The role of N-methyl-D-aspartate (NMDA) receptors in pain and morphine tolerance

Minerva Anestesiologica

Volumn 71, Issue 7-8, 2005, Pages 401-403

  Inturrisi, C E ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Central sensitization; Conditional knock out; Cre loxP; Formalin pain; NMDA receptor; Spinal cord dorsal horn; Synaptic transmission

Indexed keywords

AMPA RECEPTOR; CRE RECOMBINASE; MESSENGER RNA; N METHYL DEXTRO ASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR 1;

CHRONIC PAIN; CONTROLLED STUDY; HUMAN; LUMBAR SPINAL CORD; MORPHINE TOLERANCE; MOTOR PERFORMANCE; NONHUMAN; PAIN THRESHOLD; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVIEW; SENSITIZATION; SPINAL CORD DORSAL HORN; SYNAPTIC TRANSMISSION;

ANALGESICS, OPIOID; ANIMALS; DRUG TOLERANCE; ELECTROPHYSIOLOGY; HUMANS; MICE; MICE, KNOCKOUT; MORPHINE; N-METHYLASPARTATE; PAIN; RECEPTORS, N-METHYL-D-ASPARTATE; SYNAPTIC TRANSMISSION;

EID: 33745308014     PISSN: 03759393     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (15)

1. Woolf CJ, Salter MW. Neuronal plasticity: increasing the gain in pain. Science 2000;288:1765-9.
2. Woolf CJ, Costigan M. Transcriptional and posttranslational plasticity and the generation of inflammatory pain. Proc Natl Acad Sci USA 1999;96:7723-30.
3. Dubner R, Ruda MA. Activity-dependent neuronal plasticity following tissue injury and inflammation. Trends Neurosci 1992;15:96-103.
4. Mao J, Price DD, Mayer DJ. Experimental mononeuropathy reduces the antinociceptive effects of morphine: implications for common intracellular mechanisms involved in morphine tolerance and neuropathic pain. Pain 1995;61:353-64.
5. Mao J, Price DD, Mayer DJ. Mechanisms of hyperalgesia and morphine tolerance: a current view of their possible interactions. Pain 1995;62:259-74.
6. Mao J. Opioid-induced abnormal pain sensitivity: implications in clinical opioid therapy. Pain 2002;100:213-7.
7. Woolf CJ, Thompson SW. The induction and maintenance of central sensitization is dependent on N-methyl-D-aspartic acid receptor activation; implications for the treatment of postinjury pain hypersensitivity states. Pain 1991;44:293-9.
8. Yamamoto T, Yaksh TL. Comparison of the antinociceptive effects of pre- and posttreatment with intrathecal morphine and mk801, an NMDA antagonist, on the formalin test in the rat. Anesthesiology 1992;77:757-63.
9. South SM, Kohno T, Kaspar BK, Hegarty D, Vissel B, Drake CT et al. A conditional deletion of the NR1 subunit of the NMDA receptor in adult spinal cord dorsal horn reduces NMDA currents and injury-induced pain. J Neurosci 2003;23:5031-40.
10. Tsien JZ, Huerta PT, Tonegawa S. The essential role of hippocampal CA1 NMDA receptor-dependent synaptic plasticity in spatial memory. Cell 1996;87:1327-38.
11. Woolf CJ, Swett JE. The cutaneous contribution to the hamstring flexor reflex in the rat: an electrophysiological and anatomical study. Brain Res 1984;303:299-312.
12. Yukhananov R, Guan J, Crosby G. Antisense oligonucleotides to N-methyl-D-aspartate receptor subunits attenuate formalin-induced nociception in the rat. Brain Res 2002; 930:163-9.
13. Rydh-Rinder M, Berge OG, Hokfelt T. Antinociceptive effects after intrathecal administration of phosphodiester-, 2′-O-allyl-, and C-5-propyne-modified antisense oligodeoxynucleotides targeting the NMDAR1 subunit in mouse. Brain Res Mol Brain Res 2001;86:23-33.
14. Davis AM, Inturrisi CE. Attenuation of hyperalgesia by LY235959, a competitive N-methyl-D-aspartate receptor antagonist. Brain Res 2001;894:150-3.
15. Chizh BA, Headley PM, Tzschentke TM. NMDA receptor antagonists as analgesics: focus on the NR2B subtype. Trends Pharmacol Sci 2001;22:636-42.