MFGE8 inhibits inflammasome-induced IL-1β production and limits postischemic cerebral injury

Journal of Clinical Investigation

Volumn 123, Issue 3, 2013, Pages 1176-1181

  Deroide, Nicolas ^a,b   Li, Xuan ^a   Lerouet, Dominique ^c   Van Vré, Emily ^d   Baker, Lauren ^a   Harrison, James ^a   Poittevin, Marine ^b   Masters, Leanne ^a   Nih, Lina ^b   Margaill, Isabelle ^c   Iwakura, Yoichiro ^e   Ryffel, Bernhard ^f   Pocard, Marc ^b   Tedgui, Alain ^d   Kubis, Nathalie ^b   Mallat, Ziad ^a,d  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b INSERM   (France)

^c Faculte de Pharmacie   (France)

^d PARIS CARDIOVASCULAR RESEARCH CENTER   (France)

^e UNIVERSITY OF TOKYO   (Japan)

^f UNIVERSITÉ D'ORLÉANS   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; BETA3 INTEGRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LACTADHERIN; PURINERGIC P2X7 RECEPTOR;

ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; APOPTOSIS; BRAIN INFARCTION SIZE; BRAIN INJURY; BRAIN ISCHEMIA; BRAIN NECROSIS; BRAIN PROTECTION; CELL DENSITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG MECHANISM; ENZYME ACTIVATION; IN VITRO STUDY; INNATE IMMUNITY; MACROPHAGE; MOUSE; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN INTERACTION; REVIEW; SUPPLEMENTATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; ANTIGENS, SURFACE; CASPASE 1; CELLS, CULTURED; IMMUNITY, INNATE; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMASOMES; INTEGRIN BETA3; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MILK PROTEINS; RECEPTORS, PURINERGIC P2X7;

EID: 84874604501     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI65167     Document Type: Review

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