Signalling pathways for transactivation by dexmedetomidine of epidermal growth factor receptors in astrocytes and its paracrine effect on neurons

British Journal of Pharmacology

Volumn 154, Issue 1, 2008, Pages 191-203

  Li, B ^a   Du, T ^a   Li, H ^a   Gu, L ^a   Zhang, H ^a   Huang, J ^b   Hertz, L ^a   Peng, L ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

ERK; Gene expression; Metalloproteinase; Neuroprotection; Paracrine effect of EGF receptor ligand; PKC; Src kinase

Indexed keywords

1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; 4 (3 CHLOROANILINO) 6,7 DIMETHOXYQUINAZOLINE; 4 AMINO 7 TERT BUTYL 5 (4 METHYLPHENYL)PYRAZOLO[3,4 D]PYRIMIDINE; DEXMEDETOMIDINE; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; ILOMASTAT; METALLOPROTEINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PERTUSSIS TOXIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; ASTROCYTE; CELL PROTECTION; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; FEMALE; GRANULE CELL; MALE; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NEWBORN; NONHUMAN; PARACRINE SIGNALING; PRIORITY JOURNAL; TRANSACTIVATION;

EID: 42949120560     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/bjp.2008.58     Document Type: Article

References (36)

1. Aantaa R, Marjamaki A, Scheinin M (1995). Molecular pharmacology of α 2 ‐adrenoceptor subtypes. Ann Med 27: 439–449.
2. Alessi DR (1997). The protein kinase C inhibitors Ro 318220 and GF 109203X are equally potent inhibitors of MAPKAP kinase‐1beta (Rsk‐2) and p70 S6 kinase. FEBS Lett 402: 121–123.
3. Bradford MM (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein‐dye binding. Anal Biochem 72: 248–254.
4. Birecree E, King Jr LE, Nanney LB (1991). Epidermal growth factor and its receptor in the developing human nervous system. Dev Brain Res 60: 145–154.
5. Dethlefsen SM, Raab G, Moses MA, Adam RM, Klagsbrun M, Freeman MR (1998). Extracellular calcium influx stimulates metalloproteinase cleavage and secretion of heparin‐binding EGF‐like growth factor independently of protein kinase C. J Cell Biochem 69: 143–153.
6. Dorn II GW, Oswald KJ, McCluskey TS, Kuhel DG, Liggett SB (1997). Alpha 2A ‐adrenergic receptor stimulated calcium release is transduced by G i ‐associated G(beta gamma)‐mediated activation of phospholipase C. Biochemistry 36: 6415–6423.
7. Du T, Yang X, Peng L (2007). mRNA expression of EGF family in primary cultures of astrocytes. Zhong Guo Yi Ke Da Xue Xue Bao 36: 500–501.
8. Ebersolt C, Perez M, Bockaert J (1981). Alpha 1 and alpha 2 adrenergic receptors in mouse brain astrocytes from primary cultures. J Neurosci Res 6: 643–652.
9. Elkeles A, Juven‐Gershon T, Israeli D, Wilder S, Zalcenstein A, Oren M (1999). The c‐fos proto‐oncogene is a target for transactivation by the p53 tumor suppressor. Mol Cell Biol 19: 2594–2600.
10. El‐Marjou A, Delouvee A, Thiery JP, Radvanyi F (2000). Involvement of epidermal growth factor receptor in chemically induced mouse bladder tumour progression. Carcinogenesis 21: 2211–2218.
11. Engelhard K, Werner C, Kaspar S, Mollenberg O, Blobner M, Bachl M et al. (2002). Effect of the [alpha] 2 ‐agonist dexmedetomidine on cerebral neurotransmitter concentrations during cerebral ischemia in rats. Anesthesiology 96: 450–457.
12. Enkvist MO, Hamalainen H, Jansson CC, Kukkonen JP, Hautala R, Courtney MJ et al. (1996). Coupling of astroglial alpha 2 ‐adrenoreceptors to second messenger pathways. J Neurochem 66: 2394–2401.
13. Falk A, Frisen J (2002). Amphiregulin is a mitogen for adult neural stem cells. J Neurosci Res 69: 757–762.
14. Gu L, Li B, Yang X, Hu X, Huand X, Hertz L, Peng L (2007). Depolarization‐induced, glutamate receptor‐mediated and transactivation‐dependent extracellular‐signal regulated kinase phosphorylation in cultured cerebellar granule neurons Neurosci 147: 342–353.
15. Hertz L, Chen Y, Gibbs ME, Zang P, Peng L (2004). Astrocytic adrenoceptors: a major drug target in neurological and psychiatric disorder ? Curr Drug Target—CNS Neurol Disord 3: 239–268.
16. Hertz L, Juurlink BHJ, Szuchet S (1985). Cell cultures. In: Lajtha A (ed) Handbook of Neurochemistry (2nd ed, Vol. 8) Plenum Press: New York, pp 603–661.
17. Hertz L, Peng L, Lai JC (1998). Functional studies in cultured astrocytes. Methods 16: 293–310.
18. Horvath G, Kovacs M, Szikszay M, Benedek G (19911992). Drugs acting at calcium channels can influence the hypnotic‐anesthetic effect of dexmedetomidine. Acta Biochim Biophys 26: 75–81.
19. Inoue D, Kido S, Matsumoto T (2004). Transcriptional induction of FosB/DeltaFosB gene by mechanical stress in osteoblasts. J Biol Chem 279: 49795–49803.
20. Izumi Y, Hirata M, Hasuwa H, Iwamoto R, Umata T, Miyado K et al. (1998). A metalloprotease‐disintegrin, MDC9/meltrin‐gamma/ADAM9 and PKCdelta are involved in TPA‐induced ectodomain shedding of membrane‐anchored heparin‐binding EGF‐like growth factor. EMBO J 17: 7260–7272.
21. Kong EK, Peng L, Chen Y, Yu AC, Hertz L (2002). Upregulation of 5‐HT 2B receptor density and receptor‐mediated glycogenolysis in mouse astrocytes by long‐term fluoxetine administration. Neurochem Res 27: 113–120.
22. Levitzki A, Gazit A (1995). Tyrosine kinase inhibition: an approach to drug development. Science 267: 1782–1788.
23. Lu YC, Qi JG, Wang TH, Zhou X, Feng ZT (2005). Distribution of epidermal growth factor in central nervous system of adult rhesus monkey. Sichuan Da Xue Xue Bao Yi Xue Ban 36: 618–621.
24. Nakagawa T, Sasahara M, Hayase Y, Haneda M, Yasuda H, Kikkawa R et al. (1998). Neuronal and glial expression of heparin‐binding EGF‐like growth factor in central nervous system of prenatal and early‐postnatal rat. Brain Res Dev Brain Res 108: 263–272.
25. Peng L, Juurlink BHJ, Hertz L (1991). Differences in transmitter release, morphology, and ischemia‐induced cell injury between cerebellar granule cell cultures developing in the presence and in the absence of a depolarizing potassium concentration. Dev Brain Res 63: 1–12.
26. Peng L, Martin‐Vasallo P, Sweadner KJ (1997). Isoforms of Na,K‐ATPase alpha and beta subunits in the rat cerebellum and in granule cell cultures. J Neurosci 17: 3488–3502.
27. Peng L, Yu ACH, Fung KY, Prevot V, Hertz L (2003). Adrenergic stimulation of ERK phosphorylation in astrocytes is α 2 ‐specific and may be mediated by transactivation. Brain Res 978: 65–71.
28. Peng L (2004). Transactivation in astrocytes as a novel mechanism of neuroprotection. In: Hertz L (ed). Non‐Neuronal Cells of the Nervous System: Function and Dysfunction. Elsevier: Amsterdam, pp. 503–518.
29. Pierce KL, Tohgo A, Ahn S, Field ME, Luttrell LM, Lefkowitz RJ (2001). Epidermal growth factor (EGF) receptor‐dependent ERK activation by G protein‐coupled receptors. J Biol Chem 276: 23155–23160.
30. Sagar SM, Edwards RH, Sharp FR (1991). Epidermal growth factor and transforming growth factor alpha induce c‐fos gene expression in retinal Muller cells in vivo. J Neurosci Res 29: 549–559.
31. Schambra UB, Mackensen GB, Stafford‐Smith M, Haines DE, Schwinn DA (2005). Neuron specific alpha‐adrenergic receptor expression in human cerebellum: implications for emerging cerebellar roles in neurologic disease. Neuroscience 135: 507–523.
32. Segal IS, Vickery RG, Walton JK, Doze VA, Maze M (1988). Dexmedetomidine diminishes halothane anesthetic requirements in rats through a postsynaptic alpha 2 adrenergic receptor. Anesthesiology 69: 818–823.
33. Shah BH, Farshori MP, Jambusaria A, Catt KJ (2003). Roles of Src and epidermal growth factor receptor transactivation in transient and sustained ERK 1/2 responses to gonadotropin‐releasing hormone receptor activation. J Biol Chem 278: 19118–19126.
34. Song ZM, Abou‐Zeid O, Fang YY (2004). Alpha 2a adrenoceptors regulate phosphorylation of microtubule‐associated protein‐2 in cultured cortical neurons. Neuroscience 123: 405–418.
35. Virtanen R (1989). Pharmacological profiles of medetomidine and its antagonist, atipamezole. Acta Vet Scand Suppl 85: 29–37.
36. Zhao Z, Code WE, Hertz L (1992). Dexmedetomidine, a potent and highly specific alpha 2 agonist, evokes cytosolic calcium surge in astrocytes but not in neurons. Neuropharmacology 31: 1077–1079.