Total gastrectomy may result in reduced drug effectiveness due to an increase in the expression of the drug-metabolizing enzyme Cytochrome P450, in the liver

European Journal of Pharmaceutical Sciences

Volumn 51, Issue 1, 2014, Pages 180-188

  Ishii, Makoto ^a   Toda, Takahiro ^a   Ikarashi, Nobutomo ^a   Kusunoki, Yoshiki ^a   Kon, Risako ^a   Ochiai, Wataru ^a   Machida, Yoshiaki ^a   Sugiyama, Kiyoshi ^a  

^a HOSHI UNIVERSITY   (Japan)

Author keywords

Cytochrome P450; Gastrectomy; Imatinib

Indexed keywords

CYTOCHROME P450 1A; CYTOCHROME P450 1A2; CYTOCHROME P450 2C; CYTOCHROME P450 2D; CYTOCHROME P450 3A; CYTOCHROME P450 3A11; IMATINIB; RNA 18S; TRIAZOLAM;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG METABOLISM; LIVER; MALE; METABOLIC RATE; MICROSOME; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TOTAL STOMACH RESECTION;

CYTOCHROME P450; GASTRECTOMY; IMATINIB;

ANIMALS; BASAL METABOLISM; BENZAMIDES; BODY WEIGHT; CYTOCHROME P-450 ENZYME SYSTEM; EATING; GASTRECTOMY; INTESTINE, LARGE; INTESTINE, SMALL; LIVER; MALE; MICE; MICE, INBRED ICR; MICROSOMES, LIVER; P-GLYCOPROTEIN; PIPERAZINES; PYRIMIDINES; TRIAZOLAM;

EID: 84885517352     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2013.09.017     Document Type: Article

References (26)

1. J.M. Bae, J.W. Park, H.K. Yang, and J.P. Kim Nutritional status of gastric cancer patients after total gastrectomy World J. Surg. 22 1998 254 260 (discussion pp. 260-251)
2. P. Bertuccio, L. Chatenoud, F. Levi, D. Praud, J. Ferlay, E. Negri, M. Malvezzi, and C. La Vecchia Recent patterns in gastric cancer: a global overview Int. J. Cancer 125 2009 666 673
3. P. Breedveld, D. Pluim, G. Cipriani, P. Wielinga, O. van Tellingen, A.H. Schinkel, and J.H. Schellens The effect of Bcrp1 (Abcg2) on the in vivo pharmacokinetics and brain penetration of imatinib mesylate (Gleevec): implications for the use of breast cancer resistance protein and P-glycoprotein inhibitors to enable the brain penetration of imatinib in patients Cancer Res. 65 2005 2577 2582 (Pubitemid 40490054)
4. C. Dornonville de la Cour, A. Lindqvist, E. Egecioglu, Y.C. Tung, V. Surve, C. Ohlsson, J.O. Jansson, C. Erlanson-Albertsson, S.L. Dickson, and R. Hakanson Ghrelin treatment reverses the reduction in weight gain and body fat in gastrectomised mice Gut 54 2005 907 913 (Pubitemid 40873899)
5. C. Emoto, H. Yamazaki, S. Yamasaki, N. Shimada, M. Nakajima, and T. Yokoi Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes Xenobiotica 30 2000 943 953
6. H.J. Eyssen, G.G. Parmentier, and J.A. Mertens Sulfate bile acids in germ-free and conventional mice Eur. J. Biochem. 66 1976 507 514
7. S. Fukumori, T. Murata, M. Taguchi, and Y. Hashimoto Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells Drug Metab. Pharmacokinet. 22 2007 377 381
8. J.D. Gray, and M. Shiner Influence of gastric pH on gastric and jejunal flora Gut 8 1967 574 581
9. U.K. Laemmli Cleavage of structural proteins during the assembly of the head of bacteriophage T4 Nature 227 1970 680 685
10. R.D. Leth, H. Abrahamsson, A. Kilander, and L.R. Lundell Malabsorption of fat after partial gastric resection. A study of pathophysiologic mechanisms Euro. J. Surg. = Acta chirurgica 157 1991 205 208
11. S. Mine, T. Sano, K. Tsutsumi, Y. Murakami, K. Ehara, M. Saka, K. Hara, T. Fukagawa, H. Udagawa, and H. Katai Large-scale investigation into dumping syndrome after gastrectomy for gastric cancer J. Am. Coll. Surg. 211 2010 628 636
12. B.M. Owen, A. Milona, S. van Mil, P. Clements, J. Holder, M. Boudjelal, W. Cairns, M. Parker, R. White, and C. Williamson Intestinal detoxification limits the activation of hepatic pregnane X receptor by lithocholic acid Drug Metab. Dispos. 38 2010 143 149
13. A. Salehi, D. Chen, R. Hakanson, G. Nordin, and I. Lundquist Gastrectomy induces impaired insulin and glucagon secretion: evidence for a gastro-insular axis in mice J. Physiol. 514 Pt 2 1999 579 591 (Pubitemid 29055983)
14. A. Schwarz, M. Buchler, K. Usinger, H. Rieger, B. Glasbrenner, H. Friess, R. Kunz, and H.G. Beger Importance of the duodenal passage and pouch volume after total gastrectomy and reconstruction with the Ulm pouch: prospective randomized clinical study World J. Surg. 20 1996 60 66 (discussion pp. 66-67)
15. P.K. Smith, R.I. Krohn, G.T. Hermanson, A.K. Mallia, F.H. Gartner, M.D. Provenzano, E.K. Fujimoto, N.M. Goeke, B.J. Olson, and D.C. Klenk Measurement of protein using bicinchoninic acid Anal. Biochem. 150 1985 76 85 (Pubitemid 16258399)
16. J.L. Staudinger, B. Goodwin, S.A. Jones, D. Hawkins-Brown, K.I. MacKenzie, A. LaTour, Y. Liu, C.D. Klaassen, K.K. Brown, J. Reinhard, T.M. Willson, B.H. Koller, and S.A. Kliewer The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity Proc. Natl. Acad Sci. USA 98 2001 3369 3374 (Pubitemid 32220852)
17. J. Sun, Y. Song, Z. Wang, P. Gao, X. Chen, Y. Xu, J. Liang, and H. Xu Benefits of hyperthermic intraperitoneal chemotherapy for patients with serosal invasion in gastric cancer: a meta-analysis of the randomized controlled trials BMC Cancer 12 2012 526
18. H. Suzuki, M. Gotoh, K. Sugihara, Y. Kitagawa, W. Kimura, S. Kondo, M. Shimada, N. Tomita, T. Nakagoe, H. Hashimoto, H. Baba, H. Miyata, and N. Motomura Nationwide survey and establishment of a clinical database for gastrointestinal surgery in Japan: targeting integration of a cancer registration system and improving the outcome of cancer treatment Cancer Sci. 102 2011 226 230
19. J. Tack, J. Arts, P. Caenepeel, D. De Wulf, and R. Bisschops Pathophysiology, diagnosis and management of postoperative dumping syndrome Nat. Rev. Gastroenterol. Hepatol. 6 2009 583 590
20. K.E. Thummel, and G.R. Wilkinson In vitro and in vivo drug interactions involving human CYP3A Annu. Rev. Pharmacol. Toxicol. 38 1998 389 430 (Pubitemid 28231501)
21. T. Toda, K. Ohi, T. Kudo, T. Yoshida, N. Ikarashi, K. Ito, and K. Sugiyama Antibiotics suppress Cyp3a in the mouse liver by reducing lithocholic acid-producing intestinal flora Yakugaku Zasshi 129 2009 601 608
22. T. Toda, K. Ohi, T. Kudo, T. Yoshida, N. Ikarashi, K. Ito, and K. Sugiyama Ciprofloxacin suppresses Cyp3a in mouse liver by reducing lithocholic acid-producing intestinal flora Drug Metab. Pharmacokinet. 24 2009 201 208
23. T. Toda, N. Saito, N. Ikarashi, K. Ito, M. Yamamoto, A. Ishige, K. Watanabe, and K. Sugiyama Intestinal flora induces the expression of Cyp3a in the mouse liver Xenobiotica 39 2009 323 334
24. T. Ueno, A. Tanaka, Y. Hamanaka, and T. Suzuki Serum drug concentrations after oral administration of paracetamol to patients with surgical resection of the gastrointestinal tract Br. J. Clin. Pharmacol. 39 1995 330 332
25. M. Yamaguchi, R. Matsunaga, K. Fukuda, M. Nakamura, and Y. Ohkura Highly sensitive determination of free polyunsaturated, long-chain fatty acids in human serum by high-performance liquid chromatography with fluorescence detection Anal. Biochem. 155 1986 256 261 (Pubitemid 16060157)
26. Zhang J., Huang W. Qatanani M., Evans R.M., Moore D.D. The constitutive androstane receptor and pregnane X receptor function coordinately to prevent bile acid-induced hepatotoxicity. J. Biol. Chem. 2004, 279, 49517-49522 (Pubitemid 39625839)