Detection, identification and in vivo treatment responsiveness of bone morphogenetic protein (BMP)-activated cell populations in the synovium of patients with rheumatoid arthritis

Annals of the Rheumatic Diseases

Volumn 68, Issue 1, 2009, Pages 117-123

  Verschueren, P C P M ^a   Lories, R J U ^a   Daans, M ^a   Theate I ^c   Durez, P ^b   Westhovens, R ^a   Luyten, F P ^a,d  

^a UNIVERSITY OF LEUVEN   (Belgium)

^b Department of Rheumatology ^*

^c CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^d UNIVERSITY HOSPITALS LEUVEN   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN; CD20 ANTIBODY; CD3 ANTIBODY; CD68 ANTIGEN; DISEASE MODIFYING ANTIRHEUMATIC DRUG; ENDOGLIN; SMAD1 PROTEIN; SMAD5 PROTEIN; SYNDECAN 1; THY 1 ANTIGEN; VON WILLEBRAND FACTOR;

ADULT; AGED; ARTICLE; CELL LINEAGE; CELL TYPE; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; ENDOTHELIUM CELL; FEMALE; FIBROBLAST; HEMATOPOIESIS; HUMAN; IMMUNOHISTOCHEMISTRY; JOINT BIOPSY; LYMPHOCYTE SUBPOPULATION; MALE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DETERMINATION; PROTEIN ISOLATION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; RHEUMATOID ARTHRITIS; SYNOVIUM; TISSUE SECTION; WESTERN BLOTTING;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTIGENS, THY-1; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BIOLOGICAL MARKERS; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; CASE-CONTROL STUDIES; CELLS, CULTURED; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PHOSPHOPROTEINS; PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMAD PROTEINS, RECEPTOR-REGULATED; SMAD1 PROTEIN; SMAD5 PROTEIN; STATISTICS, NONPARAMETRIC; STIMULATION, CHEMICAL; SYNOVIAL MEMBRANE; TREATMENT OUTCOME; VON WILLEBRAND FACTOR;

EID: 58349107039     PISSN: 00034967     EISSN: 14682060     Source Type: Journal    
DOI: 10.1136/ard.2007.080127     Document Type: Article

References (34)

1. Sesin CA, Bingham CO III. Remission in rheumatoid arthritis: wishful thinking or clinical reality? Semin Arthritis Rheum 2005; 35:185-96.
2. Lories RJ, Luyten FP. Bone morphogenetic protein signaling in joint homeostasis and disease. Cytokine Growth Factor Rev 2005; 16:287-98.
3. Luyten FP, Lories RJ, Verschueren P, de Vlam K, Westhovens R. Contemporary concepts of inflammation, damage and repair in rheumatic diseases. Best Pract Res Clin Rheumatol 2006; 20:829-48.
4. Luyten FP. Mesenchymal stem cells in arthritis. In: Panayi G, Firestein G, Wollheim F, eds. Rheumatoid arthritis: frontiers in pathofysiology and treatment. Oxford, UK: Oxford University Press, 2005.
5. Marinova-Mutafchieva L, Taylor P, Funa K, Maini RN, Zvaifler NJ. Mesenchymal cells expressing bone morphogenetic protein receptors are present in the rheumatoid arthritis joint. Arthritis Rheum 2000; 43:2046-55.
6. De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP. Multipotent mesenchymal stem cells from adult human synovial membrane. Arthritis Rheum 2001; 44:1928-42.
7. Jones EA, English A, Henshaw K, Kinsey SE, Markham AF, Emery P, et al. Enumeration and phenotypic characterization of synovial fluid multipotential mesenchymal progenitor cells in inflammatory and degenerative arthritis. Arthritis Rheum 2004; 50:817-27.
8. Ruger B, Giurea A, Wanivenhaus AH, Zehetgruber H, Hollemann D, Yanagida G, et al. Endothelial precursor cells in the synovial tissue of patients with rheumatoid arthritis and osteoarthritis. Arthritis Rheum 2004; 50:2157-66.
9. Giurea A, Ruger BM, Hollemann D, Yanagida G, Kotz R, Fischer MB. STRO-1 + mesenchymal precursor cells located in synovial surface projections of patients with osteoarthritis. Osteoarthritis Cartilage 2006; 14:938-43.
10. Firestein GS. Invasive fibroblast-like synoviocytes in rheumatoid arthritis. Passive responders or transformed aggressors? Arthritis Rheum 1996; 39:1781-90.
11. Marinova-Mutafchieva L, Williams RO. Funa K, Maini FIN, Zvaifler NJ. Inflammation is preceded by tumor necrosis factor-dependent infiltration of mesenchymal cells in experimental arthritis. Arthritis Rheum 2002; 46:507-13.
12. Buckley CD. Why does chronic inflammatory joint disease persist? Clin Med 2003; 3:361-6.
13. Buckley CD, Filer A, Haworth O, Parsonage G, Salmon M. Defining a role for fibroblasts in the persistence of chronic inflammatory joint disease. Ann Rheum Dis 2004; 63(Suppl 2):ii92-5.
14. Parsonage G, Filer AD, Haworth O, Nash GB, Rainger GE, Salmon M, et al. A stromal address code defined by fibroblasts. Trends Immunol 2005; 26:150-6.
15. Corr M, Zvaifler NJ. Mesenchymal precursor cells. Ann Rheum Dis 2002; 61:3-5.
16. Luyten FP. A scientific basis for the biologic regeneration of synovial joints. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1997; 83:167-9.
17. Urist MR. Bone: formation by autoinduction. Science 1965; 150:893-9.
18. Luyten FP, Lories RJ, De Valck D, De Bari C, Dell'Accio F. Bone morphogenetic proteins and the synovial joints. In: Vukicevic S, Sampath KT, eds. Bone morphogenetic proteins: regeneration of bone and beyond. Basel, Switzerland: Birkhäuser Verlag, 2004:187-212.
19. Reddi AH. BMPs: from bone morphogenetic proteins to body morphogenetic proteins. Cytokine Growth Factor Rev 2005; 16:249-50.
20. Ten Dijke P, Korchynskyi O, Valdimarsdottir G, Goumans MJ. Controlling cell fate by bone morphogenetic protein receptors. Mol Cell Endocrinol 2003; 211:105-13.
21. Hartung A, Bitton-Worms K, Rechtman MM, Wenzel V, Boergermann JH, Hassel S, et al. Different routes of bone morphogenic protein (BMP) receptor endocytosis influence BMP signaling. Mol Cell Biol 2006; 26:7791-805.
22. Lories RJ, Derese I, Luyten FP. Modulation of bone morphogenetic protein signaling inhibits the onset and progression of ankylosing enthesitis. J Clin Invest 2005; 115:1571-9.
23. Lories RJ, Daans M, Derese I, Matthys P, Kasran A, Tylzanowski P, et al. Noggin haploinsufficiency differentially affects tissue responses in destructive and remodeling arthritis. Arthritis Rheum 2006; 54:1736-46.
24. Lories RJ, Derese I, Ceuppens JL, Luyten FP. Bone morphogenetic proteins 2 and 6, expressed in arthritic synovium, are regulated by proinflammatory cytokines and differentially modulate fibroblast-like synoviocyte apoptosis. Arthritis Rheum 2003; 48:2807-18.
25. Bramlage CP, Haupl T, Kaps C, Ungethum U, Krenn V, Pruss A, et al. Decrease in expression of bone morphogenetic proteins 4 and 5 in synovial tissue of patients with osteoarthritis and rheumatoid arthritis. Arthritis Res Ther 2006; 8:R58.
26. Durez P, Malghem J, Nzeusseu TA, Depresseux G, Lauwerys BR, Westhovens R, et al. Treatment of early rheumatoid arthritis: a randomized magnetic resonance imaging study comparing the effects of methotrexate alone, methotrexate in combination with infliximab, and methotrexate in combination with intravenous pulse methylprednisolone. Arthritis Rheum 2007; 56:3919-27.
27. Toukap AN, Galant C, Theate I, Maudoux AL, Lories RJ, Houssiau FA, et al. Identification of distinct gene expression profiles in the synovium of patients with systemic lupus erythematosus. Arthritis Rheum 20075; 56:1579-88.
28. Valdimarsdottir G, Goumans MJ, Rosendahl A, Brugman M, Itoh S, Lebrin F, et al. Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells. Circulation 20021; 106:2263-70.
29. Vandenabeele F, De Bari C, Moreels M, Lambrichts I, Dell'Accio F, Lippens PL, et al. Morphological and immunocytochemical characterization of cultured fibroblastlike cells derived from adult human synovial membrane. Arch Histol Cytol 2003; 66:145-53.
30. Carmeliet P. Angiogenesis in health and disease. Nat Med 2003; 9:653-60.
31. Takeda M, Otsuka F, Nakamura K, Inagaki K, Suzuki J, Miura D, et al. Characterization of the bone morphogenetic protein (BMP) system in human pulmonary arterial smooth muscle cells isolated from a sporadic case of primary pulmonary hypertension: roles of BMP type IB receptor (activin receptor-like kinase-6) in the mitotic action. Endocrinology 2004; 145:4344-54.
32. Morse JH, Deng Z, Knowles JA. Genetic aspects of pulmonary arterial hypertension. Ann Med 2001; 33:596-603.
33. McAllister KA, Grogg KM, Johnson DW, Gallione CJ, Baldwin MA, Jackson CE, et al. Endoglin, a TGF-β binding protein of endothelial cells, is the gene for hereditary haemorrhagic telangiectasia type 1. Nat Genet 1994; 8:345-51.
34. Kaiser M, Haag J, Soder S, Bau B, Aigner T. Bone morphogenetic protein and transforming growth factor β inhibitory Smads 6 and 7 are expressed in human adult normal and osteoarthritic cartilage in vivo and are differentially regulated in vitro by interleukin-1 β. Arthritis Rheum 2004; 50:3535-40.