Tolerance develops to the antiallodynic effects of the peripherally acting opioid loperamide hydrochloride in nerve-injured rats

Pain

Volumn 154, Issue 11, 2013, Pages 2477-2486

  He, Shao Qiu ^a   Yang, Fei ^a   Perez, Federico M ^b   Xu, Qian ^a,c   Shechter, Ronen ^a   Cheong, Yong Kwan ^a,d   Carteret, Alene F ^a   Dong, Xinzhong ^a   Sweitzer, Sarah M ^b   Raja, Srinivasa N ^a   Guan, Yun ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SOUTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c NANJING UNIVERSITY   (China)

^d Wonkwang University   (South Korea)

Author keywords

Nerve injury; Neuropathic pain; Peripheral opioid receptor; Rats; Tolerance

Indexed keywords

DIZOCILPINE; ENKEPHALIN; LOPERAMIDE; NALTREXONE; OPIATE AGONIST; AMINO ACID RECEPTOR BLOCKING AGENT; CALCIUM; DIZOCILPINE MALEATE; MU OPIATE RECEPTOR; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST;

ALLODYNIA; ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; DRUG TOLERANCE; HYPERSENSITIVITY; NERVE INJURY; NEUROPATHIC PAIN; NONHUMAN; PRIORITY JOURNAL; RAT; SPINAL GANGLION; SPINAL NERVE; WESTERN BLOTTING; ANIMAL; ANIMAL BEHAVIOR; DOSE RESPONSE; DRUG EFFECTS; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; LIGATION; MALE; METABOLISM; PHOSPHORYLATION; SPINAL CORD; SPRAGUE DAWLEY RAT; STIMULATION;

ANALGESICS, OPIOID; ANIMALS; BEHAVIOR, ANIMAL; BLOTTING, WESTERN; CALCIUM; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG TOLERANCE; EXCITATORY AMINO ACID ANTAGONISTS; GANGLIA, SPINAL; HYPERALGESIA; IMMUNOHISTOCHEMISTRY; LIGATION; LOPERAMIDE; MALE; NALTREXONE; NARCOTIC ANTAGONISTS; PHOSPHORYLATION; PHYSICAL STIMULATION; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU; SPINAL CORD; SPINAL NERVES;

EID: 84886314372     PISSN: 03043959     EISSN: 18726623     Source Type: Journal    
DOI: 10.1016/j.pain.2013.07.023     Document Type: Article

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