Acidic pH of tumor microenvironment enhances cytotoxicity of the disulfiram/Cu2+ complex to breast and colon cancer cells

Chemotherapy

Volumn 59, Issue 2, 2013, Pages 112-120

  Navrátilová, Jarmila ^a   Hankeová, Tereza ^a   Beneš, Petr ^a,b   Šmarda, Jan ^a  

^a MASARYK UNIVERSITY   (Czech Republic)

^b ST ANNE S UNIVERSITY HOSPITAL   (Czech Republic)

Author keywords

Breast cancer; Colon cancer; Cytotoxicity; Disulfiram; Reactive oxygen species; Tumor microenvironment

Indexed keywords

DISULFIRAM; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROTEIN KINASE B; CRYSTAL VIOLET; CUPRIC ION; GLUCOSE; LACTIC ACID; REACTIVE OXYGEN METABOLITE;

ACIDOSIS; ARTICLE; BREAST CARCINOMA; CANCER CELL; CELL METABOLISM; COLON CARCINOMA; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HYPOXIA; PH; PHENOTYPE; PRIORITY JOURNAL; TUMOR MICROENVIRONMENT; CELL PROLIFERATION; CELL VIABILITY; COMPARATIVE STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; GEL ELECTROPHORESIS; GLUCOSE TRANSPORT; GLYCOLYSIS; HT 29 CELL LINE; IMMUNOBLOTTING; MCF 7 CELL LINE; STAINING; TRANSACTIVATION;

ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; CELL PROLIFERATION; CELL SURVIVAL; COLONIC NEOPLASMS; COORDINATION COMPLEXES; COPPER; DISULFIRAM; FEMALE; HT29 CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; MCF-7 CELLS; NF-KAPPA B; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; TUMOR MICROENVIRONMENT;

EID: 84886437077     PISSN: 00093157     EISSN: 14219794     Source Type: Journal    
DOI: 10.1159/000353915     Document Type: Article

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