Apoptosis induction and reduced proliferation in human osteoblasts by rhBMP-2, -4 and -7

Journal of Musculoskeletal Neuronal Interactions

Volumn 9, Issue 1, 2009, Pages 53-60

  Gautschi, Oliver P ^a,b,c   Cadosch, D ^a,b   Zellweger, R ^a   Joesbury, K A ^a   Filgueira, L ^b  

^a ROYAL PERTH HOSPITAL   (Australia)

^b UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^c CANTONAL HOSPITAL ST GALLEN   (Switzerland)

Author keywords

Apoptosis; Bone morphogenetic protein; Growth factors; Molecular pathways; Osteoblasts

Indexed keywords

BONE MORPHOGENETIC PROTEIN; RECOMBINANT BONE MORPHOGENETIC PROTEIN 2; RECOMBINANT BONE MORPHOGENETIC PROTEIN 4; RECOMBINANT OSTEOGENIC PROTEIN 1; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CELL IMMORTALIZATION; CELL PROLIFERATION; CELL STRAIN; COLORIMETRY; CONTROLLED STUDY; DRUG EFFICACY; FRACTURE HEALING; HUMAN; HUMAN CELL; IN VITRO STUDY; NICK END LABELING; OSTEOBLAST;

APOPTOSIS; BONE MORPHOGENETIC PROTEIN 2; BONE MORPHOGENETIC PROTEIN 4; BONE MORPHOGENETIC PROTEIN 7; CELL LINE, TRANSFORMED; CELL PROLIFERATION; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; IN SITU NICK-END LABELING; OSTEOBLASTS; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 67649452531     PISSN: 11087161     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (60)

1. Sykaras N, Opperman LA. Bone morphogenetic proteins (BMPs): how do they function and what can they offer the clinician? J Oral Sci 2003;45:57-73.
2. Wiss DA, Stetson WB. Tibial nonunion: treatment alternatives. J Am Acad Orthop Surg 1996;4:249-57.
3. Bassett CA, Pilla AA, Pawluk RJ. A non-operative salvage of surgically-resistant pseudarthroses and non-unions by pulsing electromagnetic fields. A preliminary report. Clin Orthop Relat Res 1977;124:128-43.
4. Brighton CT, Friedenberg ZB, Zemsky LM, Pollis PR. Direct-current stimulation of non-union and congenital pseudarthrosis. Exploration of its clinical application. J Bone Joint Surg Am 1975;57:368-77.
5. Heckman JD, Ryaby JP, McCabe J, Frey JJ, Kilcoyne RF. Acceleration of tibial fracture-healing by non-invasive, low-intensity pulsed ultrasound. J Bone Joint Surg Am 1994;76:26-34.
6. Groscurth P, Filgueira L. Killing mechanisms of cytotoxic T lymphocytes. News Physiol Sci 1998; 13:17-21.
7. Ripamonti U. Soluble osteogenic molecular signals and the induction of bone formation. Biomaterials 2006; 27:807-22.
8. Subramaniam M, Jalal SM, Rickard DJ, Harris SA, Bolander ME, Spelsberg TC. Further characterization of human fetal osteoblastic hFOB 1.19 and hFOB/ER alpha cells: bone formation in vivo and karyotype analysis using multicolor fluorescent in situ hybridization. J Cell Biochem 2002;87:9-15.
9. Filgueira L, Meagher J, Al-Mushaiqri M, Skirving AP, Zellweger R. Fulvestrant, an estrogen receptor antagonist, blocks proliferation and differentiation of cultured primary human osteoblasts. Bone 2005;36(Suppl.): S463-4.
10. Seeherman H, Wozney JM. Delivery of bone morphogenetic proteins for orthopedic tissue regeneration. Cytokine Growth Factor Rev 2005;16:329-45.
11. Adachi T, Takanaga H, Kunimoto M, Asou H. Influence of LIF and BMP-2 on differentiation and development of glial cells in primary cultures of embryonic rat cerebral hemisphere. J Neurosci Res 2005; 79:608-15.
12. Hogan BL. Bone morphogenetic proteins: multifunctional regulators of vertebrate development. Genes Dev 1996;10:1580-94.
13. Zou H, Choe KM, Lu Y, Massague J, Niswander L. BMP signaling and vertebrate limb development. Cold Spring Harb Symp Quant Biol 1997;62:269-72.
14. Massague J, Weis-Garcia F. Serine/threonine kinase receptors: mediators of transforming growth factor beta family signals. Cancer Surv 1996;27:41-64.
15. Yamashita H, Ten Dijke P, Heldin CH, Miyazono K. Bone morphogenetic protein receptors. Bone 1996; 19:569-74.
16. Heldin CH, Miyazono K, ten Dijke P. TGF-beta signalling from cell membrane to nucleus through SMAD proteins. Nature 1997;390:465-71.
17. Massague J. TGF-beta signal transduction. Annu Rev Biochem 1998;67:753-91.
18. Wrana JL. Regulation of Smad activity. Cell 2000; 100:189-92.
19. Urist MR. Bone morphogenetic protein: the molecularization of skeletal system development. J Bone Miner Res 1997;12:343-6.
20. Westerhuis RJ, van Bezooijen RL, Kloen P. Use of bone morphogenetic proteins in traumatology. Injury 2005;36:1405-12.
21. Wozney JM. The bone morphogenetic protein family and osteogenesis. Mol Reprod Dev 1992;32:160-7.
22. Govender S, Csimma C, Genant HK, Valentin-Opran A, Amit Y, Arbel R. Recombinant human bone morphogenetic protein-2 for treatment of open tibial fractures: a prospective, controlled, randomized study of four hundred and fifty patients. J Bone Joint Surg Am 2002;84-A:2123-34.
23. Friedlaender GE, Perry CR, Cole JD, Cook SD, Cierny G, Muschler GF, Zych GA, Calhoun JH, Laforte AJ, Yin S. Osteogenic protein-1 (bone morphogenetic protein-7) in the treatment of tibial nonunions. J Bone Joint Surg Am 2001; 83-A(Suppl.1):S151-8.
24. De Biase P, Capanna R. Clinical applications of BMPs. Injury 2005;36(Suppl.3):S43-6.
25. Boden SD, Kang J, Sandhu H, Heller JG. Use of recombinant human bone morphogenetic protein-2 to achieve posterolateral lumbar spine fusion in humans: a prospective, randomized clinical pilot trial: 2002 Volvo Award in Clinical Studies. Spine 2002;27:2662-73.
26. Kang Q, Sun MH, Cheng H, Peng Y, Montag AG, Deyrup AT, Jiang W, Luu HH, Luo J, Szatkowski JP, Vanichakarn P, Park JY, Li Y, Haydon RC, He TC. Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. Gene Ther 2004;11:1312-20.
27. Yeh LC, Adamo ML, Olson MS, Lee JC. Osteogenic protein-1 and insulin-like growth factor I synergistically stimulate rat osteoblastic cell differentiation and proliferation. Endocrinology 1997;138:4181-90.
28. Hulbert SF, Young FA, Mathews RS, Klawitter JJ, Talbert CD, Stelling FH. Potential of ceramic materials as permanently implantable skeletal prostheses. J Biomed Mater Res 1970;4:433-56.
29. Kuboki Y, Takita H, Kobayashi D, Tsuruga E, Inoue M, Murata M, Nagai N, Dohi Y, Ohgushi H. BMP-induced osteogenesis on the surface of hydroxyapatite with geometrically feasible and nonfeasible structures: topology of osteogenesis. J Biomed Mater Res 1998;39:190-9.
30. Cho TJ, Gerstenfeld LC, Einhorn TA. Differential temporal expression of members of the transforming growth factor beta superfamily during murine fracture healing. J Bone Miner Res 2002;17:513-20.
31. Wang EA. Bone morphogenetic proteins (BMPs): therapeutic potential in healing bony defects. Trends Biotechnol 1993;11:379-83.
32. Canalis E, Economides AN, Gazzerro E. Bone morphogenetic proteins, their antagonists, and the skeleton. Endocr Rev 2003;24:218-35.
33. Murnaghan M, McILmurray L, Mushipe MT, Li G. Time for treating bone fracture using rhBMP-2: a randomized placebo controlled mouse fracture trial. J Orthop Res 2005;23:625-31.
34. Li X, Cao X. BMP signaling and skeletogenesis. Ann NY Acad Sci 2006;1068:26-40.
35. McCullough KA, Waits CA, Garimella R, Tague SE, Sipe JB, Anderson HC. Immunohistochemical localization of bone morphogentic proteins (BMPs) 2, 4, 6, and 7 during induced heterotopic bone formation. J Orthop Res 2007;25:465-72.
36. Rosen V. BMP and BMP inhibitors in bone. Ann NY Acad Sci 2006;1068:19-25.
37. Osyczka AM, Diefenderfer DL, Bhargave G, Leboy PS. Different effects of BMP-2 on marrow stromal cells from human and rat bone. Cells Tissues Organs 2004; 176:109-19.
38. Yen ML, Chien CC, Chin IM, Huang HI, Chen YC, Hu HI, Yen BL. Multilineage differentiation and characterization of the human foetal osteoblastic 1.19 cell line: a possible in vitro model of human mesenchymal progenitors. Stem Cells 2007; 25:125-31.
39. Chen S, Guttridge DC, Tang E, Shi S, Guan KL, Wang CY. Suppression of tumor necrosis factor-mediated apoptosis by nuclear factor kB-independent bone morphogenetic protein/Smad signaling. J Biol Chem 2001; 276:39259-63.
40. Hay E, Lemonnier J, Fromigue O, Guenou H, Marie PJ. Bone morphogenetic protein receptor IB signaling mediates apoptosis independently of differentiation in osteoblastic cells. J Biol Chem 2004;279:1650-8.
41. Hay E, Lemonnier J, Fromigue O, Marie PJ. Bone morphogenetic protein-2 promotes osteoblast apoptosis through a Smad-independent, protein kinase C-dependent signaling pathway. J Biol Chem 2001; 276:29028-36.
42. Bilic R, Simic P, Jelic M, Stern-Padovan R, Dodiq D, Van Meerdervoort HP, Martinovic S, Ivankovic D, Pecina M, Vukicevic S. Osteogenic protein-1 (BMP-7) accelerates healing of scaphoid non-union with proximal pole sclerosis. Int Orthop 2006;30:128-34.
43. Dimitriou R, Dahabreh Z, Katsoulis E, Matthew SJ, Branfoot T, Fiannoudis PV. Application of recombinant BMP-7 on persistent upper and lower limb non-unions. Injury 2005;36S:S51-9.
44. Jones AL, Bucholz RW, Bosse MJ, Mirza SK, Lyon TR, Webb LX, Pollak AN, Golden JD, Valentin-Opran A; BMP-2 Evaluation in Surgery for Tibial Trauma-Allgraft (BESTT-ALL) Study Group. Recombinant human BMP-2 and allograft compared with autogenous bone graft for reconstruction of diaphyseal tibial fractures with cortical defects. A randomized, controlled trial. J Bone Joint Surg Am 2006; 88:1431-41.
45. Sugimoto H, Yang C, LeBleu VS, Soubasakos MA, Giraldo M, Zeisberg M, Kalluri R. BMP-7 fucntions as a nover hormone to facilitate liver regeneration. FASEB J 2007;21:256-64.
46. Wildemann B, Kadow-Romacker A, Pruss A, Haas NP, Schmidmaier G. Quantification of growth factors in allogenic bone grafts extracted with three different methods. Cell Tissue Bank 2007;8:107-14.
47. 3-induced differentiation of human osteoblasts. Exp Cell Res 2002;275:132-42.
48. Fiedler J, Roderer G, Gunther KP, Brenner RE. BMP-2, BMP-4, and PDGF-bb stimulate chemotactic migration of primary human mesenchymal progenitor cells. J Cell Biochem 2002;87:305-12.
49. Fernhead HO, Chwalinski M, Snowden RT, Ormerod MG, Cohen GM. Dexamethasone and etoposide induce apoptosis in rat thymocytes from different phases of the cell cycle. Biochem Pharmacol 1994;48:1073-9.
50. Mogi M, Togari A. Activation of caspases is required for osteoblastic differentiation. J Biol Chem 2003; 278:47477-82.
51. Chaudhary LR, Hofmeister AM, Hruska KA. Differential growth factor control of bone formation through osteoprogenitor differentiation. Bone 2004; 34:402-11.
52. Gersbach CA, Guldber RE, Garcia J. In vitro and in vivo osteoblastic differentiation of BMP2- and Runx2-engineered skeletal myoblasts. J Cell Biochem 2007; 100:1324-36.
53. Gutierrez J, Osses N, Brandan E. Changes in secreted and cell associated proteoglycan synthesis during conversion of myoblasts to osteoblasts in response to bone morphogenetic protein-2: role of decorin in cell response to BMP-2. J Cell Physiol 2006;206:58-67.
54. Komaki M, Asakura A, Rudnicki MA, Sodek J, Cheifetz S. MyoD enhances BMP7-induced osteogenic differentiation of myogenic cell cultures. J Cell Science 2003;117:1457-68.
55. Peng H, Usas A, Gearhart B, Olshanski A, Shen HC, Huard J. Converse relationship between in vitro osteogenic differentiation and in vivo bone healing elicited by different populations of muscle-derived cells genetically engineered to express BMP4. J Bone Miner Res 2004;19:630-41.
56. Wright V, Peng H, Usas A, Young B, Gearhart B, Cummins J, Huard J. BMP4-expressing muscle-derived stem cells differentiate into osteogenic lineage and improve bone healing in immunocompetent mice. Mol Ther 2002;6:169-78.
57. Kloen P, DiPaola M, Borens O, Richmond J, Perino G, Helfet DL, Goumans MJ. BMP signaling components are expressed in human callus. Bone 2003; 33:362-71.
58. Kloen P, Doty SB, Gordon E, Rubel IF, Goumans MJ, Helfet DL. Expression and activation of the BMP-signaling components in human fracture nonunions. J Bone Joint Surg Am 2002;84:1909-18.
59. Fromigue O, Modrowski D, Marie PJ. Apoptosis in membranous bone formation: role of fibroblast growth factor and bone morphogenetic protein signaling. Crit Rev Eukaryot Gene Expr 2005;15:75-92.
60. Rice D, Kim H, Thesleff I. Apoptosis in murine calvarial bone and suture development. Eur J Oral Sci 1999; 107:265-75.