Ammonia-induced Na,K-ATPase/ouabain-mediated EGF receptor transactivation, MAPK/ERK and PI3K/AKT signaling and ROS formation cause astrocyte swelling

Neurochemistry International

Volumn 63, Issue 6, 2013, Pages 610-625

  Dai, Hongliang ^a   Song, Dan ^a   Xu, Junnan ^a   Li, Baoman ^a   Hertz, Leif ^a   Peng, Liang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

AKT; Ammonia; Astrocytes; EGF receptor; ERK1 2; Ouabain; Src

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); AMMONIA; CAVEOLIN 1; EPIDERMAL GROWTH FACTOR RECEPTOR; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 3; OUABAIN; PHOSPHATIDYLINOSITOL 3 KINASE; REACTIVE OXYGEN METABOLITE; TATA BINDING PROTEIN; BUFADIENOLIDE DERIVATIVE; ENZYME INHIBITOR; MARINOBUFAGENIN; ONCOPROTEIN; SMALL INTERFERING RNA;

ANIMAL CELL; ARTICLE; ASTROCYTE; BRAIN EDEMA; CELL SWELLING; CONTROLLED STUDY; HEMISPHERE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIMARY CULTURE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSACTIVATION; UPREGULATION; WESTERN BLOTTING; ANIMAL; CELL CULTURE; DRUG EFFECTS; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY; PIG; TRANSCRIPTION INITIATION; ULTRASTRUCTURE;

STROPHANTHUS GRATUS;

AMMONIA; ANIMALS; ASTROCYTES; BUFANOLIDES; CELLS, CULTURED; ENZYME INHIBITORS; MAP KINASE SIGNALING SYSTEM; MICE; ONCOGENE PROTEIN V-AKT; OUABAIN; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; REACTIVE OXYGEN SPECIES; RECEPTOR, EPIDERMAL GROWTH FACTOR; RNA, SMALL INTERFERING; SODIUM-POTASSIUM-EXCHANGING ATPASE; SWINE; TRANSCRIPTIONAL ACTIVATION;

EID: 84885441346     PISSN: 01970186     EISSN: 18729754     Source Type: Journal    
DOI: 10.1016/j.neuint.2013.09.005     Document Type: Article

References (112)

1. A.G. Bader, S. Kang, L. Zhao, and P.K. Vogt Oncogenic PI3K deregulates transcription and translation Nat. Rev. Cancer 5 2005 921 929 (Pubitemid 41766781)
2. J.S. Biscardi, M.C. Maa, D.A. Tice, M.E. Cox, T.H. Leu, and S.J. Parsons C-Src-mediated phosphorylation of the epidermal growth factor receptor on Tyr845 and Tyr1101 is associated with modulation of receptor function J. Biol. Chem. 274 1999 8335 8343
3. + channels of freshly isolated cells from the thick ascending limb of Henle's loop Pflugers Arch. 429 1995 345 354
4. R.F. Butterworth Molecular neurobiology of acute liver failure Semin. Liver Dis. 23 2003 251 258 (Pubitemid 37052450)
5. +-induced swelling but follows hypotonicity-induced swelling Neuropathology 31 2011 250 264
6. E. Castellano, and J. Downward RAS interaction with PI3K: more than just another effector pathway Genes Cancer 2 2011 261 274
7. L. Chavarria, J. Alonso, R. García-Martínez, M. Simón-Talero, M. Ventura-Cots, C. Ramírez, M. Torrens, V. Vargas, A. Rovira, and J. Córdoba Brain magnetic resonance spectroscopy in episodic hepatic encephalopathy J. Cereb. Blood Flow Metab. 33 2013 272 277
8. D. Commandeur, M. Danguy Des Deserts, C. Giacardi, S. Eyrieux, M. Ould-Ahmed, and I. Drouillard Pharmacokinetics of biological tags in a case of acute valpromide self poisoning Ann. Biol. Clin. 68 2010 234 238
9. D.A. Cross, D.R. Alessi, J.R. Vandenheede, H.E. McDowell, H.S. Hundal, and P. Cohen The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf Biochem. J. 303 1994 21 26 (Pubitemid 24302893)
10. D.C. Dawson Cellular mechanisms for K transport across epithelial cell layers Semin. Nephrol. 7 1987 185 192
11. R.A. Deisz, T.N. Lehmann, P. Horn, C. Dehnicke, and R. Nitsch Components of neuronal chloride transport in rat and human neocortex J. Physiol. 589 2011 1317 1347
12. 1/2 phosphorylation in primary cultures of astrocytes are concentration-dependent J. Neurochem. 115 2010 1007 1023
13. 2-adrenergic transactivation of EGF receptors Neurochem. Int. 55 2009 593 600
14. T. Du, D. Song, H. Li, B. Li, L. Cai, L. Hertz, and L. Peng Stimulation by vasopressin of ERK phosphorylation and vector-driven water flux in astrocytes is transactivation-dependent Eur. J. Pharmacol. 587 2008 73 77
15. R.J. Ede, and R.W. Williams Hepatic encephalopathy and cerebral edema Semin. Liver Dis. 6 1986 107 118
16. M. Ehrlich, F. Plum, and T.E. Duffy Blood and brain ammonia concentrations after portacaval anastomosis. Effects of acute ammonia loading J. Neurochem. 34 1980 1538 1542 (Pubitemid 10114395)
17. A. el-Marjou, A. Delouvée, J.P. Thiery, and F. Radvanyi Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression Carcinogenesis 21 2000 2211 2218 (Pubitemid 32049227)
18. J.A. Engelman, J. Luo, and L.C. Cantley The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism Nat. Rev. Genet. 7 2006 606 619 (Pubitemid 44100518)
19. G.M. Enns, S.A. Berry, G.T. Berry, W.J. Rhead, S.W. Brusilow, and A. Hamosh Survival after treatment with phenylacetate and benzoate for urea-cycle disorders N. Engl. J. Med. 356 2007 2282 2292 (Pubitemid 46849158)
20. F.H. Epstein, and P. Silva Na-K-Cl cotransport in chloride-transporting epithelia Ann. N. Y. Acad. Sci. 456 1985 187 197 (Pubitemid 16110669)
21. A. Eva, U. Kirch, and G. Scheiner-Bobis Signaling pathways involving the sodium pump stimulate NO production in endothelial cells Biochim. Biophys. Acta 1758 2006 1809 1814 (Pubitemid 44666689)
22. I.M. Ferby, I. Waga, C. Sakanaka, K. Kume, and T. Shimizu Wortmannin inhibits mitogen-activated protein kinase activation induced by platelet-activating factor in guinea pig neutrophils J. Biol. Chem. 269 1994 30485 30488 (Pubitemid 24376529)
23. +-ATPase alterations in ouabain and adducin-dependent hypertension Am. J. Physiol. Regul. Integr. Comp. Physiol. 290 2006 R529 R535
24. T. Fujita, Y. Azuma, R. Fukuyama, Y. Hattori, C. Yoshida, M. Koida, K. Ogita, and T. Komori Runx2 induces osteoblast and chondrocyte differentiation and enhances their migration by coupling with PI3K-Akt signaling J. Cell. Biol. 166 2004 85 95 (Pubitemid 38931919)
25. +-phosphatase activity in gill microsomes from the crab Callinectes ornatus acclimated to low salinity: novel property of a primordial pump Arch. Biochem. Biophys. 530 2012 55 63
26. T.C. Grammer, and J. Blenis Evidence for MEK-independent pathways regulating the prolonged activation of the ERK-MAP kinases Oncogene 14 1997 1635 1642 (Pubitemid 27198935)
27. P.G. Gunasekar, A.G. Kanthasamy, J.L. Borowitz, and G.E. Isom NMDA receptor activation produces concurrent generation of nitric oxide and reactive oxygen species: implication for cell death J. Neurochem. 65 1995 2016 2021
28. - cotransporters in mammalian epithelial cells J. Physiol. 568 2005 123 135 (Pubitemid 41448625)
29. - cotransporter NKCC1 in mammalian epithelial cells J. Physiol. 588 2010 4089 4101
30. +-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases J. Biol. Chem. 277 2002 18694 186702
31. B.E. Hawes, L.M. Luttrell, T. van Biesen, and R.J. Lefkowitz Phosphatidylinositol 3-kinase is an early intermediate in the G beta gamma-mediated mitogen-activated protein kinase signaling pathway J. Biol. Chem. 271 1996 12133 12136
32. L. Hertz Isotope-based quantitation of uptake, release, and metabolism of glutamate and glucose in cultured astrocytes Methods Mol. Biol. 814 2012 305 323
33. L. Hertz The glutamate-glutamine (GABA) cycle: importance of late postnatal development and potential reciprocal interactions between biosynthesis and degradation Front. Endocrinol. 4 2013 59
34. L. Hertz, Y. Chen, M.E. Gibbs, P. Zang, and L. Peng Astrocytic adrenoceptors: a major drug target in neurological and psychiatric disorders? Curr. Drug Targets CNS Neurol. Disord. 3 2004 239 267 (Pubitemid 38854918)
35. L. Hertz, L. Peng, and J.C. Lai Functional studies in cultured astrocytes Methods 16 1998 293 310
36. L. Hertz, and M. Schou Univalent cations and the respiration of brain-cortex slices Biochem. J. 85 1962 93 104
37. B. Hindfelt On mechanisms in hyperammonemic coma-with particular reference to hepatic encephalopathy Ann. N. Y. Acad. Sci. 252 1975 116 123
38. R. Huang, G. Kala, R.K. Murthy, and L. Hertz Effects of chronic exposure to ammonia on glutamate and glutamine interconversion and compartmentation in homogeneous primary cultures of mouse astrocytes Neurochem. Res. 19 1994 257 265 (Pubitemid 24054795)
39. A.R. Jayakumar, M. Liu, M. Moriyama, R. Ramakrishnan, B. Forbush 3rd., P.V. Reddy, and M.D. Norenberg Na-K-Cl cotransporter-1 in the mechanism of ammonia-induced astrocyte swelling J. Biol. Chem. 283 2008 33874 33882
40. A.R. Jayakumar, and M.D. Norenberg The Na-K-Cl co-transporter in astrocyte swelling Metab. Brain Dis. 25 2010 31 38
41. A.R. Jayakumar, and M.D. Norenberg Endothelial-astrocytic interactions in acute liver failure Metab. Brain Dis. 28 2013 183 186
42. A.R. Jayakumar, V. Valdes, and M.D. Norenberg The Na-K-Cl cotransporter in the brain edema of acute liver failure J. Hepatol. 54 2011 272 278
43. G. Kala, and L. Hertz Ammonia effects on pyruvate/lactate production in astrocytes - interaction with glutamate Neurochem. Int. 47 2005 4 12 (Pubitemid 40848687)
44. G. Kala, R. Kumarathasan, L. Peng, F.H. Leenen, and L. Hertz Stimulation of Na+, K+-ATPase activity, increase in potassium uptake, and enhanced production of ouabain-like compounds in ammonia-treated mouse astrocytes Neurochem. Int. 36 2000 203 211 (Pubitemid 30047012)
45. L.M. Karnitz, L.A. Burns, S.L. Sutor, J. Blenis, and R.T. Abraham Interleukin-2 triggers a novel phosphatidylinositol 3-kinase-dependent MEK activation pathway Mol. Cell. Biol. 15 1995 3049 3057
46. T.M. Kauppinen, W.Y. Chan, S.W. Suh, A.K. Wiggins, E.J. Huang, and R.A. Swanson Direct phosphorylation and regulation of poly(ADP-ribose) polymerase-1 by extracellular signal-regulated kinases 1/2 Proc. Natl. Acad. Sci. U.S.A. 103 2006 7136 7141
47. T. Kelly, K.W. Kafitz, C. Roderigo, and C.R. Rose Ammonium-evoked alterations in intracellular sodium and pH reduce glial glutamate transport activity Glia 57 2009 921 934
48. T. Kelly, and C.R. Rose Ammonium influx pathways into astrocytes and neurones of hippocampal slices J. Neurochem. 115 2010 1123 1136
49. S.J. Khundmiri, V. Amin, J. Henson, J. Lewis, M. Ameen, M.J. Rane, and N.A. Delamere Ouabain stimulates protein kinase B (Akt) phosphorylation in opossum kidney proximal tubule cells through an ERK-dependent pathway Am. J. Physiol. Cell. Physiol. 293 2007 C1171 1180
50. S.J. Khundmiri, M.A. Metzler, M. Ameen, V. Amin, M.J. Rane, and N.A. Delamere Ouabain induces cell proliferation through calcium-dependent phosphorylation of Akt (protein kinase B) in opossum kidney proximal tubule cells Am. J. Physiol. Cell. Physiol. 291 2006 C1247 1257
51. 2B receptor density and receptor-mediated glycogenolysis in mouse astrocytes by long-term fluoxetine administration Neurochem. Int. 27 2002 113 120 (Pubitemid 34242437)
52. S.C. Lange, L.K. Bak, H.S. Waagepetersen, A. Schousboe, and M.D. Norenberg Primary cultures of astrocytes: their value in understanding astrocytes in health and disease Neurochem. Res. 37 2012 2569 2588
53. R. Lefloch, J. Pouysségur, and P. Lenormand Single and combined silencing of ERK1 and ERK2 reveals their positive contribution to growth signaling depending on their expression levels Mol. Cell. Biol. 28 2008 511 527
54. B. Li, L. Dong, B. Wang, L. Cai, N. Jiang, and L. Peng Cell type-specific gene expression and editing responses to chronic fluoxetine treatment in the in vivo mouse brain and their relevance for stress-induced anhedonia Neurochem. Res. 37 2012 2480 2495
55. B. Li, T. Du, H. Li, L. Gu, H. Zhang, J. Huang, L. Hertz, and L. Peng Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons Br. J. Pharmacol. 154 2008 191 203 (Pubitemid 351620397)
56. B. Li, L. Hertz, and L. Peng Aralar mRNA and protein levels in neurons and astrocytes freshly isolated from young and adult mouse brain and in maturing cultured astrocytes Neurochem. Int. 61 2012 1325 1332
57. B. Li, L. Hertz, and L. Peng Cell-specific mRNA alterations in Na+, K+-ATPase α and β isoforms and FXYD in mice treated chronically with carbamazepine, an anti-bipolar drug Neurochem. Res. 38 2013 834 841
58. 2C receptors Neurochem. Int. 57 2010 432 439
59. 2B receptor stimulation in astrocytes causes EGF receptor transactivation and ERK phosphorylation Psychopharmacology (Berl) 201 2008 443 458
60. A. Link, B.T. Kaplan, and M. Böhm 21-year-old woman with Reye's syndrome after influenza Dtsch. Med. Wochenschr. 137 2012 1853 1856
61. +-ATPase Biochemistry 50 2011 8664 8673
62. J. Liu, D.J. Kennedy, Y. Yan, and J.I. Shapiro Reactive oxygen species modulation of Na/K-ATPase regulates fibrosis and renal proximal tubular sodium handling Int. J. Nephrol. 2012 2012 381320
63. J. Liu, M. Liang, L. Liu, D. Malhotra, Z. Xie, and J.I. Shapiro Ouabain-induced endocytosis of the plasmalemmal Na/K-ATPase in LLC-PK1 cells requires caveolin-1 Kidney Int. 67 2005 1844 1854 (Pubitemid 40577720)
64. A.H. Lockwood, J.M. McDonald, R.E. Reiman, A.S. Gelbard, J.S. Laughlin, T.E. Duffy, and F. Plum The dynamics of ammonia metabolism in man. Effects of liver disease and hyperammonemia J. Clin. Invest. 63 1979 449 460 (Pubitemid 9130208)
65. O.H. Lowry, N.J. Rosebrough, A.L. Farr, and R.J. Randall Protein measurement with the Folin phenol reagent J. Biol. Chem. 193 1951 265 275
66. E. Meier, L. Hertz, and A. Schousboe Neurotransmitters as developmental signals Neurochem. Int. 19 1991 1 15
67. K. Miyazawa Encountering unpredicted off-target effects of pharmacological inhibitors J. Biochem. 150 2011 1 3
68. C.R. Murthy, and L. Hertz Pyruvate decarboxylation in astrocytes and in neurons in primary cultures in the presence and the absence of ammonia Neurochem. Res. 13 1988 57 61 (Pubitemid 18066939)
69. M.D. Norenberg Hepatic encephalopathy: a disorder of astrocytes S. Fedoroff, A. Vernadakis, Astrocytes: Cell Biology and Pathology of Astrocytes 1986 Academic Press New York 425 460
70. M.D. Norenberg, and A.S. Bender Astrocyte swelling in liver failure: role of glutamine and benzodiazepines Acta Neurochir. Suppl. (Wien) 60 1994 24 27
71. M.D. Norenberg, A.R. Jayakumar, K.V. Rama Rao, and K.S. Panickar New concepts in the mechanism of ammonia-induced astrocyte swelling Metab. Brain Dis. 22 2007 219 234 (Pubitemid 47624314)
72. G. Panayotou, and M.D. Waterfield Phosphatidyl-inositol 3-kinase: a key enzyme in diverse signalling processes Trends Cell Biol. 2 1992 358 360
73. - cotransport in the heart, brain, and blood Am. J. Physiol. Regul. Integr. Comp. Physiol. 291 2006 R1 R25
74. L. Peng Transactivation in astrocytes as a novel mechanism of neuroprotection L. Hertz, Non-Neuronal Cells of the Nervous System: Function and Dysfunction 2004 Elsevier Amsterdam 503 518
75. 2B serotonergic signaling Neurochem. Int. 57 2010 421 431
76. L. Peng, P. Martin-Vasallo, and K.J. Sweadner Isoforms of Na,K-ATPase alpha and beta subunits in the rat cerebellum and in granule cell cultures J. Neurosci. 17 1997 3488 3502 (Pubitemid 27200578)
77. K.L. Pierce, A. Tohgo, S. Ahn, M.E. Field, L.M. Luttrell, and R.J. Lefkowitz Epidermal growth factor (EGF) receptor-dependent ERK activation by G protein-coupled receptors: a co-culture system for identifying intermediates upstream and downstream of heparin-binding EGF shedding J. Biol. Chem. 276 2001 23155 23160
78. A. Piiper, I. Dikic, M.P. Lutz, J. Leser, B. Kronenberger, R. Elez, H. Cramer, W. Müller-Esterl, and S. Zeuzem Cyclic AMP induces transactivation of the receptors for epidermal growth factor and nerve growth factor, thereby modulating activation of MAP kinase, Akt, and neurite outgrowth in PC12 cells J. Biol. Chem. 277 2002 43623 43630 (Pubitemid 36157777)
79. A.A. Rabinstein Treatment of brain edema in acute liver failure Curr. Treat Options Neurol. 12 2010 129 141
80. +)-dependent adenosine triphosphatase Arch. Biochem. Biophys. 139 1970 17 27
81. C. Rose Increased extracellular brain glutamate in acute liver failure: decreased uptake or increased release? Metab. Brain Dis. 17 2002 251 261 (Pubitemid 36204755)
82. +)-activated adenosinetriphosphatase Eur. J. Biochem. 85 1978 561 570 (Pubitemid 8335279)
83. P.G. Rychahou, L.N. Jackson, S.R. Silva, S. Rajaraman, and B.M. Evers Targeted molecular therapy of the PI3K pathway: therapeutic significance of PI3K subunit targeting in colorectal carcinoma Ann. Surg. 243 2006 833 842 (Pubitemid 44297494)
84. S. Schenker, D.W. McCandless, E. Brophy, and M.S. Lewis Studies on the intracerebral toxicity of ammonia J. Clin. Invest. 46 1967 838 848
85. A. Semplicini, L. Serena, R. Valle, G. Ceolotto, M. Felice, A. Fontebasso, and A.C. Pessina Ouabain-inhibiting activity of aldosterone antagonists Steroids 60 1995 110 113
86. J.C. Skou, and M. Esmann The Na,K-ATPase J. Bioenerg. Biomembr. 24 1992 249 261
87. E. Solenov, H. Watanabe, G.T. Manley, and A.S. Verkman Sevenfold-reduced osmotic water permeability in primary astrocyte cultures from AQP-4-deficient mice, measured by a fluorescence quenching method Am. J. Physiol. Cell. Physiol. 286 2004 C426 C432
88. D. Song, B. Li, E. Yan, Y. Man, M. Wolfson, Y. Chen, and L. Peng Chronic treatment with anti-bipolar drugs causes intracellular alkalinization in astrocytes, altering their functions Neurochem. Res. 37 2012 2524 2540
89. J. Stephan, N. Haack, K.W. Kafitz, S. Durry, D. Koch, P. Hochstrate, G. Seifert, C. Steinhäuser, and C.R. Rose Kir4.1 channels mediate a depolarization of hippocampal astrocytes under hyperammonemic conditions in situ Glia 60 2012 965 978
90. I. Suárez, G. Bodega, M. Rubio, and B. Fernández Induction of NOS and nitrotyrosine expression in the rat striatum following experimental hepatic encephalopathy Metab. Brain Dis. 24 2009 395 408
91. H. Sugimoto, R.C. Koehler, D.A. Wilson, S.W. Brusilow, and R.J. Traystman Methionine sulfoximine, a glutamine synthetase inhibitor, attenuates increased extracellular potassium activity during acute hyperammonemia J. Cereb. Blood Flow Metab. 17 1997 44 49 (Pubitemid 27014906)
92. K.J. Sweadner Overlapping and diverse distribution of Na-K ATPase isozymes in neurons and glia Can. J. Physiol. Pharmacol. 70 1992 S255 S259
93. D.M. Tal, and S.J. Karlish Do canrenone and 6,7-dihydroxylated derivatives compete with ouabain at the same site on Na,K-ATPase? Mol. Pharmacol. 34 1998 245 249
94. +-ATPase forms a functional signaling complex Mol. Biol. Cell 17 2006 317 326 (Pubitemid 43049484)
95. J. Tian, X. Li, M. Liang, L. Liu, J.X. Xie, Q. Ye, P. Kometiani, M. Tillekeratne, R. Jin, and Z. Xie Changes in sodium pump expression dictate the effects of ouabain on cell growth J. Biol. Chem. 284 2009 14921 14929
96. J. Tian, A. Shidyak, S.M. Periyasamy, S. Haller, M. Taleb, N. El-Okdi, J. Elkareh, S. Gupta, S. Gohara, O.V. Fedorova, C.J. Cooper, Z. Xie, D. Malhotra, A.Y. Bagrov, and J.I. Shapiro Spironolactone attenuates experimental uremic cardiomyopathy by antagonizing marinobufagenin Hypertension 54 2009 1313 1320
97. D.A. Tice, J.S. Biscardi, A.L. Nickles, and S.J. Parsons Mechanism of biological synergy between cellular Src and epidermal growth factor receptor Proc. Natl. Acad. Sci. U.S.A. 96 1999 1415 1420 (Pubitemid 29098465)
98. K. Tokuda, K.A. O'Dell, Y. Izumi, and C.F. Zorumski Midazolam inhibits hippocampal long-term potentiation and learning through dual central and peripheral benzodiazepine receptor activation and neurosteroidogenesis J. Neurosci. 30 2010 16788 16795
99. B. Vanhaesebroeck, and M.D. Waterfield Signaling by distinct classes of phosphoinositide 3-kinases Exp. Cell Res. 253 1999 239 254
100. S.M. Wall Ammonium transport and the role of the Na,K-ATPase Miner. Electrolyte Metab. 22 1996 311 317 (Pubitemid 26370440)
101. +-ATPase J. Biol. Chem. 279 2004 17250 17259 (Pubitemid 38560483)
102. G.I. Welsh, E.J. Foulstone, S.W. Young, J.M. Tavaré, and C.G. Proud Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase Biochem. J. 303 1994 15 20 (Pubitemid 24302892)
103. W. Wu, L.M. Graves, G.N. Gill, S.J. Parsons, and J.M. Samet Src-dependent phosphorylation of the epidermal growth factor receptor on tyrosine 845 is required for zinc-induced Ras activation J. Biol. Chem. 277 2002 24252 24257 (Pubitemid 34951942)
104. +-ATPase to hypertrophy and its marker genes in cardiac myocytes J. Biol. Chem. 274 1999 19323 19328
105. + homeostasis and glycogen usage in brain Neurochem. Res. 38 2013 472 485
106. 2 isoform gene expression by ammonia in astrocytes and in brain in vivo Neurochem. Int. 57 2010 395 403
107. Q. Ye, F. Lai, M. Banerjee, Q. Duan, Z. Li, S. Si, and Z. Xie Expression of mutant α1 Na/K-ATPase defective in conformational transition attenuates Src-mediated signal transduction J. Biol. Chem. 288 2013 5803 5814
108. 14C-labeled glutamate in astrocytes in primary cultures J. Neurochem. 42 1984 594 597 (Pubitemid 14185618)
109. H.S. Yu, S.H. Kim, H.G. Park, Y.S. Kim, and Y.M. Ahn Activation of Akt signaling in rat brain by intracerebroventricular injection of ouabain: a rat model for mania Prog. Neuropsychopharmacol. Biol. Psychiatry 34 2010 888 894
110. Z. Yuan, T. Cai, J. Tian, A.V. Ivanov, D.R. Giovannucci, and Z. Xie Na/K-ATPase tethers phospholipase C and IP3 receptor into a calcium-regulatory complex Mol. Biol. Cell 16 2005 4034 4045 (Pubitemid 41262876)
111. L.L. Zhang, E. Delpire, and N. Vardi NKCC1 does not accumulate chloride in developing retinal neurons J. Neurophysiol. 98 2007 266 277 (Pubitemid 47084818)
112. E. Zwick, H. Daub, N. Aoki, Y. Yamaguchi-Aoki, I. Tinhofer, K. Maly, and A. Ullrich Critical role of calcium-dependent epidermal growth factor receptor transactivation in PC12 cell membrane depolarization and bradykinin signaling J. Biol. Chem. 272 1997 24767 24770 (Pubitemid 27415645)