Mapping of the factor Xa binding site on factor Va by site-directed mutagenesis

Journal of Biological Chemistry

Volumn 283, Issue 30, 2008, Pages 20805-20812

  Steen, Mårten ^a   Tran, Sinh ^a   Autin, Ludovic ^b   Villoutreix, Bruno O ^b   Tholander, Ann Louise ^a   Dahlbäck, Björn ^a  

^a LUND UNIVERSITY   (Sweden)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

AMINES; AMINO ACIDS; BINDING ENERGY; CARBOHYDRATES; COAGULATION; GLYCOPROTEINS; ORGANIC ACIDS; VANADIUM COMPOUNDS;

ACTIVATED PROTEINS; BINDING AFFINITIES; BINDING ASSAYS; BINDING SURFACES; BINDING TESTS; CHARGED AMINO ACIDS; COAGULATION FACTORS; COFACTOR; COFACTOR ACTIVITIES; DO-MAINS; FUNCTIONAL PROPERTIES; KEY FACTORS; PROTHROMBINASE; SIDE CHAINS; V FUNCTIONS;

BINDING SITES;

ACTIVATED PROTEIN C; ALANINE; ARGININE; ASPARAGINASE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; PROTHROMBIN; THROMBOPLASTIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CONTROLLED STUDY; ENZYME ASSAY; ENZYME BINDING; GENE MAPPING; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN VARIANT; RESIDUE ANALYSIS; SITE DIRECTED MUTAGENESIS; ANIMAL; CELL STRAIN COS1; CERCOPITHECUS; CHEMISTRY; GENETICS; HUMAN; KINETICS; MUTATION; PROTEIN BINDING; THERMODYNAMICS;

ALANINE; ANIMALS; BINDING SITES; CERCOPITHECUS AETHIOPS; COS CELLS; FACTOR VA; FACTOR XA; HUMANS; KINETICS; MUTAGENESIS, SITE-DIRECTED; MUTATION; PROTEIN BINDING; PROTHROMBIN; THERMODYNAMICS; THROMBOPLASTIN;

EID: 51049092534     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M802703200     Document Type: Article

References (39)

1. Mann, K. G., Butenas, S., and Brummel, K. (2003) Arterioscler. Thromb. Vasc. Biol. 23, 17-25
2. Dahlback, B. (2005) J. Intern. Med. 257, 209-223
3. Nesheim, M. E., Taswell, J. B., and Mann, K. G. (1979) J. Biol. Chem. 254, 10952-10962
4. Rosing, J., Tans, G., Govers-Riemslag, J. W., Zwaal, R. F., and Hemker, H. C. (1980) J. Biol. Chem. 255, 274-283
5. Kane, W. H., and Davie, E. W. (1988) Blood 71, 539-555
6. Mann, K. G., and Kalafatis, M. (2003) Blood 101, 20-30
7. Nicolaes, G. A., and Dahlback, B. (2002) Arterioscler. Thromb. Vasc. Biol. 22, 530-538
8. Nicolaes, G. A., Villoutreix, B. O., and Dahlback, B. (2000) Blood Coagul. Fibrinolysis 11, 89-100
9. Saleh, M., Peng, W., Quinn-Allen, M. A., Macedo-Ribeiro, S., Fuentes-Prior, P., Bode, W., and Kane, W. H. (2004) Thromb. Haemost. 91, 16-27
10. Gale, A. J., Yegneswaran, S., Xu, X., Pellequer, J. L., and Griffin, J. H. (2007) J. Biol. Chem. 282, 21848-21855
11. Heeb, M. J., Kojima, Y., Hackeng, T. M., and Griffin, J. H. (1996) Protein Sci. 5, 1883-1889
12. Kalafatis, M., and Beck, D. O. (2002) Biochemistry 41, 12715-12728
13. Kalafatis, M., Xue, J., Lawler, C. M., and Mann, K. G. (1994) Biochemistry 33, 6538-6545
14. Kojima, Y., Heeb, M. J., Gale, A. J., Hackeng, T. M., and Griffin, J. H. (1998) J. Biol. Chem. 273, 14900-14905
15. Steen, M., and Dahlback, B. (2002) J. Biol. Chem. 277, 38424-38430
16. Steen, M., Villoutreix, B. O., Norstrom, E. A., Yamazaki, T., and Dahlback, B. (2002) J. Biol. Chem. 277, 50022-50029
17. Fay, P. J., Beattie, T., Huggins, C. F., and Regan, L. M. (1994) J. Biol. Chem. 269, 20522-20527
18. Jenkins, P. V., Dill, J. L., Zhou, Q., and Fay, P. J. (2004) Biochemistry 43, 5094-5101
19. Jenkins, P. V., Dill, J. L., Zhou, Q., and Fay, P. J. (2004) J. Thromb. Haemost. 2, 452-458
20. Jenkins, P. V., Freas, J., Schmidt, K. M., Zhou, Q., and Fay, P. J. (2002) Blood 100, 501-508
21. Lenting, P. J., van de Loo, J. W., Donath, M. J., van Mourik, J. A., and Mertens, K. (1996) J. Biol. Chem. 271, 1935-1940
22. Mertens, K., Celie, P. H., Kolkman, J. A., and Lenting, P. J. (1999) Thromb. Haemost. 82, 209-217
23. Celie, P. H., Van Stempvoort, G., Jorieux, S., Mazurier, C., Van Mourik, J. A., and Mertens, K. (1999) Br. J. Haematol. 106, 792-800
24. Dahlback, B., and Villoutreix, B. O. (2005) Arterioscler. Thromb. Vasc. Biol. 25, 1311-1320
25. Pellequer, J. L., Gale, A. J., Getzoff, E. D., and Griffin, J. H. (2000) Thromb. Haemost. 84, 849-857
26. Villoutreix, B. O., and Dahlback, B. (1998) Protein Sci. 7, 1317-1325
27. Adams, T. E., Hockin, M. F., Mann, K. G., and Everse, S. J. (2004) Proc. Natl. Acad. Sci. U. S. A. 101, 8918-8923
28. Singh, L. S., Bukys, M. A., Beck, D. O., and Kalafatis, M. (2003) J. Biol. Chem. 278, 28335-28345
29. Autin, L., Steen, M., Dahlback, B., and Villoutreix, B. O. (2006) Proteins 63, 440-450
30. Lundblad, R. L., Uhteg, L. C., Vogel, C. N., Kingdon, H. S., and Mann, K. G. (1975) Biochem. Biophys. Res. Commun. 66, 482-489
31. Dahlback, B., and Stenflo, J. (1978) Biochemistry 17, 4938-4945
32. Norstrom, E. A., Tran, S., Steen, M., and Dahlback, B. (2006) J. Biol. Chem. 281, 31486-31494
33. Sun, Y. H., Tran, S., Norstrom, E. A., and Dahlback, B. (2004) J. Biol. Chem. 279, 47528-47535
34. Norstrom, E., Thorelli, E., and Dahlback, B. (2002) Blood 100, 524-530
35. Nicolaes, G. A., Tans, G., Thomassen, M. C., Hemker, H. C., Pabinger, I., Varadi, K., Schwarz, H. P., and Rosing, J. (1995) J. Biol. Chem. 270, 21158-21166
36. Camire, R. M., Kalafatis, M., and Tracy, P. B. (1998) Biochemistry 37, 11896-11906
37. Krishnaswamy, S. (1990) J. Biol. Chem. 265, 3708-3718
38. Thiec, F., Cherel, G., and Christophe, O. D. (2003) J. Biol. Chem. 278, 10393-10399
39. Gale, A. J., Xu, X., Pellequer, J. L., Getzoff, E. D., and Griffin, J. H. (2002) Protein Sci. 11, 2091-2101