메뉴 건너뛰기




Volumn 8, Issue 1, 2008, Pages 2-7

Adenosine as a neuromodulator in neurological diseases

Author keywords

[No Author keywords available]

Indexed keywords

5 AMINO 2 (2 FURYL) 7 (2 PHENYLETHYL)PYRAZOLO[4,3 E][1,2,4]TRIAZOLO[1,5 C]PYRIMIDINE; ADENOSINE; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE A2 RECEPTOR; ADENOSINE A2 RECEPTOR ANTAGONIST; ADENOSINE KINASE INHIBITOR; ISTRADEFYLLINE;

EID: 38649097860     PISSN: 14714892     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coph.2007.09.002     Document Type: Review
Times cited : (197)

References (50)
  • 2
    • 33644770260 scopus 로고    scopus 로고
    • Adenosine receptors as therapeutic targets
    • Jacobson K.A., and Gao Z.G. Adenosine receptors as therapeutic targets. Nat Rev Drug Discov 5 (2006) 247-264
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 247-264
    • Jacobson, K.A.1    Gao, Z.G.2
  • 3
    • 33846271369 scopus 로고    scopus 로고
    • Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus
    • Cunha-Reis D., Fontinha B.M., Ribeiro J.A., and Sebastiao A.M. Tonic adenosine A1 and A2A receptor activation is required for the excitatory action of VIP on synaptic transmission in the CA1 area of the hippocampus. Neuropharmacol 52 (2007) 313-320
    • (2007) Neuropharmacol , vol.52 , pp. 313-320
    • Cunha-Reis, D.1    Fontinha, B.M.2    Ribeiro, J.A.3    Sebastiao, A.M.4
  • 4
    • 34247131684 scopus 로고    scopus 로고
    • Adenosine-based cell therapy approaches for pharmacoresistant epilepsies
    • Boison D. Adenosine-based cell therapy approaches for pharmacoresistant epilepsies. Neurodegener Dis 4 (2007) 28-33
    • (2007) Neurodegener Dis , vol.4 , pp. 28-33
    • Boison, D.1
  • 5
    • 16344372309 scopus 로고    scopus 로고
    • Neuroprotection by adenosine in the brain: from A1 receptor activation to A2A receptor blockade
    • Cunha R.A. Neuroprotection by adenosine in the brain: from A1 receptor activation to A2A receptor blockade. Purinergic Signal 1 (2005) 111-134
    • (2005) Purinergic Signal , vol.1 , pp. 111-134
    • Cunha, R.A.1
  • 6
    • 33745760564 scopus 로고    scopus 로고
    • The role of the basal ganglia in habit formation
    • Yin H.H., and Knowlton B.J. The role of the basal ganglia in habit formation. Nat Rev Neurosci 7 (2006) 464-476
    • (2006) Nat Rev Neurosci , vol.7 , pp. 464-476
    • Yin, H.H.1    Knowlton, B.J.2
  • 7
    • 34447634291 scopus 로고    scopus 로고
    • Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons
    • Silva C.G., Porciuncula L.O., Canas P.M., Oliveira C.R., and Cunha R.A. Blockade of adenosine A(2A) receptors prevents staurosporine-induced apoptosis of rat hippocampal neurons. Neurobiol Dis (2007)
    • (2007) Neurobiol Dis
    • Silva, C.G.1    Porciuncula, L.O.2    Canas, P.M.3    Oliveira, C.R.4    Cunha, R.A.5
  • 9
    • 34548535812 scopus 로고    scopus 로고
    • Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function
    • Fuxe K., Ferre S., Genedani S., Franco R., and Agnati L.F. Adenosine receptor-dopamine receptor interactions in the basal ganglia and their relevance for brain function. Physiol Behav (2007)
    • (2007) Physiol Behav
    • Fuxe, K.1    Ferre, S.2    Genedani, S.3    Franco, R.4    Agnati, L.F.5
  • 10
    • 33751585955 scopus 로고    scopus 로고
    • Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission
    • Martin E.D., Fernandez M., Perea G., Pascual O., Haydon P.G., Araque A., and Cena V. Adenosine released by astrocytes contributes to hypoxia-induced modulation of synaptic transmission. Glia 55 (2007) 36-45
    • (2007) Glia , vol.55 , pp. 36-45
    • Martin, E.D.1    Fernandez, M.2    Perea, G.3    Pascual, O.4    Haydon, P.G.5    Araque, A.6    Cena, V.7
  • 11
    • 34250317399 scopus 로고    scopus 로고
    • Synaptic islands defined by the territory of a single astrocyte
    • Halassa M.M., Fellin T., Takano H., Dong J.H., and Haydon P.G. Synaptic islands defined by the territory of a single astrocyte. J Neurosci 27 (2007) 6473-6477
    • (2007) J Neurosci , vol.27 , pp. 6473-6477
    • Halassa, M.M.1    Fellin, T.2    Takano, H.3    Dong, J.H.4    Haydon, P.G.5
  • 12
    • 33846621575 scopus 로고    scopus 로고
    • The tripartite synapse: roles for gliotransmission in health and disease
    • Halassa M.M., Fellin T., and Haydon P.G. The tripartite synapse: roles for gliotransmission in health and disease. Trends Mol Med 13 (2007) 54-63
    • (2007) Trends Mol Med , vol.13 , pp. 54-63
    • Halassa, M.M.1    Fellin, T.2    Haydon, P.G.3
  • 13
    • 33748450680 scopus 로고    scopus 로고
    • Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme
    • Studer F.E., Fedele D.E., Marowsky A., Schwerdel C., Wernli K., Vogt K., Fritschy J.-M., and Boison D. Shift of adenosine kinase expression from neurons to astrocytes during postnatal development suggests dual functionality of the enzyme. Neuroscience 142 (2006) 125-137
    • (2006) Neuroscience , vol.142 , pp. 125-137
    • Studer, F.E.1    Fedele, D.E.2    Marowsky, A.3    Schwerdel, C.4    Wernli, K.5    Vogt, K.6    Fritschy, J.-M.7    Boison, D.8
  • 14
    • 33745873475 scopus 로고    scopus 로고
    • Astrocyte control of synaptic transmission and neurovascular coupling
    • Haydon P.G., and Carmignoto G. Astrocyte control of synaptic transmission and neurovascular coupling. Physiol Rev 86 (2006) 1009-1031
    • (2006) Physiol Rev , vol.86 , pp. 1009-1031
    • Haydon, P.G.1    Carmignoto, G.2
  • 15
    • 26444552361 scopus 로고    scopus 로고
    • Astrocytic purinergic signaling coordinates synaptic networks
    • By generating inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes, the vesicular release of neurotransmitters was selectively blocked in astrocytes. Using these animals it was demonstrated for the first time that adenosine-mediated tonic suppression of synaptic transmission was dependent on astrocytic vesicular release of ATP. These studies demonstrated that astrocytes are crucially involved in regulating and fine-tuning synaptic strength and plasticity.
    • Pascual O., Casper K.B., Kubera C., Zhang J., Revilla-Sanchez R., Sul J.Y., Takano H., Moss S.J., McCarthy K., and Haydon P.G. Astrocytic purinergic signaling coordinates synaptic networks. Science 310 (2005) 113-116. By generating inducible transgenic mice that express a dominant-negative SNARE domain selectively in astrocytes, the vesicular release of neurotransmitters was selectively blocked in astrocytes. Using these animals it was demonstrated for the first time that adenosine-mediated tonic suppression of synaptic transmission was dependent on astrocytic vesicular release of ATP. These studies demonstrated that astrocytes are crucially involved in regulating and fine-tuning synaptic strength and plasticity.
    • (2005) Science , vol.310 , pp. 113-116
    • Pascual, O.1    Casper, K.B.2    Kubera, C.3    Zhang, J.4    Revilla-Sanchez, R.5    Sul, J.Y.6    Takano, H.7    Moss, S.J.8    McCarthy, K.9    Haydon, P.G.10
  • 16
    • 33750943168 scopus 로고    scopus 로고
    • Adenosine kinase, epilepsy and stroke: mechanisms and therapies
    • Boison D. Adenosine kinase, epilepsy and stroke: mechanisms and therapies. Trends Pharmacol Sci 27 (2006) 652-658
    • (2006) Trends Pharmacol Sci , vol.27 , pp. 652-658
    • Boison, D.1
  • 17
    • 13544274000 scopus 로고    scopus 로고
    • Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies
    • Boison D. Adenosine and epilepsy: from therapeutic rationale to new therapeutic strategies. Neuroscientist 11 (2005) 25-36
    • (2005) Neuroscientist , vol.11 , pp. 25-36
    • Boison, D.1
  • 22
    • 26044440838 scopus 로고    scopus 로고
    • Astrogliosis in epilepsy leads to overexpression of adenosine kinase resulting in seizure aggravation
    • This is a demonstration that transgenic overexpression of adenosine kinase in brain alters seizure susceptibility. Upregulated ADK was associated with a reduced tone of the endogenous anticonvulsant adenosine and with spontaneous seizures and lowered seizure thresholds.
    • Fedele D.E., Gouder N., Güttinger M., Gabernet L., Scheurer L., Rulicke T., Crestani F., and Boison D. Astrogliosis in epilepsy leads to overexpression of adenosine kinase resulting in seizure aggravation. Brain 128 (2005) 2383-2395. This is a demonstration that transgenic overexpression of adenosine kinase in brain alters seizure susceptibility. Upregulated ADK was associated with a reduced tone of the endogenous anticonvulsant adenosine and with spontaneous seizures and lowered seizure thresholds.
    • (2005) Brain , vol.128 , pp. 2383-2395
    • Fedele, D.E.1    Gouder, N.2    Güttinger, M.3    Gabernet, L.4    Scheurer, L.5    Rulicke, T.6    Crestani, F.7    Boison, D.8
  • 23
    • 34249694599 scopus 로고    scopus 로고
    • Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants
    • Embryonic stem cells engineered to release adenosine by biallelic disruption of the adenosine kinase gene were differentiated into neural precursor cells and transplanted into the infrahippocampal cleft of rats before the onset of kindling. Animals with adenosine releasing intrahippocampal implants were characterized with a significant suppression of kindling development. This is the first study to demonstrate an antiepileptogenic potential of adenosine.
    • Li T., Steinbeck J.A., Lusardi T., Koch P., Lan J.Q., Wilz A., Segschneider M., Simon R.P., Brustle O., and Boison D. Suppression of kindling epileptogenesis by adenosine releasing stem cell-derived brain implants. Brain 130 (2007) 1276-1288. Embryonic stem cells engineered to release adenosine by biallelic disruption of the adenosine kinase gene were differentiated into neural precursor cells and transplanted into the infrahippocampal cleft of rats before the onset of kindling. Animals with adenosine releasing intrahippocampal implants were characterized with a significant suppression of kindling development. This is the first study to demonstrate an antiepileptogenic potential of adenosine.
    • (2007) Brain , vol.130 , pp. 1276-1288
    • Li, T.1    Steinbeck, J.A.2    Lusardi, T.3    Koch, P.4    Lan, J.Q.5    Wilz, A.6    Segschneider, M.7    Simon, R.P.8    Brustle, O.9    Boison, D.10
  • 24
    • 34347389850 scopus 로고    scopus 로고
    • Cell and gene therapies for refractory epilepsy
    • Boison D. Cell and gene therapies for refractory epilepsy. Curr Neuropharmacol 5 (2007) 115-125
    • (2007) Curr Neuropharmacol , vol.5 , pp. 115-125
    • Boison, D.1
  • 25
    • 34248202688 scopus 로고    scopus 로고
    • Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus
    • Frenguelli B.G., Wigmore G., Llaudet E., and Dale N. Temporal and mechanistic dissociation of ATP and adenosine release during ischaemia in the mammalian hippocampus. J Neurochem 101 (2007) 1400-1413
    • (2007) J Neurochem , vol.101 , pp. 1400-1413
    • Frenguelli, B.G.1    Wigmore, G.2    Llaudet, E.3    Dale, N.4
  • 26
    • 33646537781 scopus 로고    scopus 로고
    • Sustained elevation of extracellular adenosine and activation of A(1) receptors underlie the post-ischemic inhibition of neuronal function in rat hippocampus in vitro
    • This study combined electrophysiology with synchronized online detection of adenosine using microelectrode biosensors for adenosine. Using this ingenious approach, the authors convincingly demonstrate a link between the post-ischemic rise in adenosine and inhibition of neurotransmission.
    • Pearson T., Damian K., Lynas R.E., and Frenguelli B.G. Sustained elevation of extracellular adenosine and activation of A(1) receptors underlie the post-ischemic inhibition of neuronal function in rat hippocampus in vitro. J Neurochem 97 (2006) 1357-1368. This study combined electrophysiology with synchronized online detection of adenosine using microelectrode biosensors for adenosine. Using this ingenious approach, the authors convincingly demonstrate a link between the post-ischemic rise in adenosine and inhibition of neurotransmission.
    • (2006) J Neurochem , vol.97 , pp. 1357-1368
    • Pearson, T.1    Damian, K.2    Lynas, R.E.3    Frenguelli, B.G.4
  • 27
    • 33745763116 scopus 로고    scopus 로고
    • Cerebral preconditioning and ischemic tolerance
    • Gidday J.M. Cerebral preconditioning and ischemic tolerance. Nat Rev Neurosci 7 (2006) 437-448
    • (2006) Nat Rev Neurosci , vol.7 , pp. 437-448
    • Gidday, J.M.1
  • 28
    • 33846635975 scopus 로고    scopus 로고
    • Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis
    • Stenzel-Poore M.P., Stevens S.L., King J.S., and Simon R.P. Preconditioning reprograms the response to ischemic injury and primes the emergence of unique endogenous neuroprotective phenotypes: a speculative synthesis. Stroke 38 (2007) 680-685
    • (2007) Stroke , vol.38 , pp. 680-685
    • Stenzel-Poore, M.P.1    Stevens, S.L.2    King, J.S.3    Simon, R.P.4
  • 29
    • 20344394152 scopus 로고    scopus 로고
    • Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning
    • Trendelenburg G., and Dirnagl U. Neuroprotective role of astrocytes in cerebral ischemia: focus on ischemic preconditioning. Glia 50 (2005) 307-320
    • (2005) Glia , vol.50 , pp. 307-320
    • Trendelenburg, G.1    Dirnagl, U.2
  • 30
    • 37549033536 scopus 로고    scopus 로고
    • Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism
    • Pignataro G., Maysami S., Studer F.E., Wilz A., Simon R.P., and Boison D. Downregulation of hippocampal adenosine kinase after focal ischemia as potential endogenous neuroprotective mechanism. J Cereb Blood Flow Metab 28 (2008) 17-23
    • (2008) J Cereb Blood Flow Metab , vol.28 , pp. 17-23
    • Pignataro, G.1    Maysami, S.2    Studer, F.E.3    Wilz, A.4    Simon, R.P.5    Boison, D.6
  • 31
    • 33845786142 scopus 로고    scopus 로고
    • Transgenic overexpression of adenosine kinase aggravates cell death in ischemia
    • Pignataro G., Simon R.P., and Boison D. Transgenic overexpression of adenosine kinase aggravates cell death in ischemia. J Cereb Blood Flow Metab 27 (2007) 1-5
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 1-5
    • Pignataro, G.1    Simon, R.P.2    Boison, D.3
  • 32
    • 34247526358 scopus 로고    scopus 로고
    • Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants
    • Pignataro G., Studer F.E., Wilz A., Simon R.P., and Boison D. Neuroprotection in ischemic mouse brain induced by stem cell-derived brain implants. J Cereb Blood Flow Metab 27 (2007) 919-927
    • (2007) J Cereb Blood Flow Metab , vol.27 , pp. 919-927
    • Pignataro, G.1    Studer, F.E.2    Wilz, A.3    Simon, R.P.4    Boison, D.5
  • 33
    • 36349022149 scopus 로고    scopus 로고
    • Adenosine and ATP receptors
    • Sawynok J. Adenosine and ATP receptors. Handb Exp Pharmacol (2007) 309-328
    • (2007) Handb Exp Pharmacol , pp. 309-328
    • Sawynok, J.1
  • 34
    • 33747780797 scopus 로고    scopus 로고
    • Purinergic control of neuropathic pain
    • McGaraughty S., and Jarvis M.F. Purinergic control of neuropathic pain. Drug Dev Res 67 (2006) 376-388
    • (2006) Drug Dev Res , vol.67 , pp. 376-388
    • McGaraughty, S.1    Jarvis, M.F.2
  • 35
    • 36148933708 scopus 로고    scopus 로고
    • Adenosine A(2A) receptors in ventral striatum, hypothalamus and nociceptive circuitry: Implications for drug addiction, sleep and pain
    • Ferre S., Diamond I., Goldberg S.R., Yao L., Hourani S.M., Huang Z.L., Urade Y., and Kitchen I. Adenosine A(2A) receptors in ventral striatum, hypothalamus and nociceptive circuitry: Implications for drug addiction, sleep and pain. Prog Neurobiol (2007)
    • (2007) Prog Neurobiol
    • Ferre, S.1    Diamond, I.2    Goldberg, S.R.3    Yao, L.4    Hourani, S.M.5    Huang, Z.L.6    Urade, Y.7    Kitchen, I.8
  • 36
    • 32144456577 scopus 로고    scopus 로고
    • Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice
    • Godfrey L., Yan L., Clarke G.D., Ledent C., Kitchen I., and Hourani S.M. Modulation of paracetamol antinociception by caffeine and by selective adenosine A2 receptor antagonists in mice. Eur J Pharmacol 531 (2006) 80-86
    • (2006) Eur J Pharmacol , vol.531 , pp. 80-86
    • Godfrey, L.1    Yan, L.2    Clarke, G.D.3    Ledent, C.4    Kitchen, I.5    Hourani, S.M.6
  • 37
    • 34248569306 scopus 로고    scopus 로고
    • Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice
    • Hussey M.J., Clarke G.D., Ledent C., Hourani S.M., and Kitchen I. Reduced response to the formalin test and lowered spinal NMDA glutamate receptor binding in adenosine A2A receptor knockout mice. Pain 129 (2007) 287-294
    • (2007) Pain , vol.129 , pp. 287-294
    • Hussey, M.J.1    Clarke, G.D.2    Ledent, C.3    Hourani, S.M.4    Kitchen, I.5
  • 40
    • 37549018072 scopus 로고    scopus 로고
    • Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease
    • Fuxe K., Marcellino D., Genedani S., and Agnati L. Adenosine A(2A) receptors, dopamine D(2) receptors and their interactions in Parkinson's disease. Mov Disord 22 (2007) 1990-2017
    • (2007) Mov Disord , vol.22 , pp. 1990-2017
    • Fuxe, K.1    Marcellino, D.2    Genedani, S.3    Agnati, L.4
  • 42
    • 33751427701 scopus 로고    scopus 로고
    • Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice
    • Dall'Igna O.P., Fett P., Gomes M.W., Souza D.O., Cunha R.A., and Lara D.R. Caffeine and adenosine A(2a) receptor antagonists prevent beta-amyloid (25-35)-induced cognitive deficits in mice. Exp Neurol 203 (2007) 241-245
    • (2007) Exp Neurol , vol.203 , pp. 241-245
    • Dall'Igna, O.P.1    Fett, P.2    Gomes, M.W.3    Souza, D.O.4    Cunha, R.A.5    Lara, D.R.6
  • 43
    • 34047161070 scopus 로고    scopus 로고
    • Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease
    • Popoli P., Blum D., Martire A., Ledent C., Ceruti S., and Abbracchio M.P. Functions, dysfunctions and possible therapeutic relevance of adenosine A2A receptors in Huntington's disease. Prog Neurobiol 81 (2007) 331-348
    • (2007) Prog Neurobiol , vol.81 , pp. 331-348
    • Popoli, P.1    Blum, D.2    Martire, A.3    Ledent, C.4    Ceruti, S.5    Abbracchio, M.P.6
  • 44
    • 28444477430 scopus 로고    scopus 로고
    • The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea
    • Maglione V., Cannella M., Martino T., De Blasi A., Frati L., and Squitieri F. The platelet maximum number of A2A-receptor binding sites (Bmax) linearly correlates with age at onset and CAG repeat expansion in Huntington's disease patients with predominant chorea. Neurosci Lett 393 (2006) 27-30
    • (2006) Neurosci Lett , vol.393 , pp. 27-30
    • Maglione, V.1    Cannella, M.2    Martino, T.3    De Blasi, A.4    Frati, L.5    Squitieri, F.6
  • 47
    • 33746768115 scopus 로고    scopus 로고
    • Targeting the dopamine D2 receptor in schizophrenia
    • Seeman P. Targeting the dopamine D2 receptor in schizophrenia. Expert Opin Ther Targets 10 (2006) 515-531
    • (2006) Expert Opin Ther Targets , vol.10 , pp. 515-531
    • Seeman, P.1
  • 50
    • 33645214436 scopus 로고    scopus 로고
    • Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a pro-cognitive and anti-psychotic phenotypic profile
    • Yee B.K., Balic E., Singer P., Schwerdel C., Grampp T., Gabernet L., Knuesel I., Benke D., Feldon J., Mohler H., et al. Disruption of glycine transporter 1 restricted to forebrain neurons is associated with a pro-cognitive and anti-psychotic phenotypic profile. J Neurosci 26 (2006) 3169-3181
    • (2006) J Neurosci , vol.26 , pp. 3169-3181
    • Yee, B.K.1    Balic, E.2    Singer, P.3    Schwerdel, C.4    Grampp, T.5    Gabernet, L.6    Knuesel, I.7    Benke, D.8    Feldon, J.9    Mohler, H.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.