Therapeutic efficacy of the adenosine A1 receptor agonist N6-cyclopentyladenosine (CPA) against organophosphate intoxication

Archives of Toxicology

Volumn 76, Issue 11, 2002, Pages 650-656

  Bueters, Tjerk J H ^a   Groen, Bas ^a   Danhof, Meindert ^b   IJzerman, Ad P ^b   Van Helden, Herman P M ^a  

^a TNO   (Netherlands)

^b LEIDEN UNIVERSITY   (Netherlands)

Author keywords

Acetylcholine release; Adenosine A1 receptor; N6 Cyclopentyladenosine; Organophosphate

Indexed keywords

ACETYLCHOLINESTERASE; ADENOSINE A1 RECEPTOR AGONIST; ADENOSINE RECEPTOR STIMULATING AGENT; CYCLOHEXYLADENOSINE; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; PARATHION; SARIN; TABUN; ACETYLCHOLINE; ADENOSINE; ADENOSINE RECEPTOR; CHOLINESTERASE; CHOLINESTERASE INHIBITOR; DRUG DERIVATIVE; N(6) CYCLOPENTYLADENOSINE; N(6)-CYCLOPENTYLADENOSINE; ORGANOPHOSPHATE; PHOSPHOROTHIOIC ACID DERIVATIVE;

ARTICLE; BIOACCUMULATION; CHOLINERGIC SYSTEM; CONCENTRATION RESPONSE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG EFFICACY; ENZYME ACTIVITY; HIPPOCAMPUS; INTOXICATION; MALE; MICRODIALYSIS; NONHUMAN; PRIORITY JOURNAL; RAT; REDUCTION; ANIMAL; DRUG POTENTIATION; ENZYMOLOGY; METABOLISM; SECRETION; WISTAR RAT;

ACETYLCHOLINE; ADENOSINE; ANIMALS; CHOLINESTERASE INHIBITORS; CHOLINESTERASES; CORPUS STRIATUM; MALE; MICRODIALYSIS; ORGANOTHIOPHOSPHORUS COMPOUNDS; PARATHION; PHOSPHORIC ACID ESTERS; RATS; RATS, WISTAR; RECEPTORS, PURINERGIC P1; SARIN;

EID: 0036460707     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00204-002-0395-x     Document Type: Article

References (29)

1. Ballantyne B, Marrs TC (1992) Clinical and Experimental Toxicology of Organophosphates and Carbamates. Butterworth-Heinemann, Oxford, England
2. 1 receptor mediated inhibition of acetylcholine release with low efficacy agonists. Drug Dev Res 50:81
3. Chebabo SR, Santos MD, Albuquerque EX (1999) The organophosphate sarin, at low concentrations, inhibits the evoked release of GABA in rat hippocampal slices. Neurotoxicology 20:871-882
4. Damsma G, Westerink BH, Imperato A, Rollema H, De Vries JB, Horn AS (1987) Automated brain dialysis of acetylcholine in freely moving rats: Detection of basal acetylcholine. Life Sci 41:873-876
5. Dawson RM (1994) Review of oximes available for treatment of nerve agent poisoning J Appl Toxicol 14:317-331
6. Eigenberg DA, Pazdernik TL, Doull J (1983) Hemoperfusion and pharmacokinetic studies with parathion and paraoxon in the rat and dog. Drug Metab Dispos 11:366-370
7. Gupta RC, Patterson GT, Dettbarn WD (1986) Mechanisms of toxicity and tolerance to diisopropylphosphorofluoridate at the neuromuscular junction of the rat. Toxicol Appl Pharmacol 84:541-550
8. Gupta RC, Patterson GT, Dettbarn WD (1991) Comparison of cholinergic and neuromuscular toxicity following acute exposure to sarin and VX in rat. Fundam Appl Toxicol 16:449-458
9. Hayward IJ, Wall HG, Jaax NK, Wade JV, Marlow DD, Nold JB (1990) Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy. J Neurol Sci 98:99-106
10. Holstege CP, Kirk M, Sidell FR (1997) Chemical warfare. Nerve agent poisoning. Crit Care Clin 13:923-942
11. Idriss MK, Aguayo LG, Rickett DL, Albuquerque EX (1986) Organophosphate and carbamate compounds have pre- and postjunctional effects at the insect glutamatergic synapse. J Pharmacol Exp Ther 239:279-285
12. Jett DA, Abdallah EAM, El-Fakahany EE, Eldefrawi ME, Eldefrawi AT (1991) High-affinity activation by paraoxon of a muscarinic receptor subtype in rat brain striatum. Pesticide Biochem Physiol 39:149-157
13. Kadar T, Shapira S, Cohen G, Sahar R, Alkalay D, Raveh L. (1995) Sarin-induced neuropathology in rats. Hum Exp Toxicol 14:252-259
14. Lallement G, Clarencon D, Masqueliez C, Baubichon D, Galonnier M, Burckhart MF, Peoc'h M, Mestries JC (1998) Nerve agent poisoning in primates: Antilethal, anti-epileptic and neuroprotective effects of GK-11. Arch Toxicol 72:84-92
15. McDonough JH Jr, McLeod CG Jr, Nipwoda MT (1987) Direct microinjection of soman or VX into the amygdala produces repetitive limbic convulsions and neuropathology. Brain Res 435:123-137
16. Nigg HN, Knaak JB (2000) Blood cholinesterases as human biomarkers of organophosphorus pesticide exposure. Rev Environ Contam Toxicol 163:29-111
17. Olsen RA, Pearson JD (1990) Cardiovascular purinoceptors. Physiol Rev 70:761-845
18. Pena-Egido MJ, Rivas-Gonzalo JC, Marino-Hernandez EL (1988) Toxicokinetics of parathion in the rabbit. Arch Toxicol 61:196-200
19. Rao KS, Aracava Y, Rickett DL, Albuquerque EX (1987) Noncompetitive blockade of the nicotinic acetylcholine receptor-ion channel complex by an irreversible cholinesterase inhibitor. J Pharmacol Exp Ther 240:337-344
20. Rocha ES, Santos MD, Chebabo SR, Aracava Y, Albuquerque EX (1999) Low concentrations of the organophosphate VX affect spontaneous and evoked transmitter release from hippocampal neurons: Toxicological relevance of cholinesterase-independent actions. Toxicol Appl Pharmacol 159:31-40
21. Shih TM, McDonough JH Jr (1997) Neurochemical mechanisms in soman-induced seizures. J Appl Toxicol 17:255-264
22. Shih TM, McDonough JH Jr (1999) Organophosphorus nerve agents-induced seizures and efficacy of atropine sulfate as anticonvulsant treatment. Pharmacol Biochem Behav 64:147-153
23. 2 muscarinic receptors of rat heart have high affinity for organophosphorus anticholinesterases. Toxicol Appl Pharmacol 103:474-481
24. Solberg Y, Belkin M (1997) The role of excitotoxicity in organophosphorous nerve agents central poisoning. Trends Pharmacol Sci 18:183-185
25. Van Helden HP, Bueters TJ (1999) Protective activity of adenosine receptor agonists in the treatment of organophosphate poisoning. Trends Pharmacol Sci 20:438-441
26. Van Helden HP, van der Wiel HJ, De Lange J, Busker RW, Melchers BP, Wolthuis OL (1992) Therapeutic efficacy of HI-6 in soman-poisoned marmoset monkeys. Toxicol Appl Pharmacol 115:50-56
27. Van Helden HP, Busker RW, Melchers BP, Bruijnzeel PL (1996) Pharmacological effects of oximes: How relevant are they? Arch Toxicol 70:779-786
28. Van Helden HP, Groen B, Moor E, Westerink BH, Bruijnzeel PL (1998) New generic approach to the treatment of organophosphate poisoning: Adenosine receptor mediated inhibition of ACh-release. Drug Chem Toxicol 21 [Suppl 1]:171-181
29. Worek F, Widmann R, Knopff O, Szinicz L (1998) Reactivating potency of obidoxime, pralidoxime, HI 6 and HLo 7 in human erythrocyte acetylcholinesterase inhibited by highly toxic organophosphorus compounds. Arch Toxicol 72:237-243