New generic approach to the treatment of organophosphate poisoning: Adenosine receptor mediated inhibition of ACh-release

Drug and Chemical Toxicology

Volumn 21, Issue SUPPL. 1, 1998, Pages 171-181

  Van Helden, Herman P M ^a   Groen, Bas ^a   Moor, Eytan ^b   Westerink, Ben H C ^b   Bruijnzeel, Piet L B ^a  

^a TNO   (Netherlands)

^b UNIVERSITY OF GRONINGEN   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

6 N CYCLOPENTYLADENOSINE; ACETYLCHOLINE; ADENOSINE 5' (N ETHYLCARBOXAMIDE); ADENOSINE RECEPTOR STIMULATING AGENT; ANTICONVULSIVE AGENT; ATROPINE; CHOLINESTERASE REACTIVATOR; DIAZEPAM; MUSCARINIC RECEPTOR BLOCKING AGENT; ORGANOPHOSPHORUS COMPOUND; OXIME; SOMAN;

ACETYLCHOLINE RELEASE; ANIMAL EXPERIMENT; ANIMAL MODEL; CONTROLLED STUDY; CONVULSION; INTOXICATION; INTRAMUSCULAR DRUG ADMINISTRATION; MASTICATION; NONHUMAN; RAT; RESPIRATORY DISTRESS; REVIEW; SALIVATION; SURVIVAL RATE;

EID: 0032453118     PISSN: 01480545     EISSN: None     Source Type: Journal    
DOI: 10.3109/01480549809007409     Document Type: Review

References (25)

1. Van Helden HPM, Busker RW, Melchers BPC, Bruijnzeel PLB (1996) Pharmacological effects of oximes: how relevant are they? Arch Toxicol 70:779-786.
2. Van Helden HPM, Busker RW, Melchers BPC, Bruijnzeel PLB (1997) Protection against continuing AChE-inhibition by manipulating the release of ACh; a new concept. Proceedings (Part I) of NATO Research Study Group, Panel VIII, on Prophylaxis and therapy against chemical agents, 16-19 June 1997, McLean, VA, page 1-13.
3. Dawson RM (1994) Review of oximes available for treatment of nerve agent poisoning. J Appl Toxicol 14:317-31.
4. Busker RW, Zijlstra JJ, Philippens, Groen B, Melchers BPC (1996) Comparison of the efficacy of single or repeated HI-6 treatment following soman poisoning in guinea pigs and marmoset monkeys. Toxicol 112:183-194.
5. Lallement G, Clarencon D, Masqueliez C, Baubichon D, Galonnier M, Burckhart M-F, Peoc'h M, Mestries J-C (1998) Nerve agent poisoning in primates: antilethal, anti-epileptic and neuroprotective effects of GK-11. Arch Toxicol 72:84-92.
6. Shih TM, McDonough JH (1997) Neurochemical mechanisms in soman-induced seizures. J Appl Toxicol 17:255-264.
7. Broomfield CA, Maxwell DM, Solana RP, Castro CA, Finger AV, Lenz DE (1991) Protection by BuChE against OP-poisoning in non-human primates. J Pharmacol Exp Ther 259:633-638.
8. Broomfield CA (1992) A purified recombinant organophosphorus acid anhydrase protects mice against soman. Pharmacol Toxicol 70:65-66.
9. Ashani Y, Leader H, Rothschild N, Dosoretz C (1998) Combined effect of organophosphorus hydrolase and oxime on the reactivation rate of diethylphosphorylacetylcholinesterase conjugates. Biochem Pharmacol 55:159-168.
10. Holmstedt B, Harkonen M, Lundgren G. Sundwall A (1967) Relationship between acetylcholine and cholinesterase activity in the brain following an organophosphorus cholinesterase inhibitor. Biochem Pharmacol 16:404-406.
11. Jovic RC (1974) Correlation between signs of toxicity and some biochemical changes in rats poisoned by soman. Eur J Pharmacol 25:159-164.
12. Buccafusco JJ, Aronstam RS (1987) Adrenergic agonists protect against soman, an irreversible acetylcholinesterase inhibitor. Toxicol Letters 38:67-76.
13. Bradley RJ(1986) Reversal of organophosphate-induced muscle block by neomycin. Brain Res 381:397-400.
14. Richardson PJ, Brown SJ, Bailyes EM, Luzio JP (1987) Ectoenzymes control modulation of immunoisolated cholinergic synapses. Nature 327:232-234.
15. Murray TF, Blaker WD, Cheney DL, Costa E (1982) Inhibition of acetylcholine turnover in rat hippocampus and cortex by intraventricular injection of adenosine analogs. J Pharmacol Exp Ther 222:550-554.
16. Pedata F, Giovanelli L, De Sarno P, Pepeu G (1986) Effect of adenosine, adenosine derivatives and caffeine on acetylcholine release from brain synaptosomes: interaction with muscarinic autoregulator mechanisms. J Neurochem 46:1593-1598.
17. Burnstock G (1980) Purinergic receptors in the heart. Circ Res 46:175-182.
18. Wu PH, Phillis JW, Thierry DL (1982) Adenosine receptor agonist inhibits K+ evoked Ca+ uptake by rat brain cortical synaptosomes. J Neurochem 39:700-708.
19. Ho S-T, Hou C-C, Yen M-H, Chang C-L, Ho W, Lin C-Y (1991) Interactions of adenosine and vecuronium in neuromuscular blockade in cats. Acta Anaesthesiol Sin 29:632-636.
20. Collis MG and Hourani SMO (1993) Adenosine receptor subtypes. TiPS 14:360-366.
21. Kirkpatrick KA, Richardson PJ (1993) Adenosine receptor-mediated modulation of acetylcholine release from rat striatal synaptosomes. Br J Pharmacol 110:949-954.
22. Kirk IP, Richardson PJ (1994) Adenosine A2a receptor-mediated modulation of striatal 3H-GABA and 3H-acetylcholine release. J Neurochem 62:960-966.
23. Correio-de-Sa P, Sebastiao AM, Ribeiro JA (1991) Inhibitory and excitatory effects of adenosine receptor agonists on evoked transmitter release from phrenic nerve ending of the rat. Br J Pharmacol 103 92:1614-1620.
24. Sebastiao AM, Stone TW, Ribeiro JA (1990) The inhibitory adenosine receptor at the neuromuscular junction and hippocampus of the rat: antagonism by 1,3,8-substituted xanthines. Br J Pharmacol 101:453-459.
25. Moor E, De Boer P, Beldhuis HJA, Westerink BHC (1994) A novel approach for studying septo-hippocampal cholinergic neurons in freely moving rats: a microdialysis study with dual-probe design. Brain Res 648:32-38.