Central Mechanisms of Seizures and Lethality Following Anticholinesterase Pesticide Exposure

Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology

Volumn , Issue , 2011, Pages 149-164

  Dekundy, Andrzej ^a,b   Kaminski, Rafal M ^c  

^a INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^b MERZ PHARMACEUTICALS GMBH   (Germany)

^c UCB PHARMA   (Belgium)

Author keywords

Central mechanisms of seizures and lethality following anticholinesterase pesticide exposure; Neuroinflammation role in anticholinesterase induced seizures; Neurotransmitter systems in seizures and lethality of anticholinesterases

Indexed keywords

EID: 84885698034     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470640500.ch12     Document Type: Chapter

References (167)

1. Alluwaimi AM and Hussein Y (2007) Diazinon immunotoxicity in mice: modulation of cytokines level and their gene expression. Toxicology 236: 123-131.
2. Anderson JJ, Kuo S and Chase TN (1994) Endogenous excitatory amino acids tonically stimulate striatal acetylcholine release through NMDA but not AMPA receptors. Neurosci Lett 176: 264-268.
3. Apland JP, Aroniadou-Anderjaska V and Braga MF (2008) Soman induces ictogenesis in the amygdala and interictal activity in the hippocampus that are reduced or blocked by a GluR5 antagonist. Program No. 451.17. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience. Online.
4. Aramakis VB, Bandrowski AE and Ashe JH (1999) Role of muscarinic receptors, G-proteins, and intracellular messengers in muscarinic modulation of NMDA receptor-mediated synaptic transmission. Synapse 32: 262-275.
5. Baille-Le Crom V, Collombet JM, Carpentier P, Brochier G, Burckhart MF, Foquin A, Pernot-Marino I, Rondouin G and Lallement G (1995) Early regional changes of GFAP MRNA in rat hippocampus and dentate gyrus during soman-induced seizures. Neuroreport 7: 365-369.
6. Baille V, Clarke PG, Brochier G, Dorandeu F, Verna JM, Four E, Lallement G and Carpentier P (2005) Soman-induced convulsions: the neuropathology revisited. Toxicology 215: 1-24.
7. Bakry NM, el-Rashidy AH, Eldefrawi AT and Eldefrawi ME (1988) Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors. J Biochem Toxicol 3: 235-259.
8. Bardin PG and van Eeden SF (1990) Organophosphate poisoning: grading the severity and comparing treatment between atropine and glycopyrrolate. Crit Care Med 18: 956-960.
9. Bardin PG, van Eeden SF, Moolman JA, Foden AP and Joubert JR (1994) Organophosphate and carbamate poisoning. Arch Intern Med 154: 1433-1441.
10. Beards SC, Kraus P and Lipman J (1994) Paralytic ileus as a complication of atropine therapy following severe organophosphate poisoning. Anaesthesia 49: 791-793.
11. Bodjarian N, Carpentier P, Baubichon D, Blanchet G and Lallement G (1995) Involvement of non-muscarinic receptors in phosphoinositide signalling during soman-induced seizures. Eur J Pharmacol 289: 291-297.
12. Boison D (2008) Adenosine as a neuromodulator in neurological diseases. Curr Opin Pharmacol 8: 2-7.
13. Bourne JA, Fosbraey P and Halliday J (2001) SCH 23390 affords protection against soman-evoked seizures in the freely moving guinea-pig: a concomitant neurochemical, electrophysiological and behavioural study. Neuropharmacology 40: 279-288.
14. Bowden CA and Krenzelok EP (1997) Clinical applications of commonly used contemporary antidotes: a US perspective. Drug Safety 16: 9-47.
15. Braitman DJ and Sparenborg S (1989) MK-801 protects against seizures induced by the cholinesterase inhibitor soman. Brain Res Bull 23: 145-148.
16. Buccafusco JJ and Aronstam RS (1987) Adrenergic agonists protect against soman, an irreversible acetylcholinesterase inhibitor. Toxicol Lett 38: 67-76.
17. Buccafusco JJ, Aronstam RS and Graham JH (1988) Role of central biogenic amines on the protection afforded by clonidine against the toxicity of soman, an irreversible cholinesterase inhibitor. Toxicol Lett 42: 291-299.
18. Bueters TJ, Groen B, Danhof M, IJzerman AP and van Helden HP (2002) Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication. Arch Toxicol 76: 650-656.
19. Bueters TJ, Joosen MJ, van Helden HP, Ijzerman AP and DanhofM (2003) Adenosine A1 receptor agonist N6-cyclopentyladenosine affects the inactivation of acetylcholinesterase in blood and brain by sarin. J Pharmacol Exp Ther 304: 1307-1313.
20. Cable GG and Doherty S (1999) Acute carbamate and organochlorine toxicity causing convulsions in an agricultural pilot: a case report. Aviat Space Environ Med 70: 68-72.
21. Calabresi P, Centonze D, Gubellini P, Pisani A and Bernardi G (1998) Endogenous ACh enhances striatal NMDA-responses via M1-like muscarinic receptors and PKC activation. Eur J Neurosci 10: 2887-2895.
22. Capacio BR and Shih TM (1991) Anticonvulsant actions of anticholinergic drugs in soman poisoning. Epilepsia 32: 604-615.
23. Carpentier P, Delamanche IS, Le Bert M, Blanchet G and Bouchaud C (1990) Seizure-related opening of the blood-brain barrier induced by soman: possible correlation with the acute neuropathology observed in poisoned rats. Neurotoxicology 11: 493-508.
24. Carpentier P, Foquin-Tarricone A, Bodjarian N, Rondouin G, Lerner-Natoli M, Kamenka JM, Blanchet G, Denoyer M and Lallement G (1994) Anticonvulsant and antilethal effects of the phencyclidine derivative TCP in soman poisoning. Neurotoxicology 15: 837-851.
25. Carpentier P, Foquin A, Rondouin G, Lerner-Natoli M, de Groot DM and Lallement G (2000) Effects of atropine sulphate on seizure activity and brain damage produced by soman in guineapigs: ECoG correlates of neuropathology. Neurotoxicology 21: 521-540.
26. Chapman S, Kadar T and Gilat E (2006) Seizure duration following sarin exposure affects neuro-inflammatory markers in the rat brain. Neurotoxicology 27: 277-283.
27. Chebabo SR, Santos MD and Albuquerque EX (1999) The organophosphate sarin, at low concentrations, inhibits the evoked release of GABA in rat hippocampal slices. Neurotoxicology 20: 871-882.
28. Cheramy A, Godeheu G, L'Hirondel M and Glowinski J (1996) Cooperative contributions of cholinergic and NMDA receptors in the presynaptic control of dopamine release from synaptosomes of the rat striatum. J Pharmacol Exp Ther 276: 616-625.
29. Chiou GC and Li BH (1994) Prevention of organophosphate intoxication with presynaptic cholinergic blockers. Life Sci 55: 69-75.
30. Chu ZG, Zhou FM and Hablitz JJ (2000) Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex. Brain Res 887: 399-405.
31. Clement JG (1994) Toxicity of the combined nerve agents GB/GF in mice: efficacy of atropine and various oximes as antidotes. Arch Toxicol 68: 64-66.
32. Collombet JM, Four E, Bernabe D, Masqueliez C, Burckhart MF, Baille V, Baubichon D and Lallement G (2005) Soman poisoning increases neural progenitor proliferation and induces long-term glial activation in mouse brain. Toxicology 208: 319-334.
33. Coudray-Lucas C, Le Guen A, Prioux-Guyonneau M, Cohen Y and Wepierre J (1987) Changes in brain monoamine content and metabolism induced by paraoxon and soman intoxication: effect of atropine. Xenobiotica 17: 1131-1138.
34. Cowan FM, Shih TM, Lenz DE, Madsen JM and Broomfield CA (1996) Hypothesis for synergistic toxicity of organophosphorus poisoning-induced cholinergic crisis and anaphylactoid reactions. J Appl Toxicol 16: 25-33.
35. Dawson RM (1994) Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 14: 317-331.
36. Dekundy A (2006) Coadministration of memantine with acetylcholinesterase inhibitors: preclinical and clinical evidence. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 35-46.
37. Dekundy A, Blaszczak P, Kaminski R and Turski WA (2001) On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Arch Toxicol 74: 702-708.
38. Dekundy A, Kaminski RM and Turski WA (2003) Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase- treated mice. Toxicol Sci 72: 289-295.
39. Dekundy A, Kaminski RM, Zielinska E and Turski WA (2007) NMDA antagonists exert distinct effects in experimental organophosphate or carbamate poisoning in mice. Toxicol Appl Pharmacol 219: 114-121.
40. Deransart C, Vercueil L, Marescaux C and Depaulis A (1998) The role of basal ganglia in the control of generalized absence seizures. Epilepsy Res 32: 213-223.
41. Deshpande SS, Smith CD and Filbert MG (1995) Assessment of primary neuronal culture as a model for soman-induced neurotoxicity and effectiveness of memantine as a neuroprotective drug. Arch Toxicol 69: 384-390.
42. Dhote F, Peinnequin A, Carpentier P, Baille V, Delacour C, Foquin A, Lallement G and Dorandeu F (2007) Prolonged inflammatory gene response following soman-induced seizures in mice. Toxicology 238: 166-176.
43. Docherty M, Bradford HF and Wu JY (1987) Co-release of glutamate and aspartate from cholinergic and GABA-ergic synaptosomes. Nature 330: 64-66.
44. Dragunow M (1988) Purinergic mechanisms in epilepsy. Prog Neurobiol 31: 85-108.
45. Egorov AV, Gloveli T and Muller W (1999) Muscarinic control of dendritic excitability and Ca2{Thorn} signaling in CA1 pyramidal neurons in rat hippocampal slice. J Neurophysiol 82: 1909-1915.
46. el-Etri MM, Nickell WT, Ennis M, Skau KA and Shipley MT (1992) Brain norepinephrine reductions in soman-intoxicated rats: association with convulsions and AChE inhibition, time course, and relation to other monoamines. Exp Neurol 118: 153-163.
47. Fosbraey P, Wetherell JR and French MC (1990) Neurotransmitter changes in guinea-pig brain regions following soman intoxication. J Neurochem 54: 72-79.
48. Galli A and Mori F (1996) Acetylcholinesterase inhibition and protection by dizocilpine (MK-801) enantiomers. J Pharm Pharmacol 48: 71-76.
49. Galloway T and Handy R (2003) Immunotoxicity of organophosphorous pesticides. Ecotoxicology 12: 345-363.
50. Gasior M, Carter RB and Witkin JM (1999) Neuroactive steroids: potential therapeutic use in neurological and psychiatric disorders. Trends Pharmacol Sci 20: 107-112.
51. Gelinas I, Gauthier S and Cyrus PA (2000) Metrifonate enhances the ability of Alzheimer's disease patients to initiate, organize, and execute instrumental and basic activities of daily living. J Geriatr Psychiatry Neurol 13: 9-16.
52. Girod R, Barazangi N, McGehee D and Role LW (2000) Facilitation of glutamatergic neurotransmission by presynaptic nicotinic acetylcholine receptors. Neuropharmacology 39: 2715-2725.
53. Gray R, Rajan AS, Radcliffe KA, Yakehiro M and Dani JA (1996) Hippocampal synaptic transmission enhanced by low concentrations of nicotine. Nature 383: 713-716.
54. Gupta M, Bagchi GK, Gupta SD, Sasmal D, Chatterjee T and Dey SN (1984) Changes of acetylcholine, catecholamines and amino acid in mice brain following treatment with nuvacron and furadan. Toxicology 30: 171-175.
55. Gupta RC (1994) Carbofuran toxicity. J Toxicol Environ Health 43: 383-418.
56. Gupta RC (2006) Classification and uses of organophosphates and carbamates. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 5-24.
57. Gupta RC and Dekundy A (2005) Memantine does not influence AChE inhibition in rat brain by donepezil or rivastigmine but does with DFP and metrifonate in in vivo studies. Drug Dev Res 64: 71-81.
58. Gupta RC and Dekundy A (2007) Donepezil- or rivastigmineinduced acetylcholinesterase inactivation is not modulated by neramexane in rat brain. Drug Dev Res 68(5): 253-260.
59. Gupta RC and Kadel WL (1989) Prevention and antagonism of acute carbofuran intoxication by memantine and atropine. J Toxicol Environ Health 28: 111-122.
60. Hiatt RL (1983) Medical management of accommodative esotropia. J Pediatr Ophthalmol Strabismus 20: 199-201.
61. Holmstedt B (1972) The ordeal bean of old Calabar: the pageant of Physostigma venenosum in medicine. In T Swain (Ed), Plants in the Development of Modern Medicine. Cambridge, MA: Harvard University Press, pp. 303-360.
62. Holmstedt B, Nordgren I, Sandoz M and Sundwall A (1978) Metrifonate: summary of toxicological and pharmacological information available. Arch Toxicol 41: 3-29.
63. Holstege CP, Kirk M and Sidell FR (1997) Chemical warfare: nerve agent poisoning. Crit Care Clin 13: 923-942.
64. Honchar MP, Olney JW and Sherman WR (1983) Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science 220: 323-325.
65. Ikarashi Y, Yuzurihara M, Takahashi A, Ishimaru H, Shiobara T and Maruyama Y (1998) Direct regulation of acetylcholine release by N-methyl-D-aspartic acid receptors in rat striatum. Brain Res 795: 215-220.
66. Jacobsson SO and Fowler CJ (1999) Dopamine and glutamate neurotoxicity in cultured chick telencephali cells: effects of NMDA antagonists, antioxidants and mao inhibitors. Neurochem Int 34: 49-62.
67. Jacobsson SO, Cassel GE, Karlsson BM, Sellstrom A and Persson SA (1997a) Release of dopamine, GABA and EAA in rats during intrastriatal perfusion with kainic acid, NMDA and soman: a comparative microdialysis study. Arch Toxicol 71: 756-765.
68. Jacobsson SO, Sellstrom A, Persson SA and Cassel GE (1997b) Correlation between cortical EEG and striatal microdialysis in soman-intoxicated rats. Neurosci Lett 231: 155-158.
69. Jafari-Sabet M (2006) NMDA receptor antagonists antagonize the facilitatory effects of post-training intra-basolateral amygdala NMDA and physostigmine on passive avoidance learning. Eur J Pharmacol 529: 122-128.
70. Jin S and Fredholm BB (1997) Electrically-evoked dopamine and acetylcholine release from rat striatal slices perfused without magnesium: regulation by glutamate acting on NMDA receptors. Br J Pharmacol 121: 1269-1276.
71. Johnson DD and Wilcox WC (1975) Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning. Eur J Pharmacol 34: 127-132.
72. Johnson PS and Michaelis EK (1992) Characterization of organophosphate interactions at N-methyl-D-aspartate receptors in brain synaptic membranes. Mol Pharmacol 41: 750-756.
73. Joosen MJ, Bueters TJ and van Helden HP (2004) Cardiovascular effects of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) decisive for its therapeutic efficacy in sarin poisoning. Arch Toxicol 78: 34-39.
74. Kadriu B, Guidotti A, Costa E and Auta J (2009) Imidazenil, a non-sedating anticonvulsant benzodiazepine, is more potent than diazepam in protecting against DFP-induced seizures and neuronal damage. Toxicology 256: 164-174.
75. Kalkan S, Ergur BU, Akgun A, Kaplan YC, Kinay AO and Tuncok Y (2005) Efficacy of an adenosine A1 receptor agonist compared with atropine and pralidoxime in a rat model of organophosphate poisoning. Hum Exp Toxicol 24: 369-375.
76. Karalliedde L (1999) Organophosphorus poisoning and anaesthesia. Anaesthesia 54: 1073-1088.
77. Kis J, Czuczwar M, Zielinska E, Bojar I, Czuczwar SJ and Turski WA (2000) Kynurenic acid does not protect against nicotineinduced seizures in mice. Pol J Pharmacol 52: 477-480.
78. Klemm WR (1983) Efficacy and toxicity of drug combinations in treatment of physostigmine toxicosis. Toxicology 27: 41-53.
79. Kobayashi K and Mori A (1977) Brain monoamines in seizure mechanism (review). Folia Psychiatr Neurol Jpn 31: 483-489.
80. Lallement G, Carpentier P, Collet A, Pernot-Marino I, Baubichon D and Blanchet G (1991a) Effects of soman-induced seizures on different extracellular amino acid levels and on glutamate uptake in rat hippocampus. Brain Res 563: 234-240.
81. Lallement G, Carpentier P, Collet A, Pernot-Marino I, Baubichon D, Sentenac-Roumanou H and Blanchet G (1991b) [Involvement of glutamatergic system of amygdala in generalized seizures induced by soman: comparison with the hippocampus]. CR Acad Sci III 313: 421-426.
82. Lallement G, Carpentier P, Pernot-Marino I, Baubichon D, Collet A and Blanchet G (1991c) Involvement of the different rat hippocampal glutamatergic receptors in development of seizures induced by soman: an autoradiographic study. Neurotoxicology 12: 655-664.
83. Lallement G, Carpentier P, Collet A, Baubichon D, Pernot-Marino I and Blanchet G (1992a) Extracellular acetylcholine changes in rat limbic structures during soman-induced seizures. Neurotoxicology 13: 557-567.
84. Lallement G, Denoyer M, Collet A, Pernot-Marino I, Baubichon D, Monmaur P and Blanchet G (1992b) Changes in hippocampal acetylcholine and glutamate extracellular levels during somaninduced seizures: influence of septal cholinoceptive cells. Neurosci Lett 139: 104-107.
85. Lallement G, Delamanche IS, Pernot-Marino I, Baubichon D, Denoyer M, Carpentier P and Blanchet G (1993) Neuroprotective activity of glutamate receptor antagonists against somaninduced hippocampal damage: quantification with an omega 3 site ligand. Brain Res 618: 227-237.
86. Lallement G, Pernot-Marino I, Baubichon D, Burckhart MF, Carpentier P and Blanchet G (1994a) Modulation of somaninduced neuropathology with an anticonvulsant regimen. Neuroreport 5: 2265-2268.
87. Lallement G, Pernot-Marino I, Foquin-Tarricone A, Baubichon D, Piras A, Blanchet G and Carpentier P (1994b) Coadministration of atropine, NBQX and TCP against soman-induced seizures. Neuroreport 5: 1113-1117.
88. Lallement G, Baubichon D, Clarencon D, Galonnier M, Peoc'h M and Carpentier P (1999) Review of the value of gacyclidine (GK-11) as adjuvant medication to conventional treatments of organophosphate poisoning: primate experiments mimicking various scenarios of military or terrorist attack by soman. Neurotoxicology 20: 675-684.
89. Lau WM, Freeman SE and Szilagyi M (1988) Binding of some organophosphorus compounds at adenosine receptors in guinea pig brain membranes. Neurosci Lett 94: 125-130.
90. Ligtenstein DA and Moes GW(1991) The synergism of atropine and the cholinesterase reactivator HI-6 in counteracting lethality by organophosphate intoxication in the rat. Toxicol Appl Pharmacol 107: 47-53.
91. Lu WY, Xiong ZG, Lei S, Orser BA, Dudek E, Browning MD and MacDonald JF (1999) G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nature Neurosci 2: 331-338.
92. Lumley LA, Moffett MC, Ward TM, Furtado MD, Estes SP, Robison CL, Kamberger KL, Schwartz JE, Schultz NK, Stone MF, Sedigh-Sarvestani M, Johnson SM, Yourick DL, Shih T and Saviolakis GA (2008) Anticonvulsant and neuroprotective effects of the neurosteroid pregnanolone against soman exposure in rats. Program No. 451.13. 2008 Neuroscience Meeting Planner. Washington, DC: Society for Neuroscience, 2008. Online.
93. Marchi N, Fan Q, Ghosh C, Fazio V, Betto G, Batra A, Carlton E, Najm I, Granata T and Janigro D (2009) Antagonism of peripheral inflammation reduces the severity of status epilepticus. Neurobiol Dis 33: 171-181.
94. Marino MJ, Rouse ST, Levey AI, Potter LT and Conn PJ (1998) Activation of the genetically defined M1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc Natl Acad Sci USA 95: 11465-11470.
95. Markram H and Segal M(1992a) Activation of protein kinase C suppresses responses to NMDA in rat CA1 hippocampal neurones. J Physiol (London) 457: 491-501.
96. Markram H and Segal M (1992b) The inositol 1,4,5- trisphosphate pathway mediates cholinergic potentiation of rat hippocampal neuronal responses to NMDA. J Physiol 447: 513-533.
97. Marrs TC (1991) Toxicology of oximes used in treatment of organophosphate poisoning. Adverse Drug React Toxicol Rev 10: 61-73.
98. Marrs TC and Vale JA (2006) Management of organophosphorus pesticide poisoning. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 715-733.
99. McDonough JH Jr and Shih TM (1993) Pharmacological modulation of soman-induced seizures. Neurosci Biobehav Rev 17: 203-215.
100. McDonough JH Jr and Shih TM (1995) A study of the N-methyl-Daspartate antagonistic properties of anticholinergic drugs. Pharmacol Biochem Behav 51: 249-253.
101. McDonough JH Jr and Shih TM (1997) Neuropharmacological mechanisms of nerve agent-induced seizure and neuropathology. Neurosci Biobehav Rev 21: 559-579.
102. McGehee DS, Heath MJ, Gelber S, Devay P and Role LW (1995) Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors [and see Comments]. Science 269: 1692-1696.
103. McLean MJ, Gupta RC, Dettbarn WD and Wamil AW (1992) Prophylactic and therapeutic efficacy of memantine against seizures produced by soman in the rat. Toxicol Appl Pharmacol 112: 95-103.
104. Mense SM, Sengupta A, Lan C, Zhou M, Bentsman G, Volsky DJ, Whyatt RM, Perera FP and Zhang L (2006) The common insecticides cyfluthrin and chlorpyrifos alter the expression of a subset of genes with diverse functions in primary human astrocytes. Toxicol Sci 93: 125-135.
105. Minton NA and Murray VS (1988) A review of organophosphate poisoning. Med Toxicol Adverse Drug Exp 3: 350-375.
106. Munro NB, Watson AP, Ambrose KR and Griffin GD (1990) Treating exposure to chemical warfare agents: implications for health care providers and community emergency planning. Environ Health Perspect 89: 205-215.
107. Nag M and Nandy N (2001) Serotonin and benzylamine oxidation by type A and type BMAO of rat brain in presence of organophosphate pesticides. Indian J Exp Biol 39: 802-806.
108. Parsons CG, Stoffler A and Danysz W (2007) Memantine: a NMDA receptor antagonist that improves memory by restoration of homeostasis in the glutamatergic system: too little activation is bad, too much is even worse. Neuropharmacology 53: 699-723.
109. Pibiri F, Kozikowski AP, Pinna G, Auta J, Kadriu B, Costa E and Guidotti A (2008) The combination of huperzine A and imidazenil is an effective strategy to prevent diisopropyl fluorophosphate toxicity in mice. Proc Natl Acad Sci USA 105: 14169-14174.
110. Puttfarcken PS, Jacobs I and Faltynek CR (2000) Characterization of nicotinic acetylcholine receptor-mediated [3H]-dopamine release from rat cortex and striatum. Neuropharmacology 39: 2673-2680
111. Rao KS, Aracava Y, Rickett DL and Albuquerque EX (1987) Noncompetitive blockade of the nicotinic acetylcholine receptor-ion channel complex by an irreversible cholinesterase inhibitor. J Pharmacol Exp Ther 240: 337-344.
112. Raveh L, Chapman S, Cohen G, Alkalay D, Gilat E, Rabinovitz I and Weissman BA (1999) The involvement of the NMDA receptor complex in the protective effect of anticholinergic drugs against soman poisoning. Neurotoxicology 20: 551-559.
113. Raveh L,Weissman BA, Cohen G, Alkalay D, Rabinovitz I, Sonego H and Brandeis R (2002) Caramiphen and scopolamine prevent soman-induced brain damage and cognitive dysfunction. Neurotoxicology 23: 7-17.
114. Ravizza T, Gagliardi B, Noe F, Boer K, Aronica E and Vezzani A (2008a) Innate and adaptive immunity during epileptogenesis and spontaneous seizures: evidence from experimental models and human temporal lobe epilepsy. Neurobiol Dis 29: 142-160.
115. Ravizza T, Noe F, Zardoni D, Vaghi V, Sifringer M and Vezzani A (2008b) Interleukin converting enzyme inhibition impairs kindling epileptogenesis in rats by blocking astrocytic IL-1beta production. Neurobiol Dis 31: 327-333.
116. Reid RT, Lloyd GK and Rao TS (1999) Pharmacological characterization of nicotine-induced acetylcholine release in the rat hippocampus in vivo: evidence for a permissive dopamine synapse. Br J Pharmacol 127: 1486-1494.
117. Reithmann C, Arbogast H, Hallek M, Auburger G and Szinicz L (1988) Studies on the role of central catecholaminergic mechanisms in the antidotal effect of the oxime HI 6 in soman poisoned mice. Arch Toxicol 62: 41-44.
118. Rocha ES, Santos MD, Chebabo SR, Aracava Y and Albuquerque EX (1999) Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: toxicological relevance of cholinesteraseindependent actions. Toxicol Appl Pharmacol 159(1): 31-40.
119. Rogawski MA (2005) Astrocytes get in the act in epilepsy. Nat Med 11: 919-920.
120. Rogawski MA and Donevan SD (1999) AMPA receptors in epilepsy and as targets for antiepileptic drugs. Adv Neurol 79: 947-963.
121. Satoh T (2006) Global epidemiology of organophosphate and carbamate poisonings. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 89-100.
122. Sharma RP (2006) Organophosphates, carbamates, and the immune system. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 495-507.
123. Sherby SM, Eldefrawi AT, Albuquerque EX and Eldefrawi ME (1985) Comparison of the actions of carbamate anticholinesterases on the nicotinic acetylcholine receptor. Mol Pharmacol 27: 343-348.
124. Shih TM (1990) Anticonvulsant effects of diazepam and MK-801 in soman poisoning. Epilepsy Res 7: 105-116.
125. Shih TM and McDonough JH Jr (1997) Neurochemical mechanisms in soman-induced seizures. J Appl Toxicol 17: 255-264.
126. Shih TM and McDonough JH Jr (1999) Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment. Pharmacol Biochem Behav 64: 147-153.
127. Shih TM and McDonough JH (2000) Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication. Arch Toxicol 74: 165-172.
128. Shih TM, Koviak TA and Capacio BR (1991) Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neurosci Biobehav Rev 15: 349-362.
129. Shih TM, Capacio BR and Cook LA (1993) Effects of anticholinergic- antiparkinsonian drugs on striatal neurotransmitter levels of rats intoxicated with soman. Pharmacol Biochem Behav 44: 615-622.
130. Shih T, McDonough JH Jr and Koplovitz I (1999) Anticonvulsants for soman-induced seizure activity. J Biomed Sci 6: 86-96.
131. Sinha C and Shukla GS (2003) Species variation in pesticideinduced blood-brain barrier dysfunction. Hum Exp Toxicol 22: 647-652.
132. Sivilotti L and Colquhoun D (1995) Acetylcholine receptors: too many channels, too few functions [and see Comments]. Science 269: 1681-1682.
133. Smith AD and Bolam JP (1990) The neural network of the basal ganglia as revealed by the study of synaptic connections of identified neurones. Trends Neurosci 13: 259-265.
134. Soininen H, Unni L and Shillcutt S (1990) Effect of acute and chronic cholinesterase inhibition on biogenic amines in rat brain. Neurochem Res 15: 1185-1190.
135. Solberg Y and Belkin M (1997) The role of excitotoxicity in organophosphorous nerve agents central poisoning. Trends Pharmacol Sci 18: 183-185.
136. Somani SM and Dube SN (1989) Physostigmine: an overview as pretreatment drug for organophosphate intoxication. Int J Clin Pharmacol Ther Toxicol 27: 367-387.
137. Sparenborg S, Brennecke LH, Jaax NK and Braitman DJ (1992) Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman. Neuropharmacology 31: 357-368.
138. Starr MS (1996) The role of dopamine in epilepsy. Synapse 22: 159-194.
139. Svensson I, Waara L, Johansson L, Bucht A and Cassel G (2001) Soman-induced interleukin-1 beta mRNA and protein in rat brain. Neurotoxicology 22: 355-362.
140. Tang J, Rose RL and Chambers JE (2006) Metabolism of organophosphorus and carbamate pesticides. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 127-143.
141. Tani Y, Saito K, Imoto M and Ohno T (1998) Pharmacological characterization of nicotinic receptor-mediated acetylcholine release in rat brain: an in vivo microdialysis study. Eur J Pharmacol 351: 181-188.
142. Tian GF, Azmi H, Takano T, Xu Q, Peng W, Lin J, Oberheim N, Lou N, Wang X, Zielke HR, Kang J and Nedergaard M (2005) An astrocytic basis of epilepsy. Nat Med 11: 973-981.
143. Tomkins O, Friedman O, Ivens S, Reiffurth C, Major S, Dreier JP, Heinemann U and Friedman A (2007) Blood-brain barrier disruption results in delayed functional and structural alterations in the rat neocortex. Neurobiol Dis 25: 367-377.
144. Tonduli LS, Testylier G, Marino IP and Lallement G (1999) Triggering of soman-induced seizures in rats: multiparametric analysis with special correlation between enzymatic, neurochemical and electrophysiological data. J Neurosci Res 58: 464-473.
145. Tuovinen K (2004) Organophosphate-induced convulsions and prevention of neuropathological damages. Toxicology 196: 31-39.
146. Turski L, Ikonomidou C, TurskiWA, Bortolotto ZA and Cavalheiro EA (1989) Review: cholinergic mechanisms and epileptogenesis. The seizures induced by pilocarpine: a novel experimental model of intractable epilepsy. Synapse 3: 154-171.
147. van Helden HP and Bueters TJ (1999) Protective activity of adenosine receptor agonists in the treatment of organophosphate poisoning. Trends Pharmacol Sci 20: 438-441.
148. van Helden HP, Busker RW, Melchers BP and Bruijnzeel PL (1996) Pharmacological effects of oximes: how relevant are they? Arch Toxicol 70: 779-786.
149. van Helden HP, Groen B, Moor E, Westerink BH and Bruijnzeel PL (1998) New generic approach to the treatment of organophosphate poisoning: adenosine receptor mediated inhibition of ACh-release. Drug Chem Toxicol 21 (Suppl 1): 171-181.
150. Vezzani A and Granata T (2005) Brain inflammation in epilepsy: experimental and clinical evidence. Epilepsia 46: 1724-1743.
151. Vezzani A, Ravizza T, Balosso S and Aronica E (2008) Glia as a source of cytokines: implications for neuronal excitability and survival. Epilepsia 49 (Suppl 2): 24-32.
152. Wade JV, Samson FE, Nelson SR and Pazdernik TL (1987) Changes in extracellular amino acids during soman- and kainic acidinduced seizures. J Neurochem 49: 645-650.
153. Wang YT and Salter MW (1994) Regulation of NMDA receptors by tyrosine kinases and phosphatases. Nature 369: 233-235.
154. Watson A, Bakshi K, Opresko D, Young R, Hauschild V and King J (2006) Cholinesterase inhibitors as chemical warfare agents: community preparedness guidelines. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 47-68.
155. Wenk GL, Quack G, Moebius HJ and Danysz W (2000) No interaction of memantine with acetylcholinesterase inhibitors approved for clinical use. Life Sci 66: 1079-1083.
156. Wetherington J, Serrano G and Dingledine R (2008) Astrocytes in the epileptic brain. Neuron 58: 168-178.
157. Williams AJ, Berti R, Yao C, Price RA, Velarde LC, Koplovitz I, Schultz SM, Tortella FC and Dave JR (2003) Central neuroinflammatory gene response following soman exposure in the rat. Neurosci Lett 349: 147-150.
158. Woltjer RL and Milatovic D (2006) Therapeutic uses of cholinesterase inhibitors in neurodegenerative diseases. In RC Gupta (Ed), Toxicology of Organophosphate and Carbamate Compounds. Burlington: Academic Press, pp. 25-33.
159. Wood SJ and Tattersall JE (2001) An improved brain slice model of nerve agent-induced seizure activity. J Appl Toxicol 21 (Suppl 1): S83-S86.
160. Worek F and Szinicz L (1993) Investigation of acute cardiovascular and respiratory toxicity of HLo 7 dimethanesulfonate and HI 6 dichloride in anaesthetized guinea-pigs. Pharmacol Toxicol 73: 91-95.
161. Worek F, Backer M, Thiermann H, Szinicz L, Mast U, Klimmek R and Eyer P (1997) Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum Exp Toxicol 16: 466-472.
162. Yurumez Y, Ikizceli I, Sozuer EM, Soyuer I, Yavuz Y,Avsarogullari L and Durukan P (2007) Effect of interleukin-10 on tissue damage caused by organophosphate poisoning. Basic Clin Pharmacol Toxicol 100: 323-327.
163. Zapata A, Capdevila JL and Trullas R (1998) Region-specific and calcium-dependent increase in dialysate choline levels by NMDA. J Neurosci 18: 3597-3605.
164. Zapata A, Capdevila JL and Trullas R (2000) Role of high-affinity choline uptake on extracellular choline and acetylcholine evoked by NMDA. Synapse 35: 272-280.
165. Zarrindast MR, Adeli R, Hosseini-Semnani S and Sharifzadeh M (1995) Effects of adenosine receptor agonists and antagonists on physostigmine-induced yawning. Eur J Pharmacol 276: 3-7.
166. Zimmer LA, Ennis M and Shipley MT (1997) Soman-induced seizures rapidly activate astrocytes and microglia in discrete brain regions. J Comp Neurol 378: 482-492.
167. Zimmerman G, Njunting M, Ivens S, Tolner EA, Behrens CJ, Gross M, Soreq H, Heinemann U and Friedman A (2008) Acetylcholine-induced seizure-like activity and modified cholinergic gene expression in chronically epileptic rats. Eur J Neurosci 27: 965-975.