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Volumn 4, Issue 1, 2011, Pages 151-155

Resveratrol attenuates azidothymidine-induced cardiotoxicity by decreasing mitochondrial reactive oxygen species generation in human cardiomyocytes

Author keywords

Azidothymidine; Cardiomyocytes; Cell death; Reactive oxygen species; Resveratrol

Indexed keywords

CASPASE 3; CASPASE 7; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE; RESVERATROL; ZIDOVUDINE;

EID: 78651403899     PISSN: 17912997     EISSN: 17913004     Source Type: Journal    
DOI: 10.3892/mmr.2010.390     Document Type: Article
Times cited : (40)

References (40)
  • 1
    • 0037529205 scopus 로고    scopus 로고
    • Immunopathogenesis of HIV-related heart muscle disease: Current perspectives
    • Currie PF and Boon NA: Immunopathogenesis of HIV-related heart muscle disease: current perspectives. AIDS 17 (Suppl 1): 21-28, 2003.
    • (2003) AIDS , vol.17 , Issue.SUPPL. 1 , pp. 21-28
    • Currie, P.F.1    Boon, N.A.2
  • 3
    • 0026046254 scopus 로고
    • Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts
    • Lewis W, Papoian T, Gonzalez B, et al: Mitochondrial ultrastructural and molecular changes induced by zidovudine in rat hearts. Lab Invest 65: 228-236, 1991.
    • (1991) Lab Invest , vol.65 , pp. 228-236
    • Lewis, W.1    Papoian, T.2    Gonzalez, B.3
  • 4
    • 0028158398 scopus 로고
    • Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine
    • Lewis W, Simpson JF and Meyer RR: Cardiac mitochondrial DNA polymerase-gamma is inhibited competitively and noncompetitively by phosphorylated zidovudine. Circ Res 74: 344-348, 1994.
    • (1994) Circ Res , vol.74 , pp. 344-348
    • Lewis, W.1    Simpson, J.F.2    Meyer, R.R.3
  • 6
    • 4744356434 scopus 로고    scopus 로고
    • Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT
    • Mak IT, Nedelec LF and Weglicki WB: Pro-oxidant properties and cytotoxicity of AZT-monophosphate and AZT. Cardiovasc Toxicol 4: 109-115, 2004.
    • (2004) Cardiovasc Toxicol , vol.4 , pp. 109-115
    • Mak, I.T.1    Nedelec, L.F.2    Weglicki, W.B.3
  • 7
    • 70249142851 scopus 로고    scopus 로고
    • Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: Implications for 3′-azido-3′-deoxythymidine-dependent cardio
    • Morris GW, Iams TA, Slepchenko KG and McKee EE: Origin of pyrimidine deoxyribonucleotide pools in perfused rat heart: implications for 3′-azido-3′-deoxythymidine-dependent cardiotoxicity Biochem J 422: 513-520, 2009.
    • (2009) Toxicity Biochem J , vol.422 , pp. 513-520
    • Morris, G.W.1    Iams, T.A.2    Slepchenko, K.G.3    McKee, E.E.4
  • 8
    • 0036889521 scopus 로고    scopus 로고
    • Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide
    • Sutliff RL, Dikalov S, Weiss D, et al: Nucleoside reverse transcriptase inhibitors impair endothelium-dependent relaxation by increasing superoxide. Am J Physiol Heart Circ Physiol 283: H2363-H2370, 2002.
    • (2002) Am J Physiol Heart Circ Physiol , vol.283
    • Sutliff, R.L.1    Dikalov, S.2    Weiss, D.3
  • 9
    • 0032897990 scopus 로고    scopus 로고
    • Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat
    • Szabados E, Fischer GM, Toth K, et al: Role of reactive oxygen species and poly-ADP-ribose polymerase in the development of AZT-induced cardiomyopathy in rat. Free Radic Biol Med 26: 309-317, 1999.
    • (1999) Free Radic Biol Med , vol.26 , pp. 309-317
    • Szabados, E.1    Fischer, G.M.2    Toth, K.3
  • 11
    • 66849115212 scopus 로고    scopus 로고
    • Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction
    • Kline ER, Bassit L, Hernandez-Santiago BI, et al: Long-term exposure to AZT, but not d4T, increases endothelial cell oxidative stress and mitochondrial dysfunction. Cardiovasc Toxicol 9: 1-12, 2009.
    • (2009) Cardiovasc Toxicol , vol.9 , pp. 1-12
    • Kline, E.R.1    Bassit, L.2    Hernandez-Santiago, B.I.3
  • 12
    • 67649861056 scopus 로고    scopus 로고
    • Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyo
    • Kohler JJ, Cucoranu I, Fields E, et al: Transgenic mitochondrial superoxide dismutase and mitochondrially targeted catalase prevent antiretroviral-induced oxidative stress and cardiomyopathy Lab Invest 89: 782-790, 2009.
    • (2009) Pathy Lab Invest , vol.89 , pp. 782-790
    • Kohler, J.J.1    Cucoranu, I.2    Fields, E.3
  • 13
    • 33644659068 scopus 로고    scopus 로고
    • Resveratrol in cardioprotection: A therapeutic promise of alternative medicine
    • Das DK and Maulik N: Resveratrol in cardioprotection: a therapeutic promise of alternative medicine. Mol Interv 6: 36-47, 2006.
    • (2006) Mol Interv , vol.6 , pp. 36-47
    • Das, D.K.1    Maulik, N.2
  • 14
    • 33745962138 scopus 로고    scopus 로고
    • Therapeutic potential of resveratrol: The in vivo evidence
    • Baur JA and Sinclair DA: Therapeutic potential of resveratrol: the in vivo evidence. Nature Reviews 5: 493-506, 2006.
    • (2006) Nature Reviews , vol.5 , pp. 493-506
    • Baur, J.A.1    Sinclair, D.A.2
  • 15
    • 31144447091 scopus 로고    scopus 로고
    • Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats
    • Sharma S, Anjaneyulu M, Kulkarni SK and Chopra K: Resveratrol, a polyphenolic phytoalexin, attenuates diabetic nephropathy in rats. Pharmacology 76: 69-75, 2006.
    • (2006) Pharmacology , vol.76 , pp. 69-75
    • Sharma, S.1    Anjaneyulu, M.2    Kulkarni, S.K.3    Chopra, K.4
  • 16
    • 34547101726 scopus 로고    scopus 로고
    • Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: Role of nitric oxide, thioredoxin, and heme oxygenase
    • Thirunavukkarasu M, Penumathsa SV, Koneru S, et al: Resveratrol alleviates cardiac dysfunction in streptozotocin-induced diabetes: role of nitric oxide, thioredoxin, and heme oxygenase. Free Radic Biol Med 43: 720-729, 2007.
    • (2007) Free Radic Biol Med , vol.43 , pp. 720-729
    • Thirunavukkarasu, M.1    Penumathsa, S.V.2    Koneru, S.3
  • 17
    • 33749349202 scopus 로고    scopus 로고
    • Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice
    • DOI 10.2337/db05-1188
    • Zang M, Xu S, Maitland-Toolan KA, et al: Polyphenols stimulate AMP-activated protein kinase, lower lipids, and inhibit accelerated atherosclerosis in diabetic LDL receptor-deficient mice. Diabetes 55: 2180-2191, 2006. (Pubitemid 44743614)
    • (2006) Diabetes , vol.55 , Issue.8 , pp. 2180-2191
    • Zang, M.1    Xu, S.2    Maitland-Toolan, K.A.3    Zuccollo, A.4    Hou, X.5    Jiang, B.6    Wierzbicki, M.7    Verbeuren, T.J.8    Cohen, R.A.9
  • 18
    • 48349110303 scopus 로고    scopus 로고
    • A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice
    • Barger JL, Kayo T, Vann JM, et al: A low dose of dietary resveratrol partially mimics caloric restriction and retards aging parameters in mice. PLoS ONE 3: e2264, 2008.
    • (2008) PLoS ONE , vol.3
    • Barger, J.L.1    Kayo, T.2    Vann, J.M.3
  • 19
    • 33751072349 scopus 로고    scopus 로고
    • Resveratrol improves health and survival of mice on a high-calorie diet
    • Baur JA, Pearson KJ, Price NL, et al: Resveratrol improves health and survival of mice on a high-calorie diet. Nature 444: 337-342, 2006.
    • (2006) Nature , vol.444 , pp. 337-342
    • Baur, J.A.1    Pearson, K.J.2    Price, N.L.3
  • 20
    • 67650659852 scopus 로고    scopus 로고
    • Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: Role of circulating factors and SIRT1
    • Csiszar A, Labinskyy N, Jimenez R, et al: Anti-oxidative and anti-inflammatory vasoprotective effects of caloric restriction in aging: role of circulating factors and SIRT1. Mech Ageing Dev 130: 518-527, 2009.
    • (2009) Mech Ageing Dev , vol.130 , pp. 518-527
    • Csiszar, A.1    Labinskyy, N.2    Jimenez, R.3
  • 21
    • 48349144852 scopus 로고    scopus 로고
    • Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span
    • Pearson KJ, Baur JA, Lewis KN, et al: Resveratrol delays age-related deterioration and mimics transcriptional aspects of dietary restriction without extending life span. Cell Metab 8: 157-168, 2008.
    • (2008) Cell Metab , vol.8 , pp. 157-168
    • Pearson, K.J.1    Baur, J.A.2    Lewis, K.N.3
  • 22
    • 76749118468 scopus 로고    scopus 로고
    • CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes
    • Mukhopadhyay P, Rajesh M, Batkai S, et al: CB1 cannabinoid receptors promote oxidative stress and cell death in murine models of doxorubicin-induced cardiomyopathy and in human cardiomyocytes. Cardiovasc Res 85: 773-784, 2010.
    • (2010) Cardiovasc Res , vol.85 , pp. 773-784
    • Mukhopadhyay, P.1    Rajesh, M.2    Batkai, S.3
  • 23
    • 38349158077 scopus 로고    scopus 로고
    • Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy
    • DOI 10.1038/nprot.2007.327, PII NPROT.2007.327
    • Mukhopadhyay P, Rajesh M, Hasko G, Hawkins BJ, Madesh M and Pacher P: Simultaneous detection of apoptosis and mitochondrial superoxide production in live cells by flow cytometry and confocal microscopy. Nat Protoc 2: 2295-2301, 2007. (Pubitemid 351565867)
    • (2007) Nature Protocols , vol.2 , Issue.9 , pp. 2295-2301
    • Mukhopadhyay, P.1    Rajesh, M.2    Hasko, G.3    Hawkins, B.J.4    Madesh, M.5    Pacher, P.6
  • 25
    • 66149110905 scopus 로고    scopus 로고
    • Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro
    • Mukhopadhyay P, Rajesh M, Batkai S, et al: Role of superoxide, nitric oxide, and peroxynitrite in doxorubicin-induced cell death in vivo and in vitro. Am J Physiol Heart Circ Physiol 296: H1466-H1483, 2009.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296
    • Mukhopadhyay, P.1    Rajesh, M.2    Batkai, S.3
  • 26
    • 70349527600 scopus 로고    scopus 로고
    • Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia
    • Weglicki WB, Chmielinska JJ, Tejero-Taldo I, et al: Neutral endopeptidase inhibition enhances substance P mediated inflammation due to hypomagnesemia. Magnes Res 22: S167-S173, 2009.
    • (2009) Magnes Res , vol.22
    • Weglicki, W.B.1    Chmielinska, J.J.2    Tejero-Taldo, I.3
  • 28
    • 35148896262 scopus 로고    scopus 로고
    • Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: The therapeutic potential of PARP inhibitors
    • DOI 10.1111/j.1527-3466.2007.00018.x
    • Pacher P and Szabo C: Role of poly(ADP-ribose) polymerase 1 (PARP-1) in cardiovascular diseases: the therapeutic potential of PARP inhibitors. Cardiovasc Drug Rev 25: 235-260, 2007. (Pubitemid 47547464)
    • (2007) Cardiovascular Drug Reviews , vol.25 , Issue.3 , pp. 235-260
    • Pacher, P.1    Szabo, C.2
  • 29
    • 33846863589 scopus 로고    scopus 로고
    • Nitric oxide and peroxynitrite in health and disease
    • DOI 10.1152/physrev.00029.2006
    • Pacher P, Beckman JS and Liaudet L: Nitric oxide and peroxynitrite in health and disease. Physiol Rev 87: 315-424, 2007. (Pubitemid 46217686)
    • (2007) Physiological Reviews , vol.87 , Issue.1 , pp. 315-424
    • Pacher, P.1    Beckman, J.S.2    Liaudet, L.3
  • 31
    • 19544392527 scopus 로고    scopus 로고
    • Nitrosative stress and pharmacological modulation of heart failure
    • DOI 10.1016/j.tips.2005.04.003, PII S0165614705001045
    • Pacher P, Schulz R, Liaudet L and Szabo C: Nitrosative stress and pharmacological modulation of heart failure. Trends Pharmacol Sci 26: 302-310, 2005. (Pubitemid 40733523)
    • (2005) Trends in Pharmacological Sciences , vol.26 , Issue.6 , pp. 302-310
    • Pacher, P.1    Schulz, R.2    Liaudet, L.3    Szabo, C.4
  • 32
    • 68149150584 scopus 로고    scopus 로고
    • Resveratrol improves endothelial function: Role of TNF{alpha} and vascular oxidative stress
    • Zhang H, Zhang J, Ungvari Z and Zhang C: Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress. Arterioscler Thromb Vasc Biol 29: 1164-1171, 2009.
    • (2009) Arterioscler Thromb Vasc Biol , vol.29 , pp. 1164-1171
    • Zhang, H.1    Zhang, J.2    Ungvari, Z.3    Zhang, C.4
  • 33
    • 70350464512 scopus 로고    scopus 로고
    • Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells
    • Ungvari Z, Labinskyy N, Mukhopadhyay P, et al: Resveratrol attenuates mitochondrial oxidative stress in coronary arterial endothelial cells. Am J Physiol Heart Circ Physiol 297: H1876-H1881, 2009.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Ungvari, Z.1    Labinskyy, N.2    Mukhopadhyay, P.3
  • 36
    • 0037466103 scopus 로고    scopus 로고
    • Upregulation and activation of eNOS by resveratrol
    • Taubert D and Berkels R: Upregulation and activation of eNOS by resveratrol. Circulation 107: e78-79, 2003.
    • (2003) Circulation , vol.107
    • Taubert, D.1    Berkels, R.2
  • 38
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase
    • DOI 10.1038/sj.emboj.7600244
    • Yeung F, Hoberg JE, Ramsey CS, et al: Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. Embo J 23: 2369-2380, 2004. (Pubitemid 38954844)
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 40
    • 49249100288 scopus 로고    scopus 로고
    • Vasoprotective effects of resveratrol and SIRT1: Attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations
    • Csiszar A, Labinskyy N, Podlutsky A, et al: Vasoprotective effects of resveratrol and SIRT1: attenuation of cigarette smoke-induced oxidative stress and proinflammatory phenotypic alterations. Am J Physiol Heart Circ Physiol 294: H2721-H2735, 2008.
    • (2008) Am J Physiol Heart Circ Physiol , vol.294
    • Csiszar, A.1    Labinskyy, N.2    Podlutsky, A.3


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