Restoring the procofactor state of factor va-like variants by complementation with b-domain peptides

Journal of Biological Chemistry

Volumn 288, Issue 42, 2013, Pages 30151-30160

  Bunce, Matthew W ^a   Bos, Mettine H A ^a,c   Krishnaswamy, Sriram ^a   Camire, Rodney M ^a,b  

^a CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOINHIBITION; B DOMAINS; COMPLEMENTATION; TRANS ACTINGS;

BIOCHEMISTRY;

BIOLOGY;

ARGININE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CIS ACTING ELEMENT; PROTHROMBIN; THROMBIN; TRANS ACTING FACTOR;

ACIDITY; AMINO ACID SEQUENCE; ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BLOOD CLOTTING; CONTROLLED STUDY; HUMAN; INHIBITION KINETICS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE;

AUTOINHIBITION; COAGULATION FACTORS; ENZYME MECHANISMS; FACTOR V; FACTOR VA; HEMOSTASIS; PROTEIN ENGINEERING; PROTHROMBINASE; RECOMBINANT PROTEIN EXPRESSION;

FACTOR VA; FACTOR XA; HUMANS; PEPTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84886881353     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.506840     Document Type: Article

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