-
1
-
-
33645769011
-
The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease
-
16567633 10.1073/pnas.0509694103 1:CAS:528:DC%2BD28Xjslejsrs%3D
-
Shillingford JM, Murcia NS, Larson CH, Low SH, Hedgepeth R, Brown N, Flask CA, Novick AC, Goldfarb DA, Kramer-Zucker A et al (2006) The mTOR pathway is regulated by polycystin-1, and its inhibition reverses renal cystogenesis in polycystic kidney disease. Proc Natl Acad Sci U S A 103:5466-5471
-
(2006)
Proc Natl Acad Sci U S A
, vol.103
, pp. 5466-5471
-
-
Shillingford, J.M.1
Murcia, N.S.2
Larson, C.H.3
Low, S.H.4
Hedgepeth, R.5
Brown, N.6
Flask, C.A.7
Novick, A.C.8
Goldfarb, D.A.9
Kramer-Zucker, A.10
-
2
-
-
0038141979
-
Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins
-
12771962 10.1038/ncb999 1:CAS:528:DC%2BD3sXktlWnsrk%3D
-
Zhang Y, Gao X, Saucedo LJ, Ru B, Edgar BA, Pan D (2003) Rheb is a direct target of the tuberous sclerosis tumour suppressor proteins. Nat Cell Biol 5:578-581
-
(2003)
Nat Cell Biol
, vol.5
, pp. 578-581
-
-
Zhang, Y.1
Gao, X.2
Saucedo, L.J.3
Ru, B.4
Edgar, B.A.5
Pan, D.6
-
3
-
-
0442323560
-
Tuberous sclerosis complex: From Drosophila to human disease
-
15102439 10.1016/j.tcb.2003.12.006 1:CAS:528:DC%2BD2cXhtVOrtL8%3D
-
Pan D, Dong J, Zhang Y, Gao X (2004) Tuberous sclerosis complex: from Drosophila to human disease. Trends Cell Biol 14:78-85
-
(2004)
Trends Cell Biol
, vol.14
, pp. 78-85
-
-
Pan, D.1
Dong, J.2
Zhang, Y.3
Gao, X.4
-
4
-
-
0347318056
-
TSC2: Filling the GAP in the mTOR signaling pathway
-
14729330 10.1016/j.tibs.2003.11.007
-
Li Y, Corradetti MN, Inoki K, Guan KL (2004) TSC2: filling the GAP in the mTOR signaling pathway. Trends Biochem Sci 29:32-38
-
(2004)
Trends Biochem Sci
, vol.29
, pp. 32-38
-
-
Li, Y.1
Corradetti, M.N.2
Inoki, K.3
Guan, K.L.4
-
5
-
-
77956035166
-
Everolimus in patients with autosomal dominant polycystic kidney disease
-
20581392 10.1056/NEJMoa1003491 1:CAS:528:DC%2BC3cXhtVyksb3I
-
Walz G, Budde K, Mannaa M, Nurnberger J, Wanner C, Sommerer C, Kunzendorf U, Banas B, Horl WH, Obermuller N et al (2010) Everolimus in patients with autosomal dominant polycystic kidney disease. N Engl J Med 363:830-840
-
(2010)
N Engl J Med
, vol.363
, pp. 830-840
-
-
Walz, G.1
Budde, K.2
Mannaa, M.3
Nurnberger, J.4
Wanner, C.5
Sommerer, C.6
Kunzendorf, U.7
Banas, B.8
Horl, W.H.9
Obermuller, N.10
-
6
-
-
51349122645
-
Effect of mTOR inhibitor on body weight: From an experimental rat model to human transplant patients
-
10.1111/j.1432-2277.2008.00710.x
-
Rovira J, Marcelo Arellano E, Burke JT, Brault Y, Moya-Rull D, Banon-Maneus E, Ramirez-Bajo MJ, Gutierrez-Dalmau A, Revuelta I, Quintana LF et al (2008) Effect of mTOR inhibitor on body weight: from an experimental rat model to human transplant patients. Transpl Int Off J Eur Soc Organ Transplant 21:992-998
-
(2008)
Transpl Int off J Eur Soc Organ Transplant
, vol.21
, pp. 992-998
-
-
Rovira, J.1
Marcelo Arellano, E.2
Burke, J.T.3
Brault, Y.4
Moya-Rull, D.5
Banon-Maneus, E.6
Ramirez-Bajo, M.J.7
Gutierrez-Dalmau, A.8
Revuelta, I.9
Quintana, L.F.10
-
7
-
-
80052472675
-
Multicenter phase 2 trial of sirolimus for tuberous sclerosis: Kidney angiomyolipomas and other tumors regress and VEGF-D levels decrease
-
21915260 10.1371/journal.pone.0023379 1:CAS:528:DC%2BC3MXht1ent7bO
-
Dabora SL, Franz DN, Ashwal S, Sagalowsky A, DiMario FJ Jr, Miles D, Cutler D, Krueger D, Uppot RN, Rabenou R et al (2011) Multicenter phase 2 trial of sirolimus for tuberous sclerosis: kidney angiomyolipomas and other tumors regress and VEGF-D levels decrease. PLoS One 6:e23379
-
(2011)
PLoS One
, vol.6
, pp. 23379
-
-
Dabora, S.L.1
Franz, D.N.2
Ashwal, S.3
Sagalowsky, A.4
Dimario, Jr.F.J.5
Miles, D.6
Cutler, D.7
Krueger, D.8
Uppot, R.N.9
Rabenou, R.10
-
8
-
-
84858272602
-
Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats
-
22014210 10.1111/j.1476-5381.2011.01716.x 1:CAS:528:DC%2BC38Xks1eqtr4%3D
-
Deblon N, Bourgoin L, Veyrat-Durebex C, Peyrou M, Vinciguerra M, Caillon A, Maeder C, Fournier M, Montet X, Rohner-Jeanrenaud F et al (2012) Chronic mTOR inhibition by rapamycin induces muscle insulin resistance despite weight loss in rats. Br J Pharmacol 165:2325-2340
-
(2012)
Br J Pharmacol
, vol.165
, pp. 2325-2340
-
-
Deblon, N.1
Bourgoin, L.2
Veyrat-Durebex, C.3
Peyrou, M.4
Vinciguerra, M.5
Caillon, A.6
Maeder, C.7
Fournier, M.8
Montet, X.9
Rohner-Jeanrenaud, F.10
-
9
-
-
42449104351
-
MTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes
-
18174523 10.2337/db07-0922 1:CAS:528:DC%2BD1cXksVGkuro%3D
-
Fraenkel M, Ketzinel-Gilad M, Ariav Y, Pappo O, Karaca M, Castel J, Berthault MF, Magnan C, Cerasi E, Kaiser N et al (2008) mTOR inhibition by rapamycin prevents beta-cell adaptation to hyperglycemia and exacerbates the metabolic state in type 2 diabetes. Diabetes 57:945-957
-
(2008)
Diabetes
, vol.57
, pp. 945-957
-
-
Fraenkel, M.1
Ketzinel-Gilad, M.2
Ariav, Y.3
Pappo, O.4
Karaca, M.5
Castel, J.6
Berthault, M.F.7
Magnan, C.8
Cerasi, E.9
Kaiser, N.10
-
10
-
-
38849201733
-
Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat
-
10.1152/ajprenal.00379.2007
-
Kramer S, Wang-Rosenke Y, Scholl V, Binder E, Loof T, Khadzhynov D, Kawachi H, Shimizu F, Diekmann F, Budde K et al (2008) Low-dose mTOR inhibition by rapamycin attenuates progression in anti-thy1-induced chronic glomerulosclerosis of the rat. Am J Physiol Ren Physiol 294:F440-F449
-
(2008)
Am J Physiol Ren Physiol
, vol.294
-
-
Kramer, S.1
Wang-Rosenke, Y.2
Scholl, V.3
Binder, E.4
Loof, T.5
Khadzhynov, D.6
Kawachi, H.7
Shimizu, F.8
Diekmann, F.9
Budde, K.10
-
11
-
-
33644859253
-
Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD)
-
16221708 10.1093/ndt/gfi181 1:CAS:528:DC%2BD28XhvVeksL8%3D
-
Wahl PR, Serra AL, Le Hir M, Molle KD, Hall MN, Wuthrich RP (2006) Inhibition of mTOR with sirolimus slows disease progression in Han:SPRD rats with autosomal dominant polycystic kidney disease (ADPKD). Nephrol Dial Transplant 21:598-604
-
(2006)
Nephrol Dial Transplant
, vol.21
, pp. 598-604
-
-
Wahl, P.R.1
Serra, A.L.2
Le Hir, M.3
Molle, K.D.4
Hall, M.N.5
Wuthrich, R.P.6
-
12
-
-
77952083662
-
Rapamycin extends maximal lifespan in cancer-prone mice
-
20363920 10.2353/ajpath.2010.091050 1:CAS:528:DC%2BC3cXmvFSqsLk%3D
-
Anisimov VN, Zabezhinski MA, Popovich IG, Piskunova TS, Semenchenko AV, Tyndyk ML, Yurova MN, Antoch MP, Blagosklonny MV (2010) Rapamycin extends maximal lifespan in cancer-prone mice. Am J Pathol 176:2092-2097
-
(2010)
Am J Pathol
, vol.176
, pp. 2092-2097
-
-
Anisimov, V.N.1
Zabezhinski, M.A.2
Popovich, I.G.3
Piskunova, T.S.4
Semenchenko, A.V.5
Tyndyk, M.L.6
Yurova, M.N.7
Antoch, M.P.8
Blagosklonny, M.V.9
-
13
-
-
67649950978
-
Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis
-
19244201 10.1165/rcmb.2008-0377OC 1:CAS:528:DC%2BD1MXhtlCktbzI
-
Korfhagen TR, Le Cras TD, Davidson CR, Schmidt SM, Ikegami M, Whitsett JA, Hardie WD (2009) Rapamycin prevents transforming growth factor-alpha-induced pulmonary fibrosis. Am J Respir Cell Mol Biol 41:562-572
-
(2009)
Am J Respir Cell Mol Biol
, vol.41
, pp. 562-572
-
-
Korfhagen, T.R.1
Le Cras, T.D.2
Davidson, C.R.3
Schmidt, S.M.4
Ikegami, M.5
Whitsett, J.A.6
Hardie, W.D.7
-
14
-
-
66249088672
-
Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice
-
19372632 10.1254/jphs.08215FP 1:CAS:528:DC%2BD1MXlsFSguro%3D
-
Chang GR, Chiu YS, Wu YY, Chen WY, Liao JW, Chao TH, Mao FC (2009) Rapamycin protects against high fat diet-induced obesity in C57BL/6J mice. J Pharmacol Sci 109:496-503
-
(2009)
J Pharmacol Sci
, vol.109
, pp. 496-503
-
-
Chang, G.R.1
Chiu, Y.S.2
Wu, Y.Y.3
Chen, W.Y.4
Liao, J.W.5
Chao, T.H.6
Mao, F.C.7
-
15
-
-
56449115916
-
Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis
-
10.1016/j.cmet.2008.10.004 1:CAS:528:DC%2BD1cXhsV2qtbjF
-
Blouet C, Ono H, Schwartz GJ (2008) Mediobasal hypothalamic p70 S6 kinase 1 modulates the control of energy homeostasis. Cell Metabol 8:459-467
-
(2008)
Cell Metabol
, vol.8
, pp. 459-467
-
-
Blouet, C.1
Ono, H.2
Schwartz, G.J.3
-
16
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
16690869 10.1126/science.1124147 1:CAS:528:DC%2BD28Xktlyhs7Y%3D
-
Cota D, Proulx K, Smith KAB, Kozma SC, Thomas G, Woods SC, Seeley RJ (2006) Hypothalamic mTOR signaling regulates food intake. Science 312:927-930
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.B.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
17
-
-
33745052121
-
MTOR tells the brain that the body is hungry
-
16761005 10.1038/nm0606-615 1:CAS:528:DC%2BD28XltlOjs7c%3D
-
Kahn BB, Myers MG (2006) mTOR tells the brain that the body is hungry. Nat Med 12:615-617
-
(2006)
Nat Med
, vol.12
, pp. 615-617
-
-
Kahn, B.B.1
Myers, M.G.2
-
18
-
-
33748931457
-
Central nervous system control of food intake and body weight
-
16988703 10.1038/nature05026 1:CAS:528:DC%2BD28Xpslalu7c%3D
-
Morton GJ, Cummings DE, Baskin DG, Barsh GS, Schwartz MW (2006) Central nervous system control of food intake and body weight. Nature 443:289-295
-
(2006)
Nature
, vol.443
, pp. 289-295
-
-
Morton, G.J.1
Cummings, D.E.2
Baskin, D.G.3
Barsh, G.S.4
Schwartz, M.W.5
-
19
-
-
78650510609
-
MTOR: From growth signal integration to cancer, diabetes and ageing
-
21157483 10.1038/nrm3025 1:CAS:528:DC%2BC3cXhsFGqsbnK
-
Zoncu R, Efeyan A, Sabatini DM (2011) mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12:21-35
-
(2011)
Nat Rev Mol Cell Biol
, vol.12
, pp. 21-35
-
-
Zoncu, R.1
Efeyan, A.2
Sabatini, D.M.3
-
20
-
-
79851500081
-
Everolimus for advanced pancreatic neuroendocrine tumors
-
21306238 10.1056/NEJMoa1009290 1:CAS:528:DC%2BC3MXhvVyiu7s%3D
-
Yao JC, Shah MH, Ito T, Bohas CL, Wolin EM, Van Cutsem E, Hobday TJ, Okusaka T, Capdevila J, de Vries EG et al (2011) Everolimus for advanced pancreatic neuroendocrine tumors. N Engl J Med 364:514-523
-
(2011)
N Engl J Med
, vol.364
, pp. 514-523
-
-
Yao, J.C.1
Shah, M.H.2
Ito, T.3
Bohas, C.L.4
Wolin, E.M.5
Van Cutsem, E.6
Hobday, T.J.7
Okusaka, T.8
Capdevila, J.9
De Vries, E.G.10
-
21
-
-
36148962868
-
Role of mTOR in solid tumor systems: A therapeutical target against primary tumor growth, metastases, and angiogenesis
-
17713840 10.1007/s10555-007-9077-8
-
Seeliger H, Guba M, Kleespies A, Jauch KW, Bruns CJ (2007) Role of mTOR in solid tumor systems: a therapeutical target against primary tumor growth, metastases, and angiogenesis. Cancer Metastasis Rev 26:611-621
-
(2007)
Cancer Metastasis Rev
, vol.26
, pp. 611-621
-
-
Seeliger, H.1
Guba, M.2
Kleespies, A.3
Jauch, K.W.4
Bruns, C.J.5
-
22
-
-
48649085311
-
Post-kidney transplant weight change as marker of poor survival outcomes
-
18497685 10.1097/TP.0b013e31816f1cd3
-
Chang SH, McDonald SP (2008) Post-kidney transplant weight change as marker of poor survival outcomes. Transplantation 85:1443-1448
-
(2008)
Transplantation
, vol.85
, pp. 1443-1448
-
-
Chang, S.H.1
McDonald, S.P.2
-
23
-
-
84859117806
-
Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity
-
22461615 10.1126/science.1215135 1:CAS:528:DC%2BC38XksVyqsbY%3D
-
Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS et al (2012) Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity. Science 335:1638-1643
-
(2012)
Science
, vol.335
, pp. 1638-1643
-
-
Lamming, D.W.1
Ye, L.2
Katajisto, P.3
Goncalves, M.D.4
Saitoh, M.5
Stevens, D.M.6
Davis, J.G.7
Salmon, A.B.8
Richardson, A.9
Ahima, R.S.10
-
24
-
-
84878834146
-
Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors
-
10.1002/ijc.28023 23319457
-
Figlin RA, Kaufmann I, Brechbiel J (2013) Targeting PI3K and mTORC2 in metastatic renal cell carcinoma: New strategies for overcoming resistance to VEGFR and mTORC1 inhibitors. Int J Cancer. doi: 10.1002/ijc.28023
-
(2013)
Int J Cancer
-
-
Figlin, R.A.1
Kaufmann, I.2
Brechbiel, J.3
-
25
-
-
56249147509
-
Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
-
18955708 10.1073/pnas.0809136105 1:CAS:528:DC%2BD1cXhsVWns7rJ
-
Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J (2008) Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci USA 105:17414-17419
-
(2008)
Proc Natl Acad Sci USA
, vol.105
, pp. 17414-17419
-
-
Choo, A.Y.1
Yoon, S.O.2
Kim, S.G.3
Roux, P.P.4
Blenis, J.5
-
26
-
-
84872054005
-
Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor
-
23184952 10.1074/jbc.M112.402461 1:CAS:528:DC%2BC3sXjtlOjsg%3D%3D
-
Dennis MD, Kimball SR, Jefferson LS (2013) Mechanistic target of rapamycin complex 1 (mTORC1)-mediated phosphorylation is governed by competition between substrates for interaction with raptor. J Biol Chem 288:10-19
-
(2013)
J Biol Chem
, vol.288
, pp. 10-19
-
-
Dennis, M.D.1
Kimball, S.R.2
Jefferson, L.S.3
-
27
-
-
3342895823
-
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
-
10.1016/j.cub.2004.06.054 1:CAS:528:DC%2BD2cXmtVamsLs%3D
-
Sarbassov DD, Ali SM, Kim DH, Guertin DA, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM (2004) Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton. Curr Biol CB 14:1296-1302
-
(2004)
Curr Biol CB
, vol.14
, pp. 1296-1302
-
-
Sarbassov, D.D.1
Ali, S.M.2
Kim, D.H.3
Guertin, D.A.4
Latek, R.R.5
Erdjument-Bromage, H.6
Tempst, P.7
Sabatini, D.M.8
-
28
-
-
85047690626
-
The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis
-
12897210 1:CAS:528:DC%2BD3sXmtFemtrg%3D
-
Cota D, Marsicano G, Tschöp M, Grübler Y, Flachskamm C, Schubert M, Auer D, Yassouridis A, Thöne-Reineke C, Ortmann S et al (2003) The endogenous cannabinoid system affects energy balance via central orexigenic drive and peripheral lipogenesis. J Clin Invest 112:423-431
-
(2003)
J Clin Invest
, vol.112
, pp. 423-431
-
-
Cota, D.1
Marsicano, G.2
Tschöp, M.3
Grübler, Y.4
Flachskamm, C.5
Schubert, M.6
Auer, D.7
Yassouridis, A.8
Thöne-Reineke, C.9
Ortmann, S.10
-
29
-
-
40949150324
-
A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss
-
18057094 10.2337/db07-0573 1:CAS:528:DC%2BD1cXjt1ChtLc%3D
-
Ropelle ER, Pauli JR, Fernandes MFA, Rocco SA, Marin RM, Morari J, Souza KK, Dias MM, Gomes-Marcondes MC, Gontijo JAR et al (2008) A central role for neuronal AMP-activated protein kinase (AMPK) and mammalian target of rapamycin (mTOR) in high-protein diet-induced weight loss. Diabetes 57:594-605
-
(2008)
Diabetes
, vol.57
, pp. 594-605
-
-
Ropelle, E.R.1
Pauli, J.R.2
Fernandes, M.F.A.3
Rocco, S.A.4
Marin, R.M.5
Morari, J.6
Souza, K.K.7
Dias, M.M.8
Gomes-Marcondes, M.C.9
Gontijo, J.A.R.10
-
30
-
-
0035798097
-
Mammalian TOR: A homeostatic ATP sensor
-
11691993 10.1126/science.1063518 1:CAS:528:DC%2BD3MXot1Krtrc%3D
-
Dennis PB, Jaeschke A, Saitoh M, Fowler B, Kozma SC, Thomas G (2001) Mammalian TOR: a homeostatic ATP sensor. Science 294:1102-1105
-
(2001)
Science
, vol.294
, pp. 1102-1105
-
-
Dennis, P.B.1
Jaeschke, A.2
Saitoh, M.3
Fowler, B.4
Kozma, S.C.5
Thomas, G.6
-
31
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
7984236 10.1038/372425a0 1:CAS:528:DyaK2MXisVGqsbs%3D
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
32
-
-
0031733326
-
Effect of fasting and leptin deficiency on hypothalamic neuropeptide y gene transcription in vivo revealed by expression of a lacZ reporter gene
-
9564880 10.1210/en.139.5.2629 1:CAS:528:DyaK1cXivFShsbs%3D
-
Schwartz MW, Erickson JC, Baskin DG, Palmiter RD (1998) Effect of fasting and leptin deficiency on hypothalamic neuropeptide Y gene transcription in vivo revealed by expression of a lacZ reporter gene. Endocrinology 139:2629-2635
-
(1998)
Endocrinology
, vol.139
, pp. 2629-2635
-
-
Schwartz, M.W.1
Erickson, J.C.2
Baskin, D.G.3
Palmiter, R.D.4
-
33
-
-
12344277552
-
Diabetes, obesity, and the brain
-
15662002 10.1126/science.1104344 1:CAS:528:DC%2BD2MXksFyhsQ%3D%3D
-
Schwartz MW, Porte D Jr (2005) Diabetes, obesity, and the brain. Science 307:375-379
-
(2005)
Science
, vol.307
, pp. 375-379
-
-
Schwartz, M.W.1
Porte, Jr.D.2
-
34
-
-
37549040190
-
The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS
-
18054335 10.1016/j.febslet.2007.11.070 1:CAS:528:DC%2BD2sXhsVOltb3E
-
Kadowaki T, Yamauchi T, Kubota N (2008) The physiological and pathophysiological role of adiponectin and adiponectin receptors in the peripheral tissues and CNS. FEBS Lett 582:74-80
-
(2008)
FEBS Lett
, vol.582
, pp. 74-80
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
-
35
-
-
0032905886
-
The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight
-
9927499 10.1172/JCI4901 1:CAS:528:DyaK1MXovVKmtg%3D%3D
-
Kopin AS, Mathes WF, McBride EW, Nguyen M, Al-Haider W, Schmitz F, Bonner-Weir S, Kanarek R, Beinborn M (1999) The cholecystokinin-A receptor mediates inhibition of food intake yet is not essential for the maintenance of body weight. J Clin Invest 103:383-391
-
(1999)
J Clin Invest
, vol.103
, pp. 383-391
-
-
Kopin, A.S.1
Mathes, W.F.2
McBride, E.W.3
Nguyen, M.4
Al-Haider, W.5
Schmitz, F.6
Bonner-Weir, S.7
Kanarek, R.8
Beinborn, M.9
-
36
-
-
27644577645
-
Role of cholecystokinin in appetite control and body weight regulation
-
10.1111/j.1467-789X.2005.00212.x 1:CAS:528:DC%2BD2MXht1OlurzN
-
Little TJ, Horowitz M, Feinle-Bisset C (2005) Role of cholecystokinin in appetite control and body weight regulation. Obes Rev Off J Int Assoc Study Obes 6:297-306
-
(2005)
Obes Rev off J Int Assoc Study Obes
, vol.6
, pp. 297-306
-
-
Little, T.J.1
Horowitz, M.2
Feinle-Bisset, C.3
-
37
-
-
0034850444
-
Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: A physiological approach toward improved metabolic control
-
11472273 10.2174/1381612013397357 1:CAS:528:DC%2BD3MXmt1Shurs%3D
-
Weyer C, Maggs DG, Young AA, Kolterman OG (2001) Amylin replacement with pramlintide as an adjunct to insulin therapy in type 1 and type 2 diabetes mellitus: a physiological approach toward improved metabolic control. Curr Pharm Des 7:1353-1373
-
(2001)
Curr Pharm des
, vol.7
, pp. 1353-1373
-
-
Weyer, C.1
Maggs, D.G.2
Young, A.A.3
Kolterman, O.G.4
-
38
-
-
0346094442
-
Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat
-
14715154 10.1016/j.brainres.2003.10.040 1:CAS:528:DC%2BD2cXjsV2gtw%3D%3D
-
Barth SW, Riediger T, Lutz TA, Rechkemmer G (2004) Peripheral amylin activates circumventricular organs expressing calcitonin receptor a/b subtypes and receptor-activity modifying proteins in the rat. Brain Res 997:97-102
-
(2004)
Brain Res
, vol.997
, pp. 97-102
-
-
Barth, S.W.1
Riediger, T.2
Lutz, T.A.3
Rechkemmer, G.4
-
39
-
-
84859733684
-
GLP-1R and amylin agonism in metabolic disease: Complementary mechanisms and future opportunities
-
21671898 10.1111/j.1476-5381.2011.01537.x 1:CAS:528:DC%2BC38XmsVaqsbk%3D
-
Roth JD, Erickson MR, Chen S, Parkes DG (2012) GLP-1R and amylin agonism in metabolic disease: complementary mechanisms and future opportunities. Br J Pharmacol 166:121-136
-
(2012)
Br J Pharmacol
, vol.166
, pp. 121-136
-
-
Roth, J.D.1
Erickson, M.R.2
Chen, S.3
Parkes, D.G.4
-
40
-
-
0035843183
-
A role for ghrelin in the central regulation of feeding
-
11196643 10.1038/35051587 1:CAS:528:DC%2BD3MXlvFSmsg%3D%3D
-
Nakazato M, Murakami N, Date Y, Kojima M, Matsuo H, Kangawa K, Matsukura S (2001) A role for ghrelin in the central regulation of feeding. Nature 409:194-198
-
(2001)
Nature
, vol.409
, pp. 194-198
-
-
Nakazato, M.1
Murakami, N.2
Date, Y.3
Kojima, M.4
Matsuo, H.5
Kangawa, K.6
Matsukura, S.7
-
41
-
-
79952103793
-
FGF21 reloaded: Challenges of a rapidly growing field
-
10.1016/j.tem.2010.11.003 1:CAS:528:DC%2BC3MXjsFCqsrk%3D
-
Kharitonenkov A, Larsen P (2011) FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol Metab TEM 22:81-86
-
(2011)
Trends Endocrinol Metab TEM
, vol.22
, pp. 81-86
-
-
Kharitonenkov, A.1
Larsen, P.2
-
42
-
-
75749104187
-
AMPK as a mediator of hormonal signalling
-
19625456 10.1677/JME-09-0063 1:CAS:528:DC%2BC3cXhvFSitro%3D
-
Lim CT, Kola B, Korbonits M (2010) AMPK as a mediator of hormonal signalling. J Mol Endocrinol 44:87-97
-
(2010)
J Mol Endocrinol
, vol.44
, pp. 87-97
-
-
Lim, C.T.1
Kola, B.2
Korbonits, M.3
-
43
-
-
1842582870
-
AMP-activated protein kinase plays a role in the control of food intake
-
14742438 10.1074/jbc.C300557200 1:CAS:528:DC%2BD2cXitl2htb8%3D
-
Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ (2004) AMP-activated protein kinase plays a role in the control of food intake. J Biol Chem 279:12005-12008
-
(2004)
J Biol Chem
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
Woods, A.4
Smith, K.5
Bloom, S.R.6
Carling, D.7
Small, C.J.8
-
44
-
-
21644453934
-
Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase
-
15899896 10.1074/jbc.C500175200 1:CAS:528:DC%2BD2MXlsFyqtL8%3D
-
Kola B, Hubina E, Tucci SA, Kirkham TC, Garcia EA, Mitchell SE, Williams LM, Hawley SA, Hardie DG, Grossman AB et al (2005) Cannabinoids and ghrelin have both central and peripheral metabolic and cardiac effects via AMP-activated protein kinase. J Biol Chem 280:25196-25201
-
(2005)
J Biol Chem
, vol.280
, pp. 25196-25201
-
-
Kola, B.1
Hubina, E.2
Tucci, S.A.3
Kirkham, T.C.4
Garcia, E.A.5
Mitchell, S.E.6
Williams, L.M.7
Hawley, S.A.8
Hardie, D.G.9
Grossman, A.B.10
-
45
-
-
34347255023
-
Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake
-
17618856 10.1016/j.cmet.2007.06.003 1:CAS:528:DC%2BD2sXotlCitLs%3D
-
Kubota N, Yano W, Kubota T, Yamauchi T, Itoh S, Kumagai H, Kozono H, Takamoto I, Okamoto S, Shiuchi T et al (2007) Adiponectin stimulates AMP-activated protein kinase in the hypothalamus and increases food intake. Cell Metab 6:55-68
-
(2007)
Cell Metab
, vol.6
, pp. 55-68
-
-
Kubota, N.1
Yano, W.2
Kubota, T.3
Yamauchi, T.4
Itoh, S.5
Kumagai, H.6
Kozono, H.7
Takamoto, I.8
Okamoto, S.9
Shiuchi, T.10
-
46
-
-
78449267024
-
Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus
-
20625797 10.1007/s11010-010-0534-2 1:CAS:528:DC%2BC3cXht1Kqsb7M
-
Wen JP, Liu CE, Hu YT, Chen G, Lin LX (2010) Globular adiponectin regulates energy homeostasis through AMP-activated protein kinase-acetyl-CoA carboxylase (AMPK/ACC) pathway in the hypothalamus. Mol Cell Biochem 344:109-115
-
(2010)
Mol Cell Biochem
, vol.344
, pp. 109-115
-
-
Wen, J.P.1
Liu, C.E.2
Hu, Y.T.3
Chen, G.4
Lin, L.X.5
-
47
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
15058305 10.1038/nature02440 1:CAS:528:DC%2BD2cXis1Gks7k%3D
-
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ et al (2004) AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428:569-574
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
Kim, Y.B.4
Lee, A.5
Xue, B.6
Mu, J.7
Foufelle, F.8
Ferre, P.9
Birnbaum, M.J.10
-
48
-
-
79958175611
-
Ghrelin in obesity and endocrine diseases
-
21345363 10.1016/j.mce.2011.02.011 1:CAS:528:DC%2BC3MXnsVynurs%3D
-
Scerif M, Goldstone AP, Korbonits M (2011) Ghrelin in obesity and endocrine diseases. Mol Cell Endocrinol 340:15-25
-
(2011)
Mol Cell Endocrinol
, vol.340
, pp. 15-25
-
-
Scerif, M.1
Goldstone, A.P.2
Korbonits, M.3
-
49
-
-
84885318604
-
Everolimus und Energiemetabolismus bei Patienten mit autosomal-dominant vererbbarer Zystennierenerkrankung
-
Berlin A44-11/1424
-
Boschmann M, Mannaa M, Pfennigwerth P, Gaedeke J, Budde K, Gollasch M (2011) Everolimus und Energiemetabolismus bei Patienten mit autosomal-dominant vererbbarer Zystennierenerkrankung. 3 Jahrestagung der Deutschen Gesellschaft für Nephrologie, Berlin A44-11/1424
-
(2011)
3 Jahrestagung der Deutschen Gesellschaft für Nephrologie
-
-
Boschmann, M.1
Mannaa, M.2
Pfennigwerth, P.3
Gaedeke, J.4
Budde, K.5
Gollasch, M.6
-
50
-
-
33645876805
-
Brain uptake of intranasally applied radioiodinated leptin in Wistar rats
-
16469809 10.1210/en.2005-1016 1:CAS:528:DC%2BD28XjvFOrtLs%3D
-
Fliedner S, Schulz C, Lehnert H (2006) Brain uptake of intranasally applied radioiodinated leptin in Wistar rats. Endocrinology 147:2088-2094
-
(2006)
Endocrinology
, vol.147
, pp. 2088-2094
-
-
Fliedner, S.1
Schulz, C.2
Lehnert, H.3
-
51
-
-
0035031036
-
Leptin transport across the blood-brain barrier: Implications for the cause and treatment of obesity
-
11172704 10.2174/1381612013398310 1:CAS:528:DC%2BD3MXhtVGqsLY%3D
-
Banks WA (2001) Leptin transport across the blood-brain barrier: implications for the cause and treatment of obesity. Curr Pharm Des 7:125-133
-
(2001)
Curr Pharm des
, vol.7
, pp. 125-133
-
-
Banks, W.A.1
-
52
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
7584987 10.1038/nm1195-1155 1:CAS:528:DyaK2MXptFahs7s%3D
-
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S et al (1995) Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1:1155-1161
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
-
53
-
-
0036000280
-
Leptin signalling
-
12020765 10.1016/S0898-6568(02)00006-2 1:CAS:528:DC%2BD38XjvVegsrs%3D
-
Sweeney G (2002) Leptin signalling. Cell Signal 14:655-663
-
(2002)
Cell Signal
, vol.14
, pp. 655-663
-
-
Sweeney, G.1
-
54
-
-
79959565386
-
Leptin receptor signaling: Pathways to leptin resistance
-
10.2741/3885
-
Wauman J, Tavernier J (2011) Leptin receptor signaling: pathways to leptin resistance. Front Biosci J Virtual Lib 17:2771-2793
-
(2011)
Front Biosci J Virtual Lib
, vol.17
, pp. 2771-2793
-
-
Wauman, J.1
Tavernier, J.2
-
55
-
-
80053258367
-
Leptin in human physiology and pathophysiology
-
21791620 10.1152/ajpendo.00315.2011 1:CAS:528:DC%2BC3MXhtlersbzE
-
Mantzoros CS, Magkos F, Brinkoetter M, Sienkiewicz E, Dardeno TA, Kim SY, Hamnvik OP, Koniaris A (2011) Leptin in human physiology and pathophysiology. Am J Physiol Endocrinol Metab 301:E567-E584
-
(2011)
Am J Physiol Endocrinol Metab
, vol.301
-
-
Mantzoros, C.S.1
Magkos, F.2
Brinkoetter, M.3
Sienkiewicz, E.4
Dardeno, T.A.5
Kim, S.Y.6
Hamnvik, O.P.7
Koniaris, A.8
-
56
-
-
33750684953
-
Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: A nutritional perspective of diabetes, obesity, and cancer
-
10.1126/stke.3462006re7 10.1126/stke.3462006re7
-
Marshall S (2006) Role of insulin, adipocyte hormones, and nutrient-sensing pathways in regulating fuel metabolism and energy homeostasis: a nutritional perspective of diabetes, obesity, and cancer. Sci STKE Sig Transduct Knowl Environ 2006:re7. doi: 10.1126/stke.3462006re7
-
(2006)
Sci STKE Sig Transduct Knowl Environ
, vol.2006
, pp. 7
-
-
Marshall, S.1
-
57
-
-
49049114337
-
The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity
-
18614690 10.1523/JNEUROSCI.1389-08.2008 1:CAS:528:DC%2BD1cXovVSgtb8%3D
-
Cota D, Matter EK, Woods SC, Seeley RJ (2008) The role of hypothalamic mammalian target of rapamycin complex 1 signaling in diet-induced obesity. J Neurosci 28:7202-7208
-
(2008)
J Neurosci
, vol.28
, pp. 7202-7208
-
-
Cota, D.1
Matter, E.K.2
Woods, S.C.3
Seeley, R.J.4
-
58
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
7624776 10.1126/science.7624776 1:CAS:528:DyaK2MXntF2ktr4%3D
-
Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
Hecht, R.4
Winters, D.5
Boone, T.6
Collins, F.7
-
59
-
-
4043082005
-
Regulation of adipocyte differentiation and insulin action with rapamycin
-
15358118 10.1016/j.bbrc.2004.07.050 1:CAS:528:DC%2BD2cXmt1OgtL0%3D
-
Cho HJ, Park J, Lee HW, Lee YS, Kim JB (2004) Regulation of adipocyte differentiation and insulin action with rapamycin. Biochem Biophys Res Commun 321:942-948
-
(2004)
Biochem Biophys Res Commun
, vol.321
, pp. 942-948
-
-
Cho, H.J.1
Park, J.2
Lee, H.W.3
Lee, Y.S.4
Kim, J.B.5
-
60
-
-
0032969115
-
Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes
-
10334301 10.2337/diabetes.48.2.272 1:CAS:528:DyaK1MXpsFKnsQ%3D%3D
-
Bradley RL, Cheatham B (1999) Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes. Diabetes 48:272-278
-
(1999)
Diabetes
, vol.48
, pp. 272-278
-
-
Bradley, R.L.1
Cheatham, B.2
-
61
-
-
10044219517
-
Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice
-
1:CAS:528:DC%2BD2cXhtVKktLrP
-
Hinault C, Mothe-Satney I, Gautier N, Lawrence JC Jr, Van Obberghen E (2004) Amino acids and leucine allow insulin activation of the PKB/mTOR pathway in normal adipocytes treated with wortmannin and in adipocytes from db/db mice. FASEB Off Publ Fed Am Soc Exp Biol 18:1894-1896
-
(2004)
FASEB off Publ Fed Am Soc Exp Biol
, vol.18
, pp. 1894-1896
-
-
Hinault, C.1
Mothe-Satney, I.2
Gautier, N.3
Lawrence, Jr.J.C.4
Van Obberghen, E.5
-
62
-
-
0033937071
-
Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats
-
10909981 10.2337/diabetes.49.7.1219 1:CAS:528:DC%2BD3cXkslOqt7s%3D
-
Burguera B, Couce ME, Curran GL, Jensen MD, Lloyd RV, Cleary MP, Poduslo JF (2000) Obesity is associated with a decreased leptin transport across the blood-brain barrier in rats. Diabetes 49:1219-1223
-
(2000)
Diabetes
, vol.49
, pp. 1219-1223
-
-
Burguera, B.1
Couce, M.E.2
Curran, G.L.3
Jensen, M.D.4
Lloyd, R.V.5
Cleary, M.P.6
Poduslo, J.F.7
-
63
-
-
0031766571
-
Plasma leptin turnover rates in lean and obese Zucker rats
-
9794453 10.1210/en.139.11.4466 1:CAS:528:DyaK1cXntFWltrs%3D
-
Vila R, Adan C, Rafecas I, Fernandez-Lopez JA, Remesar X, Alemany M (1998) Plasma leptin turnover rates in lean and obese Zucker rats. Endocrinology 139:4466-4469
-
(1998)
Endocrinology
, vol.139
, pp. 4466-4469
-
-
Vila, R.1
Adan, C.2
Rafecas, I.3
Fernandez-Lopez, J.A.4
Remesar, X.5
Alemany, M.6
-
64
-
-
0028787490
-
A novel serum protein similar to C1q, produced exclusively in adipocytes
-
7592907 10.1074/jbc.270.45.26746 1:CAS:528:DyaK2MXpsVGmurY%3D
-
Scherer PE, Williams S, Fogliano M, Baldini G, Lodish HF (1995) A novel serum protein similar to C1q, produced exclusively in adipocytes. J Biol Chem 270:26746-26749
-
(1995)
J Biol Chem
, vol.270
, pp. 26746-26749
-
-
Scherer, P.E.1
Williams, S.2
Fogliano, M.3
Baldini, G.4
Lodish, H.F.5
-
65
-
-
34547828786
-
Adiponectin is a novel humoral vasodilator
-
17617391 10.1016/j.cardiores.2007.05.025
-
Fesus G, Dubrovska G, Gorzelniak K, Kluge R, Huang Y, Luft FC, Gollasch M (2007) Adiponectin is a novel humoral vasodilator. Cardiovasc Res 75:719-727
-
(2007)
Cardiovasc Res
, vol.75
, pp. 719-727
-
-
Fesus, G.1
Dubrovska, G.2
Gorzelniak, K.3
Kluge, R.4
Huang, Y.5
Luft, F.C.6
Gollasch, M.7
-
66
-
-
42049101804
-
AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus
-
18394428 10.1016/j.febslet.2008.03.037 1:CAS:528:DC%2BD1cXkvVOiu74%3D
-
Coope A, Milanski M, Araujo EP, Tambascia M, Saad MJ, Geloneze B, Velloso LA (2008) AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus. FEBS Lett 582:1471-1476
-
(2008)
FEBS Lett
, vol.582
, pp. 1471-1476
-
-
Coope, A.1
Milanski, M.2
Araujo, E.P.3
Tambascia, M.4
Saad, M.J.5
Geloneze, B.6
Velloso, L.A.7
-
67
-
-
34548673078
-
Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease
-
17874043 10.1007/s00795-007-0364-9 1:CAS:528:DC%2BD2sXhtVCgu7jL
-
Takeuchi T, Adachi Y, Ohtsuki Y, Furihata M (2007) Adiponectin receptors, with special focus on the role of the third receptor, T-cadherin, in vascular disease. Med Mol Morphol 40:115-120
-
(2007)
Med Mol Morphol
, vol.40
, pp. 115-120
-
-
Takeuchi, T.1
Adachi, Y.2
Ohtsuki, Y.3
Furihata, M.4
-
68
-
-
33745834319
-
Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
-
16823476 10.1172/JCI29126 1:CAS:528:DC%2BD28XmvV2ltL0%3D
-
Kadowaki T, Yamauchi T, Kubota N, Hara K, Ueki K, Tobe K (2006) Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome. J Clin Invest 116:1784-1792
-
(2006)
J Clin Invest
, vol.116
, pp. 1784-1792
-
-
Kadowaki, T.1
Yamauchi, T.2
Kubota, N.3
Hara, K.4
Ueki, K.5
Tobe, K.6
-
69
-
-
55749105417
-
Adipokines and insulin resistance
-
19009016 10.2119/2008-00058.Rabe 1:CAS:528:DC%2BD1cXhsVOgu7jN
-
Rabe K, Lehrke M, Parhofer KG, Broedl UC (2008) Adipokines and insulin resistance. Mol Med 14:741-751
-
(2008)
Mol Med
, vol.14
, pp. 741-751
-
-
Rabe, K.1
Lehrke, M.2
Parhofer, K.G.3
Broedl, U.C.4
-
70
-
-
41649109108
-
BetaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c
-
18187602 10.1210/me.2007-0313 1:CAS:528:DC%2BD1cXkt1Cntr8%3D
-
Suzuki M, Uehara Y, Motomura-Matsuzaka K, Oki J, Koyama Y, Kimura M, Asada M, Komi-Kuramochi A, Oka S, Imamura T (2008) betaKlotho is required for fibroblast growth factor (FGF) 21 signaling through FGF receptor (FGFR) 1c and FGFR3c. Mol Endocrinol 22:1006-1014
-
(2008)
Mol Endocrinol
, vol.22
, pp. 1006-1014
-
-
Suzuki, M.1
Uehara, Y.2
Motomura-Matsuzaka, K.3
Oki, J.4
Koyama, Y.5
Kimura, M.6
Asada, M.7
Komi-Kuramochi, A.8
Oka, S.9
Imamura, T.10
-
71
-
-
34249697012
-
BetaKlotho is required for metabolic activity of fibroblast growth factor 21
-
17452648 10.1073/pnas.0701600104 1:CAS:528:DC%2BD2sXlslGhtr4%3D
-
Ogawa Y, Kurosu H, Yamamoto M, Nandi A, Rosenblatt KP, Goetz R, Eliseenkova AV, Mohammadi M, Kuro-o M (2007) BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci USA 104:7432-7437
-
(2007)
Proc Natl Acad Sci USA
, vol.104
, pp. 7432-7437
-
-
Ogawa, Y.1
Kurosu, H.2
Yamamoto, M.3
Nandi, A.4
Rosenblatt, K.P.5
Goetz, R.6
Eliseenkova, A.V.7
Mohammadi, M.8
Kuro-O, M.9
-
72
-
-
0034333526
-
Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein
-
11044614 10.1016/S0925-4773(00)00439-1 1:CAS:528:DC%2BD3cXot12qtb0%3D
-
Ito S, Kinoshita S, Shiraishi N, Nakagawa S, Sekine S, Fujimori T, Nabeshima YI (2000) Molecular cloning and expression analyses of mouse betaklotho, which encodes a novel Klotho family protein. Mech Dev 98:115-119
-
(2000)
Mech Dev
, vol.98
, pp. 115-119
-
-
Ito, S.1
Kinoshita, S.2
Shiraishi, N.3
Nakagawa, S.4
Sekine, S.5
Fujimori, T.6
Nabeshima, Y.I.7
-
73
-
-
77950290841
-
Ghrelin: From gene to physiological function
-
19859676 10.1007/400-2009-32 1:CAS:528:DC%2BC3cXovVKis74%3D
-
Kojima M, Kangawa K (2010) Ghrelin: from gene to physiological function. Results Probl Cell Differ 50:185-205
-
(2010)
Results Probl Cell Differ
, vol.50
, pp. 185-205
-
-
Kojima, M.1
Kangawa, K.2
-
74
-
-
38149059686
-
Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents
-
17936372 10.1016/j.regpep.2007.09.006 1:CAS:528:DC%2BD1cXosFKgsg%3D%3D
-
Egecioglu E, Stenstrom B, Pinnock SB, Tung LY, Dornonville de la Cour C, Lindqvist A, Hakanson R, Syversen U, Chen D, Dickson SL (2008) Hypothalamic gene expression following ghrelin therapy to gastrectomized rodents. Regul Pept 146:176-182
-
(2008)
Regul Pept
, vol.146
, pp. 176-182
-
-
Egecioglu, E.1
Stenstrom, B.2
Pinnock, S.B.3
Tung, L.Y.4
Dornonville De La Cour, C.5
Lindqvist, A.6
Hakanson, R.7
Syversen, U.8
Chen, D.9
Dickson, S.L.10
-
75
-
-
0037456519
-
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis
-
12597862 10.1016/S0896-6273(03)00063-1 1:CAS:528:DC%2BD3sXhvFelt7c%3D
-
Cowley MA, Smith RG, Diano S, Tschop M, Pronchuk N, Grove KL, Strasburger CJ, Bidlingmaier M, Esterman M, Heiman ML et al (2003) The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron 37:649-661
-
(2003)
Neuron
, vol.37
, pp. 649-661
-
-
Cowley, M.A.1
Smith, R.G.2
Diano, S.3
Tschop, M.4
Pronchuk, N.5
Grove, K.L.6
Strasburger, C.J.7
Bidlingmaier, M.8
Esterman, M.9
Heiman, M.L.10
-
76
-
-
79958242398
-
Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure
-
21173384 10.1210/er.2010-0018 1:CAS:528:DC%2BC3MXovVenu78%3D
-
Zamani N, Brown CW (2011) Emerging roles for the transforming growth factor-{beta} superfamily in regulating adiposity and energy expenditure. Endocr Rev 32:387-403
-
(2011)
Endocr Rev
, vol.32
, pp. 387-403
-
-
Zamani, N.1
Brown, C.W.2
-
77
-
-
0032518236
-
Bone morphogenetic proteins and their receptors: Potential functions in the brain
-
9469567 10.1002/(SICI)1097-4547(19980115)51:2<139: AID-JNR2>3.0.CO;2-E 1:CAS:528:DyaK1cXntF2rsg%3D%3D
-
Ebendal T, Bengtsson H, Soderstrom S (1998) Bone morphogenetic proteins and their receptors: potential functions in the brain. J Neurosci Res 51:139-146
-
(1998)
J Neurosci Res
, vol.51
, pp. 139-146
-
-
Ebendal, T.1
Bengtsson, H.2
Soderstrom, S.3
-
78
-
-
84860897594
-
Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway
-
10.1096/fj.11-199067
-
Townsend KL, Suzuki R, Huang TL, Jing E, Schulz TJ, Lee K, Taniguchi CM, Espinoza DO, McDougall LE, Zhang H et al (2012) Bone morphogenetic protein 7 (BMP7) reverses obesity and regulates appetite through a central mTOR pathway. FASEB Jour Off Publ Fed Am Soc Exp Biol. doi: 10.1096/fj.11-199067
-
(2012)
FASEB Jour off Publ Fed Am Soc Exp Biol
-
-
Townsend, K.L.1
Suzuki, R.2
Huang, T.L.3
Jing, E.4
Schulz, T.J.5
Lee, K.6
Taniguchi, C.M.7
Espinoza, D.O.8
McDougall, L.E.9
Zhang, H.10
-
79
-
-
50049127055
-
New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure
-
18719589 10.1038/nature07221 1:CAS:528:DC%2BD1cXhtVWns7rP
-
Tseng YH, Kokkotou E, Schulz TJ, Huang TL, Winnay JN, Taniguchi CM, Tran TT, Suzuki R, Espinoza DO, Yamamoto Y et al (2008) New role of bone morphogenetic protein 7 in brown adipogenesis and energy expenditure. Nature 454:1000-1004
-
(2008)
Nature
, vol.454
, pp. 1000-1004
-
-
Tseng, Y.H.1
Kokkotou, E.2
Schulz, T.J.3
Huang, T.L.4
Winnay, J.N.5
Taniguchi, C.M.6
Tran, T.T.7
Suzuki, R.8
Espinoza, D.O.9
Yamamoto, Y.10
-
80
-
-
0024155485
-
Cholecystokinin-58 is the major molecular form in man, dog and cat but not in pig, beef and rat intestine
-
3244567 10.1016/0196-9781(88)90079-4 1:CAS:528:DyaL1MXmvFOgtg%3D%3D
-
Eberlein GA, Eysselein VE, Goebell H (1988) Cholecystokinin-58 is the major molecular form in man, dog and cat but not in pig, beef and rat intestine. Peptides 9:993-998
-
(1988)
Peptides
, vol.9
, pp. 993-998
-
-
Eberlein, G.A.1
Eysselein, V.E.2
Goebell, H.3
-
81
-
-
0035145814
-
The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33
-
11232009 10.1210/jc.86.1.251 1:CAS:528:DC%2BD3MXhtVGnsb4%3D
-
Rehfeld JF, Sun G, Christensen T, Hillingso JG (2001) The predominant cholecystokinin in human plasma and intestine is cholecystokinin-33. J Clin Endocrinol Metab 86:251-258
-
(2001)
J Clin Endocrinol Metab
, vol.86
, pp. 251-258
-
-
Rehfeld, J.F.1
Sun, G.2
Christensen, T.3
Hillingso, J.G.4
-
82
-
-
1642539151
-
Gastrointestinal satiety signals II. Cholecystokinin
-
14715515 10.1152/ajpgi.00434.2003 1:CAS:528:DC%2BD2cXhsFartrY%3D
-
Moran TH, Kinzig KP (2004) Gastrointestinal satiety signals II. Cholecystokinin. Am J Physiol Gastrointest Liver Physiol 286:G183-G188
-
(2004)
Am J Physiol Gastrointest Liver Physiol
, vol.286
-
-
Moran, T.H.1
Kinzig, K.P.2
-
83
-
-
0019381381
-
C-terminal octapeptide of cholecystokinin decreases food intake in man
-
6259918 1:STN:280:DyaL3M7lslSisA%3D%3D
-
Kissileff HR, Pi-Sunyer FX, Thornton J, Smith GP (1981) C-terminal octapeptide of cholecystokinin decreases food intake in man. Am J Clin Nutr 34:154-160
-
(1981)
Am J Clin Nutr
, vol.34
, pp. 154-160
-
-
Kissileff, H.R.1
Pi-Sunyer, F.X.2
Thornton, J.3
Smith, G.P.4
-
84
-
-
78650523345
-
Sulfated cholecystokinin-8 activates phospho-mTOR immunoreactive neurons of the paraventricular nucleus in rats
-
20933028 10.1016/j.peptides.2010.09.025 1:CAS:528:DC%2BC3cXhs1agt7rF
-
Lembke V, Goebel M, Frommelt L, Inhoff T, Lommel R, Stengel A, Tache Y, Grotzinger C, Bannert N, Wiedenmann B et al (2011) Sulfated cholecystokinin-8 activates phospho-mTOR immunoreactive neurons of the paraventricular nucleus in rats. Peptides 32:65-70
-
(2011)
Peptides
, vol.32
, pp. 65-70
-
-
Lembke, V.1
Goebel, M.2
Frommelt, L.3
Inhoff, T.4
Lommel, R.5
Stengel, A.6
Tache, Y.7
Grotzinger, C.8
Bannert, N.9
Wiedenmann, B.10
-
85
-
-
43549123547
-
Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations
-
18469245 1:CAS:528:DC%2BD1cXmtFWjsro%3D
-
Chearskul S, Delbridge E, Shulkes A, Proietto J, Kriketos A (2008) Effect of weight loss and ketosis on postprandial cholecystokinin and free fatty acid concentrations. Am J Clin Nutr 87:1238-1246
-
(2008)
Am J Clin Nutr
, vol.87
, pp. 1238-1246
-
-
Chearskul, S.1
Delbridge, E.2
Shulkes, A.3
Proietto, J.4
Kriketos, A.5
-
86
-
-
80054955347
-
Long-term persistence of hormonal adaptations to weight loss
-
22029981 10.1056/NEJMoa1105816 1:CAS:528:DC%2BC3MXhsVSrsrbP
-
Sumithran P, Prendergast LA, Delbridge E, Purcell K, Shulkes A, Kriketos A, Proietto J (2011) Long-term persistence of hormonal adaptations to weight loss. N Engl J Med 365:1597-1604
-
(2011)
N Engl J Med
, vol.365
, pp. 1597-1604
-
-
Sumithran, P.1
Prendergast, L.A.2
Delbridge, E.3
Purcell, K.4
Shulkes, A.5
Kriketos, A.6
Proietto, J.7
-
87
-
-
0035430349
-
Metabolic and hemodynamic response of adipose tissue to angiotensin II
-
11500529 10.1038/oby.2001.63 1:CAS:528:DC%2BD3MXmvVemtbg%3D
-
Boschmann M, Ringel J, Klaus S, Sharma AM (2001) Metabolic and hemodynamic response of adipose tissue to angiotensin II. Obes Res 9:486-491
-
(2001)
Obes Res
, vol.9
, pp. 486-491
-
-
Boschmann, M.1
Ringel, J.2
Klaus, S.3
Sharma, A.M.4
-
88
-
-
0036875581
-
Gender-specific response to interstitial angiotensin II in human white adipose tissue
-
10.1055/s-2002-38262 1:CAS:528:DC%2BD3sXis1alur4%3D
-
Boschmann M, Jordan J, Schmidt S, Adams F, Luft FC, Klaus S (2002) Gender-specific response to interstitial angiotensin II in human white adipose tissue. Horm Metab Res Horm Stoffwechselforschung Horm Metab 34:726-730
-
(2002)
Horm Metab Res Horm Stoffwechselforschung Horm Metab
, vol.34
, pp. 726-730
-
-
Boschmann, M.1
Jordan, J.2
Schmidt, S.3
Adams, F.4
Luft, F.C.5
Klaus, S.6
-
89
-
-
27944491573
-
Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients
-
16269974 10.1097/01.hjh.0000188734.98463.82 1:CAS:528:DC%2BD2MXhtFOhsLfE
-
Jordan J, Engeli S, Boschmann M, Weidinger G, Luft FC, Sharma AM, Kreuzberg U (2005) Hemodynamic and metabolic responses to valsartan and atenolol in obese hypertensive patients. J Hypertens 23:2313-2318
-
(2005)
J Hypertens
, vol.23
, pp. 2313-2318
-
-
Jordan, J.1
Engeli, S.2
Boschmann, M.3
Weidinger, G.4
Luft, F.C.5
Sharma, A.M.6
Kreuzberg, U.7
-
90
-
-
0037409237
-
The adipose-tissue renin-angiotensin-aldosterone system: Role in the metabolic syndrome?
-
12676168 10.1016/S1357-2725(02)00311-4 1:CAS:528:DC%2BD3sXisFShurk%3D
-
Engeli S, Schling P, Gorzelniak K, Boschmann M, Janke J, Ailhaud G, Teboul M, Massiera F, Sharma AM (2003) The adipose-tissue renin-angiotensin- aldosterone system: role in the metabolic syndrome? Int J Biochem Cell Biol 35:807-825
-
(2003)
Int J Biochem Cell Biol
, vol.35
, pp. 807-825
-
-
Engeli, S.1
Schling, P.2
Gorzelniak, K.3
Boschmann, M.4
Janke, J.5
Ailhaud, G.6
Teboul, M.7
Massiera, F.8
Sharma, A.M.9
-
91
-
-
33745003718
-
The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects
-
10.1055/s-2006-925406 1:CAS:528:DC%2BD28XnsVeit78%3D
-
Boschmann M, Kreuzberg U, Engeli S, Adams F, Franke G, Klaua S, Scholze J, Weidinger G, Luft FC, Sharma AM et al (2006) The effect of oral glucose loads on tissue metabolism during angiotensin II receptor and beta-receptor blockade in obese hypertensive subjects. Horm Metab Res Horm Stoffwechselforschung Horm Metab 38:323-329
-
(2006)
Horm Metab Res Horm Stoffwechselforschung Horm Metab
, vol.38
, pp. 323-329
-
-
Boschmann, M.1
Kreuzberg, U.2
Engeli, S.3
Adams, F.4
Franke, G.5
Klaua, S.6
Scholze, J.7
Weidinger, G.8
Luft, F.C.9
Sharma, A.M.10
-
92
-
-
0036837826
-
Regulation of arterial tone by smooth muscle myosin type II
-
12372799 10.1152/ajpcell.01369.2000 1:CAS:528:DC%2BD38XovVOmu7w%3D
-
Lohn M, Kampf D, Gui-Xuan C, Haller H, Luft FC, Gollasch M (2002) Regulation of arterial tone by smooth muscle myosin type II. Am J Physiol Cell Physiol 283:C1383-C1389
-
(2002)
Am J Physiol Cell Physiol
, vol.283
-
-
Lohn, M.1
Kampf, D.2
Gui-Xuan, C.3
Haller, H.4
Luft, F.C.5
Gollasch, M.6
-
93
-
-
7644221766
-
Paracrine role for periadventitial adipose tissue in the regulation of arterial tone
-
15530643 10.1016/j.tips.2004.10.005 1:CAS:528:DC%2BD2cXpsVSjt70%3D
-
Gollasch M, Dubrovska G (2004) Paracrine role for periadventitial adipose tissue in the regulation of arterial tone. Trends Pharmacol Sci 25:647-653
-
(2004)
Trends Pharmacol Sci
, vol.25
, pp. 647-653
-
-
Gollasch, M.1
Dubrovska, G.2
-
94
-
-
84855717043
-
Vasodilator signals from perivascular adipose tissue
-
21486288 10.1111/j.1476-5381.2011.01430.x 1:CAS:528:DC%2BC38XhtlWruro%3D
-
Gollasch M (2012) Vasodilator signals from perivascular adipose tissue. Br J Pharmacol 165:633-642
-
(2012)
Br J Pharmacol
, vol.165
, pp. 633-642
-
-
Gollasch, M.1
-
95
-
-
77951971550
-
Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats
-
10.1038/hr.2010.11 1:CAS:528:DC%2BC3cXlslSrt7g%3D
-
Ma L, Ma S, He H, Yang D, Chen X, Luo Z, Liu D, Zhu Z (2010) Perivascular fat-mediated vascular dysfunction and remodeling through the AMPK/mTOR pathway in high-fat diet-induced obese rats. Hypertens Res Off J Jpn Soc Hypertens 33:446-453
-
(2010)
Hypertens Res off J Jpn Soc Hypertens
, vol.33
, pp. 446-453
-
-
Ma, L.1
Ma, S.2
He, H.3
Yang, D.4
Chen, X.5
Luo, Z.6
Liu, D.7
Zhu, Z.8
-
96
-
-
0037382861
-
Rapamycin attenuates load-induced cardiac hypertrophy in mice
-
12668503 10.1161/01.CIR.0000057979.36322.88 1:CAS:528: DC%2BD3sXit12msL4%3D
-
Shioi T, McMullen JR, Tarnavski O, Converso K, Sherwood MC, Manning WJ, Izumo S (2003) Rapamycin attenuates load-induced cardiac hypertrophy in mice. Circulation 107:1664-1670
-
(2003)
Circulation
, vol.107
, pp. 1664-1670
-
-
Shioi, T.1
McMullen, J.R.2
Tarnavski, O.3
Converso, K.4
Sherwood, M.C.5
Manning, W.J.6
Izumo, S.7
-
97
-
-
84876438500
-
The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001
-
10.1002/mc.21878 22290600
-
De Angel RE, Conti CJ, Wheatley KE, Brenner AJ, Otto G, Degraffenried LA, Hursting SD (2012) The enhancing effects of obesity on mammary tumor growth and Akt/mTOR pathway activation persist after weight loss and are reversed by RAD001. Mol Carcinog. doi: 10.1002/mc.21878
-
(2012)
Mol Carcinog
-
-
De Angel, R.E.1
Conti, C.J.2
Wheatley, K.E.3
Brenner, A.J.4
Otto, G.5
Degraffenried, L.A.6
Hursting, S.D.7
-
98
-
-
33646352217
-
Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats
-
16597691 10.1681/ASN.2005050549 1:CAS:528:DC%2BD28XkvVKrsbo%3D
-
Lloberas N, Cruzado JM, Franquesa M, Herrero-Fresneda I, Torras J, Alperovich G, Rama I, Vidal A, Grinyo JM (2006) Mammalian target of rapamycin pathway blockade slows progression of diabetic kidney disease in rats. J Am Soc Nephrol 17:1395-1404
-
(2006)
J Am Soc Nephrol
, vol.17
, pp. 1395-1404
-
-
Lloberas, N.1
Cruzado, J.M.2
Franquesa, M.3
Herrero-Fresneda, I.4
Torras, J.5
Alperovich, G.6
Rama, I.7
Vidal, A.8
Grinyo, J.M.9
|