Characterization of cytochrome P450 enzymes involved in drug oxidations in mouse intestinal microsomes

Xenobiotica

Volumn 30, Issue 10, 2000, Pages 943-953

  Emoto, C ^a   Yamazaki, H ^a   Yamasaki, S ^a   Shimada, N ^b   Nakajima, M ^a   Yokoi, T ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b DAIICHI PURE CHEMICALS CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

APROTININ; BESTATIN; BUFFER; BUFURALOL; CHLORZOXAZONE; CYTOCHROME P450; DIETHYLDITHIOCARBAMIC ACID; EDETIC ACID; GLYCEROL; KETOCONAZOLE; LEUPEPTIN; METHANESULFONYL FLUORIDE; MIDAZOLAM; NIFEDIPINE; OXYGENASE; PROTEINASE INHIBITOR; QUININE; SOYBEAN TRYPSIN INHIBITOR; TESTOSTERONE; TOLBUTAMIDE;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; DRUG METABOLISM; DRUG OXIDATION; ENZYME ACTIVITY; ENZYME ANALYSIS; FIRST PASS EFFECT; HYDROXYLATION; IMMUNOBLOTTING; INTESTINE; LIVER MICROSOME; MALE; MICROSOME; MOUSE; NONHUMAN;

ANIMALIA; CINCHONA PUBESCENS; GLYCINE MAX;

EID: 0033695149     PISSN: 00498254     EISSN: None     Source Type: Journal    
DOI: 10.1080/00498250050200104     Document Type: Article

References (28)

1. Expression of a human liver cytochrome P450 protein with tolbutamide hydroxylase activity in Saccharomyces cerevisiae
2. Reaction and significance of cytochrome P-450 enzymes
3. Analysis and characterization of enzymes
4. Human cytochrome P450 enzymes
5. Purification of cytochromes P450: Products of bacterial recombinant expression systems
6. Metabolism of rifabutin in human enterocyte and liver microsomes: Kinetic parameters, identification of enzyme systems, and drug interactions with macrolides and antifungal agents
7. Comparative effects of omeprazole on xenobiotic metabolizing enzymes in the rat and human
8. Establishment for evaluation system of small intestinal metabolism
9. Extrahepatic metabolism of drugs in humans
10. High-performance liquid chromatographic assays for bufuralol 1'-hydroxylase, debrisoquine 4-hydroxylase, and dextromethorphan O-demethylase in microsomes and purified cytochrome P450 isozymes of human liver
11. Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4
12. Cleavage of structural proteins during the assembly of the head of bacteriophage T4
13. Protein measurement with the Folin phenol reagent
14. Characterization of interintestinal and intraintestinal variations in human CYP3A-dependent metabolism
15. First-pass metabolism of midazolam by the human intestine
16. Effects of freezing, thawing, and storing human liver microsomes on cytochrome P450 activity
17. Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P450IIE1
18. Comparative studies of drug-metabolizing enzymes in dog, monkey, and human small intestines, and in Caco-2 cells
19. Induction of cyp2e-1 protein in mouse colon
20. A novel female-specific member of the CYP3A gene subfamily in the mouse liver
21. Interindividual variations in human liver cytochrome P450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: Studies with liver microsomes of 30 Japanese and 30 Caucasians
22. Preparation and storage of human intestinal microsomes
23. Identification of glucocorticoid-inducible cytochromes P450 in the intestinal mucosa of rats and man
24. Bufuralol hydroxylation by cytochrome P450 2D6 and 1A2 enzymes in human liver microsomes
25. Effects of freezing, thawing, and storage of human liver samples on the microsomal contents and activities of cytochrome P450 enzymes
26. Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes
27. 1
28. Characterization of rat small intestinal cytochrome P450 composition and inducibility