메뉴 건너뛰기




Volumn 74, Issue 3, 2000, Pages 165-172

Efficacy of biperiden and atropine as anticonvulsant treatment for organophosphorus nerve agent intoxication

Author keywords

Anticholinergic compounds; Anticonvulsants; Atropine; Biperiden; Cholinesterase inhibitors; Convulsions; EEG activity; GF; Organophosphorus compounds; Sarin; Seizures; Soman; Tabun; VX

Indexed keywords

ANTICONVULSIVE AGENT; ATROPINE; BIPERIDEN; METHYLPHOSPHONOTHIOIC ACID S (2 DIISOPROPYLAMINOETHYL) O ETHYL ESTER; NERVE GAS; ORGANOPHOSPHORUS COMPOUND; PRALIDOXIME CHLORIDE; PYRIDOSTIGMINE; SARIN; SOMAN; TABUN;

EID: 0034040340     PISSN: 03405761     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002040050670     Document Type: Article
Times cited : (65)

References (39)
  • 1
    • 0014759764 scopus 로고
    • The use of carbamates and atropine in protection of animals against poisoning by 1,2,2-trimethyl-propyl methylphosphonofluoridate
    • Berry W, Davis DR (1970) The use of carbamates and atropine in protection of animals against poisoning by 1,2,2-trimethyl-propyl methylphosphonofluoridate. Biochem Pharmacol 19: 927-934
    • (1970) Biochem Pharmacol , vol.19 , pp. 927-934
    • Berry, W.1    Davis, D.R.2
  • 2
    • 0003214423 scopus 로고
    • The statistics of bioassay with special reference to the vitamins
    • Academic Press, New York
    • Bliss CI (1952) The statistics of bioassay with special reference to the vitamins. In: Vitamin methods, vol II. Academic Press, New York
    • (1952) Vitamin Methods , vol.2
    • Bliss, C.I.1
  • 3
    • 77957174612 scopus 로고
    • The treatment of soman poisoning and its perspectives
    • Boskovic B (1981) The treatment of soman poisoning and its perspectives. Fundam Appl Toxicol 1: 203-213
    • (1981) Fundam Appl Toxicol , vol.1 , pp. 203-213
    • Boskovic, B.1
  • 4
    • 0026008682 scopus 로고
    • Anticonvulsant actions of anticholinergic drugs in soman poisoning
    • Capacio BR, Shih T-M (1991) Anticonvulsant actions of anticholinergic drugs in soman poisoning. Epilepsia 32: 604-615
    • (1991) Epilepsia , vol.32 , pp. 604-615
    • Capacio, B.R.1    Shih, T.-M.2
  • 5
    • 0027729201 scopus 로고
    • Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats
    • Clement JG, Broxup B (1993) Efficacy of diazepam and avizafone against soman-induced neuropathology in brain of rats. Neurotoxicology 14: 485-504
    • (1993) Neurotoxicology , vol.14 , pp. 485-504
    • Clement, J.G.1    Broxup, B.2
  • 6
    • 0028132872 scopus 로고
    • Review of oximes available for treatment of nerve agent poisoning
    • Dawson RM (1994) Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 14: 317-331
    • (1994) J Appl Toxicol , vol.14 , pp. 317-331
    • Dawson, R.M.1
  • 8
    • 0024397299 scopus 로고
    • Progress in medical defense against nerve agents
    • Dunn MA, Sidell FR (1989) Progress in medical defense against nerve agents. JAMA 262: 649-652
    • (1989) JAMA , vol.262 , pp. 649-652
    • Dunn, M.A.1    Sidell, F.R.2
  • 9
    • 0013782630 scopus 로고
    • Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolylmethylphosphonofluoridate
    • Fleisher JH, Harris LW (1965) Dealkylation as a mechanism for aging of cholinesterase after poisoning with pinacolylmethylphosphonofluoridate. Biochem Pharmacol 14: 641-650
    • (1965) Biochem Pharmacol , vol.14 , pp. 641-650
    • Fleisher, J.H.1    Harris, L.W.2
  • 10
    • 0000726155 scopus 로고
    • Electroencephalographic correlates of nerve agent poisoning
    • Dun NJ, Perlman RL (eds). Plenum Press, New York
    • Glenn JF, Hinman DJ, McMaster SB (1987) Electroencephalographic correlates of nerve agent poisoning. In: Dun NJ, Perlman RL (eds) Neurobiology of acetylcholine. Plenum Press, New York, pp 503-534
    • (1987) Neurobiology of Acetylcholine , pp. 503-534
    • Glenn, J.F.1    Hinman, D.J.2    McMaster, S.B.3
  • 11
    • 0025050780 scopus 로고
    • Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy
    • Hayward IJ, Wall HG, Jaax NK, Wade JV, Marlow DD, Nold JB (1990) Decreased brain pathology in organophosphate-exposed rhesus monkeys following benzodiazepine therapy. J Neurol Sci 98: 99-106
    • (1990) J Neurol Sci , vol.98 , pp. 99-106
    • Hayward, I.J.1    Wall, H.G.2    Jaax, N.K.3    Wade, J.V.4    Marlow, D.D.5    Nold, J.B.6
  • 12
    • 0016797504 scopus 로고
    • Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning
    • Johnson DD, Wilcox WC (1975) Studies on the mechanism of the protective and antidotal actions of diazepam in organophosphate poisoning. Eur J Pharmacol 34: 127-132
    • (1975) Eur J Pharmacol , vol.34 , pp. 127-132
    • Johnson, D.D.1    Wilcox, W.C.2
  • 14
    • 0025893153 scopus 로고
    • Pyridostigmine used as a nerve agent pretreatment under wartime conditions
    • Keeler JR, Hurst CG, Dunn MA (1991) Pyridostigmine used as a nerve agent pretreatment under wartime conditions. JAMA 266: 693-695
    • (1991) JAMA , vol.266 , pp. 693-695
    • Keeler, J.R.1    Hurst, C.G.2    Dunn, M.A.3
  • 15
    • 0002684071 scopus 로고
    • Efficacy of pyridostigmine pretreatment against acute soman intoxication in a primate model
    • US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD
    • Kluwe WM, Chinn JW, Feder JW, Olson C, Joiner R (1987) Efficacy of pyridostigmine pretreatment against acute soman intoxication in a primate model. In: Proceedings of the Sixth Medical Chemical Defense Bioscience Review, AD No. B121516. US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, pp 227-234
    • (1987) Proceedings of the Sixth Medical Chemical Defense Bioscience Review, AD No. B121516 , pp. 227-234
    • Kluwe, W.M.1    Chinn, J.W.2    Feder, J.W.3    Olson, C.4    Joiner, R.5
  • 16
    • 0031971366 scopus 로고    scopus 로고
    • Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats
    • Koplovitz I, Skvorak JP (1998) Electrocorticographic changes during generalized convulsive status epilepticus in soman intoxicated rats. Epilepsy Res 30: 159-164
    • (1998) Epilepsy Res , vol.30 , pp. 159-164
    • Koplovitz, I.1    Skvorak, J.P.2
  • 17
    • 0020634082 scopus 로고
    • Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound
    • Lemercier G, Carpentier P, Sentenac-Roumanou H, Moralis P (1983) Histological and histochemical changes in the central nervous system of the rat poisoned by an irreversible anticholinesterase organophosphorus compound. Acta Neuropathol (Berl) 61: 123-129
    • (1983) Acta Neuropathol (Berl) , vol.61 , pp. 123-129
    • Lemercier, G.1    Carpentier, P.2    Sentenac-Roumanou, H.3    Moralis, P.4
  • 18
    • 0022198106 scopus 로고
    • Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality
    • Lennox WJ, Harris LW, Talbot BG, Anderson DR (1985) Relationship between reversible acetylcholinesterase inhibition and efficacy against soman lethality. Life Sci 37: 793-798
    • (1985) Life Sci , vol.37 , pp. 793-798
    • Lennox, W.J.1    Harris, L.W.2    Talbot, B.G.3    Anderson, D.R.4
  • 19
    • 0014331640 scopus 로고
    • Cerebral electrical activity following soman administration
    • Lipp JA (1968) Cerebral electrical activity following soman administration. Arch Int Pharmacodyn 175: 161-169
    • (1968) Arch Int Pharmacodyn , vol.175 , pp. 161-169
    • Lipp, J.A.1
  • 20
    • 0015335799 scopus 로고
    • Effect of diazepam upon soman-induced seizure activity and convulsions
    • Lipp JA (1972) Effect of diazepam upon soman-induced seizure activity and convulsions. EEG Clin Neurophys 32: 557-560
    • (1972) EEG Clin Neurophys , vol.32 , pp. 557-560
    • Lipp, J.A.1
  • 21
    • 0015607829 scopus 로고
    • Effect of benzodiazepine derivatives on soman-induced seizure activity and convulsions in the monkey
    • Lipp JA (1973) Effect of benzodiazepine derivatives on soman-induced seizure activity and convulsions in the monkey. Arch Int Pharmacodyn Ther 202: 244-251
    • (1973) Arch Int Pharmacodyn Ther , vol.202 , pp. 244-251
    • Lipp, J.A.1
  • 22
    • 0030453341 scopus 로고    scopus 로고
    • Characterization and treatment of the toxicity of 0-isobutyl S-(2-(diethylamino)ethyl)methylphosphonothioate, a structural isomer of VX, in guinea pigs
    • Maxwell DM, Brecht KM, Koplovitz I (1997) Characterization and treatment of the toxicity of 0-isobutyl S-(2-(diethylamino)ethyl)methylphosphonothioate, a structural isomer of VX, in guinea pigs. J Am Coll Toxicol 15 [Suppl 2]: S78-S88
    • (1997) J Am Coll Toxicol , vol.15 , Issue.SUPPL. 2
    • Maxwell, D.M.1    Brecht, K.M.2    Koplovitz, I.3
  • 23
    • 0027263472 scopus 로고
    • Pharmacological modulation of soman-induced seizures
    • McDonough JH, Shih T-M (1993) Pharmacological modulation of soman-induced seizures. Neurosci Biobehav Rev 17: 203-215
    • (1993) Neurosci Biobehav Rev , vol.17 , pp. 203-215
    • McDonough, J.H.1    Shih, T.-M.2
  • 24
    • 0030726679 scopus 로고    scopus 로고
    • Neuropharmacological mechanisms of nerve agent-induced seizures and neuropathology
    • McDonough JH, Shih T-M (1997) Neuropharmacological mechanisms of nerve agent-induced seizures and neuropathology. Neurosci Biobehav Rev 21: 559-579
    • (1997) Neurosci Biobehav Rev , vol.21 , pp. 559-579
    • McDonough, J.H.1    Shih, T.-M.2
  • 25
    • 77957178558 scopus 로고
    • Atropine and/or diazepam therapy protects against soman-induced neural and cardiac pathology
    • McDonough JH, Jaax NK, Crowley RA, Mays MZ, Modrow HE (1989) Atropine and/or diazepam therapy protects against soman-induced neural and cardiac pathology. Fundam Appl Toxicol 13: 256-276
    • (1989) Fundam Appl Toxicol , vol.13 , pp. 256-276
    • McDonough, J.H.1    Jaax, N.K.2    Crowley, R.A.3    Mays, M.Z.4    Modrow, H.E.5
  • 26
    • 0028941725 scopus 로고
    • Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment
    • McDonough JH, Dochterman LW, Smith CD, Shih T-M (1995) Protection against nerve agent-induced neuropathology, but not cardiac pathology, is associated with the anticonvulsant action of drug treatment. Neurotoxicology 15: 123-132
    • (1995) Neurotoxicology , vol.15 , pp. 123-132
    • McDonough, J.H.1    Dochterman, L.W.2    Smith, C.D.3    Shih, T.-M.4
  • 28
    • 0001472256 scopus 로고
    • Review of nerve agent inhibitors and reactivators of acetylcholinesterase
    • Quinn DM, Balasubramanian AS, Doctor BP, Taylor P (eds). Plenum Press, New York
    • Moore DH, Clifford CB, Crawford IT, Cole GM, Baggett JM (1995) Review of nerve agent inhibitors and reactivators of acetylcholinesterase. In: Quinn DM, Balasubramanian AS, Doctor BP, Taylor P (eds) Enzymes of the cholinesterase family. Plenum Press, New York, pp 297-304
    • (1995) Enzymes of the Cholinesterase Family , pp. 297-304
    • Moore, D.H.1    Clifford, C.B.2    Crawford, I.T.3    Cole, G.M.4    Baggett, J.M.5
  • 30
    • 0028399229 scopus 로고
    • Neurology and neuropathology of soman-induced brain injury: An overview
    • Petras JM (1994) Neurology and neuropathology of soman-induced brain injury: an overview. J Exp Anal Behav 61: 319-329
    • (1994) J Exp Anal Behav , vol.61 , pp. 319-329
    • Petras, J.M.1
  • 31
    • 0015699932 scopus 로고
    • Effects of diazepam on epileptiform patterns of bioelectrical activity of the rabbit's brain induced by fluostigmine
    • Rump S, Grudzinska E, Edelwein Z (1973) Effects of diazepam on epileptiform patterns of bioelectrical activity of the rabbit's brain induced by fluostigmine. Neuropharmacology 12: 813-817
    • (1973) Neuropharmacology , vol.12 , pp. 813-817
    • Rump, S.1    Grudzinska, E.2    Edelwein, Z.3
  • 32
    • 0025133547 scopus 로고
    • Anticonvulsant effects of diazepam and MK-801 in soman poisoning
    • Shih T-M (1990) Anticonvulsant effects of diazepam and MK-801 in soman poisoning. Epilepsy Res 7: 105-116
    • (1990) Epilepsy Res , vol.7 , pp. 105-116
    • Shih, T.-M.1
  • 33
    • 0013648989 scopus 로고    scopus 로고
    • Pharmacological antagonism of nerve agent-induced seizures
    • US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD
    • Shih T-M, McDonough JH (1996) Pharmacological antagonism of nerve agent-induced seizures. In: Proceedings of the 1996 Medical Defense Bioscience Review, AD No. A321840, Vol I. US Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD, pp 435-446
    • (1996) Proceedings of the 1996 Medical Defense Bioscience Review, AD No. A321840 , vol.1 , pp. 435-446
    • Shih, T.-M.1    McDonough, J.H.2
  • 34
    • 0025768994 scopus 로고
    • Anticonvulsants for poisoning by the organophosphorus compound soman: Pharmacological mechanisms
    • Shih T-M, Koviak TA, Capacio BR (1991a) Anticonvulsants for poisoning by the organophosphorus compound soman: pharmacological mechanisms. Neurosci Biobehav Rev 15: 349-362
    • (1991) Neurosci Biobehav Rev , vol.15 , pp. 349-362
    • Shih, T.-M.1    Koviak, T.A.2    Capacio, B.R.3
  • 35
    • 0026071119 scopus 로고
    • A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning
    • Shih T-M, Whalley CE, Valdes JJ (1991b) A comparison of cholinergic effects of HI-6 and pralidoxime-2-chloride (2-PAM) in soman poisoning. Toxicol Lett 55: 131-147
    • (1991) Toxicol Lett , vol.55 , pp. 131-147
    • Shih, T.-M.1    Whalley, C.E.2    Valdes, J.J.3
  • 36
    • 0030480410 scopus 로고    scopus 로고
    • Evaluation of anticonvulsant drugs for soman-induced seizure activity
    • Shih T-M, Koplovitz I, McDonough JH (1996) Evaluation of anticonvulsant drugs for soman-induced seizure activity. J Am Coll Toxicol 15 [Suppl 2]: S43-S60
    • (1996) J Am Coll Toxicol , vol.15 , Issue.SUPPL. 2
    • Shih, T.-M.1    Koplovitz, I.2    McDonough, J.H.3
  • 37
    • 0000249736 scopus 로고
    • Anticholinesterase agents
    • Gilman AG, Goodman LS, Rall TW, Murad F (eds) Macmillan, New York
    • Taylor P (1985) Anticholinesterase agents. In: Gilman AG, Goodman LS, Rall TW, Murad F (eds) The pharmacological basis of therapeutics, 6th edn. Macmillan, New York, pp 110-129
    • (1985) The Pharmacological Basis of Therapeutics, 6th Edn. , pp. 110-129
    • Taylor, P.1
  • 38
    • 0010983918 scopus 로고
    • Morphological changes in the brains of guinea pigs following VX poisoning
    • Thornton KR, Brigden EG (1962) Morphological changes in the brains of guinea pigs following VX poisoning. Suffield Tech Paper no. 230
    • (1962) Suffield Tech Paper , vol.230
    • Thornton, K.R.1    Brigden, E.G.2
  • 39
    • 0010986214 scopus 로고
    • Morphological changes in the brains of M. mulatta treated for VX poisoning with atropine, metaraminol and P2S
    • Thornton KR, Fukuyama GS (1961) Morphological changes in the brains of M. mulatta treated for VX poisoning with atropine, metaraminol and P2S. Suffield Tech Paper no. 228
    • (1961) Suffield Tech Paper , vol.228
    • Thornton, K.R.1    Fukuyama, G.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.