Apoptosis factor EI24/PIG8 is a novel endoplasmic reticulum-localized Bcl-2-binding protein which is associated with suppression of breast cancer invasiveness

Cancer Research

Volumn 65, Issue 6, 2005, Pages 2125-2129

  Zhao, Xiansi ^a   Ayer, Robert E ^a   Davis, Shannon L ^a   Ames, Sarah J ^a   Florence, Brian ^a   Torchinsky, Cyrus ^a   Liou, James S ^a   Shen, Ling ^a   Spanjaard, Remco A ^a  

^a BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; BINDING PROTEIN; ETOPOSIDE INDUCED PROTEIN 24; TUMOR SUPPRESSOR PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; BREAST CARCINOMA; CANCER INHIBITION; CANCER INVASION; CELL FRACTIONATION; CELL NUCLEUS MEMBRANE; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; GENE LOCATION; IMMUNOFLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOPRECIPITATION; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEPLETION; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN MICROARRAY; PROTEIN PROTEIN INTERACTION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BREAST NEOPLASMS; ENDOPLASMIC RETICULUM; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; NEOPLASM INVASIVENESS; NIH 3T3 CELLS; NUCLEAR PROTEINS; PEPTIDE MAPPING; PHOSPHOPROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS C-BCL-2;

EID: 16844383632     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-04-3377     Document Type: Article

References (28)

1. Prives C, Hall PA. The p53 pathway. J Pathol 1999;187:112-26.
2. Rich T, Wyllie RL, Wyllie AH. Defying death after DNA damage. Nature 2000;407:777-83.
3. Malkin D. The role of p53 in human cancer. J Neurooncol 2001;51:231-43.
4. Attardi LD, Jacks T. The role of p53 in tumour suppression: lessons from mouse models. Cell Mol Life Sci 1999;55:48-63.
5. Williams KJ, Boyle JM, Birch JM, Norton JD, Scott D. Cell cycle arrest defect in Li-Fraumeni Syndrome: a mechanism of cancer predisposition? Oncogene 1997;14:277-82.
6. Polyak K, Xia Y, Zweier JL, Kinzler KW, Vogelstein B. A model for p53-induced apoptosis. Nature 1997;389:300-5.
7. Lehar SM, Nacht M, Jacks T, Vater CA, Chittenden T, Guild BC. Identification and cloning of EI24, a gene induced by p53 in etoposide-treated cells. Oncogene 1996;12:1181-7.
8. Gu Z, Flemington C, Chittenden T, Zambetti GP. ei24, a p53 response gene involved in growth suppression and apoptosis. Mol Cell Biol 2000;20:233-41.
9. Beck GR Jr, Zerler B, Moran E. Gene array analysis of osteoblast differentiation. Cell Growth Differ 2001;12:61-83.
10. Burns TF, Bernhard EJ, El-Deiry WS. Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo. Oncogene 2001;20:4601-12.
11. Zhao X, Demary K, Wong L, et al. Retinoic acid receptor-independent mechanism of apoptosis of melanoma cells by the retinoid CD437 (AHPN). Cell Death Differ 2001;8:878-86.
12. Gu Z, Gilbert DJ, Valentine VA, Jenkins NA, Copeland NG, Zambetti GP. The p53-inducible gene EI24/PIG8 localizes to human chromosome 11q23 and the proximal region of mouse chromosome 9. Cytogenet Cell Genet 2000;89:230-3.
13. Gentile M, Ahnstrom M, Schon F, Wingren S. Candidate tumour suppressor genes at 11q23-q24 in breast cancer: evidence of alterations in PIG8, a gene involved in p53-induced apoptosis. Oncogene 2001;20:7753-60.
14. Gentile M, Wiman A, Thorstenson S, Loman N, Borg A, Wingren S. Deletion mapping of chromosome segment 11q24-q25, exhibiting extensive allelic loss in early onset breast cancer. Int J Cancer 2001;92:208-13.
15. Dallner GD. Isolation of rough and smooth microsomes. Methods Enzymol 1974;31:191-201.
16. Xia W, Zhang J, Ostaszewski BL, Kimberly, et al. Presenilin 1 regulates the processing of β-amyloid precursor protein C-terminal fragments and the generation of amyloid β-protein in endoplasmic reticulum and Golgi. Biochem 1998;37:16455-71.
17. Zhao X, Patton JR, Davis SL, Florence B, Ames SJ, Spanjaard RA. Regulation of nuclear receptor activity by a pseudouridine synthase through posttranscriptional modification of steroid receptor RNA activator. Mol Cell 2004;15:549-58.
18. Liou JS, Chen CY, Chen JS, Faller DV. Oncogenic ras mediates apoptosis in response to protein kinase C inhibition through the generation of reactive oxygen species. J Biol Chem 2000;275:39001-11.
19. Breckenridge DG, Germain M, Mathai JP, Nguyen M, Shore GC. Regulation of apoptosis by endoplasmic reticulum pathways. Oncogene 2003;22:8608-18.
20. Ferri KF, Kroemer G. Organelle-specific initiation of cell death pathways. Nat Cell Biol 2001;3:E255-63.
21. Adams JM, Cory S. The Bcl-2 protein family: arbiters of cell survival. Science 1998;281:1322-6.
22. Cheng EH, Wei MC, Weiler S, et al. Bcl-2, Bcl-XI sequester BH3 domain-only molecules preventing Bax-and Bak-mediated mitochondrial apoptosis. Mol Cell 2001;10:705-11.
23. Reynolds JE, Jinfang L, Craig RW, Eastman A. Bcl-2 and Mcl-I expression in Chinese hamster ovary cells (CHO) inhibits intracellular acidification and apoptosis induced by staurosporine. Exp Cell Res 1996;225:430-6.
24. 2+ stores. J Biol Chem 2002;277:9219-25.
25. Krajewski S, Tanaka S, Takayama S, et al. Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes. Cancer Res 1993;53:4701-14.
26. Cook SA, Sugden PH, Clerk A. Regulation of Bcl-2 family proteins during development and in response to oxidative stress in cardiac myocytes. Association with changes in mitochondrial membrane potential. Circ Res 1999;85:940-9.
27. 2+: a control point for apoptosis. Science 2003;300:135-9.
28. Hacki J, Egger L, Monney L, et al. Apoptotic crosstalk between the endoplasmic reticulum and mitochondria controlled by Bcl-2. Oncogene 2000;19:2286-95.