Selective antagonism of the ataxic effects of zolpidem and triazolam by the GABAA/α1-preferring antagonist β-CCt in squirrel monkeys

Psychopharmacology

Volumn 164, Issue 2, 2002, Pages 151-159

  Platt, Donna M ^a   Rowlett, James K ^a   Spealman, Roger D ^a   Cook, James ^b   Ma, Chunrong ^b,c  

^a HARVARD MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

^c PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

Benzodiazepines; GABAA receptor subtypes; Motoric side effects; Squirrel monkey (Saimiri sciureus)

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR BLOCKING AGENT; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; BENZODIAZEPINE DERIVATIVE; BENZODIAZEPINE RECEPTOR BLOCKING AGENT; BENZODIAZEPINE RECEPTOR STIMULATING AGENT; BETA CCT; FLUMAZENIL; TRIAZOLAM; UNCLASSIFIED DRUG; ZOLPIDEM;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ATAXIA; BODY POSTURE; CONTROLLED STUDY; DOSE RESPONSE; DRUG RESPONSE; HYPNOSIS; LOCOMOTION; MALE; MOTOR DYSFUNCTION; NONHUMAN; PRIORITY JOURNAL; REST; SEDATION; SQUIRREL MONKEY; TRANSGENIC MOUSE;

ANIMALS; ATAXIA; BENZODIAZEPINES; CARBOLINES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG INTERACTIONS; FLUMAZENIL; GABA AGONISTS; GABA MODULATORS; MALE; MOTOR ACTIVITY; PYRIDINES; RECEPTORS, GABA-A; SAIMIRI; SOCIAL BEHAVIOR; TRIAZOLAM;

EID: 0036918252     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00213-002-1189-9     Document Type: Article

References (47)

1. Ator NA, Weerts EM, Kaminski BJ, Kautz MA, Griffiths RR (2000) Zaleplon and triazolam physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons. Drug Alcohol Depend 61:69-84
2. Baldwin JD (1985) The behavior of squirrel monkeys (Saimiri) in natural environments. In: Rosenblum LA, Coe CL (eds) Handbook of Squirrel Monkey Research. Plenum Press, New York, pp 35-53
3. 1 receptor antagonist, blocks the anti-anxiety but not the amnesic action of chlordiazepoxide in mice. Behav Pharmacol 11:125-131
4. Costa E, Guidotti A (1996) Benzodiazepines on trial: A research strategy for their rehabilitation. Trends Pharmacol Sci 17:192-200
5. A receptor mutant mouse studies. Nature Neurosci 3:1059
6. Crestani F, Martin JR, Möhler H, Rudolph U (2000b) Mechanism of action of the hypnotic zolpidem in vivo. Br J Pharmacol 131:1251-1254
7. Crestani F, Löw K, Keist R, Mandelli M, Möhler H, Rudolph U (2001) Molecular targets for the myorelaxant action of diazepam. Mol Pharmacol 56:442-445
8. Depoortere H, Zivkovic B, Lloyd KG, Sanger DJ, Perrault G, Langer SZ, Bartholini G (1986) Zolpidem, a novel non-benzodiazepine hypnotic: I. Neuropharmacological and behavioral effects. J Pharmacol Exp Ther 237:649-658
9. Doble A, Martin IL (1992) Multiple benzodiazepines receptors: No reason for anxiety. Trends Pharmacol Sci 13:76-81
10. A receptor. Eur J Pharmacol 244:29-35
11. Dumond FV (1968) The squirrel monkey in a seminatural environment. In: Rosenblum LA, Cooper RW (eds) The Squirrel Monkey. Academic Press, New York, pp 87-145
12. Evans SM, Funderburk FR, Griffiths RR (1990) Zolpidem and triazolam in humans: Behavioral and subjective effects and abuse reliability. J Pharmacol Exp Ther 255:1246-1255
13. Griebel G, Perrault G, Letang V, Granger P, Avenet P, Schoemaker H, Sanger DJ (1999) New evidence that the pharmacological effects of benzodiazepine receptor ligands can be associated with activities at different BZ (ω) receptor subtypes. Psychopharmacology 146:205-213
14. Griffiths RR, Wolf B (1990) Relative abuse liability of different benzodiazepines in drug abusers. J Clin Psychopharmacol 10:237-243
15. Griffiths RR, Sannerud CA, Ator NA, Brady JV (1992) Zolpidem behavioral pharmacology in baboons: Self-injection, discrimination, tolerance and withdrawal. J Pharmacol Exp Ther 260:1199-1208
16. A receptor α1 subtype in the ventral pallidum regulates alcohol seeking behaviors. J Neurosci 22:3765-3775
17. Hopf S, Hartmann-Wiesner E, Kuhlmorgen B, Mayer S (1974) The behavioral repertoire of the squirrel monkey (Saimiri). Folia Primatol 21:225-249
18. 2 via a comprehensive ligand-mapping approach. J Med Chem 43:71-95
19. A receptors containing α5 subunits in the CA1 and CA3 hippocampal fields regulate ethanol-motivated behaviors: An extended ethanol reward circuitry
20. Kelleher RT, Gill CA, Riddle WC, Cook L (1963) On the use of the squirrel monkey in behavioral and pharmacological experiments. J Exp Anal Behav 6:249-252
21. A-receptor subtypes: Clinical efficacy and selectivity of benzodiazepine site ligands. Ann Med 29:275-282
22. Lelas S, Rowlett JK, Spealman RD, Cook JM, Yin W (2001) The role of BZ/α1 and BZ/α5 receptors in the discriminative stimulus effects of triazolam in squirrel monkeys. Soc Neurosci Abstr 27:959.11
23. Lippa AS, Coupet J, Greenblatt EN, Klepner CA, Beer B (1979) A synthetic non-benzodiazepine ligand for benzodiazepine receptors: A probe for investigating neuronal substrates of anxiety. Pharmacol Biochem Behav 11:99-106
24. Löw K, Crestani F, Keist R, Benke D, Brünig I, Benson JA, Fritschy J, Rülicke T, Bluethmann H, Möhler H, Rudolph U (2000) Molecular and neuronal substrate for the selective attenuation of anxiety. Science 290:131-134
25. A receptor selective for a behavioural alcohol antagonist
26. A/benzodiazepine receptor heterogeneity: Neurophysiological implications. Neuropharmacology 34:245-254
27. Mailliet F, Galloux P, Poisson D (2001) Comparative effects of melatonin, zolpidem and diazepam on sleep, body temperature, blood pressure and heart rate measured by radiotelemetry in Wistar rats. Psychopharmacology 156:417-426
28. A-receptor subtypes really occur in the brain? Trends Pharmacol Sci 19:139-143
29. 1 subtype. Nat Neurosci 3:587-592)
30. Mintzer MZ, Frey JM, Griffiths RR (1998) Zolpidem is differentiated from triazolam in humans using a three-response drug discrimination procedure. Behav Pharmacol 9:545-559
31. A receptor binding in human brain by neuroactive steroids: Species and brain regional differences. Synapse 19:77-87
32. 2 values of benzodiazepine antagonists and partial agonists in monkeys. J Pharmacol Exp Ther 290:1222-1229
33. A receptors may mediate the anticonflict and response-rate decreasing effects of zaleplon, zolpidem, and midazolam in squirrel monkeys. Psychopharmacology 156:461-468
34. 1 receptor partial agonists SKF 83959 and SKF 77434. J Pharmacol Exp Ther 293:1017-1026
35. A-benzodiazepine receptors produced in transfected cells. Science 245:1389-1392
36. - currents. Mol Pharmacol 39:691-696
37. Rowlett JK, Woolverton WL (1997) Disciminative stimulus effects of zolpidem in pentobarbital-trained subjects: I. Comparison with triazolam in rhesus monkeys and rats. J Pharmacol Exp Ther 280:162-173
38. Rowlett JK, Tornatzky W, Cook JM, Ma C, Miczek KA (2001) Zolpidem, triazolam, and diazepam decrease distress vocalizations in mouse pups: Differential antagonism by flumazenil and β-carboline-3-carboxylate-t-butyl ester (β-CCt). J Pharmacol Exp Ther 297:247-253
39. A receptor subtypes: Dissecting their pharmacological functions. Trends Pharmacol Sci 22:188-194
40. Rush CR (1998) Behavioral pharmacology of zolpidem relative to benzodiazepines: A review. Pharmacol Biochem Behav 61:253-269
41. Sanger DJ, Benavides J, Perrault G, Morel E, Cohen C, Joly D, Zivkovic B (1994) Recent developments in the behavioral pharmacology of benzodiazepines (ω) receptors: Evidence for the functional significance of receptor subtypes. Neurosci Biobehav Rev 18:355-372
42. Schmid L, Bottlaender M, Fuseau C, Fournier D, Brouillet E, Maziere M (1995) Zolpidem displays heterogeneity in its binding to the nonhuman primate benzodiazepine receptor in vivo. J Neurochem 65:1880-1886
43. A/benzodiazepine receptors using radioligands and monoclonal antibodies. Brain Res 473:314-320
44. A receptor subtypes
45. A receptor in rat thalamus. Mol Pharmacol 56:110-115
46. Weerts EM, Ator NA, Grech DM, Griffiths RR (1998) Zolpidem physical dependence assessed across increasing doses under a once-daily dosing regimen in baboons. J Pharmacol Exp Ther 285:41-53
47. A receptor subtypes. Int Rev Neurobiol 38:95-138