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Volumn 125, Issue 5, 2013, Pages 699-709

Early intraneuronal accumulation and increased aggregation of phosphorylated Abeta in a mouse model of Alzheimer's disease

Author keywords

Alzheimer; Intraneuronal Abeta; Phospho amyloid; Phosphorylation; Post translational modification; Transgenic mice

Indexed keywords

AMYLOID BETA PROTEIN; PHOSPHOSPECIFIC ANTIBODY; SERINE;

EID: 84886703257     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1107-8     Document Type: Article
Times cited : (75)

References (51)
  • 1
    • 84856296092 scopus 로고    scopus 로고
    • Transgenic expression of intraneuronal Abeta42 but not Abeta40 leads to cellular Abeta lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology
    • Abramowski D, Rabe S, Upadhaya AR, Reichwald J, Danner S et al (2012) Transgenic expression of intraneuronal Abeta42 but not Abeta40 leads to cellular Abeta lesions, degeneration, and functional impairment without typical Alzheimer's disease pathology. J Neurosci 32:1273-1283
    • (2012) J Neurosci , vol.32 , pp. 1273-1283
    • Abramowski, D.1    Rabe, S.2    Upadhaya, A.R.3    Reichwald, J.4    Danner, S.5
  • 2
    • 84899571989 scopus 로고    scopus 로고
    • Intracellular accumulation of amyloid- Beta - A predictor for synaptic dysfunction and neuron loss in Alzheimer's disease
    • Bayer TA, Wirths O (2010) Intracellular accumulation of amyloid- Beta - a predictor for synaptic dysfunction and neuron loss in Alzheimer's disease. Front Aging Neurosci 2:8
    • (2010) Front Aging Neurosci , vol.2 , pp. 8
    • Bayer, T.A.1    Wirths, O.2
  • 3
    • 79960882442 scopus 로고    scopus 로고
    • Intraneuronal Abeta as a trigger for neuron loss: Can this be translated into human pathology?
    • Bayer TA, Wirths O (2011) Intraneuronal Abeta as a trigger for neuron loss: can this be translated into human pathology? Biochem Soc Trans 39:857-861
    • (2011) Biochem Soc Trans , vol.39 , pp. 857-861
    • Bayer, T.A.1    Wirths, O.2
  • 4
    • 14644442872 scopus 로고    scopus 로고
    • Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice
    • Billings LM, Oddo S, Green KN, McGaugh JL, LaFerla FM (2005) Intraneuronal Abeta causes the onset of early Alzheimer's disease-related cognitive deficits in transgenic mice. Neuron 45:675-688
    • (2005) Neuron , vol.45 , pp. 675-688
    • Billings, L.M.1    Oddo, S.2    Green, K.N.3    McGaugh, J.L.4    Laferla, F.M.5
  • 5
    • 4644276796 scopus 로고    scopus 로고
    • Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model
    • Casas C, Sergeant N, Itier JM, Blanchard V, Wirths O et al (2004) Massive CA1/2 neuronal loss with intraneuronal and N-terminal truncated Abeta42 accumulation in a novel Alzheimer transgenic model. Am J Pathol 165:1289-1300
    • (2004) Am J Pathol , vol.165 , pp. 1289-1300
    • Casas, C.1    Sergeant, N.2    Itier, J.M.3    Blanchard, V.4    Wirths, O.5
  • 6
    • 56749152364 scopus 로고    scopus 로고
    • Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice
    • Christensen DZ, Kraus SL, Flohr A, Cotel MC, Wirths O, Bayer TA (2008) Transient intraneuronal A beta rather than extracellular plaque pathology correlates with neuron loss in the frontal cortex of APP/PS1KI mice. Acta Neuropathol 116:647-655
    • (2008) Acta Neuropathol , vol.116 , pp. 647-655
    • Christensen, D.Z.1    Kraus, S.L.2    Flohr, A.3    Cotel, M.C.4    Wirths, O.5    Bayer, T.A.6
  • 7
    • 15044339964 scopus 로고    scopus 로고
    • Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease
    • Crowther DC, Kinghorn KJ, Miranda E, Page R, Curry JA et al (2005) Intraneuronal Abeta, non-amyloid aggregates and neurodegeneration in a Drosophila model of Alzheimer's disease. Neuroscience 132:123-135
    • (2005) Neuroscience , vol.132 , pp. 123-135
    • Crowther, D.C.1    Kinghorn, K.J.2    Miranda, E.3    Page, R.4    Curry, J.A.5
  • 8
    • 0035120525 scopus 로고    scopus 로고
    • Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease
    • D'Andrea MR, Nagele RG, Wang HY, Peterson PA, Lee DH (2001) Evidence that neurones accumulating amyloid can undergo lysis to form amyloid plaques in Alzheimer's disease. Histopathology 38:120-134
    • (2001) Histopathology , vol.38 , pp. 120-134
    • D'Andrea, M.R.1    Nagele, R.G.2    Wang, H.Y.3    Peterson, P.A.4    Lee, D.H.5
  • 9
    • 0346106076 scopus 로고    scopus 로고
    • Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: Raman microscopic evidence
    • Dong J, Atwood CS, Anderson VE, Siedlak SL, Smith MA et al (2003) Metal binding and oxidation of amyloid-beta within isolated senile plaque cores: raman microscopic evidence. Biochemistry 42:2768-2773
    • (2003) Biochemistry , vol.42 , pp. 2768-2773
    • Dong, J.1    Atwood, C.S.2    Anderson, V.E.3    Siedlak, S.L.4    Smith, M.A.5
  • 10
    • 8444233219 scopus 로고    scopus 로고
    • Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons
    • Echeverria V, Ducatenzeiler A, Dowd E, Janne J, Grant SM et al (2004) Altered mitogen-activated protein kinase signaling, tau hyperphosphorylation and mild spatial learning dysfunction in transgenic rats expressing the beta-amyloid peptide intracellularly in hippocampal and cortical neurons. Neuroscience 129:583-592
    • (2004) Neuroscience , vol.129 , pp. 583-592
    • Echeverria, V.1    Ducatenzeiler, A.2    Dowd, E.3    Janne, J.4    Grant, S.M.5
  • 11
    • 84871860097 scopus 로고    scopus 로고
    • Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein. 1984
    • Glenner GG, Wong CW (2012) Alzheimer's disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. 1984. Biochem Biophys Res Commun 425:534-539
    • (2012) Biochem Biophys Res Commun , vol.425 , pp. 534-539
    • Glenner, G.G.1    Wong, C.W.2
  • 12
    • 25144501662 scopus 로고    scopus 로고
    • Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease
    • Gouras GK, Almeida CG, Takahashi RH (2005) Intraneuronal Abeta accumulation and origin of plaques in Alzheimer's disease. Neurobiol Aging 26:235-1244
    • (2005) Neurobiol Aging , vol.26 , pp. 235-1244
    • Gouras, G.K.1    Almeida, C.G.2    Takahashi, R.H.3
  • 14
    • 84869506753 scopus 로고    scopus 로고
    • Critical role of intraneuronal Abeta in Alzheimer's disease: Technical challenges in studying intracellular Abeta
    • Gouras GK, Willen K, Tampellini D (2012) Critical role of intraneuronal Abeta in Alzheimer's disease: technical challenges in studying intracellular Abeta. Life Sci 91:1153-1158
    • (2012) Life Sci , vol.91 , pp. 1153-1158
    • Gouras, G.K.1    Willen, K.2    Tampellini, D.3
  • 16
    • 13044287361 scopus 로고    scopus 로고
    • Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models
    • Hsia AY, Masliah E, McConlogue L, Yu GQ, Tatsuno G et al (1999) Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models. Proc Natl Acad Sci USA 96:3228-3233
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 3228-3233
    • Hsia, A.Y.1    Masliah, E.2    McConlogue, L.3    Yu, G.Q.4    Tatsuno, G.5
  • 17
    • 0029849644 scopus 로고    scopus 로고
    • Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques
    • Iwatsubo T, Saido TC, Mann DM, Lee VM, Trojanowski JQ (1996) Full-length amyloid-beta (1-42(43)) and amino-terminally modified and truncated amyloid-beta 42(43) deposit in diffuse plaques. Am J Pathol 149:1823-1830
    • (1996) Am J Pathol , vol.149 , pp. 1823-1830
    • Iwatsubo, T.1    Saido, T.C.2    Mann, D.M.3    Lee, V.M.4    Trojanowski, J.Q.5
  • 18
    • 80655144756 scopus 로고    scopus 로고
    • Pyroglutamate amyloidbeta (Abeta): A hatchet man in Alzheimer disease
    • Jawhar S, Wirths O, Bayer TA (2011) Pyroglutamate amyloidbeta (Abeta): a hatchet man in Alzheimer disease. J Biol Chem 286:38825-38832
    • (2011) J Biol Chem , vol.286 , pp. 38825-38832
    • Jawhar, S.1    Wirths, O.2    Bayer, T.A.3
  • 19
    • 79957919528 scopus 로고    scopus 로고
    • Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease
    • Kumar S, Rezaei-Ghaleh N, Terwel D, Thal DR, Richard M et al (2011) Extracellular phosphorylation of the amyloid beta-peptide promotes formation of toxic aggregates during the pathogenesis of Alzheimer's disease. EMBO J 30:2255-2265
    • (2011) EMBO J , vol.30 , pp. 2255-2265
    • Kumar, S.1    Rezaei-Ghaleh, N.2    Terwel, D.3    Thal, D.R.4    Richard, M.5
  • 20
    • 84863236980 scopus 로고    scopus 로고
    • Phosphorylation of amyloid-beta peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes
    • Kumar S, Singh S, Hinze D, Josten M, Sahl HG et al (2012) Phosphorylation of amyloid-beta peptide at serine 8 attenuates its clearance via insulin-degrading and angiotensin-converting enzymes. J Biol Chem 287:8641-8651
    • (2012) J Biol Chem , vol.287 , pp. 8641-8651
    • Kumar, S.1    Singh, S.2    Hinze, D.3    Josten, M.4    Sahl, H.G.5
  • 22
    • 80052410564 scopus 로고    scopus 로고
    • Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation
    • Kummer MP, Hermes M, Delekarte A, Hammerschmidt T, Kumar S et al (2011) Nitration of tyrosine 10 critically enhances amyloid beta aggregation and plaque formation. Neuron 71:833-844
    • (2011) Neuron , vol.71 , pp. 833-844
    • Kummer, M.P.1    Hermes, M.2    Delekarte, A.3    Hammerschmidt, T.4    Kumar, S.5
  • 23
    • 0035918312 scopus 로고    scopus 로고
    • Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains
    • Kuo YM, Kokjohn TA, Beach TG, Sue LI, Brune D et al (2001) Comparative analysis of amyloid-beta chemical structure and amyloid plaque morphology of transgenic mouse and Alzheimer's disease brains. J Biol Chem 276:12991-12998
    • (2001) J Biol Chem , vol.276 , pp. 12991-12998
    • Kuo, Y.M.1    Kokjohn, T.A.2    Beach, T.G.3    Sue, L.I.4    Brune, D.5
  • 24
    • 0344431341 scopus 로고    scopus 로고
    • Structural neurology: Are seeds at the root of neuronal degeneration?
    • Lansbury PT Jr (1997) Structural neurology: are seeds at the root of neuronal degeneration? Neuron 19:1151-1154
    • (1997) Neuron , vol.19 , pp. 1151-1154
    • Lansbury Jr., P.T.1
  • 25
    • 34748872706 scopus 로고    scopus 로고
    • The role of intracellular amyloid beta in Alzheimer's disease
    • Li M, Chen L, Lee DH, Yu LC, Zhang Y (2007) The role of intracellular amyloid beta in Alzheimer's disease. Prog Neurobiol 83:131-139
    • (2007) Prog Neurobiol , vol.83 , pp. 131-139
    • Li, M.1    Chen, L.2    Lee, D.H.3    Yu, L.C.4    Zhang, Y.5
  • 26
    • 84860330689 scopus 로고    scopus 로고
    • Neurological phenotypes for down syndrome across the life span
    • Lott IT (2012) Neurological phenotypes for down syndrome across the life span. Prog Brain Res 197:101-121
    • (2012) Prog Brain Res , vol.197 , pp. 101-121
    • Lott, I.T.1
  • 27
    • 0029813177 scopus 로고    scopus 로고
    • Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease
    • Masliah E, Sisk A, Mallory M, Mucke L, Schenk D, Games D (1996) Comparison of neurodegenerative pathology in transgenic mice overexpressing V717F beta-amyloid precursor protein and Alzheimer's disease. J Neurosci 16:5795-5811
    • (1996) J Neurosci , vol.16 , pp. 5795-5811
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Mucke, L.4    Schenk, D.5    Games, D.6
  • 29
    • 0035807929 scopus 로고    scopus 로고
    • Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase
    • Milton NG (2001) Phosphorylation of amyloid-beta at the serine 26 residue by human cdc2 kinase. NeuroReport 12:3839-3844
    • (2001) NeuroReport , vol.12 , pp. 3839-3844
    • Milton, N.G.1
  • 30
    • 15944383442 scopus 로고    scopus 로고
    • Phosphorylated amyloid-beta: The toxic intermediate in alzheimer's disease neurodegeneration
    • Milton NG (2005) Phosphorylated amyloid-beta: the toxic intermediate in alzheimer's disease neurodegeneration. Subcell Biochem 38:381-402
    • (2005) Subcell Biochem , vol.38 , pp. 381-402
    • Milton, N.G.1
  • 32
    • 0028544334 scopus 로고
    • Racemization: Its biological significance on neuropathogenesis of Alzheimer's disease
    • Mori H, Ishii K, Tomiyama T, Furiya Y, Sahara N et al (1994) Racemization: its biological significance on neuropathogenesis of Alzheimer's disease. Tohoku J Exp Med 174:251-262
    • (1994) Tohoku J Exp Med , vol.174 , pp. 251-262
    • Mori, H.1    Ishii, K.2    Tomiyama, T.3    Furiya, Y.4    Sahara, N.5
  • 33
    • 37549010347 scopus 로고    scopus 로고
    • Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro
    • Murakami K, Uno M, Masuda Y, Shimizu T, Shirasawa T, Irie K (2008) Isomerization and/or racemization at Asp23 of Abeta42 do not increase its aggregative ability, neurotoxicity, and radical productivity in vitro. Biochem Biophys Res Commun 366:745-751
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 745-751
    • Murakami, K.1    Uno, M.2    Masuda, Y.3    Shimizu, T.4    Shirasawa, T.5    Irie, K.6
  • 34
    • 33749521100 scopus 로고    scopus 로고
    • Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: Potential factors in amyloid plaque formation
    • Oakley H, Cole SL, Logan S, Maus E, Shao P et al (2006) Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation. J Neurosci 26:10129-10140
    • (2006) J Neurosci , vol.26 , pp. 10129-10140
    • Oakley, H.1    Cole, S.L.2    Logan, S.3    Maus, E.4    Shao, P.5
  • 35
    • 0042697305 scopus 로고    scopus 로고
    • Triple-transgenic model of Alzheimer's disease with plaques and tangles: Intracellular Abeta and synaptic dysfunction
    • Oddo S, Caccamo A, Shepherd JD, Murphy MP, Golde TE et al (2003) Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction. Neuron 39:409-421
    • (2003) Neuron , vol.39 , pp. 409-421
    • Oddo, S.1    Caccamo, A.2    Shepherd, J.D.3    Murphy, M.P.4    Golde, T.E.5
  • 36
    • 0028855851 scopus 로고
    • Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques
    • Saido TC, Iwatsubo T, Mann DM, Shimada H, Ihara Y, Kawashima S (1995) Dominant and differential deposition of distinct beta-amyloid peptide species, A beta N3(pE), in senile plaques. Neuron 14:457-466
    • (1995) Neuron , vol.14 , pp. 457-466
    • Saido, T.C.1    Iwatsubo, T.2    Mann, D.M.3    Shimada, H.4    Ihara, Y.5    Kawashima, S.6
  • 37
    • 0030582387 scopus 로고    scopus 로고
    • Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain
    • Saido TC, Yamao-Harigaya W, Iwatsubo T, Kawashima S (1996) Amino- and carboxyl-terminal heterogeneity of beta-amyloid peptides deposited in human brain. Neurosci Lett 215:173-176
    • (1996) Neurosci Lett , vol.215 , pp. 173-176
    • Saido, T.C.1    Yamao-Harigaya, W.2    Iwatsubo, T.3    Kawashima, S.4
  • 38
    • 53549099647 scopus 로고    scopus 로고
    • Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology
    • Schilling S, Zeitschel U, Hoffmann T, Heiser U, Francke M et al (2008) Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology. Nat Med 14:1106-1111
    • (2008) Nat Med , vol.14 , pp. 1106-1111
    • Schilling, S.1    Zeitschel, U.2    Hoffmann, T.3    Heiser, U.4    Francke, M.5
  • 39
    • 0035066332 scopus 로고    scopus 로고
    • Alzheimer's disease: Genes, proteins, and therapy
    • Selkoe DJ (2001) Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81:741-766
    • (2001) Physiol Rev , vol.81 , pp. 741-766
    • Selkoe, D.J.1
  • 41
    • 84860425072 scopus 로고    scopus 로고
    • Amyloid and Alzheimer's disease: Inside and out
    • Tam JH, Pasternak SH (2012) Amyloid and Alzheimer's disease: inside and out. Can J Neurol Sci 39:286-298
    • (2012) Can J Neurol Sci , vol.39 , pp. 286-298
    • Tam, J.H.1    Pasternak, S.H.2
  • 43
    • 0032084472 scopus 로고    scopus 로고
    • Structural and kinetic features of amyloid beta-protein fibrillogenesis
    • Teplow DB (1998) Structural and kinetic features of amyloid beta-protein fibrillogenesis. Amyloid 5:121-142
    • (1998) Amyloid , vol.5 , pp. 121-142
    • Teplow, D.B.1
  • 44
    • 0028177534 scopus 로고
    • Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues
    • Tomiyama T, Asano S, Furiya Y, Shirasawa T, Endo N, Mori H (1994) Racemization of Asp23 residue affects the aggregation properties of Alzheimer amyloid beta protein analogues. J Biol Chem 269:10205-10208
    • (1994) J Biol Chem , vol.269 , pp. 10205-10208
    • Tomiyama, T.1    Asano, S.2    Furiya, Y.3    Shirasawa, T.4    Endo, N.5    Mori, H.6
  • 45
    • 48749125839 scopus 로고    scopus 로고
    • Diversity of Abeta deposits in the aged brain: A window on molecular heterogeneity?
    • Walker LC, Rosen RF, LeVine H III (2008) Diversity of Abeta deposits in the aged brain: a window on molecular heterogeneity? Rom J Morphol Embryol 49:5-11
    • (2008) Rom J Morphol Embryol , vol.49 , pp. 5-11
    • Walker, L.C.1    Rosen, R.F.2    Levine III, H.3
  • 46
    • 0035477333 scopus 로고    scopus 로고
    • The cell biology of Alzheimer's disease: Uncovering the secrets of secretases
    • Walter J, Kaether C, Steiner H, Haass C (2001) The cell biology of Alzheimer's disease: uncovering the secrets of secretases. Curr Opin Neurobiol 11:585-590
    • (2001) Curr Opin Neurobiol , vol.11 , pp. 585-590
    • Walter, J.1    Kaether, C.2    Steiner, H.3    Haass, C.4
  • 47
    • 0027361386 scopus 로고
    • Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides
    • Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG et al (1993) Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proc Natl Acad Sci USA 90:9513-9517
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 9513-9517
    • Wertkin, A.M.1    Turner, R.S.2    Pleasure, S.J.3    Golde, T.E.4    Younkin, S.G.5
  • 48
    • 79957653811 scopus 로고    scopus 로고
    • Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: Implications for tau versus Abeta-mediated Alzheimer neurodegeneration
    • Winton MJ, Lee EB, Sun E, Wong MM, Leight S et al (2011) Intraneuronal APP, not free Abeta peptides in 3xTg-AD mice: implications for tau versus Abeta-mediated Alzheimer neurodegeneration. J Neurosci 31:7691-7699
    • (2011) J Neurosci , vol.31 , pp. 7691-7699
    • Winton, M.J.1    Lee, E.B.2    Sun, E.3    Wong, M.M.4    Leight, S.5
  • 49
    • 84869493355 scopus 로고    scopus 로고
    • Intraneuronal Abeta accumulation and neurodegeneration: Lessons from transgenic models
    • Wirths O, Bayer TA (2012) Intraneuronal Abeta accumulation and neurodegeneration: lessons from transgenic models. Life Sci 91:1148-1152
    • (2012) Life Sci , vol.91 , pp. 1148-1152
    • Wirths, O.1    Bayer, T.A.2
  • 50
    • 0035933279 scopus 로고    scopus 로고
    • Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice
    • Wirths O, Multhaup G, Czech C, Blanchard V, Moussaoui S et al (2001) Intraneuronal Abeta accumulation precedes plaque formation in beta-amyloid precursor protein and presenilin-1 double-transgenic mice. Neurosci Lett 306:116-120
    • (2001) Neurosci Lett , vol.306 , pp. 116-120
    • Wirths, O.1    Multhaup, G.2    Czech, C.3    Blanchard, V.4    Moussaoui, S.5


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