Ei24, a novel E2F target gene, affects p53-independent cell death upon ultraviolet C irradiation

Journal of Biological Chemistry

Volumn 288, Issue 43, 2013, Pages 31261-31267

  Sung, Young Hoon ^a   Jin, Young ^a   Kang, Yunhwa ^a   Devkota, Sushil ^a   Lee, Jaehoon ^a,b   Roh, Jae Il ^a   Lee, Han Woong ^a  

^a Yonsei University   (South Korea)

^b Sungkyunkwan University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY; CHROMATIN IMMUNOPRECIPITATION ASSAY; MOUSE EMBRYONIC FIBROBLASTS; RETINOBLASTOMA; TARGET GENES; THERAPEUTIC TARGETS; UV-C IRRADIATIONS;

CELL CULTURE; CELL DEATH; CHEMOTHERAPY; IRRADIATION; MAMMALS; RUBIDIUM; TRANSCRIPTION;

GENE THERAPY;

MESSENGER RNA; PROTEIN P53; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1;

ANIMAL CELL; APOPTOSIS; ARTICLE; AUTOPHAGY; CELL SURVIVAL; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; EI24 GENE; FIBROBLAST; GENE; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; NORTHERN BLOTTING; PIG8 GENE; PRIORITY JOURNAL; PROMOTER REGION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; ULTRAVIOLET C RADIATION; UPREGULATION;

CELL DEATH; E2F TRANSCRIPTION FACTOR; EI24; P53; PIG8; RETINOBLASTOMA (RB); TRANSCRIPTION TARGET GENES;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; CELL DEATH; CELL SURVIVAL; E2F1 TRANSCRIPTION FACTOR; HUMANS; MICE; MICE, KNOCKOUT; NEOPLASMS; NIH 3T3 CELLS; NUCLEAR PROTEINS; RESPONSE ELEMENTS; RETINOBLASTOMA PROTEIN; TRANSCRIPTION, GENETIC; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

EID: 84886687086     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.477570     Document Type: Article

References (39)

1. Goodrich, D. W., and Lee, W. H. (1993) Molecular characterization of the retinoblastoma susceptibility gene. Biochim. Biophys. Acta 1155, 43-61
2. Iaquinta, P. J., and Lees, J. A. (2007) Life and death decisions by the E2F transcription factors. Curr. Opin. Cell Biol. 19, 649-657
3. Qin, X. Q., Livingston, D. M., Ewen, M., Sellers, W. R., Arany, Z., and Kaelin, W. G., Jr. (1995) The transcription factor E2F-1 is a downstream target of RB action. Mol. Cell. Biol. 15, 742-755
4. Johnson, D. G., Schwarz, J. K., Cress, W. D., and Nevins, J. R. (1993) Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature 365, 349-352
5. Polager, S., and Ginsberg, D. (2009) p53 and E2F: partners inlife and death. Nat. Rev. Cancer 9, 738-748
6. Hollstein, M., Sidransky, D., Vogelstein, B., and Harris, C. C. (1991) p53 mutations in human cancers. Science 253, 49-53
7. Harris, C. C. (1993) p53: at the crossroads of molecular carcinogenesis and risk assessment. Science 262, 1980-1981
8. Vogelstein, B., Lane, D., and Levine, A. J. (2000) Surfing the p53 network. Nature 408, 307-310
9. Zetterberg, A., Larsson, O., and Wiman, K. G. (1995) What is the restriction point? Curr. Opin. Cell Biol. 7, 835-842
10. Yamasaki, L., Jacks, T., Bronson, R., Goillot, E., Harlow, E., and Dyson, N. J. (1996) Tumor induction and tissue atrophyin mice lacking E2F-1. Cell 85, 537-548
11. Field, S. J., Tsai, F. Y., Kuo, F., Zubiaga, A. M., Kaelin, W. G., Jr., Livingston, D. M., Orkin, S. H., and Greenberg, M. E. (1996) E2F-1 functions in mice to promote apoptosis and suppress proliferation. Cell 85, 549-561
12. Leone, G., Sears, R., Huang, E., Rempel, R., Nuckolls, F., Park, C. H., Giangrande, P., Wu, L., Saavedra, H. I., Field, S. J., Thompson, M. A., Yang, H., Fujiwara, Y., Greenberg, M. E., Orkin, S., Smith, C., and Nevins, J. R. (2001) Myc requires distinct E2F activities to induce S phase and apoptosis. Mol. Cell 8, 105-113
13. Lehar, S. M., Nacht, M., Jacks, T., Vater, C. A., Chittenden, T., and Guild, B. C. (1996) Identification and cloning of Ei24, a gene induced by p53 in etoposide-treated cells. Oncogene 12, 1181-1187
14. Gu, Z., Flemington, C, Chittenden, T., and Zambetti, G. P. (2000) Ei24, a p53 response gene involved in growth suppression and apoptosis. Mol. Cell. Biol. 20, 233-241
15. Tian, Y., Li, Z., Hu, W., Ren, H., Tian, E., Zhao, Y., Lu, Q., Huang, X., Yang, P., Li, X., Wang, X., Kovács, A. L., Yu, L., and Zhang, H. (2010) Celegans screen identifies autophagy genes specific to multicellular organisms. Cell 141, 1042-1055
16. Gentile, M., Ahnström, M., Schon, F., and Wingren, S. (2001) Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis.. Oncogene 20, 7753-7760
17. Zhao, X., Ayer, R. E., Davis, S. L., Ames, S. J., Florence, B., Torchinsky, C, Liou, J. S., Shen, L., and Spanjaard, R. A. (2005) Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness.. Cancer Res. 65, 2125-2129
18. Devkota, S., Sung, Y. H., Choi, J. M., Lee, J., Ha, N. Y., Kim, H, Cho, B. C, Song, J., and Lee, H. W. (2012) Ei24-deficiency attenuates protein kinase Ca signaling and skin carcinogenesis in mice. Int. J. Biochem. Cell Biol. 44, 1887-1896
19. Sung, Y. H, Kim, H. J., and Lee, H. W. (2007) Identification of a novel Rb-regulated gene associated with the cell cycle. Mol. Cells 24, 409-415
20. Sung, Y. H., Kim, H. J., Devkota, S., Roh, J., Lee, J., Rhee, K., Bahk, Y. Y., and Lee, H. W. (2010) Pierce1, a novel p53 target gene contributing to the ultraviolet-induced DNA damage response. Cancer Res. 70, 10454-10463
21. Naviaux, R. K., Costanzi, E., Haas, M., and Verma, I. M. (1996) The pCL vector system: rapid production of helper-free, high-titer, recombinant retroviruses. J. Virol. 70, 5701-5705
22. Polager, S., and Ginsberg, D. (2003) E2F mediates sustained G2 arrest and down-regulation of Stathmin and AIM-1 expression in response to genotoxic stress. J. Biol. Chem. 278, 1443-1449
23. Moroni, M. C, Hickman, E. S., Lazzerini Denchi, E., Caprara, G., Colli, E., Cecconi, F., Müller, H., and Helin, K. (2001) Apaf-1 is a transcriptional target for E2F and p53. Nat. Cell Biol. 3, 552-558
24. ARF links the tumour suppressors RB and p53. Nature 395, 124-125
25. Vigo, E., Müller, H, Prosperini, E., Hateboer, G., Cartwright, P., Moroni, M. C, and Helin, K. (1999) CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol. Cell. Biol. 19, 6379-6395
26. Heinemeyer, T., Chen, X., Karas, H., Kel, A. E., Kel, O. V., Liebich, I., Meinhardt, T., Reuter, I., Schacherer, F., and Wingender, E. (1999) Expanding the TRANSFAC database towards an expert system of regulatory molecular mechanisms. Nucleic Acids Res. 27, 318-322
27. Wang, C, Chen, L., Hou, X., Li, Z., Kabra, N, Ma, Y., Nemoto, S., Finkel, T., Gu, W., Cress, W. D., and Chen, J. (2006) Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat. Cell Biol. 8, 1025-1031
28. Lin, W. C, Lin, F. T., and Nevins, J. R. (2001) Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev. 15, 1833-1844
29. Zindy, F., Eischen, C. M., Randle, D. H, Kamijo, T., Cleveland, J. L., Sherr, C. J., and Roussel, M. F. (1998) Myc signaling via the ARF tumor suppressor regulates p53-dependent apoptosis and immortalization. Genes Dev. 12, 2424-2433
30. Quelle, D. E., Zindy, F., Ashmun, R. A., and Sherr, C. J. (1995) Alternative reading frames of the INk4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest.. Cell 83, 993-1000
31. Weber, J. D., Taylor, L. J., Roussel, M. F., Sherr, C. J., and Bar-Sagi, D. (1999) Nucleolar Arf sequesters Mdm2 and activates p53. Nat. Cell Biol. 1, 20-26
32. ARF with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.. EMBO J. 18, 22-27
33. Sherr, C. J. (2001) The INk4a/ARF network in tumour suppression. Nat. Rev. Mol. Cell Biol. 2, 731-737
34. Nahle, Z., Polakoff, J., Davuluri, R. V., McCurrach, M. E., Jacobson, M. D., Narita, M., Zhang, M. Q., Lazebnik, Y., Bar-Sagi, D., and Lowe, S. W. (2002) Direct coupling of the cell cycle and cell death machinery by E2F. Nat. Cell Biol. 4, 859-864
35. Latonen, L., Taya, Y., and Laiho, M. (2001) UV-radiation induces dose-dependent regulation of p53 response and modulates p53-HDM2 interaction in human fibroblasts.. Oncogene 20, 6784-6793
36. Mailand, N., Falck, J., Lukas, C., Syljuâsen, R. G., Welcker, M., Bartek, J., and Lukas, J. (2000) Rapid destruction of human Cdc25A in response to DNA damage. Science 288, 1425-1429
37. Black, A. R., and Azizkhan-Clifford, J. (1999) Regulation of E2F: a family of transcription factors involved in proliferation control. Gene 237, 281-302
38. Mork, C. N., Faller, D. V., and Spanjaard, R. A. (2007) Loss of putative tumor suppressor EI24/PIG8 confers resistance to etoposide. FEBS Lett. 581, 5440-5444
39. Polager, S., Ofir, M., and Ginsberg, D. (2008) E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene 27, 4860-4864