Grape (vitis vinifera) seed extract inhibits the cytotoxicity and oxidative stress in liver of rats treated with carbon tetrachloride

Global Journal of Pharmacology

Volumn 7, Issue 3, 2013, Pages 258-269

  Ragab, Ghada M A ^a   El Denshary, Ezzeldeen S ^a,b   Hassan, AAziza M ^c,d   Abdel Azeim, Sekena H ^c   Hassan, Nabila S ^c   Mannaa, Fathia A ^c   Abdel Wahhab, Mosaad A ^c  

^a Misr University for Science and Technology   (Egypt)

^b CAIRO UNIVERSITY   (Egypt)

^c NATIONAL RESEARCH CENTRE   (Egypt)

^d TAIF UNIVERSITY   (Saudi Arabia)

Author keywords

Antioxidant; Cytogenetic; Gene expression; Grape seed extract; Liver; Oxidative stress

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; CARBON TETRACHLORIDE; CHOLESTEROL; DNA; FAS ANTIGEN; GRAPE SEED EXTRACT; LACTATE DEHYDROGENASE; LIPID; MALONALDEHYDE; NITRIC OXIDE; RNA; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BLOOD ANALYSIS; CHEMICAL ANALYSIS; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; CYTOGENETICS; DNA CONTENT; DNA FRAGMENTATION; DRUG MEGADOSE; FEMALE; GENE EXPRESSION; HISTOCHEMISTRY; HISTOPATHOLOGY; LACTATE DEHYDROGENASE BLOOD LEVEL; LIPID BLOOD LEVEL; LIVER; LIVER DISEASE; LIVER PROTECTION; LIVER TOXICITY; LOW DRUG DOSE; NONHUMAN; OXIDATIVE STRESS; PROTEIN BLOOD LEVEL; RAT; RNA ANALYSIS; TRIACYLGLYCEROL BLOOD LEVEL;

EID: 84886820600     PISSN: 19920075     EISSN: None     Source Type: Journal    
DOI: 10.5829/idosi.gjp.2013.7.3.7637     Document Type: Article

References (70)

1. Ferlay, J., H.R. Shin, F. Bray, D. Forman, C. Mathers and D.M. Parkin, 2010. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int. J. Cancer, 127(12): 1893-2917.
2. El-Shenawy, S.Z., M.M. El. Sabawi, N. Sheble, M. Abd El-Raof, M.M. Allam and S.K. Fath Allah, 2012. Diagnostic role of serum glypican-3 as a tumor marker for hepatocellular carcinoma. J. Nat. Sci., 10(4): 32-38.
3. WHO, 2012. Hepatitis C. World Health Organization, department of communicable diseases surveillance and response.
4. Heintges, T. and J.R. Wands, 1997. Hepatitis C virus: epidemiology and transmission. J. Hepatol, 26: 521-526.
5. Arun, K. and U. Balasubramanian, 2010. Comparative Study on hepatoprotective activity of Phyllanthus amarus and Eclipta prostrata against alcohol induced in albino rats. J. Environ. Sci., 2(1): 361-379.
6. Hemamalini, K., B. Preethi, A. Bhargav and U. Vasireddy, 2012. Hepatoprotective activity of Kigelia africana and Anogeissus accuminata against paracetamol induced hepatotoxicity in rats. Int. J. Pharma. Biomed. Res., 3(3): 152-156.
7. Singh, D. and R.S. Gupta, 2011. Hepatoprotective activity of methanol extract of Tecomella undulate against alcohol and paracetamol induced hepatotoxicity in rats. Life Sci. Med. Res., 26: 1-8.
8. Haggag, M.H., 2011. Protective effect of Coriandrum sativum plant of hepatotoxicity and nephrotoxicity induced by carbon tetrachloride in male albino rats. In 'The 6th Arab and 3rd International Annual Scientific Conference on: Development of Higher Specific Education Programs in Egypt and the Arab World in the Light of Knowledge Era Requirements'. pp: 2332-2348.
9. Sreelatha, S., P.R. Padma and M. Umadevi. 2009. Protective effects of Coriandrum sativum extracts on carbon tetrachloride-induced hepatotoxicity in rats. Food Chem. Toxicol, 47: 702-708.
10. Abdel-Wahhab, M.A., N.S. Hassan, A.A. El-Kady, Y.A. Mohamed, A.A. El-Nekeety, S.R. Mohamed, H.A. Sharaf and F.A. Mannaa, 2010. Red ginseng extract protects against aflatoxin B1 and Fumonisins-induced hepatic pre-cancerous lesions in rats. Food Chem. Toxicol, 48(2): 733-742.
11. El-Denshary, E.S., M.A. Al-Gahazali, F.A. Mannaa, H.S. Salem, N.S. Hassan and M.A. Abdel-Wahhab, 2012. Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats. Exper. Toxicol. Pathol, 64: 753-760.
12. Nichols, J.A. and S.K. Katiyar, 2010. Skin photoprotection by natural polyphenols: antiinflammatory, anti-oxidant and DNA repair mechanisms. Arch. Dermatol. Res., 302(2): 71-83.
13. Silva, R.C., J. Rigaud, V. Cheynier and A. Chemina, 1991. Procyanidin dimers and trimers from grape seeds. Phytochem, 30: 1259-1264.
14. Katiyar, S., 2008. Grape seed proanthocyanidins and cancer prevention: inhibition of oxidative stress and protection of immune system. Mol. Nut. Food Res., 52: 871-876.
15. Bhragual, D.D., N. Kumar, V.K. Garg and P.K. Sharma, 2010. Review on plants having hepatoprotective activity. J. Pharm. Res., 3(9): 2077-2082.
16. Mirzaei, A., M. Mirzaei and N. Mirzaei, 2011. Hepatoprotectivity of grape seed and jaft extracts formulation in hepatoxic rats. J. Clin. Bioch. Poster-[A-10-225-3].
17. Feng, Y., K.Y. Siu, X. Ye, N. Wang, MF. Yuen, C.H. Leung, Y. Tong and S. Kobayashi, 2010. Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin. Med., 5: 33-38.
18. Pallarès, V., A. Ferncndez-Iglesias, L. Cedó, A. Castell-Auví, M. Pinent, A. Ardévol, M. J. Salvadó, S. Garcia-Vallvé, M. Blay, 2013. Grape seed procyanidin extract reduces the endotoxic effects induced by lipopolysaccharide in rats. Free Radic Biol Med., 60: 107-114.
19. Lin, CC, Y.F. Hsu, T.C. Lin, FL. Hsu and H.Y. Hsu, 1998. Antioxidant and hepatoproductive activity of punicalagin and punicalin on carbon tetrachloride induced liver damage in rats. J. Pharmacol, 50: 789-794.
20. Drury, R., E. Wallington and R. Cancerson, 1976. Carleton's histological technique. 4th ed. Oxford University Press, London.
21. Bregman, A., 1983. Laboratory Investigation and Cell Biology. John Wiley and Sons, New York, pp: 51-60.
22. Perandones, C.E., VA. Illera, D. Peckham, L.L. Stunz and R.F. Ashman, 1993. Regulation of apoptosis in vitro in mature murine spleen T cells. J. Immunol. 151(7): 3521-3529.
23. K. Burton, K., 1956. A study of the conditions and mechanisms of the diphenylamine reaction for the estimation of deoxyribonucleic acid. Biochem. J., 62: 315-323.
24. Brun, M.E., S. Gasca, C. Girard, K. Bouton, B. De Massy and A. De Sario, 2006. Characterization and expression analysis during embryo development of the mouse ortholog of MLL3. Gene, 371: 25-33.
25. Hassan, A.M., S.H. Abdel-Aziem and MA. Abdel-Wahhab, 2012. Modulation of DNA damage and alteration of gene expression during aflatoxicosis via dietary supplementation of Spirulina (Arthrospira) and whey protein concentrate. Ecotoxicol. Environ. Safety, 79: 294-300.
26. Abdel-Aziem, S.H., A.M. Hassan and M.A. Abdel-Wahhab, 2011. Dietary supplementation with whey protein and ginseng extract counteract the oxidative stress and DNA damage in rats fed aflatoxins-contaminated diet. Mutat. Res., 723: 65-71.
27. SAS Institute, Inc., 1982. SAS User's Guide. Statistics. SAS Institute, Cary, NC.
28. Waller, R.A. and D.B. Duncan, 1969. A Bayes rule for the symmetric multiple comparison problems. J. Am. Stat. Assoc, 64: 1484-1503.
29. Noguchi, T., K.L. Fong, E. Lai, S.S. Alexander, M.M. King, L. Olson, J.L. Poyer and P.B. Mccay, 1982. Specificity of a phenobarbital induced cytochrome P450 for metabolism of carbontetrachloride to the trichloromethyl radical. Biochem. Pharmacol, 31: 615-624.
30. Packer, J.E., T.F. Slater and R.L. Willson, 1978. Reactions of the carbon tetrachlonde-related peroxy free radical with amino acids: pulse radiolysis evidence. Life Sci., 23: 2617-2620.
31. Sarhan, N.A., E.S. El-Denshary, N.S. Hassan, F.M. Abou-Salem and M.A. Abdel-Wahhab, 2012. Isoflavones-Enriched soy protein prevents CCL4-induced hepatotoxicity in rats. ISRN Pharmacol. 347930. Epub 2012 Mar.1.
32. Abdel-Aziem, S.H., A.M. Hassan, A.S. Salman, A.I. Waly and M.A. Abdel-Wahhab, 2011. Genetic alterations and gene expression profile in male Balb/c mice treated with carbon tetrachloride with or without carboxymethyl chitosan. J. Am. Sci. 7(6): 7-17.
33. Nyblom, H., U. Berggren, J. Balldin and R. Olsson, 2004. High AST/ALT ratio may indicate advanced alcoholic liver disease rather than heavy drinking. Alcohol Alcohol, 39: 336-339.
34. Ramaiah, S.K., 0000. A toxicologist guide to the diagnostic interpretation of hepatic biochemical parameters. Food Chem. Toxicol, 45: 1551-1557.
35. Kaplan, M.M., 1987. Primary biliary cirrhosis. New Engl. J. Med., 316: 521-526.
36. Abdel-Wahhab, M.A. and S.E. Aly, 2003. Antioxidants and radical scavenging properties of vegetable extracts in rats fed aflatoxin-contaminated diet. J. Agric. Food Chem., 51(8): 2409-2414.
37. Abdel-Wahhab, M.A. and S.E. Aly, 2005. Antioxidant property of Nagilia Sativa (Black cumin) and Syzygium Aromaticum (Clove) rats during aflatoxicosis. J. Appl. Toxicol, 25: 218-223.
38. Abdel-Wahhab, M.A., S.A. Nada and M.S. Arbid, 1999. Ochratoxicosis: prevention of developmental toxicity by L methionine in rats. J. Appl. Toxicol. 19(1): 7-12.
39. Abdel-Wahab, M., N. El-Ghawalby, M. Mostafa, A. Sultan, M. El-Sadany, O. Fathy, T. Salah and F. Ezzat, 2007. Epidemiology of hepatocellular carcinoma in lower Egypt. Mansoura Gastroenterology Center, Hepato-gastroenterol. 54(73): 157-162.
40. Barton, C.C., E.X. Barton, P.E. Ganey, S.L. Kunkel and R.A. Roth, 2001. Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor. Hepatol, 33(1): 66-73.
41. Shyamal, S., P.G. Latha, S.R. Suja, V.J. Shine, G.I. Anuja, S. Sini, S. Pradeep, P. Shikha and S. Rajasekharan, 2010. Hepatoprotective effect of three herbal extracts on aflatoxin B1-intoxicated rat liver. Singapore Med. J., 51: 326-331.
42. Bhattacharjee, R. and P.C. Sil, 2007. Protien isolate from herb, Phyllanthus niruri L. (Euphorbiaceae), plays hepatoprotective role against carbon tetrachloride induced liver damage via its antioxidant properties. Food Chem. Toxicol, 45: 817-826.
43. Abdel-Wahhab, M.A., H.H. Ahmed and M.M. Hagazi, 2006, Prevention of aflatoxin B1-initiated hepatotoxicity in rat by marine algae extracts. J. Appl. Toxicol, 26(3): 229-238.
44. Halliwell, B., 1999. Antioxidant defence mechanisms: from the beginning to the end (of the beginning). Free Rad. Res., 31(4): 261-272.
45. El-Denshary, E.S., M.A. Al-Gahazali, F.A. Mannaa, H.A. Salem, N.S. Hassan and M.A. Abdel-Wahhab, 2011. Dietary honey and ginseng protect against carbon tetrachloride-induced hepatonephrotoxicity in rats. Exp. Toxicol. Pathol., 64: 753-760.
46. Schinella, G.R., H.A. Tournier, J.M. Prieto, D.B.P. Mordujovich and J.L. Rios, 2002. Antioxidant activity of anti-inflammatory plant extracts. Life Sci. 18: 1023-1033.
47. Abdel-Wahhab, M.A., A.A. Ibrahim, A.A. El-Nekeety, N.S. Hassan and A.A. Mohamed, 2012. Panax ginseng C.A. Meyer extract counteracts the oxidative stress in rats fed multi-mycotoxins-contaminated diet. Comunicata Scientiae, 3(3): 143-153.
48. Mansour, M.A., 2000. Protective effect of thymoquinone and desferrioxamine against hepatotoxicity of carbon tetrachloride in mice. Life Sci., 66: 2583-2591.
49. Moon, E.Y. and S. Pyo, 2000. Aflatoxin B1 inhibits CD14-mediated nitric oxide production in murine peritoneal macrophages. Int. J. Immunopharmacol. 22(3): 237-246.
50. Azeredo-Martins, A.K., S. Lortz, S. Lenzen, R. Curi, D.L. Eizirik and M. Tiedge, 2003. Improvement of the mitochondrial antioxidant defense status prevents cytokine induced nuclear factor-kappa B activation in insulin-producing cells. Diabetes, 52: 93-101.
51. Bartosz, G., 2009. Reactive oxygen species: destroyers or messengers? Biochem. Pharmacol. 77(8): 1303-1315.
52. Rouzer, C.A., A.K. Chaudhary, M. Nokubo, D.M. Ferguson, G.R. Reddy, I.A. Blair and L.J. Marnett, 1997. Analysis of the malondialdehyde-2V-deoxyguanosine adduct pyrimidopurinone in human leukocyte DNA by gas chromatography/electron capture/negative chemical ionization/mass spectrometry. Chem. Res. Toxicol, 10: 181-188.
53. Masson, S., M. Scotte, S. Garnier, A. Francois, P. Teniere, J. Fallu, J. Salier and M. Daveau, 2000. Differential expression of apoptosis-associated genes post-hepatoectomy in cirrhotic vs. normal rats. Apoptosis, 5(2): 173-179.
54. Lee, T.Y., H.H. Chang, G.J. Wang, J.H. Chitu, Y.Y. Yang and H.C. Lin, 2006. Water-soluble extract of Salvia miltiorrhiza ameliorates carbon tetrachloride-mediated hepatic apoptosis in rats. J. Pharm. Pharmacol, 58(5). 659-665.
55. Vanitha, A., K.N. Chidambara, V. Kumar, G. Sakthivelu and J.M. Veigas, 2007. Effect of the carotenoid-producing alga, Dunaliella bardawil, on Ccl4-induced toxicity in rats. Int. J. Toxicol, 26: 159-167.
56. Latt, S.A., J.W. Allen, S.E. Bloom, A. Carrano, E. Flake, D. Kram, E. Schneider, R. Schreck, B. Whitefield and S. Wolf, 1981. Sister chromatid exchanges: a report of Gen-Tox Program. Mutat. Res., 87: 17-62.
57. Louis, H., J.L. Van, W. Wu, E. Quertinmont, C. Degraef and K. Van, 1998. Interleukin-10 controls neutrophilic infiltration, hepatocyte proliferation and liver fibrosis induced by carbon tetrachloride in mice. Hepatol, 28: 1607-1615.
58. Kato, H., 1977. Mechanisms for sister chromatid exchanges and their relation to the production of chromosomal aberrations. Chromosoma, 59: 179-191.
59. Lasne, C., Z.W. Gu, W. Venegas and I. Chouroulinkov, 1984. The in vitro micronucleus assay for detection of cytogenetic effects induced by mutagen carcinogens: Comparison with in vitro sister chromatid exchanges assay. Mutat. Res., 130: 273-282.
60. Song, J.Y., L. Li, J.B. Ahn, J.G. Park, J.S. Jo and D.H. Park, 2007. Acute liver toxicity by carbon tetrachloride in HSP70 knockout mice. Exp. Toxicol. Pathol, 59(1): 29-34.
61. Geerts, A.M., E. Vanheule, M. Praet, H. Van, M. DeVos and I. Colle, 2008. Comparison of three research models of portal hypertension in mice: macroscopic, histological and portal pressure evaluation. Int. J. Exp. Pathol, 89(4): 251-63.
62. Kuriakose, G.C. and G.M. Kurup, 2008. Antioxidant activity of Aulosira fertilisima on CCl4 induced hepatotoxicity in rats. Ind. J. Exp. Biol., 46(1): 52-59.
63. Bilgin, H.M., M. Atmaca, B.D. Obay, S. Oz̈ekinci, E. Tas-demir and A. Ketani, 2011. Protective effects of coumarin and coumarin derivatives against carbon tetrachloride-induced acute hepatotoxicity in rats. Exp. Toxicol. Pathol, 67(4): 569-576.
64. Wang, M.E., Y.C. Chen, I.S. Chen, S.C. Hsieh, S.S. Chen and C.H. Chiu, 2012. Curcumin protects against thioacetamide-induced hepatic fibrosis by attenuating the inflammatory response and inducing apoptosis of damaged hepatocytes. J. Nutr. Biochem. 23(10): 1352-366.
65. Li, J., J. Li, S. Li, B. He, Y. Mi, H. Cao, C. Zhang and L. Li, 2012. Ameliorative effect of grape seed proanthocyanidin extract on thioacetamide-induced mouse hepatic fibrosis. Toxicol. Lett., 213: 353-360.
66. Rice-Evans, C.A. and L. Packer, 1997. Flavonoids in Health and Disease. Marcel Dekker, NY, USA.
67. Kolodziej, H., C. Haberl and, H.J. Woerdenbag and A.W.T. Konings, 1995. Moderate cytotoxicity of proanthocyanidins to human tumor cell lines. Phytoth. Res., 9(6): 410-415.
68. Rice-Evans, C.A., N.J. Miller and G. Paganda, 1996. Structure antioxidant activity relationships of ?avonoids and phenolic acids. Free Rad. Biol. Med. 20(7): 933-956.
69. Caligaris-Cappio, F. and T.J. Hamblin, 1999. B-cell chronic lymphocytic leukemia: a bird of a different feather. J. Clin. Oncol, 17: 399-408.
70. Joshi, S.S., C.A. Kuszynski, M. Bagchi and D. Bagchi, 2000. Chemopreventive effects of grape seed proanthocyanidin extract on Chang liver cells. Toxicology, 155: 83-90.