: inhibition by overexpression of Bcl-2 and Abl. J. Exp. Med. 182:1545-1556.
23. Frasch, S.C., et al. 2000. Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta. J. Biol. Chem. 275:23065-23073.
24. van den Eijnde, S.M., et al. 2001. Transient expression of phosphatidylserine at cell-cell contact areas is required for myotube formation. J. Cell Sci. 114:3631-3642.
25. Frasch, S.C., et al. 2004. Phospholipid flip-flop and phospholipid scramblase 1 (PLSCR1) co-localize to uropod rafts in formylated Met-Leu-Phe-stimulated neutrophils. J. Biol. Chem. 279:17625- 17633.
26. Newton, A.C. 1995. Protein kinase C: structure, function, and regulation. J. Biol. Chem. 270:28495-28498.
27. Finkielstein, C.V., Overduin, M., and Capelluto, D.G. 2006. Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1. J. Biol. Chem. 281:27317-27326.
28. Ensslin, M.A., and Shur, B.D. 2007. The EGF repeat and discoidin domain protein, SED1/MFG-E8, is required for mammary gland branching morphogenesis. Proc. Natl. Acad. Sci. 104:2715-2720.
29. McKaig, B.C., Makh, S.S., Hawkey, C.J., Podolsky, D.K., and Mahida, Y.R. 1999. Normal human colonic subepithelial myofibroblasts enhance epithelial migration (restitution) via TGF-beta3. Am. J. Physiol. 276:G1087-G1093.
30. Ridley, A.J., Comoglio, P.M., and Hall, A. 1995. Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol. Cell Biol. 15:1110-1122.
31. Uberall, F., et al. 1997. Conventional PKC-alpha, novel PKC-epsilon and PKC-theta, but not atypical PKC-lambda are MARCKS kinases in intact NIH 3T3 fibroblasts. J. Biol. Chem. 272:4072-4078.
32. Song, J.C., Hrnjez, B.J., Farokhzad, O.C., and Matthews, J.B. 1999. PKC-epsilon regulates basolateral endocytosis in human T84 intestinal epithelia: role of F-actin and MARCKS. Am. J. Physiol. 277:C1239-C1249.
33. Wong, M.H., Rubinfeld, B., and Gordon, J.I. 1998. Effects of forced expression of an NH2-terminal truncated beta-Catenin on mouse intestinal epithelial homeostasis. J. Cell Biol. 141:765-777.
34. Mashimo, H., Wu, D.C., Podolsky, D.K., and Fishman, M.C. 1996. Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science. 274:262-265.
35. Qureshi, F.G., et al. 2005. Increased expression and function of integrins in enterocytes by endotoxin impairs epithelial restitution. Gastroenterology. 128:1012-1022.
36. Ait-Oufella, H., et al. 2007. Lactadherin deficiency leads to apoptotic cell accumulation and accelerated atherosclerosis in mice. Circulation. 115:2168-2177.
37. Atabai, K., et al. 2005. Mfge8 is critical for mammary gland remodeling during involution. Mol. Biol. Cell. 16:5528-5537.
38. Zhu, Y.Q., and Tan, X.D. 2005. TFF3 modulates NF-kappaB and a novel negative regulatory molecule of NF-kappaB in intestinal epithelial cells via a mechanism distinct from TNF-alpha. Am. J. Physiol. Cell Physiol. 289:C1085-C1093.