A pivotal role for tryptophan 447 in enzymatic coupling of human endothelial nitric oxide synthase (eNOS): Effects on tetrahydrobiopterin- dependent catalysis and eNOS dimerization

Journal of Biological Chemistry

Volumn 288, Issue 41, 2013, Pages 29836-29845

  Benson, Matthew A ^b   Batchelor, Helen ^a   Chuaiphichai, Surawee ^a   Bailey, Jade ^a   Zhu, Hanneng ^b   Stuehr, Dennis J ^c   Bhattacharya, Shoumo ^a   Channon, Keith M ^a   Crabtree, Mark J ^a  

^a UNIVERSITY OF OXFORD   (United Kingdom)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC STACKING INTERACTIONS; DELETERIOUS EFFECTS; ENDOTHELIAL NITRIC-OXIDE SYNTHASE (ENOS); GTP CYCLOHYDROLASE I; RATE-LIMITING ENZYMES; SUPEROXIDE PRODUCTION; TETRAHYDROBIOPTERIN; TRYPTOPHAN RESIDUES;

AMINO ACIDS; BIOCHEMISTRY; CATALYSIS; CELL CULTURE; CELLS; COENZYMES; CRYSTAL STRUCTURE; DIMERS; HYDROGEN BONDS; NITRIC OXIDE; OXYGEN;

DIMERIZATION;

DIHYDROBIOPTERIN; ENDOTHELIAL NITRIC OXIDE SYNTHASE; GUANOSINE TRIPHOSPHATE CYCLOHYDROLASE I; MONOMER; MUTANT PROTEIN; NITRIC OXIDE; SUPEROXIDE; TETRACYCLINE; TETRAHYDROBIOPTERIN; TRYPTOPHAN;

ANIMAL CELL; ARTICLE; BINDING SITE; BIOSYNTHESIS; CATALYSIS; CELL LEVEL; CELL LINE; CONTROLLED STUDY; DIMERIZATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME REGULATION; ENZYME SYNTHESIS; FIBROBLAST; HUMAN; MOUSE; NONHUMAN; OXIDATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION;

ENDOTHELIAL DYSFUNCTION; NITRIC OXIDE SYNTHASE; SUPEROXIDE; SUPEROXIDE ION; TETRAHYDROBIOPTERIN; TRYPTOPHAN; UNCOUPLING;

3T3 CELLS; AMINO ACID SUBSTITUTION; ANIMALS; BINDING SITES; BIOCATALYSIS; BIOPTERIN; BLOTTING, WESTERN; CATALYTIC DOMAIN; HUMANS; MICE; MODELS, MOLECULAR; MUTATION; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; OXIDATION-REDUCTION; PROTEIN MULTIMERIZATION; SUPEROXIDES; TRYPTOPHAN;

EID: 84885579468     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.493023     Document Type: Article

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