Characterization of the antihyperalgesic action of a novel peripheral mu-opioid receptor agonist - loperamide

Anesthesiology

Volumn 90, Issue 1, 1999, Pages 225-234

  Nozaki Taguchi, Natsuko ^a,b   Yaksh, Tony L ^b  

^a CHIBA UNIVERSITY   (Japan)

^b University of California at San Diego   (United States)

Author keywords

Hyperalgesia; Inflammation; Peripheral opiate action

Indexed keywords

ANALGESIC AGENT; LOPERAMIDE; MORPHINE; MU OPIATE RECEPTOR; NALOXONE; NARCOTIC ANALGESIC AGENT; NARCOTIC ANTAGONIST;

ANIMAL; ARTICLE; BURN; DRUG EFFECT; DRUG POTENTIATION; DRUG TOLERANCE; HINDLIMB; HYPERALGESIA; MALE; NOCICEPTIVE RECEPTOR; PAIN ASSESSMENT; PAIN THRESHOLD; PATHOPHYSIOLOGY; RAT; SPRAGUE DAWLEY RAT;

ANALGESICS; ANALGESICS, OPIOID; ANIMALS; BURNS; DRUG TOLERANCE; HINDLIMB; HYPERALGESIA; LOPERAMIDE; MALE; MORPHINE; NALOXONE; NARCOTIC ANTAGONISTS; NOCICEPTORS; PAIN MEASUREMENT; PAIN THRESHOLD; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, OPIOID, MU;

EID: 0032622187     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199901000-00029     Document Type: Article

References (30)

1. Levine JD, Taiwo YO: Involvement of the mu-opiate receptor in peripheral analgesia. Neuroscience 1989; 32:571-5
2. Stein C, Millan MJ, Shippenberg TS, Peter K, Herz A: Peripheral opioid receptors mediating antinociception in inflammation: Evidence for involvement of mu, delta and kappa receptors. J Pharmacol Exp Ther 1989; 248:1269-75
3. Nagasaka H, Awad H, Yaksh TL: Peripheral and spinal actions of opioids in the blockade of the autonomic response evoked by compression of the inflamed knee joint. ANESTHESIOLOGY 1996; 85:808-16
4. Stein C, Comisel K, Haimerl E, Yassouridis A, Lehrberger K, Herz A, Peter K: Analgesic effect of intraarticular morphine after arthroscopic knee surgery. N Engl J Med 1991; 325:1123-6
5. Kalso E, Tramèr MR, Carroll D, McQuay HJ, Moore RA: Pain relief from intra-articular morphine after knee surgery: A qualitative systematic review. Pain 1997; 71:127-34
6. Gilman AG, Rall TSV, Nies AS, Taylor P: The pharmacological basis of therapeutics, Opioid Analgesics and Antagonists. 8th edition. Edited by Jaffe JH, Martin WR. New York, McGraw-Hill, 1993, PP 485-521
7. Wüster M, Herz A: Opiate agonist action of antidiarrheal agents in vitro and in vivo-findings in support for selective action. Naunyn-Schmiedeberg's Arch Pharmacol 1978; 301:187-94
8. Heel RC, Brogden-RN, Speight TM, Avery GS: Loperamide: A review of its pharmacological properties and therapeutic efficacy in diarrhoea. Drugs 1978; 15:33-52
9. Jun JH, Yaksh TL: The effect of intrathecal gabapentin and 3-isobutyl gamma-aminobutyric acid on the hyperalgesia observed after thermal injury in the rat.-Anesth Analg 1998; 86:348-54
10. Gibson RD, Tingstad JE: Formulation of a morphine implantation pellet suitable for tolerance-physical dependence studies in mice. J Pharmacol Sci 1970; 59: 426-7
11. Hargreaves K, Dubner R, Brown F, Flores C, Joris J: A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia. Pain 1988; 32:77-88
12. Dirig DM, Yaksh TL: Thermal hyperalgesia in rat evoked by intrathecal substance P at multiple stimulus intensities reflects an increase in the gain of nociceptive processing. Neurosci Lett 1996; 220:93-6
13. Dirig DM, Salami A, Rathbun ML, Ozaki GT, Yaksh TL: Characterization of variables defining hindpaw withdrawal latency evoked by radiant thermal stimuli. J Neurosci Methods 1997; 76:183-91
14. 13a. DeHaven-Hudkins DL, Cortes Burgos L, Cassel JA, Daubert JD, DeHaven RN, Mansson E, Nagasaka H, Yu G, Yaksh TL: Loperamide (ADL2-1294), an opioid antihyperalgesic agent with peripheral selectivity. J Pharmacol Exp Ther 1998; in press
15. Sayre LM, Takemori AE, Portoghese PS: Alkylation of opioid receptor subtypes by alpha-chlornaltrexamine produces concurrent irreversible agonistic and irreversible antagonistic activities. J Med Chem 1983; 26:503-6
16. Kayser V, Gobeaux D, Lombard MC, Guilbaud G, Besson JM: Potent and long lasting antinociceptivc effects after injection of low doses of a mu-opioid receptor agonist, fentanyl, into the brachial plexus sheath of the rat. Pain 1990; 42:215-25
17. Jaffe RA, Rowe MA: A comparison of the local anesthetic effects of meperidine, fentanyl, and sufentanil on dorsal root axons. Anesth Analg 1996; 83:776-81
18. Reynolds IJ, Gould RJ, Snyder SH: Loperamide: Blockade of calcium channels as a mechanism for antidiarrheal effects. J Pharmacol Exp Ther 1984; 231:628-32
19. Xiao WH, Bennett GJ: Synthetic omega-conopeptides applied to the site of nerve injury suppress neuropathic pains in rats. J Pharmacol Exp Ther 1995; 274:666-72
20. Aley KO, Green PG, Levine JD: Opioid and adenosine peripheral antinociception are subject to tolerance and withdrawal. J Neurosci 1995; 15:8031-8
21. Stein C, Pflüger M, Yassouridis A, Hoelzl J, Lehrberger K, Welte C: No tolerance to peripheral morphine analgesia in presence of opioid expression in inflamed synovia. J Clin Invest 1996; 98:793-9
22. Hassan AHS, Ableitner A, Stein C, Herz A: Inflammation of the rat paw enhances axonal transport of opioid receptors in the sciatic nerve and increases their density in the inflamed tissue. Neuroscience 1993; 55:185-95
23. Schäfer M, Imai Y, Uhl GR, Stein C: Inflammation enhances peripheral μ-opioid receptor-mediated analgesia, but not μ-opioid receptor transcription in dorsal root ganglia. Eur J Pharmacol 1995; 279:165-9
24. Stein C: The control of pain in peripheral tissue by opioids. N Engl J Med 1995; 332:1685-90
25. Stevens CW, Yaksh TL: Potency of infused spinal antinociceptive agents is inversely related to magnitude of tolerance after continuous infusion. J Pharmacol Exp Ther 1989; 250:1-8
26. Sosnowski M, Yaksh TL: Differential cross-tolerance between intrathecal morphine and sufentanil in the rat. ANESTHESIOLOGY 1990; 73: 1141-7
27. Andreev N, Urban L, Dray A: Opioids suppress spontaneous activity of polymodal nociceptors in rat paw skin induced by ultraviolet irradiation. Neuroscience 1994; 58:793-8
28. Gold MS, Levine JD: DAMGO inhibits prostaglandin E2-induced potentiation of a TTX-resistant Na+ current in rat sensory neurons in vitro. Neurosci Lett 1996; 212:83-6
29. Schroeder JE, Fischbach PS, Zheng D, McCleskey EW: Activation of mu opioid receptors inhibit transient high- and low-threshold Ca2+ currents, but spares a sustained current. Neuron 1991; 6:13-20
30. Antonijevic I, Mousa SA, Schäfer M, Stein C: Perineurial defect and peripheral opioid analgesia in inflammation. J Neurosci 1995; 15:165-72