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Volumn 14, Issue 7, 2013, Pages 453-461

IL7RA haplotype-associated alterations in cellular immune function and gene expression patterns in multiple sclerosis

Author keywords

interleukin 7 receptor; multiple sclerosis; polymorphism

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR ALPHA; MESSENGER RNA; STAT5 PROTEIN; TRANSCRIPTOME;

EID: 84886720726     PISSN: 14664879     EISSN: 14765470     Source Type: Journal    
DOI: 10.1038/gene.2013.40     Document Type: Article
Times cited : (25)

References (54)
  • 1
    • 17644396349 scopus 로고    scopus 로고
    • Immunology of multiple sclerosis
    • Sospedra M, Martin R. Immunology of multiple sclerosis. Annu Rev Immunol 2005; 23: 683-747.
    • (2005) Annu Rev Immunol , vol.23 , pp. 683-747
    • Sospedra, M.1    Martin, R.2
  • 2
    • 45549092100 scopus 로고    scopus 로고
    • The genetics of multiple sclerosis: SNPs to pathways to pathogenesis
    • Oksenberg JR, Baranzini SE, Sawcer S, Hauser SL. The genetics of multiple sclerosis: SNPs to pathways to pathogenesis. Nat Rev Genet 2008; 9: 516-526.
    • (2008) Nat Rev Genet , vol.9 , pp. 516-526
    • Oksenberg, J.R.1    Baranzini, S.E.2    Sawcer, S.3    Hauser, S.L.4
  • 3
    • 0025767289 scopus 로고
    • HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation
    • Olerup O, Hillert J. HLA class II-associated genetic susceptibility in multiple sclerosis: A critical evaluation. Tissue Antigens 1991; 38: 1-15.
    • (1991) Tissue Antigens , vol.38 , pp. 1-15
    • Olerup, O.1    Hillert, J.2
  • 4
    • 79954545784 scopus 로고    scopus 로고
    • Genome-wide association studies in multiple sclerosis: Lessons and future prospects
    • Kemppinen A, Sawcer S, Compston A. Genome-wide association studies in multiple sclerosis: Lessons and future prospects. Brief Funct Genomics 2011; 10: 61-70.
    • (2011) Brief Funct Genomics , vol.10 , pp. 61-70
    • Kemppinen, A.1    Sawcer, S.2    Compston, A.3
  • 6
    • 34548368541 scopus 로고    scopus 로고
    • Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    • Lundmark F, Duvefelt K, Iacobaeus E, Kockum I, Wallström E, Khademi M et al. Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis. Nat Genet 2007; 39: 1108-1113.
    • (2007) Nat Genet , vol.39 , pp. 1108-1113
    • Lundmark, F.1    Duvefelt, K.2    Iacobaeus, E.3    Kockum, I.4    Wallström, E.5    Khademi, M.6
  • 7
    • 34548351247 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis
    • Gregory SG, Schmidt S, Seth P, Oksenberg JR, Hart J, Prokop A et al. Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 2007; 39: 1083-1091.
    • (2007) Nat Genet , vol.39 , pp. 1083-1091
    • Gregory, S.G.1    Schmidt, S.2    Seth, P.3    Oksenberg, J.R.4    Hart, J.5    Prokop, A.6
  • 8
    • 34548299105 scopus 로고    scopus 로고
    • Risk alleles for multiple sclerosis identified by a genomewide study
    • The International Multiple Sclerosis Genetics Consortium.
    • The International Multiple Sclerosis Genetics Consortium. Hafler DA, Compston A, Sawcer S, Lander ES, Daly MJ, De Jager PL et al. Risk alleles for multiple sclerosis identified by a genomewide study. N Engl J Med 2007; 357: 851-862.
    • (2007) N Engl J Med , vol.357 , pp. 851-862
    • Haflee, D.A.1    Compston, A.2    Sawcer, S.3    Lander, E.S.4    Daly, M.J.5    De Jager, P.L.6
  • 9
    • 77951910573 scopus 로고    scopus 로고
    • Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells
    • Hoe E, McKay FC, Schibeci SD, Gandhi K, Heard RN, Stewart GJ et al. Functionally significant differences in expression of disease-associated IL-7 receptor alpha haplotypes in CD4 T cells and dendritic cells. J Immunol 2010; 184: 2512-2517.
    • (2010) J Immunol , vol.184 , pp. 2512-2517
    • Hoe, E.1    McKay, F.C.2    Schibeci, S.D.3    Gandhi, K.4    Heard, R.N.5    Stewart, G.J.6
  • 10
    • 38549180589 scopus 로고    scopus 로고
    • Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis
    • McKay FC, Swain LI, Schibeci SD, Rubio JP, Kilpatrick TJ, Heard RN et al. Haplotypes of the interleukin 7 receptor alpha gene are correlated with altered expression in whole blood cells in multiple sclerosis. Genes Immun 2008; 9: 1-6.
    • (2008) Genes Immun , vol.9 , pp. 1-6
    • McKay, F.C.1    Swain, L.I.2    Schibeci, S.D.3    Rubio, J.P.4    Kilpatrick, T.J.5    Heard, R.N.6
  • 11
    • 77953123877 scopus 로고    scopus 로고
    • Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants
    • Broux B, Hellings N, Venken K, Rummens J-L, Hensen K, Van Wijmeersch B et al. Haplotype 4 of the multiple sclerosis-associated interleukin-7 receptor alpha gene influences the frequency of recent thymic emigrants. Genes Immun 2010; 11: 326-333.
    • (2010) Genes Immun , vol.11 , pp. 326-333
    • Broux, B.1    Hellings, N.2    Venken, K.3    Rummens, J.-L.4    Hensen, K.5    Van Wijmeersch, B.6
  • 12
    • 77952561277 scopus 로고    scopus 로고
    • Interleukin 7 receptor alpha chain haplotypes vary in their influence on multiple sclerosis susceptibility and response to interferon Beta
    • Hoe E, McKay F, Schibeci S, Heard R, Stewart G, Booth D. Interleukin 7 receptor alpha chain haplotypes vary in their influence on multiple sclerosis susceptibility and response to interferon Beta. J Interferon Cytokine Res 2010; 30: 291-298.
    • (2010) J Interferon Cytokine Res , vol.30 , pp. 291-298
    • Hoe, E.1    McKay, F.2    Schibeci, S.3    Heard, R.4    Stewart, G.5    Booth, D.6
  • 13
    • 0029859982 scopus 로고    scopus 로고
    • Interleukin-7 is a critical growth factor in early human T-cell development
    • Plum J, De Smedt M, Leclercq G, Verhasselt B, Vandekerckhove B. Interleukin-7 is a critical growth factor in early human T-cell development. Blood 1996; 88: 4239-4245.
    • (1996) Blood , vol.88 , pp. 4239-4245
    • Plum, J.1    De Smedt, M.2    Leclercq, G.3    Verhasselt, B.4    Vandekerckhove, B.5
  • 15
    • 79955418828 scopus 로고    scopus 로고
    • Harnessing the biology of IL-7 for therapeutic application
    • Mackall CL, Fry TJ, Gress RE. Harnessing the biology of IL-7 for therapeutic application. Nat Rev Immunol 2011; 11: 330-342.
    • (2011) Nat Rev Immunol , vol.11 , pp. 330-342
    • Mackall, C.L.1    Fry, T.J.2    Gress, R.E.3
  • 18
    • 33846632842 scopus 로고    scopus 로고
    • Interleukin-7 receptor expression: Intelligent design
    • Mazzucchelli R, Durum SK. Interleukin-7 receptor expression: Intelligent design. Nat Rev Immunol 2007; 7: 144-154.
    • (2007) Nat Rev Immunol , vol.7 , pp. 144-154
    • Mazzucchelli, R.1    Durum, S.K.2
  • 19
    • 67649876115 scopus 로고    scopus 로고
    • New insights into the regulation of T cells by gamma(c) family cytokines
    • Rochman Y, Spolski R, Leonard WJ. New insights into the regulation of T cells by gamma(c) family cytokines. Nat Rev Immunol 2009; 9: 480-490.
    • (2009) Nat Rev Immunol , vol.9 , pp. 480-490
    • Rochman, Y.1    Spolski, R.2    Leonard, W.J.3
  • 20
    • 0037310778 scopus 로고    scopus 로고
    • Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis
    • Van Roon JAG, Glaudemans KAFM, Bijlsma JWJ, Lafeber FPJG. Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis 2003; 62: 113-119.
    • (2003) Ann Rheum Dis , vol.62 , pp. 113-119
    • Van Roon, J.A.G.1    Glaudemans, K.A.F.M.2    Bijlsma, J.W.J.3    Lafeber, F.P.J.G.4
  • 21
    • 69449099657 scopus 로고    scopus 로고
    • Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    • Hartgring SaY, Van Roon JaG, Wenting-van Wijk M, Jacobs KMG, Jahangier ZN, Willis CR et al. Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis. Arthritis Rheum 2009; 60: 2595-2605.
    • (2009) Arthritis Rheum , vol.60 , pp. 2595-2605
    • Hartgring, S.Y.1    Van Roon, J.G.2    Wenting-Van Wijk, M.3    Jacobs, K.M.G.4    Jahangier, Z.N.5    Willis, C.R.6
  • 22
    • 79960787295 scopus 로고    scopus 로고
    • IL-7 promotes TH1 development and serum IL-7 predicts clinical response to interferon-b in multiple sclerosis
    • 93ra68-93ra68
    • Lee L-F, Axtell R, Tu GH, Logronio K, Dilley J, Yu J et al. IL-7 promotes TH1 development and serum IL-7 predicts clinical response to interferon-b in multiple sclerosis. Sci Transl Med 2011; 3: 93ra68-93ra68.
    • (2011) Sci Transl Med , vol.3
    • Lee, L.-F.1    Axtell, R.2    Tu, G.H.3    Logronio, K.4    Dilley, J.5    Yu, J.6
  • 23
    • 84876801098 scopus 로고    scopus 로고
    • IL7Ra contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages
    • Ashbaugh JJ, Brambilla R, Karmally Sa, Cabello C, Malek TR, Bethea Jr. IL7Ra contributes to experimental autoimmune encephalomyelitis through altered T cell responses and nonhematopoietic cell lineages. J Immunol 2013; 190: 4525-4534.
    • (2013) J Immunol , vol.190 , pp. 4525-4534
    • Ashbaugh, J.J.1    Brambilla, R.2    Karmally, S.A.3    Cabello, C.4    Malek, T.R.5    Bethea, J.R.6
  • 24
    • 77956380527 scopus 로고    scopus 로고
    • Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
    • Hartgring SAY, Willis CR, Alcorn D, Nelson LJ, Bijlsma JWJ, Lafeber FPJG et al. Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators. Arthritis Rheum 2010; 62: 2716-2725.
    • (2010) Arthritis Rheum , vol.62 , pp. 2716-2725
    • Hartgring, S.A.Y.1    Willis, C.R.2    Alcorn, D.3    Nelson, L.J.4    Bijlsma, J.W.J.5    Lafeber, F.P.J.G.6
  • 25
    • 79951713941 scopus 로고    scopus 로고
    • IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology
    • Pellegrini M, Calzascia T, Toe JG, Preston SP, Lin AE, Elford AR et al. IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology. Cell 2011; 144: 601-613.
    • (2011) Cell , vol.144 , pp. 601-613
    • Pellegrini, M.1    Calzascia, T.2    Toe, J.G.3    Preston, S.P.4    Lin, A.E.5    Elford, A.R.6
  • 26
    • 42549108701 scopus 로고    scopus 로고
    • IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations
    • Weber F, Fontaine B, Cournu-Rebeix I, Kroner a, Knop M, Lutz S et al. IL2RA and IL7RA genes confer susceptibility for multiple sclerosis in two independent European populations. Genes Immun 2008; 9: 259-263.
    • (2008) Genes Immun , vol.9 , pp. 259-263
    • Weber, F.1    Fontaine, B.2    Cournu-Rebeix, I.3    Kronera Knop, M.4    Lutz, S.5
  • 27
    • 0025350049 scopus 로고
    • Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily
    • Goodwin RG, Friend D, Ziegler SF, Jerzy R, Falk Ba, Gimpel S et al. Cloning of the human and murine interleukin-7 receptors: Demonstration of a soluble form and homology to a new receptor superfamily. Cell 1990; 60: 941-951.
    • (1990) Cell , vol.60 , pp. 941-951
    • Goodwin, R.G.1    Friend, D.2    Ziegler, S.F.3    Jerzy, R.4    Falk, B.A.5    Gimpel, S.6
  • 28
    • 77954491956 scopus 로고    scopus 로고
    • Soluble IL-7 R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection
    • Crawley AM, Faucher S, Angel JB. Soluble IL-7 R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol 2010; 184: 4679-4687.
    • (2010) J Immunol , vol.184 , pp. 4679-4687
    • Crawley, A.M.1    Faucher, S.2    Angel, J.B.3
  • 30
    • 67649158212 scopus 로고    scopus 로고
    • Identification and biochemical characterization of human plasma soluble IL-7R: Lower concentrations in HIV-1-infected patients
    • Rose T, Lambotte O, Pallier C, Delfraissy J-F, Colle J-H. Identification and biochemical characterization of human plasma soluble IL-7R: Lower concentrations in HIV-1-infected patients. J Immunol 2009; 182: 7389-7397.
    • (2009) J Immunol , vol.182 , pp. 7389-7397
    • Rose, T.1    Lambotte, O.2    Pallier, C.3    Delfraissy, J.-F.4    Colle, J.-H.5
  • 31
    • 84861563048 scopus 로고    scopus 로고
    • Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes
    • Zhu B, Kang K, Yu J, Chen W. Genome-wide analyses reveal the extent of opportunistic STAT5 binding that does not yield transcriptional activation of neighboring genes. Nucleic Acids Res 2012; 40: 4461-4472.
    • (2012) Nucleic Acids Res , vol.40 , pp. 4461-4472
    • Zhu, B.1    Kang, K.2    Yu, J.3    Chen, W.4
  • 32
    • 84861193543 scopus 로고    scopus 로고
    • IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis
    • Carrette F, Surh CD. IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin Immunol 2012; 24: 209-217.
    • (2012) Semin Immunol , vol.24 , pp. 209-217
    • Carrette, F.1    Surh, C.D.2
  • 33
    • 84864508237 scopus 로고    scopus 로고
    • Anti-IL-7 receptor-A reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function
    • Lee L, Logronio K, Tu GH, Zhai W, Ni I, Mei L et al. Anti-IL-7 receptor-a reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci USA 2012; 109: 12674-12679.
    • (2012) Proc Natl Acad Sci USA , vol.109 , pp. 12674-12679
    • Lee, L.1    Logronio, K.2    Tu, G.H.3    Zhai, W.4    Ni, I.5    Mei, L.6
  • 34
    • 84867301807 scopus 로고    scopus 로고
    • Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis
    • Willis CR, Seamons A, Maxwell J, Treuting PM, Nelson L, Chen G et al. Interleukin-7 receptor blockade suppresses adaptive and innate inflammatory responses in experimental colitis. J Inflamm 2012; 9: 39.
    • (2012) J Inflamm , vol.9 , pp. 39
    • Willis, C.R.1    Seamons, A.2    Maxwell, J.3    Treuting, P.M.4    Nelson, L.5    Chen, G.6
  • 35
    • 34548833894 scopus 로고    scopus 로고
    • Interlinking interleukin-7
    • Kittipatarin C, Khaled AR. Interlinking interleukin-7. Cytokine 2007; 39: 75-83.
    • (2007) Cytokine , vol.39 , pp. 75-83
    • Kittipatarin, C.1    Khaled, A.R.2
  • 36
    • 84870727272 scopus 로고    scopus 로고
    • Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
    • Perales M-A, Goldberg JD, Yuan J, Koehne G, Lechner L, Papadopoulos EB et al. Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. Blood 2012; 120: 4882-4891.
    • (2012) Blood , vol.120 , pp. 4882-4891
    • Perales, M.-A.1    Goldberg, J.D.2    Yuan, J.3    Koehne, G.4    Lechner, L.5    Papadopoulos, E.B.6
  • 37
    • 0033868149 scopus 로고    scopus 로고
    • Association between clinical disease activity and Epstein-Barr virus reactivation in MS
    • Wandinger K, Jabs W, Siekhaus A, Bubel S, Trillenberg P, Wagner H et al. Association between clinical disease activity and Epstein-Barr virus reactivation in MS. Neurology 2000; 55: 178-184.
    • (2000) Neurology , vol.55 , pp. 178-184
    • Wandinger, K.1    Jabs, W.2    Siekhaus, A.3    Bubel, S.4    Trillenberg, P.5    Wagner, H.6
  • 38
    • 84860292959 scopus 로고    scopus 로고
    • Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: A comprehensive study in the GRIV cohort
    • Limou S, Melica G, Coulonges C, Lelièvre J-D, Do H, McGinn S et al. Identification of IL7RA risk alleles for rapid progression during HIV-1 infection: A comprehensive study in the GRIV cohort. Curr HIV Res 2012; 10: 143-150.
    • (2012) Curr HIV Res , vol.10 , pp. 143-150
    • Limou, S.1    Melica, G.2    Coulonges, C.3    Lelièvre, J.-D.4    Do, H.5    McGinn, S.6
  • 39
    • 78751611599 scopus 로고    scopus 로고
    • Natural killer cells: Fighting viruses and much more
    • Colonna M, Jonjic S, Watzl C. Natural killer cells: Fighting viruses and much more. Nat Immunol 2011; 12: 107-110.
    • (2011) Nat Immunol , vol.12 , pp. 107-110
    • Colonna, M.1    Jonjic, S.2    Watzl, C.3
  • 40
    • 2942537826 scopus 로고    scopus 로고
    • Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta
    • Bielekova B, Richert N, Howard T, Blevins G, Markovic-Plese S, McCartin J et al. Humanized anti-CD25 (daclizumab) inhibits disease activity in multiple sclerosis patients failing to respond to interferon beta. Proc Natl Acad Sci USA 2004; 101: 8705-8708.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 8705-8708
    • Bielekova, B.1    Richert, N.2    Howard, T.3    Blevins, G.4    Markovic-Plese, S.5    McCartin, J.6
  • 41
    • 0028874612 scopus 로고
    • Circulating natural killer cells but not cytotoxic T lymphocytes are reduced in patients with active relapsing multiple sclerosis and little clinical disability as compared to controls
    • Munschauer FE, Hartrich LA, Stewart CC, Jacobs L. Circulating natural killer cells but not cytotoxic T lymphocytes are reduced in patients with active relapsing multiple sclerosis and little clinical disability as compared to controls. J Neuroimmunol 1995; 62: 177-181.
    • (1995) J Neuroimmunol , vol.62 , pp. 177-181
    • Munschauer, F.E.1    Hartrich, L.A.2    Stewart, C.C.3    Jacobs, L.4
  • 42
    • 33645812129 scopus 로고    scopus 로고
    • Regulatory CD56 (bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis
    • Bielekova B, Catalfamo M. Regulatory CD56 (bright) natural killer cells mediate immunomodulatory effects of IL-2Ralpha-targeted therapy (daclizumab) in multiple sclerosis. Proc Natl Acad Sci USA 2006; 103: 5941-5946.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 5941-5946
    • Bielekova, B.1    Catalfamo, M.2
  • 43
    • 84865261493 scopus 로고    scopus 로고
    • TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis
    • Gregory AP, Dendrou Ca, Attfield KE, Haghikia A, Xifara DK, Butter F et al. TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis. Nature 2012; 488: 508-511.
    • (2012) Nature , vol.488 , pp. 508-511
    • Gregory, A.P.1    Dendrou, C.A.2    Attfield, K.E.3    Haghikia, A.4    Xifara, D.K.5    Butter, F.6
  • 47
    • 84860774312 scopus 로고    scopus 로고
    • Mitochondrial changes within axons in multiple sclerosis: An update
    • Campbell GR, Ohno N, Turnbull DM, Mahad DJ. Mitochondrial changes within axons in multiple sclerosis: An update. Curr Opin Neurol 2012; 25: 221-230.
    • (2012) Curr Opin Neurol , vol.25 , pp. 221-230
    • Campbell, G.R.1    Ohno, N.2    Turnbull, D.M.3    Mahad, D.J.4
  • 48
    • 0030579161 scopus 로고    scopus 로고
    • Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain
    • Michaelson MD, Mehler MF, Xu H, Gross RE, Kessler Ja. Interleukin-7 is trophic for embryonic neurons and is expressed in developing brain. Dev Biol 1996; 179: 251-263.
    • (1996) Dev Biol , vol.179 , pp. 251-263
    • Michaelson, M.D.1    Mehler, M.F.2    Xu, H.3    Gross, R.E.4    Kessler, J.A.5
  • 49
    • 77957237015 scopus 로고    scopus 로고
    • Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration
    • Barrette B, Calvo E, Valliè res N, Lacroix S. Transcriptional profiling of the injured sciatic nerve of mice carrying the Wld(S) mutant gene: Identification of genes involved in neuroprotection, neuroinflammation, and nerve regeneration. Brain Behav Immun 2010; 24: 1254-1267.
    • (2010) Brain Behav Immun , vol.24 , pp. 1254-1267
    • Barrette, B.1    Calvo, E.2    Vallières, N.3    Lacroix, S.4
  • 50
    • 0034955141 scopus 로고    scopus 로고
    • Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis
    • McDonald WI, Compston a, Edan G, Goodkin D, Hartung HP, Lublin FD et al. Recommended diagnostic criteria for multiple sclerosis: Guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol 2001; 50: 121-127.
    • (2001) Ann Neurol , vol.50 , pp. 121-127
    • McDonald, W.I.1    Compston, A.2    Edan, G.3    Goodkin, D.4    Hartung, H.P.5    Lublin, F.D.6
  • 51
    • 13444269543 scopus 로고    scopus 로고
    • Haploview: Analysis and visualization of LD and haplotype maps
    • Barrett J, Fry B, Maller J, Daly M. Haploview: Analysis and visualization of LD and haplotype maps. Bioinformatics 2005; 21: 263-265.
    • (2005) Bioinformatics , vol.21 , pp. 263-265
    • Barrett, J.1    Fry, B.2    Maller, J.3    Daly, M.4
  • 53
  • 54
    • 77954069195 scopus 로고    scopus 로고
    • A flexible R package for nonnegative matrix factorization
    • Gaujoux R, Seoighe C. A flexible R package for nonnegative matrix factorization. BMC Bioinformatics 2010; 11: 367.
    • (2010) BMC Bioinformatics , vol.11 , pp. 367
    • Gaujoux, R.1    Seoighe, C.2


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