Gamma-secretase inhibition attenuates oxaliplatin-induced apoptosis through increased Mcl-1 and/or Bcl-xL in human colon cancer cells

Apoptosis

Volumn 18, Issue 10, 2013, Pages 1163-1174

  Timme, Cindy R ^a,c   Gruidl, Mike ^a   Yeatman, Timothy J ^b  

^a H LEE MOFFITT CANCER CENTER AND RESEARCH INSTITUTE   (United States)

^b Gibbs Cancer Center   (United States)

^c UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Bcl xL; Colon; Gamma secretase inhibitor; Mcl 1; Oxaliplatin

Indexed keywords

CYTOCHROME C; GAMMA SECRETASE INHIBITOR; MRK 003; OBATOCLAX; OXALIPLATIN; PROTEIN BCL XL; PROTEIN MCL 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; CANCER CELL; CELL ASSAY; CELL CYCLE; CELL GROWTH; COLON CANCER; CONTROLLED STUDY; DRUG EFFECT; ENZYME INHIBITION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; LONG TERM SURVIVAL; PRIORITY JOURNAL; RNA INTERFERENCE; WESTERN BLOTTING;

ADENOCARCINOMA; AMYLOID PRECURSOR PROTEIN SECRETASES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BCL-X PROTEIN; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLIC S-OXIDES; DRUG SYNERGISM; HUMANS; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; ORGANOPLATINUM COMPOUNDS; PYRROLES; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; THIADIAZOLES;

EID: 84885425467     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-013-0883-x     Document Type: Article

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