메뉴 건너뛰기




Volumn 25, Issue 11, 2013, Pages 1088-1094

Progesterone and cerebral ischaemia: The relevance of ageing

Author keywords

Ischaemia; Neuroactive steroids; Neuroprotection; Progestogens; Steroids; Stroke

Indexed keywords

PROGESTERONE; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; NEUROPROTECTIVE AGENT;

EID: 84886643243     PISSN: 09538194     EISSN: 13652826     Source Type: Journal    
DOI: 10.1111/jne.12042     Document Type: Review
Times cited : (10)

References (80)
  • 1
    • 84886650896 scopus 로고    scopus 로고
    • WHO. The World Health Report (2003). Available at:
    • WHO. The World Health Report (2003). 2003; Available at: http://www.who.int/whr/2003/en/whr03_en.pdf.
    • (2003)
  • 2
    • 0023748709 scopus 로고
    • The Lausanne Stroke Registry: analysis of 1000 consecutive patients with first stroke
    • Bogousslavsky J, Van Melle G, Regli F. The Lausanne Stroke Registry: analysis of 1000 consecutive patients with first stroke. Stroke 1988; 19: 1083-1092.
    • (1988) Stroke , vol.19 , pp. 1083-1092
    • Bogousslavsky, J.1    Van Melle, G.2    Regli, F.3
  • 3
    • 77956257659 scopus 로고    scopus 로고
    • Current and future use of intravenous thrombolysis for acute ischaemic stroke
    • Elijovich L, Chong JY. Current and future use of intravenous thrombolysis for acute ischaemic stroke. Curr Atheroscler Rep 2010; 12: 316-321.
    • (2010) Curr Atheroscler Rep , vol.12 , pp. 316-321
    • Elijovich, L.1    Chong, J.Y.2
  • 4
    • 0036402443 scopus 로고    scopus 로고
    • Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective
    • Green AR. Why do neuroprotective drugs that are so promising in animals fail in the clinic? An industry perspective. Clin Exp Pharmacol Physiol 2002; 29: 1030-1034.
    • (2002) Clin Exp Pharmacol Physiol , vol.29 , pp. 1030-1034
    • Green, A.R.1
  • 5
    • 5444233626 scopus 로고    scopus 로고
    • Pathophysiology of stroke: lessons from animal models
    • Mergenthaler P, Dirnagl U, Meisel A. Pathophysiology of stroke: lessons from animal models. Metab Brain Dis 2004; 19: 151-167.
    • (2004) Metab Brain Dis , vol.19 , pp. 151-167
    • Mergenthaler, P.1    Dirnagl, U.2    Meisel, A.3
  • 7
    • 70350349527 scopus 로고    scopus 로고
    • Pathophysiological basis of translational stroke research
    • Hossmann K-A. Pathophysiological basis of translational stroke research. Folio Neuropathol 2009; 47: 213-227.
    • (2009) Folio Neuropathol , vol.47 , pp. 213-227
    • Hossmann, K.-A.1
  • 8
    • 0034093231 scopus 로고    scopus 로고
    • The global burden of disease study: implications for neurology
    • Menken M, Munsat TL, Toole JF. The global burden of disease study: implications for neurology. Arch Neurol 2000; 57: 418-420.
    • (2000) Arch Neurol , vol.57 , pp. 418-420
    • Menken, M.1    Munsat, T.L.2    Toole, J.F.3
  • 9
    • 34547108082 scopus 로고    scopus 로고
    • Acute ischaemic stroke and transient ischaemic attack in the very old - risk factor profile and stroke subtype between patients older than 80 years and patients aged less than 80 years
    • Rojas JI, Zurru MC, Romano M, Patrucco L, Cristiano E. Acute ischaemic stroke and transient ischaemic attack in the very old - risk factor profile and stroke subtype between patients older than 80 years and patients aged less than 80 years. Eur J Neurol 2007; 14: 895-899.
    • (2007) Eur J Neurol , vol.14 , pp. 895-899
    • Rojas, J.I.1    Zurru, M.C.2    Romano, M.3    Patrucco, L.4    Cristiano, E.5
  • 10
    • 0033921751 scopus 로고    scopus 로고
    • Role of a stroke data bank in evaluating cerebral infarction subtypes: patterns and outcomes of 1776 consecutive patients from the Besancon stroke registry
    • Moulin T, Tatu L, Vuiller F, Berger E, Chavot D, Rumbach L. Role of a stroke data bank in evaluating cerebral infarction subtypes: patterns and outcomes of 1776 consecutive patients from the Besancon stroke registry. Cerebrovasc Dis 2000; 10: 261-271.
    • (2000) Cerebrovasc Dis , vol.10 , pp. 261-271
    • Moulin, T.1    Tatu, L.2    Vuiller, F.3    Berger, E.4    Chavot, D.5    Rumbach, L.6
  • 11
    • 42449124177 scopus 로고    scopus 로고
    • Risk factors for ischaemic stroke
    • Allen CL, Bayraktutan U. Risk factors for ischaemic stroke. Int J Stroke 2008; 3: 105-116.
    • (2008) Int J Stroke , vol.3 , pp. 105-116
    • Allen, C.L.1    Bayraktutan, U.2
  • 12
    • 0032876535 scopus 로고    scopus 로고
    • Smoking and risk of stroke
    • Hankey GJ. Smoking and risk of stroke. J Cardiovasc Risk 1999; 6: 207-211.
    • (1999) J Cardiovasc Risk , vol.6 , pp. 207-211
    • Hankey, G.J.1
  • 13
    • 61349119915 scopus 로고    scopus 로고
    • Differentiating ischemic stroke subtypes: risk factors and secondary prevention
    • Kirshner HS. Differentiating ischemic stroke subtypes: risk factors and secondary prevention. J Neurol Sci 2009; 279: 1-8.
    • (2009) J Neurol Sci , vol.279 , pp. 1-8
    • Kirshner, H.S.1
  • 14
    • 65249125762 scopus 로고    scopus 로고
    • Sex differences in stroke epidemiology: a systematic review
    • Appelros P, Stegmayr B, Terent A. Sex differences in stroke epidemiology: a systematic review. Stroke 2009; 40: 1082-1090.
    • (2009) Stroke , vol.40 , pp. 1082-1090
    • Appelros, P.1    Stegmayr, B.2    Terent, A.3
  • 17
    • 0034054903 scopus 로고    scopus 로고
    • Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia
    • Kharlamov A, Kharlamov E, Armstrong DM. Age-dependent increase in infarct volume following photochemically induced cerebral infarction: putative role of astroglia. J Gerontol A Biol Sci Med Sci 2000; 55: B135-B141.
    • (2000) J Gerontol A Biol Sci Med Sci , vol.55
    • Kharlamov, A.1    Kharlamov, E.2    Armstrong, D.M.3
  • 18
    • 0029843180 scopus 로고    scopus 로고
    • Effect of age in rodent models of focal forebrain ischaemia
    • Sutherland GR, Dix GA, Auer RN. Effect of age in rodent models of focal forebrain ischaemia. Stroke 1996; 27: 1663-1667.
    • (1996) Stroke , vol.27 , pp. 1663-1667
    • Sutherland, G.R.1    Dix, G.A.2    Auer, R.N.3
  • 19
    • 34548033977 scopus 로고    scopus 로고
    • Age-related decrease of striatal neurogenesis is associated with apoptosis of neural precursors and newborn neurons in rat brain after ischaemia
    • Chen Y, Sun FY. Age-related decrease of striatal neurogenesis is associated with apoptosis of neural precursors and newborn neurons in rat brain after ischaemia. Brain Res 2007; 1166: 9-19.
    • (2007) Brain Res , vol.1166 , pp. 9-19
    • Chen, Y.1    Sun, F.Y.2
  • 20
    • 79959962447 scopus 로고    scopus 로고
    • Age-related differences in experimental stroke: possible involvement of mitochondrial dysfunction and oxidative damage
    • Li N, Kong X, Ye R, Yang Q, Han J, Xiong L. Age-related differences in experimental stroke: possible involvement of mitochondrial dysfunction and oxidative damage. Rejuvenation Res 2011; 14: 261-273.
    • (2011) Rejuvenation Res , vol.14 , pp. 261-273
    • Li, N.1    Kong, X.2    Ye, R.3    Yang, Q.4    Han, J.5    Xiong, L.6
  • 21
    • 0037169236 scopus 로고    scopus 로고
    • Aging has a complex effect on a rat model of ischaemic stroke
    • Shapira S, Sapir M, Wengier A, Grauer E, Kadar T. Aging has a complex effect on a rat model of ischaemic stroke. Brain Res 2002; 925: 148-158.
    • (2002) Brain Res , vol.925 , pp. 148-158
    • Shapira, S.1    Sapir, M.2    Wengier, A.3    Grauer, E.4    Kadar, T.5
  • 22
    • 80054766188 scopus 로고    scopus 로고
    • Attenuated inflammatory response in aged mice brains following stroke
    • Sieber MW, Claus RA, Witte OW, Frahm C. Attenuated inflammatory response in aged mice brains following stroke. PLoS One 2011; 6: e26288.
    • (2011) PLoS One , vol.6
    • Sieber, M.W.1    Claus, R.A.2    Witte, O.W.3    Frahm, C.4
  • 24
    • 77954660823 scopus 로고    scopus 로고
    • Expression of NA-K-Cl transporter and edema formation are age dependent after ischaemic stroke
    • Liu F, Akella P, Benashski SE, Xu Y, McCullough LD. Expression of NA-K-Cl transporter and edema formation are age dependent after ischaemic stroke. Exp Neurol 2010; 224: 356-361.
    • (2010) Exp Neurol , vol.224 , pp. 356-361
    • Liu, F.1    Akella, P.2    Benashski, S.E.3    Xu, Y.4    McCullough, L.D.5
  • 26
    • 33751192462 scopus 로고    scopus 로고
    • Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke
    • Won SJ, Xie L, Kim SH, Tang H, Wang Y, Mao X, Banwait S, Jin K. Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res 2006; 1123: 237-244.
    • (2006) Brain Res , vol.1123 , pp. 237-244
    • Won, S.J.1    Xie, L.2    Kim, S.H.3    Tang, H.4    Wang, Y.5    Mao, X.6    Banwait, S.7    Jin, K.8
  • 27
    • 0037210863 scopus 로고    scopus 로고
    • Effect of age in rats following middle cerebral artery occlusion
    • Wang RY, Wang PS, Yang YR. Effect of age in rats following middle cerebral artery occlusion. Gerontology 2003; 49: 27-32.
    • (2003) Gerontology , vol.49 , pp. 27-32
    • Wang, R.Y.1    Wang, P.S.2    Yang, Y.R.3
  • 28
    • 23244459514 scopus 로고    scopus 로고
    • Treadmill training effects in different age groups following middle cerebral artery occlusion in rats
    • Wang RY, Yu SM, Yang YR. Treadmill training effects in different age groups following middle cerebral artery occlusion in rats. Gerontology 2005; 51: 161-165.
    • (2005) Gerontology , vol.51 , pp. 161-165
    • Wang, R.Y.1    Yu, S.M.2    Yang, Y.R.3
  • 29
    • 0023629050 scopus 로고
    • Hormonal state affects recovery from fontal cortex lesions in adult female rats
    • Atella MJ, Nattinville A, Stein DG. Hormonal state affects recovery from fontal cortex lesions in adult female rats. Behav Neur Biol 1987; 48: 352-367.
    • (1987) Behav Neur Biol , vol.48 , pp. 352-367
    • Atella, M.J.1    Nattinville, A.2    Stein, D.G.3
  • 30
    • 0027522598 scopus 로고
    • Gender influences outcome of brain injury: progesterone plays a protective role
    • Roof RL, Duvdevani R, Stein DG. Gender influences outcome of brain injury: progesterone plays a protective role. Brain Res 1993; 607: 333-336.
    • (1993) Brain Res , vol.607 , pp. 333-336
    • Roof, R.L.1    Duvdevani, R.2    Stein, D.G.3
  • 31
    • 82255182183 scopus 로고    scopus 로고
    • Is progesterone a worthy candidate as a novel therapy for traumatic brain injury?
    • Stein DG. Is progesterone a worthy candidate as a novel therapy for traumatic brain injury? Dialogues Clin Neurosci 2011; 13: 352-359.
    • (2011) Dialogues Clin Neurosci , vol.13 , pp. 352-359
    • Stein, D.G.1
  • 33
    • 43249131666 scopus 로고    scopus 로고
    • Improved outcomes from the administration of progesterone to patients with acute severe traumatic brain injury: a randomized controlled trial
    • Xiao G, Wei J, Yan W, Wand W, Lu Z. Improved outcomes from the administration of progesterone to patients with acute severe traumatic brain injury: a randomized controlled trial. Crit Care 2008; 12: R61.
    • (2008) Crit Care , vol.12
    • Xiao, G.1    Wei, J.2    Yan, W.3    Wand, W.4    Lu, Z.5
  • 34
    • 43949131780 scopus 로고    scopus 로고
    • Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice
    • Aggarwal R, Medhi B, Pathak A, Dhawan V, Chakrabarti A. Neuroprotective effect of progesterone on acute phase changes induced by partial global cerebral ischaemia in mice. J Pharm Pharmacol 2008; 60: 731-737.
    • (2008) J Pharm Pharmacol , vol.60 , pp. 731-737
    • Aggarwal, R.1    Medhi, B.2    Pathak, A.3    Dhawan, V.4    Chakrabarti, A.5
  • 35
    • 0033976986 scopus 로고    scopus 로고
    • Neuroprotective effects of female gonadal steroids in reproductively senescent female rats
    • Alkayed NJ, Traystman RJ, Hurn PD, Miller VM. Neuroprotective effects of female gonadal steroids in reproductively senescent female rats. Stroke 2000; 31: 161-168.
    • (2000) Stroke , vol.31 , pp. 161-168
    • Alkayed, N.J.1    Traystman, R.J.2    Hurn, P.D.3    Miller, V.M.4
  • 36
    • 47149112183 scopus 로고    scopus 로고
    • Two different molecular mechanisms underlying progesterone neuroprotection against ischaemic brain damage
    • Cai W, Zhu Y, Furuya K, Li Z, Sokabe M, Chen L. Two different molecular mechanisms underlying progesterone neuroprotection against ischaemic brain damage. Neuropharmacology 2008; 55: 127-138.
    • (2008) Neuropharmacology , vol.55 , pp. 127-138
    • Cai, W.1    Zhu, Y.2    Furuya, K.3    Li, Z.4    Sokabe, M.5    Chen, L.6
  • 37
    • 0032724682 scopus 로고    scopus 로고
    • Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat
    • Chen J, Chopp M, Li Y. Neuroprotective effects of progesterone after transient middle cerebral artery occlusion in rat. J Neurol Sci 1999; 171: 24-30.
    • (1999) J Neurol Sci , vol.171 , pp. 24-30
    • Chen, J.1    Chopp, M.2    Li, Y.3
  • 38
    • 79954735874 scopus 로고    scopus 로고
    • Gonadal steroids prevent cell damage and stimulate behavioural recovery after transient middle cerebral artery occlusion in male and female rats
    • Dang J, Mitkari B, Kipp M, Beyer C. Gonadal steroids prevent cell damage and stimulate behavioural recovery after transient middle cerebral artery occlusion in male and female rats. Brain Behav Immun 2011; 25: 715-726.
    • (2011) Brain Behav Immun , vol.25 , pp. 715-726
    • Dang, J.1    Mitkari, B.2    Kipp, M.3    Beyer, C.4
  • 39
    • 3042773856 scopus 로고    scopus 로고
    • Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice
    • Gibson CL, Murphy SP. Progesterone enhances functional recovery after middle cerebral artery occlusion in male mice. J Cereb Blood Flow Metab 2004; 24: 805-813.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 805-813
    • Gibson, C.L.1    Murphy, S.P.2
  • 40
    • 18144409121 scopus 로고    scopus 로고
    • Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischaemia
    • Gibson CL, Constantin DC, Prior MJW, Bath PMW, Murphy SP. Progesterone suppresses the inflammatory response and nitric oxide synthase-2 expression following cerebral ischaemia. Exp Neurol 2005; 193: 522-530.
    • (2005) Exp Neurol , vol.193 , pp. 522-530
    • Gibson, C.L.1    Constantin, D.C.2    Prior, M.J.W.3    Bath, P.M.W.4    Murphy, S.P.5
  • 41
    • 79959711271 scopus 로고    scopus 로고
    • Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice
    • Gibson CL, Coomber B, Murphy SP. Progesterone is neuroprotective following cerebral ischaemia in reproductively ageing female mice. Brain 2011; 134: 2125-2133.
    • (2011) Brain , vol.134 , pp. 2125-2133
    • Gibson, C.L.1    Coomber, B.2    Murphy, S.P.3
  • 42
    • 0031833744 scopus 로고    scopus 로고
    • Progeserone: protective effects on the cat hippocampal neuronal damage due to acute global cerebral ischaemia
    • Gonzalez-Vidal MD, Cervera-Gaviria M, Ruelas R, Escobar A, Morali G, Cervantes M. Progeserone: protective effects on the cat hippocampal neuronal damage due to acute global cerebral ischaemia. Arch Med Res 1998; 29: 117-124.
    • (1998) Arch Med Res , vol.29 , pp. 117-124
    • Gonzalez-Vidal, M.D.1    Cervera-Gaviria, M.2    Ruelas, R.3    Escobar, A.4    Morali, G.5    Cervantes, M.6
  • 43
    • 63349089474 scopus 로고    scopus 로고
    • Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischaemia in rats
    • Ishrat T, Sayeed I, Atif F, Stein DG. Effects of progesterone administration on infarct volume and functional deficits following permanent focal cerebral ischaemia in rats. Brain Res 2009; 1257: 94-101.
    • (2009) Brain Res , vol.1257 , pp. 94-101
    • Ishrat, T.1    Sayeed, I.2    Atif, F.3    Stein, D.G.4
  • 44
    • 77957780905 scopus 로고    scopus 로고
    • Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischaemia by regulating the expression of matrix metalloproteinases
    • Ishrat T, Sayeed I, Atif F, Hua F, Stein DG. Progesterone and allopregnanolone attenuate blood-brain barrier dysfunction following permanent focal ischaemia by regulating the expression of matrix metalloproteinases. Exp Neurol 2010; 226: 183-90.
    • (2010) Exp Neurol , vol.226 , pp. 183-190
    • Ishrat, T.1    Sayeed, I.2    Atif, F.3    Hua, F.4    Stein, D.G.5
  • 45
    • 84861186845 scopus 로고    scopus 로고
    • Progesterone is neuroprotective against ischaemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway
    • Ishrat T, Sayeed I, Atif F, Hua F, Stein DG. Progesterone is neuroprotective against ischaemic brain injury through its effects on the phosphoinositide 3-kinase/protein kinase B signaling pathway. Neuroscience 2012; 210: 442-450.
    • (2012) Neuroscience , vol.210 , pp. 442-450
    • Ishrat, T.1    Sayeed, I.2    Atif, F.3    Hua, F.4    Stein, D.G.5
  • 46
    • 0030607198 scopus 로고    scopus 로고
    • Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats
    • Jiang N, Chopp M, Stein D, Feit H. Progesterone is neuroprotective after transient middle cerebral artery occlusion in male rats. Brain Res 1996; 735: 101-107.
    • (1996) Brain Res , vol.735 , pp. 101-107
    • Jiang, N.1    Chopp, M.2    Stein, D.3    Feit, H.4
  • 47
    • 68449084536 scopus 로고    scopus 로고
    • Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke
    • Jiang C, Wang J, Li X, Liu C, Chen N, Hao Y. Progesterone exerts neuroprotective effects by inhibiting inflammatory response after stroke. Inflamm Res 2009; 58: 619-624.
    • (2009) Inflamm Res , vol.58 , pp. 619-624
    • Jiang, C.1    Wang, J.2    Li, X.3    Liu, C.4    Chen, N.5    Hao, Y.6
  • 48
    • 0034016139 scopus 로고    scopus 로고
    • Neuroprotective effect of postischaemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischaemia
    • Kumon Y, Kim SC, Tompkins P, Stevens A, Sakaki S, Loftus CM. Neuroprotective effect of postischaemic administration of progesterone in spontaneously hypertensive rats with focal cerebral ischaemia. J Neurosurg 2000; 92: 848-852.
    • (2000) J Neurosurg , vol.92 , pp. 848-852
    • Kumon, Y.1    Kim, S.C.2    Tompkins, P.3    Stevens, A.4    Sakaki, S.5    Loftus, C.M.6
  • 50
    • 0036791875 scopus 로고    scopus 로고
    • Progesterone administration during reperfusion, but not preischaemia alone, reduces injury in ovariectomised rats
    • Murphy SJ, Littleton-Kearney MT, Hurn PD. Progesterone administration during reperfusion, but not preischaemia alone, reduces injury in ovariectomised rats. J Cereb Blood Flow Metab 2002; 22: 367-388.
    • (2002) J Cereb Blood Flow Metab , vol.22 , pp. 367-388
    • Murphy, S.J.1    Littleton-Kearney, M.T.2    Hurn, P.D.3
  • 51
    • 33645002699 scopus 로고    scopus 로고
    • Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion
    • Sayeed I, Guo Q, Hoffman SW, Stein DG. Allopregnanolone, a progesterone metabolite, is more effective than progesterone in reducing cortical infarct volume after transient middle cerebral artery occlusion. Ann Emerg Med 2006; 47: 381-389.
    • (2006) Ann Emerg Med , vol.47 , pp. 381-389
    • Sayeed, I.1    Guo, Q.2    Hoffman, S.W.3    Stein, D.G.4
  • 52
    • 34548089961 scopus 로고    scopus 로고
    • Progesterone inhibits ischaemic brain injury in a rat model of permanent middle cerebral artery occlusion
    • Sayeed I, Wali B, Stain DG. Progesterone inhibits ischaemic brain injury in a rat model of permanent middle cerebral artery occlusion. Restor Neurol Neurosci 2007; 25: 151-159.
    • (2007) Restor Neurol Neurosci , vol.25 , pp. 151-159
    • Sayeed, I.1    Wali, B.2    Stain, D.G.3
  • 53
    • 77249145948 scopus 로고    scopus 로고
    • Neuroprotective effects of progesterone following stroke in aged rats
    • Wang J, Jiang C, Liu C, Li X, Chen N, Hao Y. Neuroprotective effects of progesterone following stroke in aged rats. Behav Brain Res 2010; 209: 119-22.
    • (2010) Behav Brain Res , vol.209 , pp. 119-122
    • Wang, J.1    Jiang, C.2    Liu, C.3    Li, X.4    Chen, N.5    Hao, Y.6
  • 54
    • 7944227783 scopus 로고    scopus 로고
    • 17 b-Estradiol prevents focal cerebral ischaemic damage via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats
    • Choi YC, Lee JH, Hong KW, Lee KS. 17 b-Estradiol prevents focal cerebral ischaemic damage via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats. Fundam Clin Pharmacol 2004; 18: 547-557.
    • (2004) Fundam Clin Pharmacol , vol.18 , pp. 547-557
    • Choi, Y.C.1    Lee, J.H.2    Hong, K.W.3    Lee, K.S.4
  • 55
    • 78049280232 scopus 로고    scopus 로고
    • Sustained levels of progesterone prior to the onset of cerebral ischaemia are not beneficial to female mice
    • Coomber B, Gibson CL. Sustained levels of progesterone prior to the onset of cerebral ischaemia are not beneficial to female mice. Brain Res 2010; 1361: 124-32.
    • (2010) Brain Res , vol.1361 , pp. 124-132
    • Coomber, B.1    Gibson, C.L.2
  • 56
    • 4944246436 scopus 로고    scopus 로고
    • Effects of combined estrogen and progesterone in brain infarction in reproductively senescent female rats
    • Toung TJ, Chen T-Y, Littleton Kearney MT, Hurn PD, Murphy SJ. Effects of combined estrogen and progesterone in brain infarction in reproductively senescent female rats. J Cereb Blood Flow Metab 2004; 24: 1160-1166.
    • (2004) J Cereb Blood Flow Metab , vol.24 , pp. 1160-1166
    • Toung, T.J.1    Chen, T.-Y.2    Littleton Kearney, M.T.3    Hurn, P.D.4    Murphy, S.J.5
  • 57
    • 0034102549 scopus 로고    scopus 로고
    • Progesterone exacerbates striatal stroke injury in progesterone-deficient animals
    • Murphy SJ, Traystman RJ, Hurn PD. Progesterone exacerbates striatal stroke injury in progesterone-deficient animals. Stroke 2000; 31: 367-388.
    • (2000) Stroke , vol.31 , pp. 367-388
    • Murphy, S.J.1    Traystman, R.J.2    Hurn, P.D.3
  • 59
    • 0032547326 scopus 로고    scopus 로고
    • Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women
    • Hulley S, Grady D, Bush T, Furberg C, Herrington D, Riggs B, Vittinghoff E. Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women. JAMA 1998; 280: 605-611.
    • (1998) JAMA , vol.280 , pp. 605-611
    • Hulley, S.1    Grady, D.2    Bush, T.3    Furberg, C.4    Herrington, D.5    Riggs, B.6    Vittinghoff, E.7
  • 61
    • 2542540731 scopus 로고    scopus 로고
    • Hormone therapy: physiological complexity belies therapeutic simplicity
    • Turgeon JL, McDonnell DP, Martin KA, Wise PM. Hormone therapy: physiological complexity belies therapeutic simplicity. Science 2004; 304: 1269-1273.
    • (2004) Science , vol.304 , pp. 1269-1273
    • Turgeon, J.L.1    McDonnell, D.P.2    Martin, K.A.3    Wise, P.M.4
  • 62
    • 38849190685 scopus 로고    scopus 로고
    • Progesterone for the treatment of experimental brain injury; a systematic review
    • Gibson CL, Gray LJ, Bath PMW, Murphy SP. Progesterone for the treatment of experimental brain injury; a systematic review. Brain 2008; 131: 318-328.
    • (2008) Brain , vol.131 , pp. 318-328
    • Gibson, C.L.1    Gray, L.J.2    Bath, P.M.W.3    Murphy, S.P.4
  • 63
    • 79951937638 scopus 로고    scopus 로고
    • Improved behavioural outcomes after progesterone administration in aged male rats with traumatic brain injury
    • Wali B, Sayeed I, Stein DG. Improved behavioural outcomes after progesterone administration in aged male rats with traumatic brain injury. Restor Neurol Neurosci 2011; 29: 61-71.
    • (2011) Restor Neurol Neurosci , vol.29 , pp. 61-71
    • Wali, B.1    Sayeed, I.2    Stein, D.G.3
  • 64
    • 0031924087 scopus 로고    scopus 로고
    • Correlation of perfusion and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) stroke
    • Tong DC, Yenari MA, Albers GW, O'Brien M, Marks MP, Moseley ME. Correlation of perfusion and diffusion-weighted MRI with NIHSS score in acute (<6.5 hour) stroke. Neurology 1998; 50: 864-870.
    • (1998) Neurology , vol.50 , pp. 864-870
    • Tong, D.C.1    Yenari, M.A.2    Albers, G.W.3    O'Brien, M.4    Marks, M.P.5    Moseley, M.E.6
  • 66
    • 4544282704 scopus 로고    scopus 로고
    • Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury
    • He J, Evans CO, Hoffman SW, Oyesiku NM, Stein DG. Progesterone and allopregnanolone reduce inflammatory cytokines after traumatic brain injury. Exp Neurol 2004; 189: 404-412.
    • (2004) Exp Neurol , vol.189 , pp. 404-412
    • He, J.1    Evans, C.O.2    Hoffman, S.W.3    Oyesiku, N.M.4    Stein, D.G.5
  • 67
    • 23844482170 scopus 로고    scopus 로고
    • Expression of glutamate receptor subunits in the hypothalamus of the female rat during the afternoon of the proestrous luteinizing hormone surge and effects of antiprogestin treatment and aging
    • Brann DW, Zamorano PL, De Sevilla L, Mahesh VB. Expression of glutamate receptor subunits in the hypothalamus of the female rat during the afternoon of the proestrous luteinizing hormone surge and effects of antiprogestin treatment and aging. Neuroendocrinology 2005; 81: 120-128.
    • (2005) Neuroendocrinology , vol.81 , pp. 120-128
    • Brann, D.W.1    Zamorano, P.L.2    De Sevilla, L.3    Mahesh, V.B.4
  • 68
    • 18844395818 scopus 로고    scopus 로고
    • Modulatory effects of progesterone on NOS-2 expression in vivo and in vitro
    • Coughlan T, Gibson CL, Murphy SP. Modulatory effects of progesterone on NOS-2 expression in vivo and in vitro. J Neurochem 2005; 93: 932-942.
    • (2005) J Neurochem , vol.93 , pp. 932-942
    • Coughlan, T.1    Gibson, C.L.2    Murphy, S.P.3
  • 70
    • 0028910427 scopus 로고
    • Blood-brain barrier breakdown and edema formation following frontal cortical contusion: does hormonal status play a role?
    • Duvdevani R, Roof RL, Fulop Z, Hoffman SW, Stein DG. Blood-brain barrier breakdown and edema formation following frontal cortical contusion: does hormonal status play a role? J Neurotrauma 1995; 12: 65-75.
    • (1995) J Neurotrauma , vol.12 , pp. 65-75
    • Duvdevani, R.1    Roof, R.L.2    Fulop, Z.3    Hoffman, S.W.4    Stein, D.G.5
  • 71
    • 33645747664 scopus 로고    scopus 로고
    • Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats
    • Guo Q, Sayeed I, Baronne L, Hoffman SW, Guennoun R, Stain DG. Progesterone administration modulates AQP4 expression and edema after traumatic brain injury in male rats. Exp Neurol 2006; 198: 469-478.
    • (2006) Exp Neurol , vol.198 , pp. 469-478
    • Guo, Q.1    Sayeed, I.2    Baronne, L.3    Hoffman, S.W.4    Guennoun, R.5    Stain, D.G.6
  • 72
    • 0029878565 scopus 로고    scopus 로고
    • Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective
    • Roof RL, Duvdevani R, Heyburn JW, Stein DG. Progesterone rapidly decreases brain edema: treatment delayed up to 24 hours is still effective. Exp Neurol 1996; 138: 246-251.
    • (1996) Exp Neurol , vol.138 , pp. 246-251
    • Roof, R.L.1    Duvdevani, R.2    Heyburn, J.W.3    Stein, D.G.4
  • 74
    • 0036141071 scopus 로고    scopus 로고
    • Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate
    • Nilsen J, Brinton RD. Impact of progestins on estrogen-induced neuroprotection: synergy by progesterone and 19-norprogesterone and antagonism by medroxyprogesterone acetate. Endocrinology 2002; 143: 205-212.
    • (2002) Endocrinology , vol.143 , pp. 205-212
    • Nilsen, J.1    Brinton, R.D.2
  • 75
    • 0347418151 scopus 로고    scopus 로고
    • Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex
    • Djebali MS, Hoffman SW, Stein DG. Allopregnanolone and progesterone decrease cell death and cognitive deficits after a contusion of the rat pre-frontal cortex. Neuroscience 2004; 123: 349-359.
    • (2004) Neuroscience , vol.123 , pp. 349-359
    • Djebali, M.S.1    Hoffman, S.W.2    Stein, D.G.3
  • 76
    • 35148842433 scopus 로고    scopus 로고
    • Neurochemical changes in the aging process: implications in medication in the elderly
    • Anyanwu EC. Neurochemical changes in the aging process: implications in medication in the elderly. Sci World J 2007; 7: 1603-1610.
    • (2007) Sci World J , vol.7 , pp. 1603-1610
    • Anyanwu, E.C.1
  • 77
    • 44349096287 scopus 로고    scopus 로고
    • Hypertension and cerebrovascular dysfunction
    • Iadecola C, Davisson RL. Hypertension and cerebrovascular dysfunction. Cell Metab 2008; 7: 476-484.
    • (2008) Cell Metab , vol.7 , pp. 476-484
    • Iadecola, C.1    Davisson, R.L.2
  • 78
    • 0038060334 scopus 로고    scopus 로고
    • Ischaemic tolerance and endogenous neuroprotection
    • Dirnagl U, Simon RP, Hallenbeck JM. Ischaemic tolerance and endogenous neuroprotection. Trends Neurosci 2003; 26: 248-254.
    • (2003) Trends Neurosci , vol.26 , pp. 248-254
    • Dirnagl, U.1    Simon, R.P.2    Hallenbeck, J.M.3
  • 79
    • 33745236064 scopus 로고    scopus 로고
    • Membrane associated functions of neurokinin B (NKB) on Abeta (25-35) induced toxicity in aging rat brain synaptosomes
    • Mantha AK, Moorthy K, Cowsik SM, Baquer NZ. Membrane associated functions of neurokinin B (NKB) on Abeta (25-35) induced toxicity in aging rat brain synaptosomes. Biogerontology 2006; 7: 19-33.
    • (2006) Biogerontology , vol.7 , pp. 19-33
    • Mantha, A.K.1    Moorthy, K.2    Cowsik, S.M.3    Baquer, N.Z.4
  • 80
    • 84873392984 scopus 로고    scopus 로고
    • Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischaemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection
    • Atif F, Yousuf S, Sayeed I, Ishrat T, Hua F, Stein DG. Combination treatment with progesterone and vitamin D hormone is more effective than monotherapy in ischaemic stroke: the role of BDNF/TrkB/Erk1/2 signaling in neuroprotection. Neuropharmacology 2013; 67: 78-87.
    • (2013) Neuropharmacology , vol.67 , pp. 78-87
    • Atif, F.1    Yousuf, S.2    Sayeed, I.3    Ishrat, T.4    Hua, F.5    Stein, D.G.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.