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Volumn 91, Issue 10, 2013, Pages 1167-1175

MTOR and regulation of energy homeostasis in humans

Author keywords

Adipokines; Adiponectin; ADRF; Bone morphogenic protein 7 (BMP7); Cholecystokinin (CCK); Eating behavior; Energy homeostasis; Everolimus; Fibroblast growth factor 21 (FGF21); Leptin; mTOR; Obesity; Rapamycin; Type 2 diabetes mellitus

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AMYLIN; CHOLECYSTOKININ; EVEROLIMUS; FIBROBLAST GROWTH FACTOR 21; GASTRIC INHIBITORY POLYPEPTIDE; GHRELIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; LEPTIN; MAMMALIAN TARGET OF RAPAMYCIN; NEUROPEPTIDE Y; OSTEOGENIC PROTEIN 1; PANCREAS POLYPEPTIDE; PEPTIDE YY; RAPAMYCIN; SOMATOMEDIN;

EID: 84885306707     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1057-6     Document Type: Review
Times cited : (23)

References (98)
  • 2
    • 0038141979 scopus 로고    scopus 로고
    • Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
    • 12771962 10.1038/ncb999 1:CAS:528:DC%2BD3sXktlWnsrk%3D
    • Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5:578-581
    • (2003) Nat Cell Biol , vol.5 , pp. 578-581
    • Zhang, Y.1    Gao, X.2    Saucedo, L.J.3    Ru, B.4    Edgar, B.A.5    Pan, D.6
  • 3
    • 0442323560 scopus 로고    scopus 로고
    • Tuberous sclerosis complex: From Drosophila to human disease
    • 15102439 10.1016/j.tcb.2003.12.006 1:CAS:528:DC%2BD2cXhtVOrtL8%3D
    • Pan D, Dong J, Zhang Y, Gao X (2004) Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 14:78-85
    • (2004) Trends Cell Biol , vol.14 , pp. 78-85
    • Pan, D.1    Dong, J.2    Zhang, Y.3    Gao, X.4
  • 4
    • 0347318056 scopus 로고    scopus 로고
    • TSC2: Filling the GAP in the mTOR signaling pathway
    • 14729330 10.1016/j.tibs.2003.11.007
    • Li Y, Corradetti MN, Inoki K, Guan KL (2004) TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci 29:32-38
    • (2004) Trends Biochem Sci , vol.29 , pp. 32-38
    • Li, Y.1    Corradetti, M.N.2    Inoki, K.3    Guan, K.L.4
  • 7
    • 80052472675 scopus 로고    scopus 로고
    • Multicenter phase 2 trial of sirolimus for tuberous sclerosis: Kidney angiomyolipomas and other tumors regress and VEGF-D levels decrease
    • 21915260 10.1371/journal.pone.0023379 1:CAS:528:DC%2BC3MXht1ent7bO
    • Dabora SL, Franz DN, Ashwal S, Sagalowsky A, DiMario FJ Jr, Miles D, Cutler D, Krueger D, Uppot RN, Rabenou R et al (2011) Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF-D levels decrease. PLoS One 6:e23379
    • (2011) PLoS One , vol.6 , pp. 23379
    • Dabora, S.L.1    Franz, D.N.2    Ashwal, S.3    Sagalowsky, A.4    Dimario, Jr.F.J.5    Miles, D.6    Cutler, D.7    Krueger, D.8    Uppot, R.N.9    Rabenou, R.10
  • 9
    • 42449104351 scopus 로고    scopus 로고
    • MTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
    • 18174523 10.2337/db07-0922 1:CAS:528:DC%2BD1cXksVGkuro%3D
    • Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N et al (2008) mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57:945-957
    • (2008) Diabetes , vol.57 , pp. 945-957
    • Fraenkel, M.1    Ketzinel-Gilad, M.2    Ariav, Y.3    Pappo, O.4    Karaca, M.5    Castel, J.6    Berthault, M.F.7    Magnan, C.8    Cerasi, E.9    Kaiser, N.10
  • 11
    • 33644859253 scopus 로고    scopus 로고
    • Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)
    • 16221708 10.1093/ndt/gfi181 1:CAS:528:DC%2BD28XhvVeksL8%3D
    • Wahl PR, Serra AL, Le Hir M, Molle KD, Hall MN, Wuthrich RP (2006) Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant 21:598-604
    • (2006) Nephrol Dial Transplant , vol.21 , pp. 598-604
    • Wahl, P.R.1    Serra, A.L.2    Le Hir, M.3    Molle, K.D.4    Hall, M.N.5    Wuthrich, R.P.6
  • 14
    • 66249088672 scopus 로고    scopus 로고
    • Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice
    • 19372632 10.1254/jphs.08215FP 1:CAS:528:DC%2BD1MXlsFSguro%3D
    • Chang GR, Chiu YS, Wu YY, Chen WY, Liao JW, Chao TH, Mao FC (2009) Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice. J Pharmacol Sci 109:496-503
    • (2009) J Pharmacol Sci , vol.109 , pp. 496-503
    • Chang, G.R.1    Chiu, Y.S.2    Wu, Y.Y.3    Chen, W.Y.4    Liao, J.W.5    Chao, T.H.6    Mao, F.C.7
  • 15
    • 56449115916 scopus 로고    scopus 로고
    • Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
    • 10.1016/j.cmet.2008.10.004 1:CAS:528:DC%2BD1cXhsV2qtbjF
    • Blouet C, Ono H, Schwartz GJ (2008) Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metabol 8:459-467
    • (2008) Cell Metabol , vol.8 , pp. 459-467
    • Blouet, C.1    Ono, H.2    Schwartz, G.J.3
  • 17
    • 33745052121 scopus 로고    scopus 로고
    • MTOR tells the brain that the body is hungry
    • 16761005 10.1038/nm0606-615 1:CAS:528:DC%2BD28XltlOjs7c%3D
    • Kahn BB, Myers MG (2006) mTOR tells the brain that the body is hungry. Nat Med 12:615-617
    • (2006) Nat Med , vol.12 , pp. 615-617
    • Kahn, B.B.1    Myers, M.G.2
  • 18
    • 33748931457 scopus 로고    scopus 로고
    • Central nervous system control of food intake and body weight
    • 16988703 10.1038/nature05026 1:CAS:528:DC%2BD28Xpslalu7c%3D
    • Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443:289-295
    • (2006) Nature , vol.443 , pp. 289-295
    • Morton, G.J.1    Cummings, D.E.2    Baskin, D.G.3    Barsh, G.S.4    Schwartz, M.W.5
  • 19
    • 78650510609 scopus 로고    scopus 로고
    • MTOR: From growth signal integration to cancer, diabetes and ageing
    • 21157483 10.1038/nrm3025 1:CAS:528:DC%2BC3cXhsFGqsbnK
    • Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3
  • 21
    • 36148962868 scopus 로고    scopus 로고
    • Role of mTOR in solid tumor systems: A therapeutical target against primary tumor growth, metastases, and angiogenesis
    • 17713840 10.1007/s10555-007-9077-8
    • Seeliger H, Guba M, Kleespies A, Jauch KW, Bruns CJ (2007) Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev 26:611-621
    • (2007) Cancer Metastasis Rev , vol.26 , pp. 611-621
    • Seeliger, H.1    Guba, M.2    Kleespies, A.3    Jauch, K.W.4    Bruns, C.J.5
  • 22
    • 48649085311 scopus 로고    scopus 로고
    • Post-kidney transplant weight change as marker of poor survival outcomes
    • 18497685 10.1097/TP.0b013e31816f1cd3
    • Chang SH, McDonald SP (2008) Post-kidney transplant weight change as marker of poor survival outcomes. Transplantation 85:1443-1448
    • (2008) Transplantation , vol.85 , pp. 1443-1448
    • Chang, S.H.1    McDonald, S.P.2
  • 24
    • 84878834146 scopus 로고    scopus 로고
    • Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors
    • 10.1002/ijc.28023 23319457
    • Figlin RA, Kaufmann I, Brechbiel J (2013) Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors. Int J Cancer. doi: 10.1002/ijc.28023
    • (2013) Int J Cancer
    • Figlin, R.A.1    Kaufmann, I.2    Brechbiel, J.3
  • 25
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • 18955708 10.1073/pnas.0809136105 1:CAS:528:DC%2BD1cXhsVWns7rJ
    • Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci USA 105:17414-17419
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 26
    • 84872054005 scopus 로고    scopus 로고
    • Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor
    • 23184952 10.1074/jbc.M112.402461 1:CAS:528:DC%2BC3sXjtlOjsg%3D%3D
    • Dennis MD, Kimball SR, Jefferson LS (2013) Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. J Biol Chem 288:10-19
    • (2013) J Biol Chem , vol.288 , pp. 10-19
    • Dennis, M.D.1    Kimball, S.R.2    Jefferson, L.S.3
  • 27
    • 3342895823 scopus 로고    scopus 로고
    • Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
    • 10.1016/j.cub.2004.06.054 1:CAS:528:DC%2BD2cXmtVamsLs%3D
    • Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol CB 14:1296-1302
    • (2004) Curr Biol CB , vol.14 , pp. 1296-1302
    • Sarbassov, D.D.1    Ali, S.M.2    Kim, D.H.3    Guertin, D.A.4    Latek, R.R.5    Erdjument-Bromage, H.6    Tempst, P.7    Sabatini, D.M.8
  • 29
    • 40949150324 scopus 로고    scopus 로고
    • A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss
    • 18057094 10.2337/db07-0573 1:CAS:528:DC%2BD1cXjt1ChtLc%3D
    • Ropelle ER, Pauli JR, Fernandes MFA, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JAR et al (2008) A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57:594-605
    • (2008) Diabetes , vol.57 , pp. 594-605
    • Ropelle, E.R.1    Pauli, J.R.2    Fernandes, M.F.A.3    Rocco, S.A.4    Marin, R.M.5    Morari, J.6    Souza, K.K.7    Dias, M.M.8    Gomes-Marcondes, M.C.9    Gontijo, J.A.R.10
  • 30
  • 31
    • 0028139089 scopus 로고
    • Positional cloning of the mouse obese gene and its human homologue
    • 7984236 10.1038/372425a0 1:CAS:528:DyaK2MXisVGqsbs%3D
    • Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
    • (1994) Nature , vol.372 , pp. 425-432
    • Zhang, Y.1    Proenca, R.2    Maffei, M.3    Barone, M.4    Leopold, L.5    Friedman, J.M.6
  • 32
    • 0031733326 scopus 로고    scopus 로고
    • Effect of fasting and leptin deficiency on hypothalamic neuropeptide y gene transcription in vivo revealed by expression of a lacZ reporter gene
    • 9564880 10.1210/en.139.5.2629 1:CAS:528:DyaK1cXivFShsbs%3D
    • Schwartz MW, Erickson JC, Baskin DG, Palmiter RD (1998) Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139:2629-2635
    • (1998) Endocrinology , vol.139 , pp. 2629-2635
    • Schwartz, M.W.1    Erickson, J.C.2    Baskin, D.G.3    Palmiter, R.D.4
  • 33
    • 12344277552 scopus 로고    scopus 로고
    • Diabetes, obesity, and the brain
    • 15662002 10.1126/science.1104344 1:CAS:528:DC%2BD2MXksFyhsQ%3D%3D
    • Schwartz MW, Porte D Jr (2005) Diabetes, obesity, and the brain. Science 307:375-379
    • (2005) Science , vol.307 , pp. 375-379
    • Schwartz, M.W.1    Porte, Jr.D.2
  • 34
    • 37549040190 scopus 로고    scopus 로고
    • The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
    • 18054335 10.1016/j.febslet.2007.11.070 1:CAS:528:DC%2BD2sXhsVOltb3E
    • Kadowaki T, Yamauchi T, Kubota N (2008) The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett 582:74-80
    • (2008) FEBS Lett , vol.582 , pp. 74-80
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3
  • 35
    • 0032905886 scopus 로고    scopus 로고
    • The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight
    • 9927499 10.1172/JCI4901 1:CAS:528:DyaK1MXovVKmtg%3D%3D
    • Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M (1999) The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 103:383-391
    • (1999) J Clin Invest , vol.103 , pp. 383-391
    • Kopin, A.S.1    Mathes, W.F.2    McBride, E.W.3    Nguyen, M.4    Al-Haider, W.5    Schmitz, F.6    Bonner-Weir, S.7    Kanarek, R.8    Beinborn, M.9
  • 36
    • 27644577645 scopus 로고    scopus 로고
    • Role of cholecystokinin in appetite control and body weight regulation
    • 10.1111/j.1467-789X.2005.00212.x 1:CAS:528:DC%2BD2MXht1OlurzN
    • Little TJ, Horowitz M, Feinle-Bisset C (2005) Role of cholecystokinin in appetite control and body weight regulation. Obes Rev Off J Int Assoc Study Obes 6:297-306
    • (2005) Obes Rev off J Int Assoc Study Obes , vol.6 , pp. 297-306
    • Little, T.J.1    Horowitz, M.2    Feinle-Bisset, C.3
  • 37
    • 0034850444 scopus 로고    scopus 로고
    • Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: A physiological approach toward improved metabolic control
    • 11472273 10.2174/1381612013397357 1:CAS:528:DC%2BD3MXmt1Shurs%3D
    • Weyer C, Maggs DG, Young AA, Kolterman OG (2001) Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. Curr Pharm Des 7:1353-1373
    • (2001) Curr Pharm des , vol.7 , pp. 1353-1373
    • Weyer, C.1    Maggs, D.G.2    Young, A.A.3    Kolterman, O.G.4
  • 38
    • 0346094442 scopus 로고    scopus 로고
    • Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat
    • 14715154 10.1016/j.brainres.2003.10.040 1:CAS:528:DC%2BD2cXjsV2gtw%3D%3D
    • Barth SW, Riediger T, Lutz TA, Rechkemmer G (2004) Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat. Brain Res 997:97-102
    • (2004) Brain Res , vol.997 , pp. 97-102
    • Barth, S.W.1    Riediger, T.2    Lutz, T.A.3    Rechkemmer, G.4
  • 39
    • 84859733684 scopus 로고    scopus 로고
    • GLP-1R and amylin agonism in metabolic disease: Complementary mechanisms and future opportunities
    • 21671898 10.1111/j.1476-5381.2011.01537.x 1:CAS:528:DC%2BC38XmsVaqsbk%3D
    • Roth JD, Erickson MR, Chen S, Parkes DG (2012) GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities. Br J Pharmacol 166:121-136
    • (2012) Br J Pharmacol , vol.166 , pp. 121-136
    • Roth, J.D.1    Erickson, M.R.2    Chen, S.3    Parkes, D.G.4
  • 41
    • 79952103793 scopus 로고    scopus 로고
    • FGF21 reloaded: Challenges of a rapidly growing field
    • 10.1016/j.tem.2010.11.003 1:CAS:528:DC%2BC3MXjsFCqsrk%3D
    • Kharitonenkov A, Larsen P (2011) FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol Metab TEM 22:81-86
    • (2011) Trends Endocrinol Metab TEM , vol.22 , pp. 81-86
    • Kharitonenkov, A.1    Larsen, P.2
  • 42
    • 75749104187 scopus 로고    scopus 로고
    • AMPK as a mediator of hormonal signalling
    • 19625456 10.1677/JME-09-0063 1:CAS:528:DC%2BC3cXhvFSitro%3D
    • Lim CT, Kola B, Korbonits M (2010) AMPK as a mediator of hormonal signalling. J Mol Endocrinol 44:87-97
    • (2010) J Mol Endocrinol , vol.44 , pp. 87-97
    • Lim, C.T.1    Kola, B.2    Korbonits, M.3
  • 46
    • 78449267024 scopus 로고    scopus 로고
    • Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus
    • 20625797 10.1007/s11010-010-0534-2 1:CAS:528:DC%2BC3cXht1Kqsb7M
    • Wen JP, Liu CE, Hu YT, Chen G, Lin LX (2010) Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus. Mol Cell Biochem 344:109-115
    • (2010) Mol Cell Biochem , vol.344 , pp. 109-115
    • Wen, J.P.1    Liu, C.E.2    Hu, Y.T.3    Chen, G.4    Lin, L.X.5
  • 47
    • 1842484296 scopus 로고    scopus 로고
    • AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
    • 15058305 10.1038/nature02440 1:CAS:528:DC%2BD2cXis1Gks7k%3D
    • Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ et al (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-574
    • (2004) Nature , vol.428 , pp. 569-574
    • Minokoshi, Y.1    Alquier, T.2    Furukawa, N.3    Kim, Y.B.4    Lee, A.5    Xue, B.6    Mu, J.7    Foufelle, F.8    Ferre, P.9    Birnbaum, M.J.10
  • 48
    • 79958175611 scopus 로고    scopus 로고
    • Ghrelin in obesity and endocrine diseases
    • 21345363 10.1016/j.mce.2011.02.011 1:CAS:528:DC%2BC3MXnsVynurs%3D
    • Scerif M, Goldstone AP, Korbonits M (2011) Ghrelin in obesity and endocrine diseases. Mol Cell Endocrinol 340:15-25
    • (2011) Mol Cell Endocrinol , vol.340 , pp. 15-25
    • Scerif, M.1    Goldstone, A.P.2    Korbonits, M.3
  • 50
    • 33645876805 scopus 로고    scopus 로고
    • Brain uptake of intranasally applied radioiodinated leptin in Wistar rats
    • 16469809 10.1210/en.2005-1016 1:CAS:528:DC%2BD28XjvFOrtLs%3D
    • Fliedner S, Schulz C, Lehnert H (2006) Brain uptake of intranasally applied radioiodinated leptin in Wistar rats. Endocrinology 147:2088-2094
    • (2006) Endocrinology , vol.147 , pp. 2088-2094
    • Fliedner, S.1    Schulz, C.2    Lehnert, H.3
  • 51
    • 0035031036 scopus 로고    scopus 로고
    • Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity
    • 11172704 10.2174/1381612013398310 1:CAS:528:DC%2BD3MXhtVGqsLY%3D
    • Banks WA (2001) Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr Pharm Des 7:125-133
    • (2001) Curr Pharm des , vol.7 , pp. 125-133
    • Banks, W.A.1
  • 52
    • 0028845877 scopus 로고
    • Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
    • 7584987 10.1038/nm1195-1155 1:CAS:528:DyaK2MXptFahs7s%3D
    • Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S et al (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
    • (1995) Nat Med , vol.1 , pp. 1155-1161
    • Maffei, M.1    Halaas, J.2    Ravussin, E.3    Pratley, R.E.4    Lee, G.H.5    Zhang, Y.6    Fei, H.7    Kim, S.8    Lallone, R.9    Ranganathan, S.10
  • 53
    • 0036000280 scopus 로고    scopus 로고
    • Leptin signalling
    • 12020765 10.1016/S0898-6568(02)00006-2 1:CAS:528:DC%2BD38XjvVegsrs%3D
    • Sweeney G (2002) Leptin signalling. Cell Signal 14:655-663
    • (2002) Cell Signal , vol.14 , pp. 655-663
    • Sweeney, G.1
  • 54
    • 79959565386 scopus 로고    scopus 로고
    • Leptin receptor signaling: Pathways to leptin resistance
    • 10.2741/3885
    • Wauman J, Tavernier J (2011) Leptin receptor signaling: pathways to leptin resistance. Front Biosci J Virtual Lib 17:2771-2793
    • (2011) Front Biosci J Virtual Lib , vol.17 , pp. 2771-2793
    • Wauman, J.1    Tavernier, J.2
  • 56
    • 33750684953 scopus 로고    scopus 로고
    • Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: A nutritional perspective of diabetes, obesity, and cancer
    • 10.1126/stke.3462006re7 10.1126/stke.3462006re7
    • Marshall S (2006) Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Sci STKE Sig Transduct Knowl Environ 2006:re7. doi: 10.1126/stke.3462006re7
    • (2006) Sci STKE Sig Transduct Knowl Environ , vol.2006 , pp. 7
    • Marshall, S.1
  • 57
    • 49049114337 scopus 로고    scopus 로고
    • The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
    • 18614690 10.1523/JNEUROSCI.1389-08.2008 1:CAS:528:DC%2BD1cXovVSgtb8%3D
    • Cota D, Matter EK, Woods SC, Seeley RJ (2008) The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci 28:7202-7208
    • (2008) J Neurosci , vol.28 , pp. 7202-7208
    • Cota, D.1    Matter, E.K.2    Woods, S.C.3    Seeley, R.J.4
  • 58
    • 0029066265 scopus 로고
    • Effects of the obese gene product on body weight regulation in ob/ob mice
    • 7624776 10.1126/science.7624776 1:CAS:528:DyaK2MXntF2ktr4%3D
    • Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
    • (1995) Science , vol.269 , pp. 540-543
    • Pelleymounter, M.A.1    Cullen, M.J.2    Baker, M.B.3    Hecht, R.4    Winters, D.5    Boone, T.6    Collins, F.7
  • 59
    • 4043082005 scopus 로고    scopus 로고
    • Regulation of adipocyte differentiation and insulin action with rapamycin
    • 15358118 10.1016/j.bbrc.2004.07.050 1:CAS:528:DC%2BD2cXmt1OgtL0%3D
    • Cho HJ, Park J, Lee HW, Lee YS, Kim JB (2004) Regulation of adipocyte differentiation and insulin action with rapamycin. Biochem Biophys Res Commun 321:942-948
    • (2004) Biochem Biophys Res Commun , vol.321 , pp. 942-948
    • Cho, H.J.1    Park, J.2    Lee, H.W.3    Lee, Y.S.4    Kim, J.B.5
  • 60
    • 0032969115 scopus 로고    scopus 로고
    • Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes
    • 10334301 10.2337/diabetes.48.2.272 1:CAS:528:DyaK1MXpsFKnsQ%3D%3D
    • Bradley RL, Cheatham B (1999) Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes 48:272-278
    • (1999) Diabetes , vol.48 , pp. 272-278
    • Bradley, R.L.1    Cheatham, B.2
  • 61
    • 10044219517 scopus 로고    scopus 로고
    • Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
    • 1:CAS:528:DC%2BD2cXhtVKktLrP
    • Hinault C, Mothe-Satney I, Gautier N, Lawrence JC Jr, Van Obberghen E (2004) Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB Off Publ Fed Am Soc Exp Biol 18:1894-1896
    • (2004) FASEB off Publ Fed Am Soc Exp Biol , vol.18 , pp. 1894-1896
    • Hinault, C.1    Mothe-Satney, I.2    Gautier, N.3    Lawrence, Jr.J.C.4    Van Obberghen, E.5
  • 62
    • 0033937071 scopus 로고    scopus 로고
    • Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
    • 10909981 10.2337/diabetes.49.7.1219 1:CAS:528:DC%2BD3cXkslOqt7s%3D
    • Burguera B, Couce ME, Curran GL, Jensen MD, Lloyd RV, Cleary MP, Poduslo JF (2000) Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes 49:1219-1223
    • (2000) Diabetes , vol.49 , pp. 1219-1223
    • Burguera, B.1    Couce, M.E.2    Curran, G.L.3    Jensen, M.D.4    Lloyd, R.V.5    Cleary, M.P.6    Poduslo, J.F.7
  • 63
  • 64
    • 0028787490 scopus 로고
    • A novel serum protein similar to C1q, produced exclusively in adipocytes
    • 7592907 10.1074/jbc.270.45.26746 1:CAS:528:DyaK2MXpsVGmurY%3D
    • Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749
    • (1995) J Biol Chem , vol.270 , pp. 26746-26749
    • Scherer, P.E.1    Williams, S.2    Fogliano, M.3    Baldini, G.4    Lodish, H.F.5
  • 66
    • 42049101804 scopus 로고    scopus 로고
    • AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
    • 18394428 10.1016/j.febslet.2008.03.037 1:CAS:528:DC%2BD1cXkvVOiu74%3D
    • Coope A, Milanski M, Araujo EP, Tambascia M, Saad MJ, Geloneze B, Velloso LA (2008) AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett 582:1471-1476
    • (2008) FEBS Lett , vol.582 , pp. 1471-1476
    • Coope, A.1    Milanski, M.2    Araujo, E.P.3    Tambascia, M.4    Saad, M.J.5    Geloneze, B.6    Velloso, L.A.7
  • 67
    • 34548673078 scopus 로고    scopus 로고
    • Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease
    • 17874043 10.1007/s00795-007-0364-9 1:CAS:528:DC%2BD2sXhtVCgu7jL
    • Takeuchi T, Adachi Y, Ohtsuki Y, Furihata M (2007) Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease. Med Mol Morphol 40:115-120
    • (2007) Med Mol Morphol , vol.40 , pp. 115-120
    • Takeuchi, T.1    Adachi, Y.2    Ohtsuki, Y.3    Furihata, M.4
  • 68
    • 33745834319 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
    • 16823476 10.1172/JCI29126 1:CAS:528:DC%2BD28XmvV2ltL0%3D
    • Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784-1792
    • (2006) J Clin Invest , vol.116 , pp. 1784-1792
    • Kadowaki, T.1    Yamauchi, T.2    Kubota, N.3    Hara, K.4    Ueki, K.5    Tobe, K.6
  • 69
    • 55749105417 scopus 로고    scopus 로고
    • Adipokines and insulin resistance
    • 19009016 10.2119/2008-00058.Rabe 1:CAS:528:DC%2BD1cXhsVOgu7jN
    • Rabe K, Lehrke M, Parhofer KG, Broedl UC (2008) Adipokines and insulin resistance. Mol Med 14:741-751
    • (2008) Mol Med , vol.14 , pp. 741-751
    • Rabe, K.1    Lehrke, M.2    Parhofer, K.G.3    Broedl, U.C.4
  • 72
    • 0034333526 scopus 로고    scopus 로고
    • Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein
    • 11044614 10.1016/S0925-4773(00)00439-1 1:CAS:528:DC%2BD3cXot12qtb0%3D
    • Ito S, Kinoshita S, Shiraishi N, Nakagawa S, Sekine S, Fujimori T, Nabeshima YI (2000) Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech Dev 98:115-119
    • (2000) Mech Dev , vol.98 , pp. 115-119
    • Ito, S.1    Kinoshita, S.2    Shiraishi, N.3    Nakagawa, S.4    Sekine, S.5    Fujimori, T.6    Nabeshima, Y.I.7
  • 73
    • 77950290841 scopus 로고    scopus 로고
    • Ghrelin: From gene to physiological function
    • 19859676 10.1007/400-2009-32 1:CAS:528:DC%2BC3cXovVKis74%3D
    • Kojima M, Kangawa K (2010) Ghrelin: from gene to physiological function. Results Probl Cell Differ 50:185-205
    • (2010) Results Probl Cell Differ , vol.50 , pp. 185-205
    • Kojima, M.1    Kangawa, K.2
  • 75
    • 0037456519 scopus 로고    scopus 로고
    • The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
    • 12597862 10.1016/S0896-6273(03)00063-1 1:CAS:528:DC%2BD3sXhvFelt7c%3D
    • Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML et al (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
    • (2003) Neuron , vol.37 , pp. 649-661
    • Cowley, M.A.1    Smith, R.G.2    Diano, S.3    Tschop, M.4    Pronchuk, N.5    Grove, K.L.6    Strasburger, C.J.7    Bidlingmaier, M.8    Esterman, M.9    Heiman, M.L.10
  • 76
    • 79958242398 scopus 로고    scopus 로고
    • Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure
    • 21173384 10.1210/er.2010-0018 1:CAS:528:DC%2BC3MXovVenu78%3D
    • Zamani N, Brown CW (2011) Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. Endocr Rev 32:387-403
    • (2011) Endocr Rev , vol.32 , pp. 387-403
    • Zamani, N.1    Brown, C.W.2
  • 77
    • 0032518236 scopus 로고    scopus 로고
    • Bone morphogenetic proteins and their receptors: Potential functions in the brain
    • 9469567 10.1002/(SICI)1097-4547(19980115)51:2<139: AID-JNR2>3.0.CO;2-E 1:CAS:528:DyaK1cXntF2rsg%3D%3D
    • Ebendal T, Bengtsson H, Soderstrom S (1998) Bone morphogenetic proteins and their receptors: potential functions in the brain. J Neurosci Res 51:139-146
    • (1998) J Neurosci Res , vol.51 , pp. 139-146
    • Ebendal, T.1    Bengtsson, H.2    Soderstrom, S.3
  • 80
    • 0024155485 scopus 로고
    • Cholecystokinin-58 is the major molecular form in man, dog and cat but not in pig, beef and rat intestine
    • 3244567 10.1016/0196-9781(88)90079-4 1:CAS:528:DyaL1MXmvFOgtg%3D%3D
    • Eberlein GA, Eysselein VE, Goebell H (1988) Cholecystokinin-58 is the major molecular form in man, dog and cat but not in pig, beef and rat intestine. Peptides 9:993-998
    • (1988) Peptides , vol.9 , pp. 993-998
    • Eberlein, G.A.1    Eysselein, V.E.2    Goebell, H.3
  • 81
    • 0035145814 scopus 로고    scopus 로고
    • The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33
    • 11232009 10.1210/jc.86.1.251 1:CAS:528:DC%2BD3MXhtVGnsb4%3D
    • Rehfeld JF, Sun G, Christensen T, Hillingso JG (2001) The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33. J Clin Endocrinol Metab 86:251-258
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 251-258
    • Rehfeld, J.F.1    Sun, G.2    Christensen, T.3    Hillingso, J.G.4
  • 82
    • 1642539151 scopus 로고    scopus 로고
    • Gastrointestinal satiety signals II. Cholecystokinin
    • 14715515 10.1152/ajpgi.00434.2003 1:CAS:528:DC%2BD2cXhsFartrY%3D
    • Moran TH, Kinzig KP (2004) Gastrointestinal satiety signals II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol 286:G183-G188
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Moran, T.H.1    Kinzig, K.P.2
  • 83
    • 0019381381 scopus 로고
    • C-terminal octapeptide of cholecystokinin decreases food intake in man
    • 6259918 1:STN:280:DyaL3M7lslSisA%3D%3D
    • Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP (1981) C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 34:154-160
    • (1981) Am J Clin Nutr , vol.34 , pp. 154-160
    • Kissileff, H.R.1    Pi-Sunyer, F.X.2    Thornton, J.3    Smith, G.P.4
  • 84
    • 78650523345 scopus 로고    scopus 로고
    • Sulfated cholecystokinin-8 activates phospho-mTOR immunoreactive neurons of the paraventricular nucleus in rats
    • 20933028 10.1016/j.peptides.2010.09.025 1:CAS:528:DC%2BC3cXhs1agt7rF
    • Lembke V, Goebel M, Frommelt L, Inhoff T, Lommel R, Stengel A, Tache Y, Grotzinger C, Bannert N, Wiedenmann B et al (2011) Sulfated cholecystokinin-8 activates phospho-mTOR immunoreactive neurons of the paraventricular nucleus in rats. Peptides 32:65-70
    • (2011) Peptides , vol.32 , pp. 65-70
    • Lembke, V.1    Goebel, M.2    Frommelt, L.3    Inhoff, T.4    Lommel, R.5    Stengel, A.6    Tache, Y.7    Grotzinger, C.8    Bannert, N.9    Wiedenmann, B.10
  • 85
    • 43549123547 scopus 로고    scopus 로고
    • Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations
    • 18469245 1:CAS:528:DC%2BD1cXmtFWjsro%3D
    • Chearskul S, Delbridge E, Shulkes A, Proietto J, Kriketos A (2008) Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. Am J Clin Nutr 87:1238-1246
    • (2008) Am J Clin Nutr , vol.87 , pp. 1238-1246
    • Chearskul, S.1    Delbridge, E.2    Shulkes, A.3    Proietto, J.4    Kriketos, A.5
  • 87
    • 0035430349 scopus 로고    scopus 로고
    • Metabolic and hemodynamic response of adipose tissue to angiotensin II
    • 11500529 10.1038/oby.2001.63 1:CAS:528:DC%2BD3MXmvVemtbg%3D
    • Boschmann M, Ringel J, Klaus S, Sharma AM (2001) Metabolic and hemodynamic response of adipose tissue to angiotensin II. Obes Res 9:486-491
    • (2001) Obes Res , vol.9 , pp. 486-491
    • Boschmann, M.1    Ringel, J.2    Klaus, S.3    Sharma, A.M.4
  • 89
    • 27944491573 scopus 로고    scopus 로고
    • Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
    • 16269974 10.1097/01.hjh.0000188734.98463.82 1:CAS:528:DC%2BD2MXhtFOhsLfE
    • Jordan J, Engeli S, Boschmann M, Weidinger G, Luft FC, Sharma AM, Kreuzberg U (2005) Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients. J Hypertens 23:2313-2318
    • (2005) J Hypertens , vol.23 , pp. 2313-2318
    • Jordan, J.1    Engeli, S.2    Boschmann, M.3    Weidinger, G.4    Luft, F.C.5    Sharma, A.M.6    Kreuzberg, U.7
  • 93
    • 7644221766 scopus 로고    scopus 로고
    • Paracrine role for periadventitial adipose tissue in the regulation of arterial tone
    • 15530643 10.1016/j.tips.2004.10.005 1:CAS:528:DC%2BD2cXpsVSjt70%3D
    • Gollasch M, Dubrovska G (2004) Paracrine role for periadventitial adipose tissue in the regulation of arterial tone. Trends Pharmacol Sci 25:647-653
    • (2004) Trends Pharmacol Sci , vol.25 , pp. 647-653
    • Gollasch, M.1    Dubrovska, G.2
  • 94
    • 84855717043 scopus 로고    scopus 로고
    • Vasodilator signals from perivascular adipose tissue
    • 21486288 10.1111/j.1476-5381.2011.01430.x 1:CAS:528:DC%2BC38XhtlWruro%3D
    • Gollasch M (2012) Vasodilator signals from perivascular adipose tissue. Br J Pharmacol 165:633-642
    • (2012) Br J Pharmacol , vol.165 , pp. 633-642
    • Gollasch, M.1
  • 95
    • 77951971550 scopus 로고    scopus 로고
    • Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
    • 10.1038/hr.2010.11 1:CAS:528:DC%2BC3cXlslSrt7g%3D
    • Ma L, Ma S, He H, Yang D, Chen X, Luo Z, Liu D, Zhu Z (2010) Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats. Hypertens Res Off J Jpn Soc Hypertens 33:446-453
    • (2010) Hypertens Res off J Jpn Soc Hypertens , vol.33 , pp. 446-453
    • Ma, L.1    Ma, S.2    He, H.3    Yang, D.4    Chen, X.5    Luo, Z.6    Liu, D.7    Zhu, Z.8
  • 97
    • 84876438500 scopus 로고    scopus 로고
    • The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001
    • 10.1002/mc.21878 22290600
    • De Angel RE, Conti CJ, Wheatley KE, Brenner AJ, Otto G, Degraffenried LA, Hursting SD (2012) The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001. Mol Carcinog. doi: 10.1002/mc.21878
    • (2012) Mol Carcinog
    • De Angel, R.E.1    Conti, C.J.2    Wheatley, K.E.3    Brenner, A.J.4    Otto, G.5    Degraffenried, L.A.6    Hursting, S.D.7


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