PDZ-RhoGEF is essential for CXCR4-driven breast tumor cell motility through spatial regulation of RhoA

Journal of Cell Science

Volumn 126, Issue 19, 2013, Pages 4514-4526

  Struckhoff, Amanda P ^a   Rana, Manish K ^b   Kher, Swapnil S ^c   Burow, Matt E ^d   Hagan, Joseph L ^e   Del Valle, Luis ^a   Worthylake, Rebecca A ^c  

^a LOUISIANA STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

^c LOUISIANA STATE UNIVERSITY SCHOOL OF DENTISTRY   (United States)

^d TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e Department of Pathology   (United States)

Author keywords

Breast cancer; Invasion; PDZ RhoGEF; PRG; RhoA

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; F ACTIN; PDZ PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ARTICLE; BIOSENSOR; BREAST CANCER; BREAST EPITHELIUM; CELL INVASION; CELL MIGRATION; CELL POLARITY; CONTROLLED STUDY; CYTOSKELETON; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; IN VITRO STUDY; PDZ DOMAIN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; TUMOR CELL;

BREAST CANCER; INVASION; PDZ-RHOGEF; PRG; RHOA;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL MOVEMENT; FEMALE; HUMANS; MCF-7 CELLS; PDZ DOMAINS; PHOSPHORYLATION; RECEPTORS, CXCR4; RHO GUANINE NUCLEOTIDE EXCHANGE FACTORS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION;

EID: 84885462779     PISSN: 00219533     EISSN: 14779137     Source Type: Journal    
DOI: 10.1242/jcs.132381     Document Type: Article

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