Mechanical Induction of BMP-7 in Osteocyte Blocks Glucocorticoid-Induced Apoptosis Through PI3K/AKT/GSK3β Pathway

Cell Biochemistry and Biophysics

Volumn 67, Issue 2, 2013, Pages 567-574

  Wang, Zhaohong ^a   Guo, Jun ^b  

^a XUZHOU CENTRAL HOSPITAL   (China)

^b CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

Apoptosis; BMP 7; GSK3 ; Osteocyte

Indexed keywords

BETA CATENIN; BMPR2 PROTEIN, MOUSE; BONE MORPHOGENETIC PROTEIN RECEPTOR 2; DEXAMETHASONE; GLUCOCORTICOID; GLYCOGEN SYNTHASE KINASE 3; GLYCOGEN SYNTHASE KINASE 3 BETA; OSTEOGENIC PROTEIN 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B;

ANIMAL; APOPTOSIS; ARTICLE; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; MECHANICS; METABOLISM; MOUSE; OSTEOCYTE; SECRETION (PROCESS); SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; BETA CATENIN; BONE MORPHOGENETIC PROTEIN 7; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; DEXAMETHASONE; GLUCOCORTICOIDS; GLYCOGEN SYNTHASE KINASE 3; MECHANICAL PROCESSES; MICE; MICE, INBRED C57BL; OSTEOCYTES; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 84886586445     PISSN: 10859195     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12013-013-9543-6     Document Type: Article

References (41)

1. van Brussel, M. S., Bultink, I. E., & Lems, W. F. (2009). Prevention of glucocorticoid-induced osteoporosis. Expert Opinion on Pharmacotherapy, 10(6), 997-1005.
2. Beavan, S., Horner, A., Bord, S., Ireland, D., & Compston, J. (2001). Colocalization of glucocorticoid and mineralocorticoid receptors in human bone. Journal of Bone and Mineral Research, 16(8), 1496-1504.
3. Bonewald, L. F. (2007). Osteocytes as dynamic multifunctional cells. Annals of the New York Academy of Sciences, 1116, 281-290.
4. Taylor, D., Hazenberg, J., & Lee, T. C. (2006). The cellular transducer in bone: What is it? Technology and Health Care, 14(4-5), 367-377.
5. Vezeridis, P. S., Semeins, C. M., Chen, Q., & Klein-Nulend, J. (2006). Osteocytes subjected to pulsating fluid flow regulate osteoblast proliferation and differentiation. Biochemical and Biophysical Research Communications, 348(3), 1082-1088.
6. Tatsumi, S., Ishii, K., Amizuka, N., Li, M., Kobayashi, T., Kohno, K., et al. (2007). Targeted ablation of osteocytes induces osteoporosis with defective mechanotransduction. Cell Metabolism, 5(6), 464-475.
7. Manolagas, S. C. (2000). Corticosteroids and fractures: A close encounter of the third cell kind. Journal of Bone and Mineral Research, 15(6), 1001-1005.
8. Aguirre, J. I., Plotkin, L. I., Stewart, S. A., Weinstein, R. S., Parfitt, A. M., Manolagas, S. C., et al. (2006). Osteocyte apoptosis is induced by weightlessness in mice and precedes osteoclast recruitment and bone loss. Journal of Bone and Mineral Research, 21(4), 605-615.
9. Clark, W. D., Smith, E. L., Linn, K. A., Paul-Murphy, J. R., Muir, P., & Cook, M. E. (2005). Osteocyte apoptosis and osteoclast presence in chicken radii 0-4 days following osteotomy. Calcified Tissue International, 77(5), 327-336.
10. Verborgt, O., Gibson, G. J., & Schaffler, M. B. (2000). Loss of osteocyte integrity in association with microdamage and bone remodeling after fatigue in vivo. Journal of Bone and Mineral Research, 15(1), 60-67.
11. Plotkin, L. I., Mathov, I., Aguirre, J. I., Parfitt, A. M., Manolagas, S. C., & Bellido, T. (2005). Mechanical stimulation prevents osteocyte apoptosis: Requirement of integrins, Src kinases, and ERKs. American Journal of Physiology. Cell Physiology, 289(3), C633-C643.
12. Lavery, K., Swain, P., Falb, D., & Alaoui-Ismaili, M. H. (2008). BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells. Journal of Biological Chemistry, 283(30), 20948-20958.
13. Lu, J., Bhargav, D., Wei, A. Q., & Diwan, A. (2008). Posterolateral intertransverse spinal fusion possible in osteoporotic rats with BMP-7 in a higher dose delivered on a composite carrier. Spine, 33(3), 242-249.
14. den Boer, F. C., Bramer, J. A., Blokhuis, T. J., van Soest, E. J., Jenner, J. M., Patka, P., et al. (2002). Effect of recombinant human osteogenic protein-1 on the healing of a freshly closed diaphyseal fracture. Bone, 31(1), 158-164.
15. Santos, A., Bakker, A. D., Willems, H. M., Bravenboer, N., Bronckers, A. L., & Klein-Nulend, J. (2011). Mechanical loading stimulates BMP7, but not BMP2, production by osteocytes. Calcified Tissue International, 89(4), 318-326.
16. Krause, C., Korchynskyi, O., de Rooij, K., Weidauer, S. E., de Gorter, D. J., van Bezooijen, R. L., et al. (2010). Distinct modes of inhibition by sclerostin on bone morphogenetic protein and Wnt signaling pathways. Journal of Biological Chemistry, 285(53), 41614-41626.
17. Kitase, Y., Barragan, L., Qing, H., Kondoh, S., Jiang, J. X., Johnson, M. L., et al. (2010). Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the beta-catenin and PKA pathways. Journal of Bone and Mineral Research, 25(12), 2657-2668.
18. Gu, G., Hentunen, T. A., Nars, M., Harkonen, P. L., & Vaananen, H. K. (2005). Estrogen protects primary osteocytes against glucocorticoid-induced apoptosis. Apoptosis, 10(3), 583-595.
19. Bacabac, R. G., Smit, T. H., Cowin, S. C., van Loon, J. J., Nieuwstadt, F. T., Heethaar, R., et al. (2005). Dynamic shear stress in parallel-plate flow chambers. Journal of Biomechanics, 38(1), 159-167.
20. Plotkin, L. I., Weinstein, R. S., Parfitt, A. M., Roberson, P. K., Manolagas, S. C., & Bellido, T. (1999). Prevention of osteocyte and osteoblast apoptosis by bisphosphonates and calcitonin. Journal of Clinical Investigation, 104(10), 1363-1374.
21. Wang, S., de Caestecker, M., Kopp, J., Mitu, G., Lapage, J., & Hirschberg, R. (2006). Renal bone morphogenetic protein-7 protects against diabetic nephropathy. Journal of the American Society of Nephrology, 17(9), 2504-2512.
22. Yu, P. B., Beppu, H., Kawai, N., Li, E., & Bloch, K. D. (2005). Bone morphogenetic protein (BMP) type II receptor deletion reveals BMP ligand-specific gain of signaling in pulmonary artery smooth muscle cells. Journal of Biological Chemistry, 280(26), 24443-24450.
23. Perron, J. C., & Dodd, J. (2009). ActRIIA and BMPRII Type II BMP receptor subunits selectively required for Smad4-independent BMP7-evoked chemotaxis. PLoS ONE, 4(12), e8198.
24. Shi, Y., & Massague, J. (2003). Mechanisms of TGF-beta signaling from cell membrane to the nucleus. Cell, 113(6), 685-700.
25. Nohe, A., Keating, E., Knaus, P., & Petersen, N. O. (2004). Signal transduction of bone morphogenetic protein receptors. Cellular Signalling, 16(3), 291-299.
26. Yun, S. I., Yoon, H. Y., Jeong, S. Y., & Chung, Y. S. (2009). Glucocorticoid induces apoptosis of osteoblast cells through the activation of glycogen synthase kinase 3 beta. Journal of Bone and Mineral Metabolism, 27(2), 140-148.
27. Shimizu, T., Kayamori, T., Murayama, C., & Miyamoto, A. (2012). Bone morphogenetic protein (BMP)-4 and BMP-7 suppress granulosa cell apoptosis via different pathways: BMP-4 via PI3K/PDK-1/Akt and BMP-7 via PI3K/PDK-1/PKC. Biochemical and Biophysical Research Communications, 417(2), 869-873.
28. Noble, B. S., Peet, N., Stevens, H. Y., Brabbs, A., Mosley, J. R., Reilly, G. C., et al. (2003). Mechanical loading: biphasic osteocyte survival and targeting of osteoclasts for bone destruction in rat cortical bone. American Journal of Physiology. Cell Physiology, 284(4), C934-C943.
29. Burger, E. H., & Klein-Nulend, J. (1999). Mechanotransduction in bone-role of the lacuno-canalicular network. FASEB Journal, 13(Suppl), S101-S112.
30. Wang, Z., Zhao, J., Zhang, J., Wei, J., & Huang, Y. (2010). Protective effect of BMP-7 against aristolochic acid-induced renal tubular epithelial cell injury. Toxicology Letters, 198(3), 348-357.
31. Xu, J. H., Zhao, Y. Y., Wang, J. K., Yuan, Z. G., & Zhang, T. Z. (2010). Effects of mouse recombinant bone morphogenetic protein-7 transfection on cell apoptosis, NF-kappaB, and downstream genes in cultured primary cardiomyocytes after simulated ischemia and reperfusion injury. Journal of Cardiovascular Pharmacology, 56(1), 69-77.
32. Gautschi, O. P., Cadosch, D., Zellweger, R., Joesbury, K. A., & Filgueira, L. (2009). Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7. Journal of Musculoskeletal and Neuronal Interactions, 9(1), 53-60.
33. Gordon, K. J., & Blobe, G. C. (2008). Role of transforming growth factor-beta superfamily signaling pathways in human disease. Biochimica et Biophysica Acta, 1782(4), 197-228.
34. Derynck, R., & Zhang, Y. E. (2003). Smad-dependent and Smad-independent pathways in TGF-beta family signalling. Nature, 425(6958), 577-584.
35. Yu, P. B., Deng, D. Y., Beppu, H., Hong, C. C., Lai, C., Hoyng, S. A., et al. (2008). Bone morphogenetic protein (BMP) type II receptor is required for BMP-mediated growth arrest and differentiation in pulmonary artery smooth muscle cells. Journal of Biological Chemistry, 283(7), 3877-3888.
36. Liu, A., & Niswander, L. A. (2005). Bone morphogenetic protein signalling and vertebrate nervous system development. Nature Reviews Neuroscience, 6(12), 945-954.
37. Dupont, J., McNeilly, J., Vaiman, A., Canepa, S., Combarnous, Y., & Taragnat, C. (2003). Activin signaling pathways in ovine pituitary and LbetaT2 gonadotrope cells. Biology of Reproduction, 68(5), 1877-1887.
38. Lee-Hoeflich, S. T., Causing, C. G., Podkowa, M., Zhao, X., Wrana, J. L., & Attisano, L. (2004). Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO Journal, 23(24), 4792-4801.
39. Yang, X., Lee, P. J., Long, L., Trembath, R. C., & Morrell, N. W. (2007). BMP4 induces HO-1 via a smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes. American Journal of Respiratory Cell and Molecular Biology, 37(5), 598-605.
40. Fong, Y. C., Li, T. M., Wu, C. M., Hsu, S. F., Kao, S. T., Chen, R. J., et al. (2008). BMP-2 increases migration of human chondrosarcoma cells via PI3K/Akt pathway. Journal of Cellular Physiology, 217(3), 846-855.
41. Gamell, C., Osses, N., Bartrons, R., Ruckle, T., Camps, M., Rosa, J. L., et al. (2008). BMP2 induction of actin cytoskeleton reorganization and cell migration requires PI3-kinase and Cdc42 activity. Journal of Cell Science, 121(Pt 23), 3960-3970.