Insights into functional pharmacology of α1 GABA A receptors: How much does partial activation at the benzodiazepine site matter?

Psychopharmacology

Volumn 230, Issue 1, 2013, Pages 113-123

  Joksimović, Srcrossed D Signan ^a   Varagic, Zdravko ^b   Kovačević, Jovana ^a   Van Linn, Michael ^c   Milić, Marija ^a   Rallapalli, Sundari ^c   Timić, Tamara ^a   Sieghart, Werner ^b   Cook, James M ^c   Savić, Miroslav M ^a  

^a UNIVERSITY OF BELGRADE   (Serbia)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

^c UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Anticonvulsant; Anxiolytic; Ataxia; Efficacy; Muscle relaxation; Recombinant receptors; Sedation

Indexed keywords

4 AMINOBUTYRIC ACID; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA1; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA2; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA3; 4 AMINOBUTYRIC ACID A RECEPTOR ALPHA5; 4 AMINOBUTYRIC ACID A RECEPTOR BETA3; 4 AMINOBUTYRIC ACID A RECEPTOR GAMMA2; 8 ETHYNYL BETA CARBOLINE 3 CARBOXYLATE TERT BUTYL ESTER; BENZODIAZEPINE; DIAZEPAM; GABAERGIC RECEPTOR AFFECTING AGENT; PENTETRAZOLE; UNCLASSIFIED DRUG; WYS 8;

ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; ATAXIA; BEHAVIOR; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG BINDING SITE; DRUG EFFECT; DRUG RECEPTOR BINDING; GABAERGIC SYSTEM; GRIP STRENGTH; IN VIVO STUDY; LOCOMOTION; MALE; MAZE TEST; MONOTHERAPY; MUSCLE RELAXATION; NERVOUS SYSTEM ELECTROPHYSIOLOGY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SEDATION; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; ANTICONVULSANTS; BEHAVIOR, ANIMAL; CARBOLINES; DIAZEPAM; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; MAZE LEARNING; MOTOR ACTIVITY; RATS; RATS, WISTAR; RECEPTORS, GABA-A;

EID: 84886291954     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-013-3143-4     Document Type: Article

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