Dizocilpine improves beneficial effects of cholinergic antagonists in anticholinesterase-treated mice

Toxicological Sciences

Volumn 72, Issue 2, 2003, Pages 289-295

  Dekundy, Andrzej ^a,b   Kaminski, Rafal M ^b   Turski, Waldemar A ^b,c  

^a MERZ PHARMACEUTICALS GMBH   (Germany)

^b INSTITUTE OF AGRICULTURAL MEDICINE   (Poland)

^c MEDICAL UNIVERSITY OF LUBLIN   (Poland)

Author keywords

Anticholinesterase; Atropine; Lethality; Mecamylamine; Mice; Muscarinic; Nicotinic; NMDA antagonist; Seizures

Indexed keywords

ATROPINE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; DICHLORVOS; DIZOCILPINE; MECAMYLAMINE; MEMANTINE; METHOMYL; MUSCARINIC RECEPTOR; MUSCARINIC RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; NICOTINIC RECEPTOR; NICOTINIC RECEPTOR BLOCKING AGENT; PESTICIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG POTENTIATION; LETHALITY; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; REGULATORY MECHANISM; SEIZURE; TOXICITY TESTING;

ANIMALS; CHOLINERGIC ANTAGONISTS; CHOLINESTERASE INHIBITORS; DICHLORVOS; DIZOCILPINE MALEATE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SYNERGISM; EXCITATORY AMINO ACID ANTAGONISTS; INSECTICIDES; LETHAL DOSE 50; MALE; METHOMYL; MICE; SEIZURES;

ANIMALIA;

EID: 0037389366     PISSN: 10966080     EISSN: None     Source Type: Journal    
DOI: 10.1093/toxsci/kfg013     Document Type: Article

References (37)

1. Bakry, N. M., el-Rashidy, A. H., Eldefrawi, A. T., and Eldefrawi, M. E. (1988). Direct actions of organophosphate anticholinesterases on nicotinic and muscarinic acetylcholine receptors. J. Biochem. Toxicol. 3, 235-259.
2. Bardin, P. G., van Eeden, S. F., Moolman, J. A., Foden, A. P., and Joubert, J. R. (1994). Organophosphate and carbamate poisoning. Arch. Intern. Med. 154, 1433-1441.
3. Bowden, C. A., and Krenzelok, E. P. (1997). Clinical applications of commonly used contemporary antidotes. A US perspective. Drug Saf. 16, 9-47.
4. Braitman, D. J., and Sparenborg, S. (1989). MK-801 protects against seizures induced by the cholinesterase inhibitor soman. Brain Res. Bull. 23, 145-148.
5. Cable, G. G., and Doherty, S. (1999). Acute carbamate and organochlorine toxicity causing convulsions in an agricultural pilot: A case report. Aviat. Space Environ. Med. 70, 68-72.
6. Chu, Z. G., Zhou, F. M., and Hablitz, J. J. (2000). Nicotinic acetylcholine receptor-mediated synaptic potentials in rat neocortex. Brain Res. 887, 399-405.
7. Clement, J. G. (1994). Toxicity of the combined nerve agents GB/GF in mice: Efficacy of atropine and various oximes as antidotes. Arch. Toxicol. 68, 64-66.
8. Dawson, R. M. (1994). Review of oximes available for treatment of nerve agent poisoning. J. Appl. Toxicol. 14, 317-331.
9. Dekundy, A., Blaszczak, P., Kaminski, R., and Turski, W. A. (2001). On the interactions between antimuscarinic atropine and NMDA receptor antagonists in anticholinesterase-treated mice. Arch. Toxicol. 74, 702-708.
10. Finney, D. J. (1948). The Fisher-Yates test of significance in 2×2 contingency tables. Biometrika 35, 145-156.
11. Girod, R., Barazangi, N., McGehee, D., and Role, L. W. (2000). Facilitation of glutamatergic neurotransmission by presynaptic nicotinic acetylcholine receptors. Neuropharmacology 39, 2715-2725.
12. Gupta, R. C. (1994). Carbofuran toxicity. J. Toxicol. Environ. Health 43, 383-418.
13. Harris, L., and Stitcher, D. (1984). Protection against diisopropylfluorophosphate intoxication by pyridostigmine and physostigmine in combination with atropine and mecamylamine. Naunyn Schmiedebergs Arch. Pharmacol. 327, 64-69.
14. Holstege, C. P., Kirk, M., and Sidell, F. R. (1997). Chemical warfare. Nerve agent poisoning. Crit. Care Clin. 13, 923-942.
15. Honchar, M. P., Olney, J. W., and Sherman, W. R. (1983). Systemic cholinergic agents induce seizures and brain damage in lithium-treated rats. Science 220, 323-325.
16. Jones, C. K., and Shannon, H. E. (2000). Muscarinic cholinergic modulation of prepulse inhibition of the acoustic startle reflex. J. Pharmacol. Exp. Ther. 294, 1017-1023.
17. Lifshitz, M., Shahak, E., Bolotin, A., and Sofer, S. (1997). Carbamate poisoning in early childhood and in adults. J. Toxicol. Clin. Toxicol. 35, 25-27.
18. Litchfield, J. T., and Wilcoxon, F. (1949). A simplified method of evaluating dose effect experimenta. J. Pharmacol. Exp. Ther. 96, 99-113.
19. Lu, W. Y., Xiong, Z. G., Lei, S., Orser, B. A., Dudek, E., Browning, M. D., and MacDonald, J. F. (1999). G-protein-coupled receptors act via protein kinase C and Src to regulate NMDA receptors. Nat. Neurosci. 2, 331-338.
20. Markram, H., and Segal, M. (1992). Activation of protein kinase C suppresses responses to NMDA in rat CA1 hippocampal neurones. J. Physiol. (Lond.) 457, 491-501.
21. Marrs, T. C. (2000). Toxicology of pesticides. In General and Applied Toxicology (B. Ballantyne, T. C. Marrs, and T. Syversen, Eds.), pp. 1993-2012. Macmillan, London.
22. McGehee, D. S., Heath, M. J., Gelber, S., Devay, P., and Role, L. W. (1995). Nicotine enhancement of fast excitatory synaptic transmission in CNS by presynaptic receptors. Science 269, 1692-1696.
23. McLean, M. J., Gupta, R. C., Dettbarn, W. D., and Wamil, A. W. (1992). Prophylactic and therapeutic efficacy of memantine against seizures produced by soman in the rat. Toxicol. Appl. Pharmacol. 112, 95-103.
24. Minton, N. A., and Murray, V. S. (1988). A review of organophosphate poisoning. Med. Toxicol. Adverse Drug Exp. 3, 350-375.
25. Munro, N. B., Watson, A. P., Ambrose, K. R., and Griffin, G. D. (1990). Treating exposure to chemical warfare agents: Implications for health care providers and community emergency planning. Environ. Health Perspect. 89, 205-215.
26. Ohbu, S., Yamashina, A., Takasu, N., Yamaguchi, T., Murai, T., Nakano, K., Matsui, Y., Mikami, R., Sakurai, K., and Hinohara, S. (1997). Sarin poisoning on Tokyo subway. South. Med. J. 90, 587-593.
27. Olivier, J., Guiavarc'h, M., Martin, Y. N., and Ducrot, P. (1988). [Organophosphorous poisoning]. Cah. Anesthesiol. 36, 371-373.
28. Racine, R. J. (1972). Modification of seizure activity by electrical stimulation. II. Motor seizure. Electroenceph. Clin. Neurophysiol. 32, 281-294.
29. Shih, T. M., Koviak, T. A., and Capacio, B. R. (1991). Anticonvulsants for poisoning by the organophosphorus compound soman: Pharmacological mechanisms. Neurosci. Biobehav. Rev. 15, 349-362.
30. Shih, T. M., and McDonough, J. H., Jr. (1997). Neurochemical mechanisms in soman-induced seizures. J. Appl. Toxicol. 17, 255-264.
31. Shih, T. M., and McDonough, J. H., Jr. (1999). Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment. Pharmacol. Biochem. Behav. 64, 147-153.
32. Sparenborg, S., Brennecke, L. H., Jaax, N. K., and Braitman, D. J. (1992). Dizocilpine (MK-801) arrests status epilepticus and prevents brain damage induced by soman. Neuropharmacology 31, 357-368.
33. Vollmer, R., Szirmai, I. G., and Rappelsberger, P. (1979). [The propagation of acetylcholine-induced seizures]. EEG EMG Z. Elektroenzephalogr. Elektromyogr. Verwandte Geb. 10, 123-131.
34. WHO Working Group (1989). Dichlorvos. Environmental Health Criteria 79.
35. Worek, F., Backer, M., Thiermann, H., Szinicz, L., Mast, U., Klimmek, R., and Eyer, P. (1997). Reappraisal of indications and limitations of oxime therapy in organophosphate poisoning. Hum. Exp. Toxicol. 16, 466-472.
36. Yamashita, M., Tanaka, J., and Ando, Y. (1997). Human mortality in organophosphate poisonings. Vet. Hum. Toxicol. 39, 84-85.
37. Zwart, R., van Kleef, R. G., Gotti, C., Smulders, C. J., and Vijverberg, H. P. (2000). Competitive potentiation of acetylcholine effects on neuronal nicotinic receptors by acetylcholinesterase-inhibiting drugs. J. Neurochem. 75, 2492-2500.