An anticoagulant RNA aptamer that inhibits proteinase-cofactor interactions within prothrombinase

Journal of Biological Chemistry

Volumn 285, Issue 8, 2010, Pages 5212-5223

  Buddai, Sai K ^a   Layzer, Juliana M ^b,d   Lu, Genmin ^a   Rusconi, Christopher P ^b,d   Sullenger, Bruce A ^b   Monroe, Dougald M ^c   Krishnaswamy, Sriram ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^d Regado Biosciences   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; APTAMERS; CARBOXYGLUTAMIC ACID; COFACTORS; COMBINATORIAL LIBRARY; ENZYME COMPLEXES; FACTOR X; FACTOR XA; HIGH AFFINITY; NANOMOLAR AFFINITY; PROTEIN SUBSTRATE; PROTHROMBINASE; RNA APTAMER; SELECTIVE INHIBITION; TIGHT BINDING;

CALCIUM; COMPLEXATION; ENZYMES; RNA;

ENZYME INHIBITION;

4 CARBOXYGLUTAMIC ACID; APTAMER; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 5A; CALCIUM ION; GENE PRODUCT; PROTHROMBIN; RNA APTAMER; THROMBIN; UNCLASSIFIED DRUG; ZYMOGEN FACTOR X; ANTICOAGULANT AGENT; BLOOD CLOTTING FACTOR 5; CALCIUM; PROTHROMBINASE COMPLEX;

ARTICLE; BINDING AFFINITY; BINDING COMPETITION; BINDING SITE; CATALYSIS; CELL STRAIN HEK293; COMBINATORIAL LIBRARY; COMPLEX FORMATION; CONTROLLED STUDY; ENZYME INHIBITION; HUMAN; HUMAN CELL; INHIBITION KINETICS; MACROMOLECULE; MOLECULAR INTERACTION; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN TARGETING; CHEMISTRY; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PROTEIN BINDING;

ANTICOAGULANTS; APTAMERS, NUCLEOTIDE; CALCIUM; FACTOR V; FACTOR XA; HUMANS; PROTEIN BINDING; THROMBIN;

EID: 77949312882     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.049833     Document Type: Article

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