Genetic association of the major histocompatibility complex with rheumatoid arthritis implicates two non-DRB1 loci

Arthritis and Rheumatism

Volumn 60, Issue 1, 2009, Pages 53-62

  Vignal, Charlotte ^a   Bansal, Aruna T ^a   Balding, David J ^b   Binks, Michael H ^a   Dickson, Marion C ^a   Montgomery, Doug S ^a   Wilson, Anthony G ^c  

^a GLAXOSMITHKLINE   (United Kingdom)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOANTIBODY; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; HLA DR ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN; RHEUMATOID FACTOR;

ADULT; ARTHRITIS; ARTICLE; CHROMOSOME 6P; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; FEMALE; GENETIC MARKER; GENETIC SUSCEPTIBILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; MAJOR HISTOCOMPATIBILITY COMPLEX; MALE; PRIORITY JOURNAL; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ARTHRITIS, RHEUMATOID; CASE-CONTROL STUDIES; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HLA-DR ANTIGENS; HUMANS; LINKAGE DISEQUILIBRIUM; LOGISTIC MODELS; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; YOUNG ADULT;

EID: 58249104988     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.24138     Document Type: Article

References (35)

1. Hinks A, Worthington J, Thomson W. The association of PTPN22 with rheumatoid arthritis and juvenile idiopathic arthritis. Rheumatology (Oxford) 2006;45:365-8.
2. Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007;447:661-78.
3. Plenge RM, Seielstad M, Padyukov L, Lee AT, Remmers EF, Ding B, et al. TRAF1-C5 as a risk locus for rheumatoid arthritis - a genomewide study. N Engl J Med 2007;357:1199-209.
4. Gregersen PK, Silver J, Winchester RJ. The shared epitope hypothesis: an approach to understanding the molecular genetics of susceptibility to rheumatoid arthritis. Arthritis Rheum 1987;30:1205-13.
5. Deighton CM, Walker DJ, Griffiths ID, Roberts DF. The contribution of HLA to rheumatoid arthritis. Clin Genet 1989;36:178-82.
6. Van der Helm-van Mil AH, Verpoort KN, Breedveld FC, Huizinga TW, Toes RE, de Vries RR. The HLA-DRB1 shared epitope alleles are primarily a risk factor for anti-cyclic citrullinated peptide antibodies and are not an independent risk factor for development of rheumatoid arthritis. Arthritis Rheum 2006;54:1117-21.
7. Mewar D, Coote A, Moore DJ, Marinou I, Keyworth J, Dickson MC, et al. Independent associations of anti-cyclical citrullinated peptide antibodies and rheumatoid factor with radiographic severity of rheumatoid arthritis. Arthritis Res Ther 2006;8:R128.
8. Newton JL, Harney SM, Timms AE, Sims AM, Rockett K, Darke C, et al. Dissection of class III major histocompatibility complex haplotypes associated with rheumatoid arthritis. Arthritis Rheum 2004;50:2212-9.
9. Kilding R, Iles MM, Timms JM, Worthington J, Wilson AG. Additional genetic susceptibility for rheumatoid arthritis telomeric of the DRB1 locus. Arthritis Rheum 2004;50:763-9.
10. Jawaheer D, Li W, Graham RR, Chen W, Damle A, Xiao X, et al. Dissecting the genetic complexity of the association between human leukocyte antigens and rheumatoid arthritis. Am J Hum Genet 2002;71:585-94.
11. Wilson AG, de Vries N, van de Putte LB, Duff GW. A tumour necrosis factor α polymorphism is not associated with rheumatoid arthritis. Ann Rheum Dis 1995;54:601-3.
12. Hajeer AH, Hutchinson IV. TNF-α gene polymorphism: clinical and biological implications. Microsc Res Tech 2000;50:216-28.
13. Okamoto K, Makino S, Yoshikawa Y, Takaki A, Nagatsuka Y, Ota M, et al. Identification of IκBL as the second major histocompatibility complex-linked susceptibility locus for rheumatoid arthritis. Am J Hum Genet 2003;72:303-12.
14. Tamiya G, Shinya M, Imanishi T, Ikuta T, Makino S, Okamoto K, et al. Whole genome association study of rheumatoid arthritis using 27 039 microsatellites. Hum Mol Genet 2005;14:2305-21.
15. Collado L, Rueda B, Caliz R, Torres B, Garcia A, Nunez-Roldan A, et al. Lack of association between the IκBL promoter polymorphism and rheumatoid arthritis. Arthritis Rheum 2004;50:2032-3.
16. Greetham D, Ellis CD, Mewar D, Fearon U, Ultaigh SN, Veale DJ, et al. Functional characterization of NF-κB inhibitor-like protein 1 (NFκBIL1), a candidate susceptibility gene for rheumatoid arthritis. Hum Mol Genet 2007;16:3027-36.
17. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum 1988;31:315-24.
18. Devlin B, Roeder K. Genomic control for association studies. Biometrics 1999;55:997-1004.
19. Barrett JC, Fry B, Maller J, Daly MJ. Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 2005;21:263-5.
20. Martinez A, Fernandez-Arquero M, Balsa A, Rubio A, Alves H, Pascual-Salcedo D, et al. Primary association of a MICA allele with protection against rheumatoid arthritis. Arthritis Rheum 2001;44:1261-5.
21. Snoek M, van Kooij M, de Groot K, van Vugt H. The mouse p52 subunit of the transcription/DNA repair factor TFIIH is not located in the class III region of the H2 complex, but resides next to a G7a/Bat6 homologue in the telomeric part of the major histocompatibility complex. Immunogenetics 2000;51:164-7.
22. Bonnefond L, Fender A, Rudinger-Thirion J, Giege R, Florentz C, Sissler M. Toward the full set of human mitochondrial aminoacyl-tRNA synthetases: characterization of AspRS and TyrRS. Biochemistry 2005;44:4805-16.
23. Hsieh SL, Campbell RD. Evidence that gene G7a in the human major histocompatibility complex encodes valyl-tRNA synthetase. Biochem J 1991;278(Pt 3):809-16.
24. Val recognition by valyl-tRNA synthetase. RNA 2003;9:100-11.
25. Park SG, Ewalt KL, Kim S. Functional expansion of aminoacyl-tRNA synthetases and their interacting factors: new perspectives on housekeepers. Trends Biochem Sci 2005;30:569-74.
26. Ibrahim SM, Koczan D, Thiesen HJ. Gene-expression profile of collagen-induced arthritis. J Autoimmun 2002;18:159-67.
27. Yen JH, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, et al. Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med 2001;193:1159-67.
28. Zanelli E, Breedveld FC, de Vries RR. HLA class II association with rheumatoid arthritis: facts and interpretations. Hum Immunol 2000;61:1254-61.
29. Zanelli E, Krco CJ, Baisch JM, Cheng S, David CS. Immune response of HLA-DQ8 transgenic mice to peptides from the third hypervariable region of HLA-DRB1 correlates with predisposition to rheumatoid arthritis. Proc Natl Acad Sci U S A 1996;93:1814-9.
30. Snijders A, Elferink DG, Geluk A, van der Zanden AL, Vos K, Schreuder GM, et al. An HLA-DRB1-derived peptide associated with protection against rheumatoid arthritis is naturally processed by human APCs. J Immunol 2001;166:4987-93.
31. Zanelli E, Huizinga TW, Guerne PA, Vischer TL, Tiercy JM, Verduyn W, et al. An extended HLA-DQ-DR haplotype rather than DRB1 alone contributes to RA predisposition. Immunogenetics 1998;48:394-401.
32. De Vries N, van Elderen C, Tijssen H, van Riel PL, van de Putte LB. No support for HLA-DQ encoded susceptibility in rheumatoid arthritis. Arthritis Rheum 1999;42:1621-7.
33. Verpoort KN, van Gaalen FA, van der Helm-van Mil AH, Schreuder GM, Breedveld FC, Huizinga TW, et al. Association of HLA-DR3 with anti-cyclic citrullinated peptide antibody-negative rheumatoid arthritis. Arthritis Rheum 2005;52:3058-62.
34. Irigoyen P, Lee AT, Wener MH, Li W, Kern M, Batliwalla F, et al. Regulation of anti-cyclic citrullinated peptide antibodies in rheumatoid arthritis: contrasting effects of HLA-DR3 and the shared epitope alleles. Arthritis Rheum 2005;52:3813-8.
35. Lee H, Li W, Lee AT, Batliwalla F, Wolfe F, Plenge RM, et al. Fine mapping across the MHC with 2,095 SNPs identifies at least 2 regions of susceptibility independent of the DRB1 locus [abstract]. Arthritis Rheum 2007;56 Suppl 9:S539.