Scube regulates synovial angiogenesis-related signaling

Medical Hypotheses

Volumn 81, Issue 5, 2013, Pages 948-953

  Yang, Min ^a,b   Guo, Mingyang ^a   Hu, Yonghe ^a   Jiang, Yong ^b  

^a General Hospital of PLA Chengdu Military Area Command   (China)

^b SOUTHERN MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BONE MORPHOGENETIC PROTEIN 2; COMPLEMENT COMPONENT C1R; COMPLEMENT COMPONENT C1S; EPIDERMAL GROWTH FACTOR; GLYCOPROTEIN; MEMBRANE PROTEIN; PROCOLLAGEN C PROTEINASE; PROTEIN; PROTEIN DISPATCHED A; PROTEIN SCUBE1; PROTEIN SCUBE2; PROTEIN SCUBE3; PROTEIN UEGF; SIGNAL PEPTIDE; SMAD1 PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD5 PROTEIN; SMAD8 PROTEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; ANGIOGENESIS; ARTICLE; GENE EXPRESSION; HUMAN; HYPOXIA; IN VIVO STUDY; INFLAMMATION; NONHUMAN; PATHOGENESIS; PHYSICAL CHEMISTRY; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION; PROTEIN STRUCTURE; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SOLUBILITY; SYNOVIUM; UPREGULATION;

ERINACEIDAE;

ARTHRITIS, RHEUMATOID; BONE MORPHOGENETIC PROTEIN 2; CALCIUM-BINDING PROTEINS; HEDGEHOG PROTEINS; HUMANS; MEMBRANE PROTEINS; MODELS, MOLECULAR; NEOVASCULARIZATION, PHYSIOLOGIC; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SYNOVIAL FLUID; TRANSFORMING GROWTH FACTOR BETA;

EID: 84886770722     PISSN: 03069877     EISSN: 15322777     Source Type: Journal    
DOI: 10.1016/j.mehy.2013.09.001     Document Type: Article

References (36)

1. Semerano L., Clavel G., Assier E., Denys A., Boissier M.-C. Blood vessels, a potential therapeutic target in rheumatoid arthritis?. Joint Bone Spine 2011, 78(2):118-123.
2. Ashraf S., Mapp P.I. Angiogenesis and the persistence of inflammation in a rat model of proliferative synovitis. Arthritis Rheum 2010, 62(7):1890-1898.
3. Yang R.-B., Ng C.K.D., Wasserman S.M., Colman S.D., Shenoy S., Mehraban F., et al. Identification of a novel family of cell-surface proteins expressed in human vascular endothelium. J Biol Chem 2002, 277(48):46364-46373.
4. Tsai M.T., Cheng C.J., Lin Y.C., Chen C.C., Wu A.R., Wu M.T., et al. Isolation and characterization of a secreted, cell-surface glycoprotein SCUBE2 from humans. Biochem J 2009, 422(1):119-128.
5. Wu B.T., Su Y.H., Tsai M.T., Wasserman S.M., Topper J.N., Yang R.B. A novel secreted, cell-surface glycoprotein containing multiple epidermal growth factor-like repeats and one CUB domain is highly expressed in primary osteoblasts and bones. J Biol Chem 2004, 279(36):37485-37490.
6. Zhuang J., Deane J.A., Yang R.-B., Li J., Ricardo S.D. SCUBE1, a novel developmental gene involved in renal regeneration and repair. Nephrol Dial Transplant 2010, 25(5):1421-1428.
7. Dai D.-F., Thajeb P., Tu C.-F., Chiang F.-T., Chen C.-H., Yang R.-B., et al. Plasma concentration of SCUBE1, a novel platelet protein, is elevated in patients with acute coronary syndrome and ischemic stroke. J Am Coll Cardiol 2008, 51(22):2173-2180.
8. Johnson J.L., Hall T.E., Dyson J.M., Sonntag C., Ayers K., Berger S., et al. Scube activity is necessary for Hedgehog signal transduction in vivo. Dev Biol 2012, 368(2):193-202.
9. Tukachinsky H., Kuzmickas R.P., Jao C.Y., Liu J., Salic A. Dispatched and scube mediate the efficient secretion of the cholesterol-modified hedgehog ligand. Cell Rep 2012, 2(2):308-320.
10. Creanga A., Glenn T.D., Mann R.K., Saunders A.M., Talbot W.S., Beachy P.A. Scube/you activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev 2012, 26(12):1312-1325.
11. Matz-Soja M., Hovhannisyan A., Gebhardt R. Hedgehog signalling pathway in adult liver: a major new player in hepatocyte metabolism and zonation?. Med Hypotheses 2013, 80(5):589-594.
12. Tu C.F., Yan Y.T., Wu S.Y., Djoko B., Tsai M.T., Cheng C.J., et al. Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J Biol Chem 2008, 283(18):12478-12488.
13. Lin Y.C., Chen C.C., Cheng C.J., Yang R.B. Domain and functional analysis of a novel breast tumor suppressor protein, SCUBE2. J Biol Chem 2011, 286(30):27039-27047.
14. Wu Y.Y., Peck K., Chang Y.L., Pan S.H., Cheng Y.F., Lin J.C., et al. SCUBE3 is an endogenous TGF-beta receptor ligand and regulates the epithelial-mesenchymal transition in lung cancer. Oncogene 2011, 30(34):3682-3693.
15. Tu C.-F., Su Y.-H., Huang Y.-N., Tsai M.-T., Li L.-T., Chen Y.-L., et al. Localization and characterization of a novel secreted protein SCUBE1 in human platelets. Cardiovasc Res 2006, 71(3):486-495.
16. Grimmond S., Larder R., Van Hateren N., Siggers P., Hulsebos T.J.M., Arkell R., et al. Cloning, mapping, and expression analysis of a gene encoding a novel mammalian EGF-related protein (SCUBE1). Genomics 2000, 70(1):74-81.
17. Grimmond S., Larder R., Van Hateren N., Siggers P., Morse S., Hacker T., et al. Expression of a novel mammalian epidermal growth factor-related gene during mouse neural development. Mech Dev 2001, 102(1-2):209-211.
18. Barton A., Thomson W., Ke X., Eyre S., Hinks A., Bowes J., et al. Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13. Nat Genet 2008, 40(10):1156-1159.
19. Xavier G.M., Cobourne M.T. Scube2 expression extends beyond the central nervous system during mouse development. J Mol Histol 2011, 42(5):383-391.
20. Van Seuningen I., Pigny P., Perrais M., Porchet N., Aubert J.P. Transcriptional regulation of the 11p15 mucin genes. Towards new biological tools in human therapy, in inflammatory diseases and cancer?. Front Biosci 2001, 6:D1216-D1234.
21. Watson G., See C.G., Woo P. Use of somatic cell hybrids and fluorescence in situ hybridization to localize the functional serum amyloid A (SAA) genes to chromosome 11p15.4-p15.1 and the entire SAA superfamily to chromosome 11p15. Genomics 1994, 23(3):694-696.
22. Vignal C., Bansal A.T., Balding D.J., Binks M.H., Dickson M.C., Montgomery D.S., et al. Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci. Arthritis Rheum 2009, 60(1):53-62.
23. Liu H., Ong S.E., Badu-Nkansah K., Schindler J., White F.M., Hynes R.O. CUB-domain-containing protein 1 (CDCP1) activates Src to promote melanoma metastasis. Proc Natl Acad Sci USA 2011, 108(4):1379-1384.
24. Franklin W., Will P. SCUBE1 solve the ischemia marker deficit?. J Am Coll Cardiol 2008, 51(22):2181-2183.
25. Verschueren P.C., Lories R.J., Daans M., Theate I., Durez P., Westhovens R., et al. Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis. Ann Rheum Dis 2009, 68(1):117-123.
26. ten Dijke P., Arthur H.M. Extracellular control of TGFbeta signalling in vascular development and disease. Nat Rev Mol Cell Biol 2007, 8(11):857-869.
27. Soltanoff C.S., Yang S., Chen W., Li Y.P. Signaling networks that control the lineage commitment and differentiation of bone cells. Crit Rev Eukaryot Gene Expr 2009, 19(1):1-46.
28. Konisti S., Kiriakidis S., Paleolog E.M. Hypoxia-a key regulator of angiogenesis and inflammation in rheumatoid arthritis. Nat Rev Rheumatol 2012, 8(3):153-162.
29. Tseng W.P., Yang S.N., Lai C.H., Tang C.H. Hypoxia induces BMP-2 expression via ILK, Akt, mTOR, and HIF-1 pathways in osteoblasts. J Cell Physiol 2010, 223(3):810-818.
30. Bijlsma M.F., Groot A.P., Oduro J.P., Franken R.J., Schoenmakers S.H., Peppelenbosch M.P., et al. Hypoxia induces a hedgehog response mediated by HIF-1alpha. J Cell Mol Med 2009, 13(8B):2053-2060.
31. Qiu H., Yang B., Pei Z.C., Zhang Z., Ding K. WSS25 inhibits growth of xenografted hepatocellular cancer cells in nude mice by disrupting angiogenesis via blocking bone morphogenetic protein (BMP)/Smad/Id1 signaling. J Biol Chem 2010, 285(42):32638-32646.
32. Goumans M.J., Liu Z., ten Dijke P. TGF-beta signaling in vascular biology and dysfunction. Cell Res 2009, 19(1):116-127.
33. Maurya A.K., Tan H., Souren M., Wang X., Wittbrodt J., Ingham P.W. Integration of Hedgehog and BMP signalling by the engrailed2a gene in the zebrafish myotome. Development 2011, 138(4):755-765.
34. Hwang S., Thangapandian S., Lee Y., Sakkiah S., John S., Lee K.W. Discovery and evaluation of potential sonic hedgehog signaling pathway inhibitors using pharmacophore modeling and molecular dynamics simulations. J Bioinform Comput Biol 2011, 9(Suppl. 1):15-35.
35. Javelaud D., Pierrat M.J., Mauviel A. Crosstalk between TGF-beta and hedgehog signaling in cancer. FEBS Lett 2012, 586(14):2016-2025.
36. Hollway G.E., Maule J., Gautier P., Evans T.M., Keenan D.G., Lohs C., et al. Scube2 mediates Hedgehog signalling in the zebrafish embryo. Dev Biol 2006, 294(1):104-118.