Bacterial lipopolysaccharide enhances aflatoxin B1 hepatotoxicity in rats by a mechanism that depends on tumor necrosis factor α

Hepatology

Volumn 33, Issue 1, 2001, Pages 66-73

  Barton, C Charles ^a   Barton, Eva X ^a   Ganey, Patricia E ^a   Kunkel, Steven L ^b   Roth, Robert A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AFLATOXIN B1; BACTERIUM LIPOPOLYSACCHARIDE; CYCLOOXYGENASE 2 INHIBITOR; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PENTOXIFYLLINE; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA ANTIBODY;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOSE RESPONSE; DRUG CROSS REACTIVITY; LIVER TOXICITY; MALE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; RAT; TRANSCRIPTION REGULATION;

EID: 0035192751     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1053/jhep.2001.20643     Document Type: Article

References (66)

1. Aflatoxins in domestic and imported foods and feeds
2. Molecular dosimetry of urinary aflatoxin-DNA adducts in people living in Guangxi Autonomous Region, People's Republic of China
3. Outbreak of acute hepatitis caused by aflatoxin poisoning in Kenya
4. Investigations into an outbreak of hepatitis in parts of western India
5. Aflatoxin-induced fatal hepatitis? A case report from Uganda
6. An outbreak of aflatoxicosis and boric acid poisoning in Malaysia: A clinicopathological study
7. Endotoxin-induced organ injury
8. 2 shows stable interindividual differences
9. Hepatic find extrahepatic pathobiology of bacterial lipopolysaccharides
10. Thrombin is a distal mediator of lipopolysaccharide-induced liver injury in the rat
11. The thrombin inhibitor, hirudin, attenuates lipopolysaccharide-induced liver injury in the rat
12. Is exposure to bacterial endotoxin a determinant of susceptibility to intoxication from xenobiotic agents?
13. 1-induced liver injury
14. 1-induced liver injury through neutrophil-dependent and independent mechanisms
15. Immunohistochemical demonstration of cytoplasmic and membrane-associated tumor necrosis factor in murine machrophages
16. Effects of inhibitors of the activity of cyclo-oxygenase-2 on the hypotension and multiple organ dysfunction caused by endotoxin: A comparison with dexamethasone
17. Bacterial lipopolysaccharide-mediated fetal death. Production of a newly recognized form of inducible cyclooxygenase (COX-2) in murine decidua in response to lipopolysaccharide
18. Pentoxifylline inhibits lipopolysaccharide-induced serum tumor necrosis factor and mortality
19. Leukocyte alterations do not account for hepatitis induced by endotoxin or TNF-α in galactosamine-sensitized mice
20. Tumor necrosis factor is a terminal mediator in galactosamine/endotoxin-induced hepatitis in mice
21. Dexamethasone and pentoxifylline inhibit endotoxin-induced cachectin/tumor necrosis factor synthesis at separate points in the signaling pathway
22. Pentoxifylline suppression of tumor necrosis factor gene transcription
23. In vivo biologic and immunohistochemical analysis of interleukin-1 alpha, beta and tumor necrosis factor during experimental endotoxemia. Kinetics, Kupffer cell expression, and glucocorticoid effects
24. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro
25. Selective inhibition of cyclooxygenase-2 by NS-398 in endotoxin shock rats in vivo
26. Serum glutamic-pyruvic transaminase in cardiac hepatic disease
27. A note on the spectrophotometric assay of glutamic-oxalacetic transaminase in human blood
28. New substrates for measuring gamma-glutamyl-transpeptidase activity
29. A kinetic method for serum 5′-nucleotidase using stabilised glutamate dehydrogenase
30. A continuous spectrophotometric method for measuring the activity of serum alkaline phosphatase
31. Direct spectrophotometry of total bile acids in serum
32. An enhancement method for immunohistochemical staining of proliferating cell nuclear antigen in archival rodent tissues
33. Platelet participation in liver injury from gram-negative bacterial lipopolysaccharide in the rat
34. Neutrophil depletion protects against liver injury from bacterial endotoxin
35. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-α, and lipopolysaccharide
36. Role of hepatocellular regeneration and hepatolobular healing in the final outcome of liver injury
37. Toxicant-inflicted injury and stimulated tissue repair are opposing toxicodynamic forces in predictive toxicology
38. Biologically active products of stimulated liver macrophages (Kupffer cells)
39. Tumor necrosis factor-alpha-induced apoptosis in hepatocytes in long-term culture
40. Tumor necrosis factor can induce both apoptic and necrotic forms of cell lysis
41. Molecular, structural, and biological characteristics of the tumor necrosis factor ligand superfamily
42. Membrane form of TNF alpha induces both cell lysis and apoptosis in susceptible target cells
43. Tumor necrosis factors: Developments during the last decade
44. Tumor necrosis factor receptors - Structure and function
45. Enhancement by galactosamine of lipopolysaccharide (LPS)-induced tumour necrosis factor production and lethality: Its suppression by LPS pretreatment
46. Lead enhances lipopolysaccharide and tumor necrosis factor liver injury
47. Acute hepatotoxicant exposure induces TNFR-mediated hepatic injury and cytokine/apoptotic gene expression
48. Inhibition of acute TCDD toxicity by treatment with anti-tumor necrosis factor antibody or dexamethasone
49. Concanavalin A-induced T-cell-mediated hepatic injury in mice: The role of tumor necrosis factor
50. Role of tumor necrosis factor-alpha in cadmium-induced hepatotoxicity
51. Expression of tumor necrosis factor-alpha and transforming growth factor-beta 1 in acute liver injury
52. Dimethylnitrosamine (DMN)-induced IL-1 beta, TNF-alpha, and IL-6 inflammatory cytokine expression
53. Prostaglandin endoperoxide synthase: Regulation of enzyme expression
54. Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing
55. Differential regulation of inducible and constitutive prostaglandin endoperoxide synthase in osteoblastic MC3T3-E1 cells
56. COX-1 and COX-2 tissue expression: Implications and predictions
57. TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue
58. The regulation and role of TIS10 prostaglandin synthase-2
59. Stimulation of the adherence of neutrophils to umbilical vein endothelium by human recombinant tumor necrosis factor
60. Stimulation of neutrophils by tumor necrosis factor
61. Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor
62. Tumor necrosis factor induced oxidative stress in isolated mouse hepatocytes
63. Transforming growth factor beta and tumor necrosis factor alpha inhibit both apoptosis and proliferation of activated rat hepatic stellate cells
64. Cytostatic effect of TNFalpha on cancer cells is independent of p21WAF1
65. Tumor necrosis factor primes hepatocytes for DNA replication in the rat