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Volumn 8, Issue 4, 2009, Pages 821-833

Dual silencing of insulin-like growth factor-I receptor and epidermal growth factor receptor in colorectal cancer cells is associated with decreased proliferation and enhanced apoptosis

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 7; EPIDERMAL GROWTH FACTOR RECEPTOR; ERLOTINIB; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; NVP AEW 541; PROTEIN KINASE B; SMALL INTERFERING RNA; SOMATOMEDIN C RECEPTOR; EGFR PROTEIN, HUMAN; MESSENGER RNA; PHOSPHOTRANSFERASE; SPHINGOSINE KINASE;

EID: 66449091211     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-09-0058     Document Type: Article
Times cited : (62)

References (63)
  • 1
    • 0034734896 scopus 로고    scopus 로고
    • ABC of colorectal cancer: Epidemiology
    • Boyle P, Langman JS. ABC of colorectal cancer: epidemiology. BMJ 2000;321:805-808
    • (2000) BMJ , vol.321 , pp. 805-808
    • Boyle, P.1    Langman, J.S.2
  • 2
    • 0033616484 scopus 로고    scopus 로고
    • Colorectal cancer
    • DOI 10.1016/S0140-6736(98)07127-X
    • Midgley R, Kerr D. Colorectal cancer. Lancet 1999;353:391-399 (Pubitemid 29088178)
    • (1999) Lancet , vol.353 , Issue.9150 , pp. 391-399
    • Midgley, R.1    Kerr, D.2
  • 3
    • 0038637045 scopus 로고    scopus 로고
    • Epidemiology, treatment and chemoprevention in colorectal cancer
    • Rougier P, Mitry E. Epidemiology, treatment and chemoprevention in colorectal cancer. Ann Oncol 2003;14 Suppl 2:ii3-5. (Pubitemid 36874131)
    • (2003) Annals of Oncology , vol.14 , Issue.SUPPL. 2
    • Rougier, P.1    Mitry, E.2
  • 4
    • 0036094194 scopus 로고    scopus 로고
    • Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts
    • Prewett MC, Hooper AT, Bassi R, Ellis LM, Waksal HW, Hicklin DJ. Enhanced antitumor activity of anti-epidermal growth factor receptor monoclonal antibody IMC-C225 in combination with irinotecan (CPT-11) against human colorectal tumor xenografts. Clin Cancer Res 2002;8:994-1003. (Pubitemid 34517632)
    • (2002) Clinical Cancer Research , vol.8 , Issue.5 , pp. 994-1003
    • Prewett, M.C.1    Hooper, A.T.2    Bassi, R.3    Ellis, L.M.4    Waksal, H.W.5    Hicklin, D.J.6
  • 8
    • 0037110602 scopus 로고    scopus 로고
    • Overexpression of the insulin-like growth factor I receptor in human colon carcinomas
    • DOI 10.1002/cncr.10945
    • Weber MM, Fottner C, Liu SB, Jung MC, Engelhardt D, Baretton GB. Overexpression of the insulin-like growth factor I receptor in human colon carcinomas. Cancer 2002;95:2086-2095 (Pubitemid 35253369)
    • (2002) Cancer , vol.95 , Issue.10 , pp. 2086-2095
    • Weber, M.M.1    Fottner, C.2    Liu, S.B.3    Jung, M.C.4    Engelhardt, D.5    Baretton, G.B.6
  • 10
    • 0026504138 scopus 로고
    • Characterization of insulin-like growth factor I receptors in human colon cancer
    • Guo YS, Narayan S, Yallampalli C, Singh P. Characterization of insulin-like growth factor I receptors in human colon cancer. Gastroenterology 1992;102:1101-1108
    • (1992) Gastroenterology , vol.102 , pp. 1101-1108
    • Guo, Y.S.1    Narayan, S.2    Yallampalli, C.3    Singh, P.4
  • 12
    • 41249093600 scopus 로고    scopus 로고
    • Role of insulin-like growth factor-1R system in colorectal carcinogenesis
    • Donovan EA, Kummar S. Role of insulin-like growth factor-1R system in colorectal carcinogenesis. Crit Rev Oncol Hematol 2008;66:91-98
    • (2008) Crit Rev Oncol Hematol , vol.66 , pp. 91-98
    • Donovan, E.A.1    Kummar, S.2
  • 13
    • 0036173548 scopus 로고    scopus 로고
    • Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis
    • Wu Y, Yakar S, Zhao L, Hennighausen L, LeRoith D. Circulating insulin-like growth factor-I levels regulate colon cancer growth and metastasis. Cancer Res 2002;62:1030-1035 (Pubitemid 34160283)
    • (2002) Cancer Research , vol.62 , Issue.4 , pp. 1030-1035
    • Wu, Y.1    Yakar, S.2    Zhao, L.3    Hennighausen, L.4    Leroith, D.5
  • 14
    • 33846874575 scopus 로고    scopus 로고
    • The role of the IGF system in cancer growth and metastasis: Overview and recent insights
    • DOI 10.1210/er.2006-0001
    • Samani AA, Yakar S, LeRoith D, Brodt P. The role of the IGF system in cancer growth and metastasis: overview and recent insights. Endocr Rev 2007;28:20-47. (Pubitemid 46220849)
    • (2007) Endocrine Reviews , vol.28 , Issue.1 , pp. 20-47
    • Samani, A.A.1    Yakar, S.2    Leroith, D.3    Brodt, P.4
  • 15
    • 35148837581 scopus 로고    scopus 로고
    • Mechanisms of Disease: Signaling of the insulin-like growth factor 1 receptor pathway - Therapeutic perspectives in cancer
    • DOI 10.1038/ncponc0934, PII NCPONC0934
    • Tao Y, Pinzi V, Bourhis J, Deutsch E. Mechanisms of disease: signaling of the insulin-like growth factor 1 receptor pathway - therapeutic perspectives in cancer. Nat Clin Pract Oncol 2007;4:591-602. (Pubitemid 47534758)
    • (2007) Nature Clinical Practice Oncology , vol.4 , Issue.10 , pp. 591-602
    • Tao, Y.1    Pinzi, V.2    Bourhis, J.3    Deutsch, E.4
  • 16
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • DOI 10.1074/jbc.M203781200
    • Fukuda R, Hirota K, Fan F, Jung YD, Ellis LM, Semenza GL. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002;277:38205-38211 (Pubitemid 35154674)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.41 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 17
    • 0037300604 scopus 로고    scopus 로고
    • The IGFI receptor gene: A molecular target for disrupted transcription factors
    • Werner H, Roberts CT, Jr. The IGFI receptor gene: a molecular target for disrupted transcription factors. Genes Chromosomes Cancer 2003;36:113-120
    • (2003) Genes Chromosomes Cancer , vol.36 , pp. 113-120
    • Werner, H.1    Roberts Jr., C.T.2
  • 18
    • 0028957113 scopus 로고
    • Molecular and cellular aspects of the insulin-like growth factor I receptor
    • LeRoith D, Werner H, Beitner-Johnson D, Roberts CT, Jr. Molecular and cellular aspects of the insulin-like growth factor I receptor. Endocr Rev 1995;16:143-163
    • (1995) Endocr Rev , vol.16 , pp. 143-163
    • LeRoith, D.1    Werner, H.2    Beitner-Johnson, D.3    Roberts Jr., C.T.4
  • 19
    • 0026336492 scopus 로고
    • The proto-oncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism
    • Reiss K, Ferber A, Travali S, Porcu P, Phillips PD, Baserga R. The proto-oncogene c-myb increases the expression of insulin-like growth factor 1 and insulin-like growth factor 1 receptor messenger RNAs by a transcriptional mechanism. Cancer Res 1991;51:5997-6000.
    • (1991) Cancer Res , vol.51 , pp. 5997-6000
    • Reiss, K.1    Ferber, A.2    Travali, S.3    Porcu, P.4    Phillips, P.D.5    Baserga, R.6
  • 20
    • 0031769052 scopus 로고    scopus 로고
    • P53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: Interaction between p53 and Sp1
    • DOI 10.1210/en.139.3.1101
    • Ohlsson C, Kley N, Werner H, LeRoith D. p53 regulates insulin-like growth factor-I (IGF-I) receptor expression and IGF-I-induced tyrosine phosphorylation in an osteosarcoma cell line: interaction between p53 and Sp1. Endocrinology 1998;139:1101-1107 (Pubitemid 28510128)
    • (1998) Endocrinology , vol.139 , Issue.3 , pp. 1101-1107
    • Ohlsson, C.1    Kley, N.2    Werner, H.3    Leroith, D.4
  • 21
    • 0347986569 scopus 로고    scopus 로고
    • Functional and Physical Interactions between BRCA1 and p53 in Transcriptional Regulation of the IGF-IR Gene
    • DOI 10.1055/s-2004-814154
    • Abramovitch S, Werner H. Functional and physical interactions between BRCA1 and p53 in transcriptional regulation of the IGF-IR gene. Horm Metab Res 2003;35:758-762 (Pubitemid 38058180)
    • (2003) Hormone and Metabolic Research , vol.35 , Issue.11-12 , pp. 758-762
    • Abramovitch, S.1    Werner, H.2
  • 22
    • 0029885334 scopus 로고    scopus 로고
    • Repression of the insulin receptor promoter by the tumor suppressor gene product p53: A possible mechanism for receptor overexpression in breast cancer
    • Webster NJ, Resnik JL, Reichart DB, Strauss B, Haas M, Seely BL. Repression of the insulin receptor promoter by the tumor suppressor gene product p53: a possible mechanism for receptor overexpression in breast cancer. Cancer Res 1996;56:2781-2788 (Pubitemid 26175738)
    • (1996) Cancer Research , vol.56 , Issue.12 , pp. 2781-2788
    • Webster, N.J.G.1    Resnik, J.L.2    Reichart, D.B.3    Strauss, B.4    Haas, M.5    Seely, B.L.6
  • 24
    • 10744228945 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway
    • Sekharam M, Zhao H, Sun M, et al. Insulin-like growth factor 1 receptor enhances invasion and induces resistance to apoptosis of colon cancer cells through the Akt/Bcl-x(L) pathway. Cancer Res 2003;63:7708-7716
    • (2003) Cancer Res , vol.63 , pp. 7708-7716
    • Sekharam, M.1    Zhao, H.2    Sun, M.3
  • 25
    • 0345826131 scopus 로고    scopus 로고
    • The Mitogenic Action of Insulin-like Growth Factor I in Normal Human Mammary Epithelial Cells Requires the Epidermal Growth Factor Receptor Tyrosine Kinase
    • DOI 10.1074/jbc.M306156200
    • Ahmad T, Farnie G, Bundred NJ, Anderson NG. The mitogenic action of insulin-like growth factor I in normal human mammary epithelial cells requires the epidermal growth factor receptor tyrosine kinase. J Biol Chem 2004;279:1713-1719 (Pubitemid 38084438)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.3 , pp. 1713-1719
    • Ahmad, T.1    Farnie, G.2    Bundred, N.J.3    Anderson, N.G.4
  • 27
    • 28244432561 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells
    • DOI 10.1158/0008-5472.CAN-04-3841
    • Nahta R, Yuan LX, Zhang B, Kobayashi R, Esteva FJ. Insulin-like growth factor-I receptor/human epidermal growth factor receptor 2 heterodimerization contributes to trastuzumab resistance of breast cancer cells. Cancer Res 2005;65:11118-11128 (Pubitemid 41713383)
    • (2005) Cancer Research , vol.65 , Issue.23 , pp. 11118-11128
    • Nahta, R.1    Yuan, L.X.H.2    Zhang, B.3    Kobayashi, R.4    Esteva, F.J.5
  • 28
    • 0022467893 scopus 로고
    • Analysis of serum insulin-like growth factor binding proteins using Western blotting: Use of the method for titration of the binding proteins and competitive binding studies
    • Hossenlopp P, Seurin D, Segovia-Quinson B, Hardouin S, Binoux M. Analysis of serum insulin-like growth factor binding proteins using Western blotting: use of the method for titration of the binding proteins and competitive binding studies. Anal Biochem 1986;154:138-143 (Pubitemid 16063354)
    • (1986) Analytical Biochemistry , vol.154 , Issue.1 , pp. 138-143
    • Hossenlopp, P.1    Seurin, D.2    Segovia-Quinson, B.3
  • 29
    • 27844526989 scopus 로고    scopus 로고
    • Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cultures of rat hepatocytes
    • DOI 10.1210/en.2005-0948
    • Scharf JG, Unterman TG, Kietzmann T. Oxygen-dependent modulation of insulin-like growth factor binding protein biosynthesis in primary cultures of rat hepatocytes. Endocrinology 2005;146:5433-5443 (Pubitemid 41653058)
    • (2005) Endocrinology , vol.146 , Issue.12 , pp. 5433-5443
    • Scharf, J.-G.1    Unterman, T.G.2    Kietzmann, T.3
  • 30
    • 0034082039 scopus 로고    scopus 로고
    • Insulin-like growth factor physiology and cancer risk
    • DOI 10.1016/S0959-8049(00)00102-7, PII S0959804900001027
    • Pollak M. Insulin-like growth factor physiology and cancer risk. Eur J Cancer 2000;36:1224-1228 (Pubitemid 30407009)
    • (2000) European Journal of Cancer , vol.36 , Issue.10 , pp. 1224-1228
    • Pollak, M.1
  • 32
    • 0034692430 scopus 로고    scopus 로고
    • Role of the insulin-like growth factor family in cancer development and progression
    • Yu H, Rohan T. Role of the insulin-like growth factor family in cancer development and progression. J Natl Cancer Inst 2000;92:1472-1489
    • (2000) J Natl Cancer Inst , vol.92 , pp. 1472-1489
    • Yu, H.1    Rohan, T.2
  • 33
    • 0034453098 scopus 로고    scopus 로고
    • The effects of insulin-like growth factors on tumorigenesis and neoplastic growth
    • DOI 10.1210/er.21.3.215
    • Khandwala HM, McCutcheon IE, Flyvbjerg A, Friend KE. The effects of insulin-like growth factors on tumorigenesis and neoplastic growth. Endocr Rev 2000;21:215-244 (Pubitemid 32275588)
    • (2000) Endocrine Reviews , vol.21 , Issue.3 , pp. 215-244
    • Khandwala, H.M.1    Mccutcheon, I.E.2    Flyvbjerg, A.3    Friend, K.E.4
  • 34
    • 0034489914 scopus 로고    scopus 로고
    • Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase
    • Sirotnak FM, Zakowski MF, Miller VA, Scher HI, Kris MG. Efficacy of cytotoxic agents against human tumor xenografts is markedly enhanced by coadministration of ZD1839 (Iressa), an inhibitor of EGFR tyrosine kinase. Clin Cancer Res 2000;6:4885-4892 (Pubitemid 32110433)
    • (2000) Clinical Cancer Research , vol.6 , Issue.12 , pp. 4885-4892
    • Sirotnak, F.M.1    Zakowski, M.F.2    Miller, V.A.3    Scher, H.I.4    Kris, M.G.5
  • 35
    • 0036362221 scopus 로고    scopus 로고
    • Epidermal growth factor receptor dependence in human tumors: More than just expression?
    • Arteaga CL. Epidermal growth factor receptor dependence in human tumors: more than just expression? Oncologist 2002;7 Suppl 4:31-39
    • (2002) Oncologist , vol.7 , Issue.SUPPL. 4 , pp. 31-39
    • Arteaga, C.L.1
  • 38
    • 56749184290 scopus 로고    scopus 로고
    • Insulin and insulin-like growth factor signalling in neoplasia
    • Pollak M. Insulin and insulin-like growth factor signalling in neoplasia. Nat Rev Cancer 2008;8:915-928
    • (2008) Nat Rev Cancer , vol.8 , pp. 915-928
    • Pollak, M.1
  • 39
    • 33847284924 scopus 로고    scopus 로고
    • Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells
    • DOI 10.1016/j.bbrc.2007.02.041, PII S0006291X07002884
    • Riedemann J, Sohail M, Macaulay VM. Dual silencing of the EGF and type 1 IGF receptors suggests dominance of IGF signaling in human breast cancer cells. Biochem Biophys Res Commun 2007;355:700-706 (Pubitemid 46330213)
    • (2007) Biochemical and Biophysical Research Communications , vol.355 , Issue.3 , pp. 700-706
    • Riedemann, J.1    Sohail, M.2    Macaulay, V.M.3
  • 41
    • 0035170259 scopus 로고    scopus 로고
    • Anticancer therapy targeting the erbB family of receptor tyrosine kinases
    • Slichenmyer WJ, Fry DW. Anticancer therapy targeting the erbB family of receptor tyrosine kinases. Semin Oncol 2001;28:67-79. (Pubitemid 33065112)
    • (2001) Seminars in Oncology , vol.28 , Issue.5 SUPPL. 16 , pp. 67-79
    • Slichenmyer, W.J.1    Fry, D.W.2
  • 42
    • 33750357154 scopus 로고    scopus 로고
    • Integration of EGFR inhibitors with radiochemotherapy
    • DOI 10.1038/nrc1953, PII NRC1953
    • Nyati MK, Morgan MA, Feng FY, Lawrence TS. Integration of EGFR inhibitors with radiochemotherapy. Nat Rev Cancer 2006;6:876-885 (Pubitemid 44629899)
    • (2006) Nature Reviews Cancer , vol.6 , Issue.11 , pp. 876-885
    • Nyati, M.K.1    Morgan, M.A.2    Feng, F.Y.3    Lawrence, T.S.4
  • 43
    • 33646712747 scopus 로고    scopus 로고
    • Mechanisms of disease: Understanding resistance to HER2-targeted therapy in human breast cancer
    • DOI 10.1038/ncponc0509, PII N0509
    • Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol 2006;3:269-280 (Pubitemid 43731112)
    • (2006) Nature Clinical Practice Oncology , vol.3 , Issue.5 , pp. 269-280
    • Nahta, R.1    Yu, D.2    Hung, M.-C.3    Hortobagyi, G.N.4    Esteva, F.J.5
  • 44
    • 0034698096 scopus 로고    scopus 로고
    • Transactivation of the EGF receptor mediates IGF-1-stimulated Shc phosphorylation and ERK1/2 activation in COS-7 cells
    • DOI 10.1074/jbc.M002915200
    • Roudabush FL, Pierce KL, Maudsley S, Khan KD, Luttrell LM. Transactivation of the EGF receptor mediates IGF-1-stimulated shc phosphorylation and ERK1/2 activation in COS-7 cells. J Biol Chem 2000;275:22583-22589 (Pubitemid 30621851)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.29 , pp. 22583-22589
    • Roudabush, F.L.1    Pierce, K.L.2    Maudsley, S.3    Khan, K.D.4    Luttrell, L.M.5
  • 45
    • 0035915421 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor signaling and resistance to transtuzumab (Herceptin)
    • Lu Y, Zi X, Zhao Y, Mascarenhas D, Pollak M. Insulin-like growth factor-I receptor signaling and resistance to trastuzumab (Herceptin). J Natl Cancer Inst 2001;93:1852-1857. (Pubitemid 34048651)
    • (2001) Journal of the National Cancer Institute , vol.93 , Issue.24 , pp. 1852-1857
    • Lu, Y.1    Zi, X.2    Zhao, Y.3    Mascarenhas, D.4    Pollak, M.5
  • 46
    • 0035854747 scopus 로고    scopus 로고
    • Anti-apoptotic Signaling of the Insulin-like Growth Factor-I Receptor through Mitochondrial Translocation of c-Raf and Nedd4
    • DOI 10.1074/jbc.M103188200
    • Peruzzi F, Prisco M, Morrione A, Valentinis B, Baserga R. Anti-apoptotic signaling of the insulin-like growth factor-I receptor through mitochondrial translocation of c-Raf and Nedd4. J Biol Chem 2001;276:25990-25996 (Pubitemid 37412806)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.28 , pp. 25990-25996
    • Peruzzi, F.1    Prisco, M.2    Morrione, A.3    Valentinis, B.4    Baserga, R.5
  • 47
    • 3142717695 scopus 로고    scopus 로고
    • Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity
    • Salatino M, Schillaci R, Proietti CJ, et al. Inhibition of in vivo breast cancer growth by antisense oligodeoxynucleotides to type I insulin-like growth factor receptor mRNA involves inactivation of ErbBs, PI-3K/Akt and p42/p44 MAPK signaling pathways but not modulation of progesterone receptor activity. Oncogene 2004;23:5161-5174
    • (2004) Oncogene , vol.23 , pp. 5161-5174
    • Salatino, M.1    Schillaci, R.2    Proietti, C.J.3
  • 48
    • 54249155585 scopus 로고    scopus 로고
    • Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor
    • Hu YP, Patil SB, Panasiewicz M, et al. Heterogeneity of receptor function in colon carcinoma cells determined by cross-talk between type I insulin-like growth factor receptor and epidermal growth factor receptor. Cancer Res 2008;68:8004-8013
    • (2008) Cancer Res , vol.68 , pp. 8004-8013
    • Hu, Y.P.1    Patil, S.B.2    Panasiewicz, M.3
  • 49
    • 54949085398 scopus 로고    scopus 로고
    • K-ras mutations and benefit from cetuximab in advanced colorectal cancer
    • Karapetis CS, Khambata-Ford S, Jonker DJ, et al. K-ras mutations and benefit from cetuximab in advanced colorectal cancer. N Engl J Med 2008;359:1757-1765
    • (2008) N Engl J Med , vol.359 , pp. 1757-1765
    • Karapetis, C.S.1    Khambata-Ford, S.2    Jonker, D.J.3
  • 51
    • 42149083899 scopus 로고    scopus 로고
    • Mutations in the RAS-MAPK, PI(3) K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers
    • Barault L, Veyrie N, Jooste V, et al. Mutations in the RAS-MAPK, PI(3) K (phosphatidylinositol-3-OH kinase) signaling network correlate with poor survival in a population-based series of colon cancers. Int J Cancer 2008;122:2255-2259
    • (2008) Int J Cancer , vol.122 , pp. 2255-2259
    • Barault, L.1    Veyrie, N.2    Jooste, V.3
  • 52
    • 0141960451 scopus 로고    scopus 로고
    • Resistance to gefitinib in PTEN-Null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling
    • She QB, Solit D, Basso A, Moasser MM. Resistance to gefitinib in PTEN-null HER-overexpressing tumor cells can be overcome through restoration of PTEN function or pharmacologic modulation of constitutive phosphatidylinositol 3′-kinase/Akt pathway signaling. Clin Cancer Res 2003;9:4340-4346 (Pubitemid 37248389)
    • (2003) Clinical Cancer Research , vol.9 , Issue.12 , pp. 4340-4346
    • She, Q.-B.1    Solit, D.2    Basso, A.3    Moasser, M.M.4
  • 55
    • 0036141447 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling
    • Chakravarti A, Loeffler JS, Dyson NJ. Insulin-like growth factor receptor I mediates resistance to anti-epidermal growth factor receptor therapy in primary human glioblastoma cells through continued activation of phosphoinositide 3-kinase signaling. Cancer Res 2002;62:200-207 (Pubitemid 34074005)
    • (2002) Cancer Research , vol.62 , Issue.1 , pp. 200-207
    • Chakravarti, A.1    Loeffler, J.S.2    Dyson, N.J.3
  • 57
    • 18044391836 scopus 로고    scopus 로고
    • Modulation of response to radiation of human lung cancer cells following insulin-like growth factor 1 receptor inactivation
    • DOI 10.1016/j.canlet.2004.10.002
    • Cosaceanu D, Carapancea M, Castro J, et al. Modulation of response to radiation of human lung cancer cells following insulin-like growth factor 1 receptor inactivation. Cancer Lett 2005;222:173-181 (Pubitemid 40603644)
    • (2005) Cancer Letters , vol.222 , Issue.2 , pp. 173-181
    • Cosaceanu, D.1    Carapancea, M.2    Castro, J.3    Ekedahl, J.4    Kanter, L.5    Lewensohn, R.6    Dricu, A.7
  • 58
    • 12144285705 scopus 로고    scopus 로고
    • In vivo antitumor activity of NVP-AEW541 - A novel, potent, and selective inhibitor of the IGF-IR kinase
    • Garcia-Echeverria C, Pearson MA, Marti A, et al. In vivo antitumor activity of NVP-AEW541 - a novel, potent, and selective inhibitor of the IGF-IR kinase. Cancer Cell 2004;5:231-239
    • (2004) Cancer Cell , vol.5 , pp. 231-239
    • Garcia-Echeverria, C.1    Pearson, M.A.2    Marti, A.3
  • 59
    • 33750139113 scopus 로고    scopus 로고
    • Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer
    • Hopfner M, Sutter AP, Huether A, Baradari V, Scherubl H. Tyrosine kinase of insulin-like growth factor receptor as target for novel treatment and prevention strategies of colorectal cancer. World J Gastroenterol 2006;12:5635-5643 (Pubitemid 44594037)
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.35 , pp. 5635-5643
    • Hopfner, M.1    Sutter, A.P.2    Huether, A.3    Baradari, V.4    Scherubl, H.5
  • 60
    • 49849098247 scopus 로고    scopus 로고
    • Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas
    • Piao W, Wang Y, Adachi Y, et al. Insulin-like growth factor-I receptor blockade by a specific tyrosine kinase inhibitor for human gastrointestinal carcinomas. Mol Cancer Ther 2008;7:1483-1493
    • (2008) Mol Cancer Ther , vol.7 , pp. 1483-1493
    • Piao, W.1    Wang, Y.2    Adachi, Y.3
  • 62
    • 10344247119 scopus 로고    scopus 로고
    • A recombinant humanized anti-insulin-like growth factor-receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts
    • DOI 10.1002/ijc.20543
    • Goetsch L, Gonzalez A, Leger O, et al. A recombinant humanized anti-insulin-like growth factor receptor type I antibody (h7C10) enhances the antitumor activity of vinorelbine and anti-epidermal growth factor receptor therapy against human cancer xenografts. Int J Cancer 2005;113:316-328 (Pubitemid 39628325)
    • (2005) International Journal of Cancer , vol.113 , Issue.2 , pp. 316-328
    • Goetsch, L.1    Gonzalez, A.2    Leger, O.3    Beck, A.4    Pauwels, P.J.5    Haeuw, J.F.6    Corvaia, N.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.