Inhibition of notch signaling reduces the stem-like population of breast cancer cells and prevents mammosphere formation

Anticancer Research

Volumn 30, Issue 10, 2010, Pages 3853-3867

  Grudzien, Peter ^a   Lo, Shelly ^b   Albain, Kathy S ^b   Robinson, Patricia ^b   Rajan, Prabha ^a   Strack, Peter R ^c   Golde, Todd E ^d   Miele, Lucio ^a,e   Foreman, Kimberly E ^a  

^a LOYOLA UNIVERSITY CHICAGO   (United States)

^b LOYOLA UNIVERSITY CHICAGO   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

^d MAYO GRADUATE SCHOOL   (United States)

^e UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Breast cancer; Cancer stem cells; Gamma secretase; Mammosphere; Notch

Indexed keywords

GAMMA SECRETASE INHIBITOR; MRK 003; NOTCH RECEPTOR; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CANCER STEM CELL; CELL POPULATION; CELL PROLIFERATION; CELL RENEWAL; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMYLOID PRECURSOR PROTEIN SECRETASES; BREAST NEOPLASMS; CELL LINE, TUMOR; CYCLIC S-OXIDES; FEMALE; HUMANS; NEOPLASTIC STEM CELLS; RECEPTOR, ERBB-2; RECEPTORS, NOTCH; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; THIADIAZOLES;

EID: 78650248243     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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