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Volumn 8, Issue 10, 2013, Pages

Zidovudine (AZT) and Hepatic Lipid Accumulation: Implication of Inflammation, Oxidative and Endoplasmic Reticulum Stress Mediators

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A ACYLTRANSFERASE; ACETYL COENZYME A CARBOXYLASE; GLUCOSE REGULATED PROTEIN 78; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INITIATION FACTOR 2ALPHA; OSTEOPONTIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; PROTEIN KINASE; PROTEIN KINASE LIKE ENDOPLASMIC RETICULUM KINASE; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; ZIDOVUDINE;

EID: 84885397513     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0076850     Document Type: Article
Times cited : (35)

References (59)
  • 1
    • 0033537620 scopus 로고    scopus 로고
    • Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens
    • Hogg RS, Yip B, Kully C, Craib KJ, O'Shaughnessy MV, et al. (1999) Improved survival among HIV-infected patients after initiation of triple-drug antiretroviral regimens. CMAJ 160: 659-665.
    • (1999) CMAJ , vol.160 , pp. 659-665
    • Hogg, R.S.1    Yip, B.2    Kully, C.3    Craib, K.J.4    O'Shaughnessy, M.V.5
  • 2
    • 2642709177 scopus 로고    scopus 로고
    • Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators
    • Palella FJ Jr, Delaney KM, Moorman AC, Loveless MO, Fuhrer J, et al. (1998) Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators. N Engl J Med 338: 853-860.
    • (1998) N Engl J Med , vol.338 , pp. 853-860
    • Palella Jr., F.J.1    Delaney, K.M.2    Moorman, A.C.3    Loveless, M.O.4    Fuhrer, J.5
  • 3
    • 33748116898 scopus 로고    scopus 로고
    • Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study
    • Palella FJ Jr, Baker RK, Moorman AC, Chmiel JS, Wood KC, et al. (2006) Mortality in the highly active antiretroviral therapy era: changing causes of death and disease in the HIV outpatient study. J Acquir Immune Defic Syndr 43: 27-34.
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 27-34
    • Palella Jr., F.J.1    Baker, R.K.2    Moorman, A.C.3    Chmiel, J.S.4    Wood, K.C.5
  • 4
    • 84878014853 scopus 로고    scopus 로고
    • Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice
    • Hansen L, Parker I, Monet Roberts L, Sutliff RL, Platt MO, et al. (2013) Azidothymidine (AZT) leads to arterial stiffening and intima-media thickening in mice. J Biomech 46: 1540-1547.
    • (2013) J Biomech , vol.46 , pp. 1540-1547
    • Hansen, L.1    Parker, I.2    Monet Roberts, L.3    Sutliff, R.L.4    Platt, M.O.5
  • 5
    • 0037727758 scopus 로고    scopus 로고
    • Beneficial effects of L-carnitine in myoblastic C2C12 cells. Interaction with zidovudine
    • Georges B, Galland S, Rigault C, Le Borgne F, Demarquoy J, (2003) Beneficial effects of L-carnitine in myoblastic C2C12 cells. Interaction with zidovudine. Biochem Pharmacol 65: 1483-1488.
    • (2003) Biochem Pharmacol , vol.65 , pp. 1483-1488
    • Georges, B.1    Galland, S.2    Rigault, C.3    Le Borgne, F.4    Demarquoy, J.5
  • 6
    • 0034008520 scopus 로고    scopus 로고
    • A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome
    • Carr A, Miller J, Law M, Cooper DA, (2000) A syndrome of lipoatrophy, lactic acidaemia and liver dysfunction associated with HIV nucleoside analogue therapy: contribution to protease inhibitor-related lipodystrophy syndrome. AIDS 14: F25-32.
    • (2000) AIDS , vol.14
    • Carr, A.1    Miller, J.2    Law, M.3    Cooper, D.A.4
  • 7
    • 0037045055 scopus 로고    scopus 로고
    • Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy
    • Sutinen J, Hakkinen AM, Westerbacka J, Seppala-Lindroos A, Vehkavaara S, et al. (2002) Increased fat accumulation in the liver in HIV-infected patients with antiretroviral therapy-associated lipodystrophy. AIDS 16: 2183-2193.
    • (2002) AIDS , vol.16 , pp. 2183-2193
    • Sutinen, J.1    Hakkinen, A.M.2    Westerbacka, J.3    Seppala-Lindroos, A.4    Vehkavaara, S.5
  • 8
    • 0034606721 scopus 로고    scopus 로고
    • Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection
    • Sulkowski MS, Thomas DL, Chaisson RE, Moore RD, (2000) Hepatotoxicity associated with antiretroviral therapy in adults infected with human immunodeficiency virus and the role of hepatitis C or B virus infection. JAMA 283: 74-80.
    • (2000) JAMA , vol.283 , pp. 74-80
    • Sulkowski, M.S.1    Thomas, D.L.2    Chaisson, R.E.3    Moore, R.D.4
  • 10
    • 0032897185 scopus 로고    scopus 로고
    • Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion
    • Chariot P, Drogou I, de Lacroix-Szmania I, Eliezer-Vanerot MC, Chazaud B, et al. (1999) Zidovudine-induced mitochondrial disorder with massive liver steatosis, myopathy, lactic acidosis, and mitochondrial DNA depletion. J Hepatol 30: 156-160.
    • (1999) J Hepatol , vol.30 , pp. 156-160
    • Chariot, P.1    Drogou, I.2    de Lacroix-Szmania, I.3    Eliezer-Vanerot, M.C.4    Chazaud, B.5
  • 11
    • 0027510616 scopus 로고
    • Hepatomegaly with severe steatosis in HIV-seropositive patients
    • Freiman JP, Helfert KE, Hamrell MR, Stein DS, (1993) Hepatomegaly with severe steatosis in HIV-seropositive patients. AIDS 7: 379-385.
    • (1993) AIDS , vol.7 , pp. 379-385
    • Freiman, J.P.1    Helfert, K.E.2    Hamrell, M.R.3    Stein, D.S.4
  • 12
    • 0032892560 scopus 로고    scopus 로고
    • Zidovudine-associated type B lactic acidosis and hepatic steatosis in an HIV-infected patient
    • Acosta BS, Grimsley EW, (1999) Zidovudine-associated type B lactic acidosis and hepatic steatosis in an HIV-infected patient. South Med J 92: 421-423.
    • (1999) South Med J , vol.92 , pp. 421-423
    • Acosta, B.S.1    Grimsley, E.W.2
  • 13
    • 0030002975 scopus 로고    scopus 로고
    • Hepatic Morphological alterations induced by zidovudine (ZDV) in an experimental model
    • Corcuera T, Alonso MJ, Picazo A, Gomez F, Roldan M, et al. (1996) Hepatic Morphological alterations induced by zidovudine (ZDV) in an experimental model. Pathol Res Pract 192: 182-187.
    • (1996) Pathol Res Pract , vol.192 , pp. 182-187
    • Corcuera, T.1    Alonso, M.J.2    Picazo, A.3    Gomez, F.4    Roldan, M.5
  • 14
    • 33748125363 scopus 로고    scopus 로고
    • Adverse effects of antiretroviral therapy in HIV-1 infected children
    • Shah I, (2006) Adverse effects of antiretroviral therapy in HIV-1 infected children. J Trop Pediatr 52: 244-248.
    • (2006) J Trop Pediatr , vol.52 , pp. 244-248
    • Shah, I.1
  • 15
    • 1842570096 scopus 로고    scopus 로고
    • AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins
    • de la Asuncion JG, del Olmo ML, Sastre J, Millan A, Pellin A, et al. (1998) AZT treatment induces molecular and ultrastructural oxidative damage to muscle mitochondria. Prevention by antioxidant vitamins. J Clin Invest 102: 4-9.
    • (1998) J Clin Invest , vol.102 , pp. 4-9
    • de la Asuncion, J.G.1    del Olmo, M.L.2    Sastre, J.3    Millan, A.4    Pellin, A.5
  • 17
    • 0032897990 scopus 로고    scopus 로고
    • Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat
    • Szabados E, Fischer GM, Toth K, Csete B, Nemeti B, et al. (1999) Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat. Free Radic Biol Med 26: 309-317.
    • (1999) Free Radic Biol Med , vol.26 , pp. 309-317
    • Szabados, E.1    Fischer, G.M.2    Toth, K.3    Csete, B.4    Nemeti, B.5
  • 18
    • 79952038139 scopus 로고    scopus 로고
    • Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells
    • Manda KR, Banerjee A, Banks WA, Ercal N, (2011) Highly active antiretroviral therapy drug combination induces oxidative stress and mitochondrial dysfunction in immortalized human blood-brain barrier endothelial cells. Free Radic Biol Med 50: 801-810.
    • (2011) Free Radic Biol Med , vol.50 , pp. 801-810
    • Manda, K.R.1    Banerjee, A.2    Banks, W.A.3    Ercal, N.4
  • 19
    • 0029127584 scopus 로고
    • Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity
    • Fromenty B, Pessayre D, (1995) Inhibition of mitochondrial beta-oxidation as a mechanism of hepatotoxicity. Pharmacol Ther 67: 101-154.
    • (1995) Pharmacol Ther , vol.67 , pp. 101-154
    • Fromenty, B.1    Pessayre, D.2
  • 20
    • 0032189850 scopus 로고    scopus 로고
    • Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway
    • Brinkman K, ter Hofstede HJ, Burger DM, Smeitink JA, Koopmans PP, (1998) Adverse effects of reverse transcriptase inhibitors: mitochondrial toxicity as common pathway. AIDS 12: 1735-1744.
    • (1998) AIDS , vol.12 , pp. 1735-1744
    • Brinkman, K.1    ter Hofstede, H.J.2    Burger, D.M.3    Smeitink, J.A.4    Koopmans, P.P.5
  • 21
    • 84866421262 scopus 로고    scopus 로고
    • Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis
    • Abdelmegeed MA, Banerjee A, Yoo SH, Jang S, Gonzalez FJ, et al. (2012) Critical role of cytochrome P450 2E1 (CYP2E1) in the development of high fat-induced non-alcoholic steatohepatitis. J Hepatol 57: 860-866.
    • (2012) J Hepatol , vol.57 , pp. 860-866
    • Abdelmegeed, M.A.1    Banerjee, A.2    Yoo, S.H.3    Jang, S.4    Gonzalez, F.J.5
  • 22
    • 33751003258 scopus 로고    scopus 로고
    • Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats
    • Moon KH, Hood BL, Kim BJ, Hardwick JP, Conrads TP, et al. (2006) Inactivation of oxidized and S-nitrosylated mitochondrial proteins in alcoholic fatty liver of rats. Hepatology 44: 1218-1230.
    • (2006) Hepatology , vol.44 , pp. 1218-1230
    • Moon, K.H.1    Hood, B.L.2    Kim, B.J.3    Hardwick, J.P.4    Conrads, T.P.5
  • 23
  • 24
    • 33644500142 scopus 로고    scopus 로고
    • Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells
    • Kim BJ, Hood BL, Aragon RA, Hardwick JP, Conrads TP, et al. (2006) Increased oxidation and degradation of cytosolic proteins in alcohol-exposed mouse liver and hepatoma cells. Proteomics 6: 1250-1260.
    • (2006) Proteomics , vol.6 , pp. 1250-1260
    • Kim, B.J.1    Hood, B.L.2    Aragon, R.A.3    Hardwick, J.P.4    Conrads, T.P.5
  • 25
    • 84864269699 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress in nonalcoholic fatty liver disease
    • Pagliassotti MJ, (2012) Endoplasmic reticulum stress in nonalcoholic fatty liver disease. Annu Rev Nutr 32: 17-33.
    • (2012) Annu Rev Nutr , vol.32 , pp. 17-33
    • Pagliassotti, M.J.1
  • 26
    • 84860483727 scopus 로고    scopus 로고
    • The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling
    • Fu S, Watkins SM, Hotamisligil GS, (2012) The role of endoplasmic reticulum in hepatic lipid homeostasis and stress signaling. Cell Metab 15: 623-634.
    • (2012) Cell Metab , vol.15 , pp. 623-634
    • Fu, S.1    Watkins, S.M.2    Hotamisligil, G.S.3
  • 27
    • 84873820488 scopus 로고    scopus 로고
    • Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F(1) Mice
    • Desai VG, Lee T, Moland CL, Branham WS, Mittelstaedt RA, et al. (2012) Evaluation of Hepatic Mitochondria and Hematological Parameters in Zidovudine-Treated B6C3F(1) Mice. AIDS Res Treat 2012: 317695.
    • (2012) AIDS Res Treat , vol.2012 , pp. 317695
    • Desai, V.G.1    Lee, T.2    Moland, C.L.3    Branham, W.S.4    Mittelstaedt, R.A.5
  • 29
    • 53249125859 scopus 로고    scopus 로고
    • Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion
    • Moon KH, Hood BL, Mukhopadhyay P, Rajesh M, Abdelmegeed MA, et al. (2008) Oxidative inactivation of key mitochondrial proteins leads to dysfunction and injury in hepatic ischemia reperfusion. Gastroenterology 135: 1344-1357.
    • (2008) Gastroenterology , vol.135 , pp. 1344-1357
    • Moon, K.H.1    Hood, B.L.2    Mukhopadhyay, P.3    Rajesh, M.4    Abdelmegeed, M.A.5
  • 30
    • 0141815741 scopus 로고    scopus 로고
    • Production of reactive oxygen species by mitochondria: central role of complex III
    • Chen Q, Vazquez EJ, Moghaddas S, Hoppel CL, Lesnefsky EJ, (2003) Production of reactive oxygen species by mitochondria: central role of complex III. J Biol Chem 278: 36027-36031.
    • (2003) J Biol Chem , vol.278 , pp. 36027-36031
    • Chen, Q.1    Vazquez, E.J.2    Moghaddas, S.3    Hoppel, C.L.4    Lesnefsky, E.J.5
  • 31
    • 53549125568 scopus 로고    scopus 로고
    • Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver
    • Moon KH, Upreti VV, Yu LR, Lee IJ, Ye X, et al. (2008) Mechanism of 3,4-methylenedioxymethamphetamine (MDMA, ecstasy)-mediated mitochondrial dysfunction in rat liver. Proteomics 8: 3906-3918.
    • (2008) Proteomics , vol.8 , pp. 3906-3918
    • Moon, K.H.1    Upreti, V.V.2    Yu, L.R.3    Lee, I.J.4    Ye, X.5
  • 32
    • 84875550946 scopus 로고    scopus 로고
    • Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury
    • Epub ahead of print
    • Abdelmegeed MA, Jang S, Banerjee A, Hardwick JP, Song BJ (2013) Robust protein nitration contributes to acetaminophen-induced mitochondrial dysfunction and acute liver injury. Free Radic Biol Med Epub ahead of print.
    • (2013) Free Radic Biol Med
    • Abdelmegeed, M.A.1    Jang, S.2    Banerjee, A.3    Hardwick, J.P.4    Song, B.J.5
  • 33
    • 0242349770 scopus 로고    scopus 로고
    • Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate
    • Kimzey AL, Weitz KK, Guengerich FP, Zangar RC, (2003) Hydroperoxy-10,12-octadecadienoic acid stimulates cytochrome P450 3A protein aggregation by a mechanism that is inhibited by substrate. Biochemistry 42: 12691-12699.
    • (2003) Biochemistry , vol.42 , pp. 12691-12699
    • Kimzey, A.L.1    Weitz, K.K.2    Guengerich, F.P.3    Zangar, R.C.4
  • 34
    • 79951633215 scopus 로고    scopus 로고
    • Does hepatic steatosis affect drug metabolizing enzymes in the liver?
    • Buechler C, Weiss TS, (2011) Does hepatic steatosis affect drug metabolizing enzymes in the liver? Curr Drug Metab 12: 24-34.
    • (2011) Curr Drug Metab , vol.12 , pp. 24-34
    • Buechler, C.1    Weiss, T.S.2
  • 35
    • 0035196704 scopus 로고    scopus 로고
    • Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress
    • Robertson G, Leclercq I, Farrell GC, (2001) Nonalcoholic steatosis and steatohepatitis. II. Cytochrome P-450 enzymes and oxidative stress. Am J Physiol Gastrointest Liver Physiol 281: G1135-1139.
    • (2001) Am J Physiol Gastrointest Liver Physiol , vol.281
    • Robertson, G.1    Leclercq, I.2    Farrell, G.C.3
  • 36
    • 41949093739 scopus 로고    scopus 로고
    • Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report
    • Lapadula G, Izzo I, Costarelli S, Cologni G, Bercich L, et al. (2007) Dideoxynucleoside HIV reverse transcriptase inhibitors and drug-related hepatotoxicity: a case report. J Med Case Rep 1: 19.
    • (2007) J Med Case Rep , vol.1 , pp. 19
    • Lapadula, G.1    Izzo, I.2    Costarelli, S.3    Cologni, G.4    Bercich, L.5
  • 37
    • 10244222704 scopus 로고    scopus 로고
    • Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir
    • Sulkowski MS, Mehta SH, Chaisson RE, Thomas DL, Moore RD, (2004) Hepatotoxicity associated with protease inhibitor-based antiretroviral regimens with or without concurrent ritonavir. AIDS 18: 2277-2284.
    • (2004) AIDS , vol.18 , pp. 2277-2284
    • Sulkowski, M.S.1    Mehta, S.H.2    Chaisson, R.E.3    Thomas, D.L.4    Moore, R.D.5
  • 38
    • 0027513470 scopus 로고
    • Growth and body composition in children infected with the human immunodeficiency virus-1
    • Miller TL, Evans SJ, Orav EJ, Morris V, McIntosh K, et al. (1993) Growth and body composition in children infected with the human immunodeficiency virus-1. Am J Clin Nutr 57: 588-592.
    • (1993) Am J Clin Nutr , vol.57 , pp. 588-592
    • Miller, T.L.1    Evans, S.J.2    Orav, E.J.3    Morris, V.4    McIntosh, K.5
  • 39
    • 68749085069 scopus 로고    scopus 로고
    • Implication of normal liver enzymes in liver disease
    • Calvaruso V, Craxi A, (2009) Implication of normal liver enzymes in liver disease. J Viral Hepat 16: 529-536.
    • (2009) J Viral Hepat , vol.16 , pp. 529-536
    • Calvaruso, V.1    Craxi, A.2
  • 40
    • 84865313269 scopus 로고    scopus 로고
    • Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy
    • Wu D, Wang X, Zhou R, Yang L, Cederbaum AI, (2012) Alcohol steatosis and cytotoxicity: the role of cytochrome P4502E1 and autophagy. Free Radic Biol Med 53: 1346-1357.
    • (2012) Free Radic Biol Med , vol.53 , pp. 1346-1357
    • Wu, D.1    Wang, X.2    Zhou, R.3    Yang, L.4    Cederbaum, A.I.5
  • 41
    • 79952703368 scopus 로고    scopus 로고
    • PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease
    • Hardwick JP, Osei-Hyiaman D, Wiland H, Abdelmegeed MA, Song BJ, (2009) PPAR/RXR Regulation of Fatty Acid Metabolism and Fatty Acid omega-Hydroxylase (CYP4) Isozymes: Implications for Prevention of Lipotoxicity in Fatty Liver Disease. PPAR Res 2009: 952734.
    • (2009) PPAR Res , vol.2009 , pp. 952734
    • Hardwick, J.P.1    Osei-Hyiaman, D.2    Wiland, H.3    Abdelmegeed, M.A.4    Song, B.J.5
  • 43
    • 77957728142 scopus 로고    scopus 로고
    • Pentoxifylline alleviates high-fat diet-induced non-alcoholic steatohepatitis and early atherosclerosis in rats by inhibiting AGE and RAGE expression
    • Wu J, Zhao MY, Zheng H, Zhang H, Jiang Y, (2010) Pentoxifylline alleviates high-fat diet-induced non-alcoholic steatohepatitis and early atherosclerosis in rats by inhibiting AGE and RAGE expression. Acta Pharmacol Sin 31: 1367-1375.
    • (2010) Acta Pharmacol Sin , vol.31 , pp. 1367-1375
    • Wu, J.1    Zhao, M.Y.2    Zheng, H.3    Zhang, H.4    Jiang, Y.5
  • 44
    • 77249116145 scopus 로고    scopus 로고
    • Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells
    • Guimaraes EL, Empsen C, Geerts A, van Grunsven LA, (2010) Advanced glycation end products induce production of reactive oxygen species via the activation of NADPH oxidase in murine hepatic stellate cells. J Hepatol 52: 389-397.
    • (2010) J Hepatol , vol.52 , pp. 389-397
    • Guimaraes, E.L.1    Empsen, C.2    Geerts, A.3    van Grunsven, L.A.4
  • 45
    • 78651403899 scopus 로고    scopus 로고
    • Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes
    • Gao RY, Mukhopadhyay P, Mohanraj R, Wang H, Horvath B, et al. (2011) Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes. Mol Med Rep 4: 151-155.
    • (2011) Mol Med Rep , vol.4 , pp. 151-155
    • Gao, R.Y.1    Mukhopadhyay, P.2    Mohanraj, R.3    Wang, H.4    Horvath, B.5
  • 47
    • 79951600838 scopus 로고    scopus 로고
    • Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease
    • Gentile CL, Frye MA, Pagliassotti MJ, (2011) Fatty acids and the endoplasmic reticulum in nonalcoholic fatty liver disease. Biofactors 37: 8-16.
    • (2011) Biofactors , vol.37 , pp. 8-16
    • Gentile, C.L.1    Frye, M.A.2    Pagliassotti, M.J.3
  • 48
    • 0033590451 scopus 로고    scopus 로고
    • Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase
    • Harding HP, Zhang Y, Ron D, (1999) Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase. Nature 397: 271-274.
    • (1999) Nature , vol.397 , pp. 271-274
    • Harding, H.P.1    Zhang, Y.2    Ron, D.3
  • 49
    • 0037326359 scopus 로고    scopus 로고
    • When translation meets metabolism: multiple links to diabetes
    • Shi Y, Taylor SI, Tan SL, Sonenberg N, (2003) When translation meets metabolism: multiple links to diabetes. Endocr Rev 24: 91-101.
    • (2003) Endocr Rev , vol.24 , pp. 91-101
    • Shi, Y.1    Taylor, S.I.2    Tan, S.L.3    Sonenberg, N.4
  • 50
    • 0029001576 scopus 로고
    • A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B
    • Pahl HL, Baeuerle PA, (1995) A novel signal transduction pathway from the endoplasmic reticulum to the nucleus is mediated by transcription factor NF-kappa B. EMBO J. 14: 2580-2588.
    • (1995) EMBO J , vol.14 , pp. 2580-2588
    • Pahl, H.L.1    Baeuerle, P.A.2
  • 51
    • 4544253996 scopus 로고    scopus 로고
    • Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis
    • Wu S, Tan M, Hu Y, Wang JL, Scheuner D, et al. (2004) Ultraviolet light activates NFkappaB through translational inhibition of IkappaBalpha synthesis. J Biol Chem 279: 34898-34902.
    • (2004) J Biol Chem , vol.279 , pp. 34898-34902
    • Wu, S.1    Tan, M.2    Hu, Y.3    Wang, J.L.4    Scheuner, D.5
  • 52
    • 0029797604 scopus 로고    scopus 로고
    • Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a
    • Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, et al. (1996) Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a. J Clin Invest 98: 1575-1584.
    • (1996) J Clin Invest , vol.98 , pp. 1575-1584
    • Shimano, H.1    Horton, J.D.2    Hammer, R.E.3    Shimomura, I.4    Brown, M.S.5
  • 53
    • 66449137379 scopus 로고    scopus 로고
    • GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice
    • Kammoun HL, Chabanon H, Hainault I, Luquet S, Magnan C, et al. (2009) GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice. J Clin Invest 119: 1201-1215.
    • (2009) J Clin Invest , vol.119 , pp. 1201-1215
    • Kammoun, H.L.1    Chabanon, H.2    Hainault, I.3    Luquet, S.4    Magnan, C.5
  • 54
    • 23944491920 scopus 로고    scopus 로고
    • HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease
    • Zhou H, Pandak WM Jr, Lyall V, Natarajan R, Hylemon PB, (2005) HIV protease inhibitors activate the unfolded protein response in macrophages: implication for atherosclerosis and cardiovascular disease. Mol Pharmacol 68: 690-700.
    • (2005) Mol Pharmacol , vol.68 , pp. 690-700
    • Zhou, H.1    Pandak Jr., W.M.2    Lyall, V.3    Natarajan, R.4    Hylemon, P.B.5
  • 55
    • 0037047284 scopus 로고    scopus 로고
    • Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP)
    • You M, Fischer M, Deeg MA, Crabb DW, (2002) Ethanol induces fatty acid synthesis pathways by activation of sterol regulatory element-binding protein (SREBP). J Biol Chem 277: 29342-29347.
    • (2002) J Biol Chem , vol.277 , pp. 29342-29347
    • You, M.1    Fischer, M.2    Deeg, M.A.3    Crabb, D.W.4
  • 56
    • 33745815985 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling in metabolic regulation
    • Long YC, Zierath JR, (2006) AMP-activated protein kinase signaling in metabolic regulation. J Clin Invest 116: 1776-1783.
    • (2006) J Clin Invest , vol.116 , pp. 1776-1783
    • Long, Y.C.1    Zierath, J.R.2
  • 57
    • 0031717105 scopus 로고    scopus 로고
    • The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell?
    • Hardie DG, Carling D, Carlson M, (1998) The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu Rev Biochem 67: 821-855.
    • (1998) Annu Rev Biochem , vol.67 , pp. 821-855
    • Hardie, D.G.1    Carling, D.2    Carlson, M.3
  • 58
    • 3042550657 scopus 로고    scopus 로고
    • Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver
    • You M, Crabb DW, (2004) Recent advances in alcoholic liver disease II. Minireview: molecular mechanisms of alcoholic fatty liver. Am J Physiol Gastrointest Liver Physiol 287: G1-6.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.287
    • You, M.1    Crabb, D.W.2
  • 59
    • 38949104356 scopus 로고    scopus 로고
    • Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver
    • Garcia-Villafranca J, Guillen A, Castro J, (2008) Ethanol consumption impairs regulation of fatty acid metabolism by decreasing the activity of AMP-activated protein kinase in rat liver. Biochimie 90: 460-466.
    • (2008) Biochimie , vol.90 , pp. 460-466
    • Garcia-Villafranca, J.1    Guillen, A.2    Castro, J.3


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