CUB-domain - Containing protein 1 (CDCP1) activates Src to promote melanoma metastasis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 4, 2011, Pages 1379-1384

  Liu, Hui ^a   Ong, Shao En ^c   Badu Nkansah, Kwabena ^a   Schindler, Jeffrey ^a   White, Forest M ^a,b   Hynes, Richard O ^a  

^a MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^b Massachusetts Institute of Technology Cambridge   (United States)

^c BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINO 7 TERT BUTYL 5 (4 CHLOROPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; CUB DOMAIN CONTAINING PROTEIN 1; DASATINIB; MEMBRANE PROTEIN; PROTEIN TYROSINE KINASE; UNCLASSIFIED DRUG;

ARTICLE; CELL ADHESION; DRUG MECHANISM; ENZYME ACTIVATION; EXTRACELLULAR MATRIX; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MASS SPECTROMETRY; MELANOMA CELL; METASTASIS; MUTATIONAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; TANDEM MASS SPECTROMETRY; TUMOR GROWTH; UPREGULATION;

ANIMALS; ANTIGENS, CD; BLOTTING, WESTERN; CELL ADHESION; CELL ADHESION MOLECULES; CELL LINE, TUMOR; CELL MEMBRANE; CELL MOVEMENT; CELL PROLIFERATION; ENZYME ACTIVATION; FLUORESCENT ANTIBODY TECHNIQUE; HEK293 CELLS; HUMANS; LUNG NEOPLASMS; MELANOMA; MELANOMA, EXPERIMENTAL; MICE; MICE, INBRED NOD; MICE, SCID; MUTATION; NEOPLASM PROTEINS; PYRIMIDINES; SRC-FAMILY KINASES; TANDEM MASS SPECTROMETRY; THIAZOLES; TRANSPLANTATION, HETEROLOGOUS;

EID: 79952147398     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1017228108     Document Type: Article

References (49)

1. Gupta GP, Massagué J (2006) Cancer metastasis: Building a framework. Cell 127:679-695. (Pubitemid 44781029)
2. Hynes RO (2003) Metastatic potential: Generic predisposition of the primary tumor or rare, metastatic variants-or both? Cell 113:821-823.
3. Nguyen DX, Bos PD, Massagué J (2009) Metastasis: From dissemination to organ-specific colonization. Nat Rev Cancer 9:274-284.
4. Weiss L (2000) Metastasis of cancer: A conceptual history from antiquity to the 1990s. Cancer Metastasis Rev 19:I-XI, 193-383.
5. Bissell MJ, Radisky D (2001) Putting tumours in context. Nat Rev Cancer 1:46-54. (Pubitemid 33741880)
6. Condeelis J, Pollard JW (2006) Macrophages: Obligate partners for tumor cell migration, invasion, and metastasis. Cell 124:263-266. (Pubitemid 43121975)
7. Joyce JA, Pollard JW (2009) Microenvironmental regulation of metastasis. Nat Rev Cancer 9:239-252.
8. Clark EA, Golub TR, Lander ES, Hynes RO (2000) Genomic analysis of metastasis reveals an essential role for RhoC. Nature 406:532-535. (Pubitemid 30625739)
9. Kang Y, et al. (2003) A multigenic program mediating breast cancer metastasis to bone. Cancer Cell 3:537-549. (Pubitemid 36808649)
10. Müller A, et al. (2001) Involvement of chemokine receptors in breast cancer metastasis. Nature 410:50-56. (Pubitemid 32225831)
11. Yang J, et al. (2004) Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis. Cell 117:927-939. (Pubitemid 38798858)
12. Dong JT, et al. (1995) KAI1, a metastasis suppressor gene for prostate cancer on human chromosome 11p11.2. Science 268:884-886.
13. Wong SY, et al. (2007) Protein 4.1B suppresses prostate cancer progression and metastasis. Proc Natl Acad Sci USA 104:12784-12789. (Pubitemid 47255232)
14. Xu L, Begum S, Hearn JD, Hynes RO (2006) GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci USA 103:9023-9028. (Pubitemid 43902526)
15. Bandyopadhyay S, et al. (2006) Interaction of KAI1 on tumor cells with DARC on vascular endothelium leads to metastasis suppression. Nat Med 12:933-938. (Pubitemid 44175145)
16. Visvader JE, Lindeman GJ (2008) Cancer stem cells in solid tumours: Accumulating evidence and unresolved questions. Nat Rev Cancer 8:755-768.
17. Vaught D, Brantley-Sieders DM, Chen J (2008) Eph receptors in breast cancer: Roles in tumor promotion and tumor suppression. Breast Cancer Res 10:217.
18. Felding-Habermann B, et al. (2001) Integrin activation controls metastasis in human breast cancer. Proc Natl Acad Sci USA 98:1853-1858. (Pubitemid 32165587)
19. Li X, et al. (2001) Integrin alphavbeta3 mediates K1735 murine melanoma cell motility in vivo and in vitro. J Cell Sci 114:2665-2672. (Pubitemid 32734414)
20. Pécheur I, et al. (2002) Integrin alpha(v)beta3 expression confers on tumor cells a greater propensity to metastasize to bone. FASEB J 16:1266-1268.
21. Hill A, McFarlane S, Johnston PG, Waugh DJ (2006) The emerging role of CD44 in regulating skeletal micrometastasis. Cancer Lett 237:1-9.
22. Kozyraki R, et al. (1999) The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein. Nat Med 5:656-661. (Pubitemid 29289429)
23. Tu CF, et al. (2008) Domain and functional analysis of a novel platelet-endothelial cell surface protein, SCUBE1. J Biol Chem 283:12478-12488.
24. Töpfer-Petersen E, Ekhlasi-Hundrieser M, Tsolova M (2008) Glycobiology of fertilization in the pig. Int J Dev Biol 52:717-736.
25. Perry SE, et al. (2007) Expression of the CUB domain containing protein 1 (CDCP1) gene in colorectal tumour cells. FEBS Lett 581:1137-1142. (Pubitemid 46385936)
26. Scherl-Mostageer M, et al. (2001) Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 20:4402-4408. (Pubitemid 32726882)
27. Hooper JD, et al. (2003) Subtractive immunization using highly metastatic human tumor cells identifies SIMA135/CDCP1, a 135 kDa cell surface phosphorylated glycoprotein antigen. Oncogene 22:1783-1794. (Pubitemid 36513138)
28. Brown TA, et al. (2004) Adhesion or plasmin regulates tyrosine phosphorylation of a novel membrane glycoprotein p80/gp140/CUB domain-containing protein 1 in epithelia. J Biol Chem 279:14772-14783. (Pubitemid 38618866)
29. Bhatt AS, Erdjument-Bromage H, Tempst P, Craik CS, Moasser MM (2005) Adhesion signaling by a novel mitotic substrate of src kinases. Oncogene 24:5333-5343. (Pubitemid 43080103)
30. Xia Y, Gil SG, Carter WG (1996) Anchorage mediated by integrin alpha6beta4 to laminin 5 (epiligrin) regulates tyrosine phosphorylation of a membrane-associated 80-kD protein. J Cell Biol 132:727-740. (Pubitemid 26069250)
31. Bühring HJ, et al. (2004) CDCP1 identifies a broad spectrum of normal and malignant stem/progenitor cell subsets of hematopoietic and nonhematopoietic origin. Stem Cells 22:334-343.
32. Conze T, et al. (2003) CDCP1 is a novel marker for hematopoietic stem cells. Ann N Y Acad Sci 996:222-226. (Pubitemid 36706603)
33. Awakura Y, et al. (2008) Microarray-based identification of CUB-domain containing protein 1 as a potential prognostic marker in conventional renal cell carcinoma. J Cancer Res Clin Oncol 134:1363-1369.
34. Ikeda J, et al. (2009) Expression of CUB domain containing protein (CDCP1) is correlated with prognosis and survival of patients with adenocarcinoma of lung. Cancer Sci 100:429-433.
35. Benes CH, et al. (2005) The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell 121:271-280.
36. Uekita T, et al. (2007) CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol 27:7649-7660. (Pubitemid 350033670)
37. Uekita T, et al. (2008) CUB-domain-containing protein 1 regulates peritoneal dissemination of gastric scirrhous carcinoma. Am J Pathol 172:1729-1739. (Pubitemid 351793363)
38. Deryugina EI, et al. (2009) Functional role of cell surface CUB domain-containing protein 1 in tumor cell dissemination. Mol Cancer Res 7:1197-1211.
39. Spassov DS, Baehner FL, Wong CH, McDonough S, Moasser MM (2009) The transmembrane src substrate Trask is an epithelial protein that signals during anchorage deprivation. Am J Pathol 174:1756-1765.
40. Tzukert K, et al. (2008) A novel dynamic matrix detachment model reveals a shift from apoptosis to necrosis in melanoma cells. Cancer Lett 272:345-354.
41. Zhang Y, Lu H, Dazin P, Kapila Y (2004) Squamous cell carcinoma cell aggregates escape suspension-induced, p53-mediated anoikis: Fibronectin and integrin alphav mediate survival signals through focal adhesion kinase. J Biol Chem 279:48342-48349. (Pubitemid 39540990)
42. Shimony N, et al. (2008) A 3D rotary renal and mesenchymal stem cell culture model unveils cell death mechanisms induced by matrix deficiency and low shear stress. Nephrol Dial Transplant 23:2071-2080. (Pubitemid 351768177)
43. Ishizawar R, Parsons SJ (2004) c-Src and cooperating partners in human cancer. Cancer Cell 6:209-214. (Pubitemid 39222033)
44. Summy JM, Gallick GE (2003) Src family kinases in tumor progression and metastasis. Cancer Metastasis Rev 22:337-358. (Pubitemid 36791891)
45. Yeatman TJ (2004) A renaissance for SRC. Nat Rev Cancer 4:470-480.
46. Abram CL, Courtneidge SA (2000) Src family tyrosine kinases and growth factor signaling. Exp Cell Res 254:1-13. (Pubitemid 30066726)
47. Hynes RO (1992) Integrins: Versatility, modulation, and signaling in cell adhesion. Cell 69:11-25.
48. Thomas SM, Brugge JS (1997) Cellular functions regulated by Src family kinases. Annu Rev Cell Dev Biol 13:513-609. (Pubitemid 28034534)
49. Windham TC, et al. (2002) Src activation regulates anoikis in human colon tumor cell lines. Oncogene 21:7797-7807. (Pubitemid 35398837)