Hydroperoxy-10,12-Octadecadienoic Acid Stimulates Cytochrome P450 3A Protein Aggregation by a Mechanism That Is Inhibited by Substrate

Biochemistry

Volumn 42, Issue 43, 2003, Pages 12691-12699

  Kimzey, Amy L ^a   Weitz, Karl K ^a   Guengerich, F Peter ^b   Zangar, Richard C ^a  

^a PACIFIC NORTHWEST NATIONAL LABORATORY   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AGGLOMERATION; CARBOXYLIC ACIDS; DEGRADATION; OXIDATION; PROTEINS; SUBSTRATES;

MICROSOMES;

BIOCHEMISTRY;

ANTIOXIDANT; CYTOCHROME P450 3A; HYDROPEROXY 10,12 OCTADECADIENOIC ACID; LIPID HYDROPEROXIDE; NICARDIPINE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME PURIFICATION; ENZYME SUBSTRATE; HUMAN; INCUBATION TIME; LIVER MICROSOME; MALE; MOLECULAR MODEL; MOLECULAR WEIGHT; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN STABILITY; RAT;

ANIMALS; ANTIOXIDANTS; ARYL HYDROCARBON HYDROXYLASES; CYTOCHROME P-450 CYP3A; HUMANS; LINOLEIC ACIDS; MALE; MICROSOMES, LIVER; OXIDATIVE STRESS; OXIDOREDUCTASES, N-DEMETHYLATING; RATS; RATS, SPRAGUE-DAWLEY; SUBSTRATE SPECIFICITY;

ANIMALIA; STAPHYLOCOCCUS PHAGE 3A;

EID: 0242349770     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi0349975     Document Type: Article

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