Receptors involved in cell activation by antiphospholipid antibodies

Thrombosis Research

Volumn 132, Issue 4, 2013, Pages 408-413

  Brandt, Karim J ^a   Kruithof, Egbert K O ^a   De Moerloose, Philippe ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

Antiphospholipid antibodies; Antiphospholipid syndrome; Pregnancy Morbidity; Thrombosis; Toll like receptors

Indexed keywords

BETA2 GLYCOPROTEIN 1; CD14 ANTIGEN; LIPOCORTIN 2; LOW DENSITY LIPOPROTEIN RECEPTOR RELATED PROTEIN; PHOSPHOLIPID ANTIBODY; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8;

ANTIPHOSPHOLIPID SYNDROME; CELL ACTIVATION; ENDOCYTOSIS; ENDOTHELIUM CELL; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INTERNALIZATION; MONOCYTE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVIEW; SIGNAL TRANSDUCTION; THROMBOCYTE ACTIVATION;

ANTIPHOSPHOLIPID ANTIBODIES; ANTIPHOSPHOLIPID SYNDROME; PREGNANCY MORBIDITY; THROMBOSIS; TOLL LIKE RECEPTORS;

ANIMALS; ANNEXIN A2; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; HUMANS; RECEPTORS, LDL; THROMBOSIS; TOLL-LIKE RECEPTORS;

EID: 84885191223     PISSN: 00493848     EISSN: 18792472     Source Type: Journal    
DOI: 10.1016/j.thromres.2013.08.015     Document Type: Review

References (94)

1. S. Miyakis, M.D. Lockshin, T. Atsumi, D.W. Branch, R.L. Brey, and R. Cervera International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS) J Thromb Haemost 4 2006 295 306
2. P. Lieby, A. Soley, H. Levallois, B. Hugel, J.M. Freyssinet, and M. Cerutti The clonal analysis of anticardiolipin antibodies in a single patient with primary antiphospholipid syndrome reveals an extreme antibody heterogeneity Blood 97 2001 3820 3828
3. A. Ruffatti, M. Tonello, M.S. Visentin, A. Bontadi, A. Hoxha, and S. De Carolis Risk factors for pregnancy failure in patients with anti-phospholipid syndrome treated with conventional therapies: a multicentre, case-control study Rheumatology (Oxford) 50 2011 1684 1689
4. V. Pengo, A. Ruffatti, T. Del Ross, M. Tonello, S. Cuffaro, and A. Hoxha Confirmation of the initial antiphospholipid antibody positivity depends on antiphospholipid antibody profile J Thromb Haemost 11 2013 1527 1531
5. Y. Shoenfeld, M. Blank, R. Cervera, J. Font, E. Raschi, and P.L. Meroni Infectious origin of the antiphospholipid syndrome Ann Rheum Dis 65 2006 2 6
6. D. Wahl, A. Membre, C. Perret-Guillaume, V. Regnault, and T. Lecompte Mechanisms of antiphospholipid-induced thrombosis: effects on the protein C system Curr Rheumatol Rep 11 2009 77 81
7. B. de Laat, C.M. Eckmann, M. van Schagen, A.B. Meijer, K. Mertens, and J.A. van Mourik Correlation between the potency of a beta2-glycoprotein I-dependent lupus anticoagulant and the level of resistance to activated protein C Blood Coagul Fibrinolysis 19 2008 757 764
8. J.H. Rand, X.-X. Wu, A.S. Quinn, A.W. Ashton, P.P. Chen, and J.J. Hathcock Hydroxychloroquine protects the annexin A5 anticoagulant shield from disruption by antiphospholipid antibodies: evidence for a novel effect for an old antimalarial drug Blood 115 2010 2292 2299
9. K. Oku, O. Amengual, and T. Atsumi Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome Eur J Clin Invest 42 2012 1126 1135
10. S.S. Pierangeli, M. Colden-Stanfield, X. Liu, J.H. Barker, G.L. Anderson, and E.N. Harris Antiphospholipid antibodies from antiphospholipid syndome patients activate endothelial cells in vitro and in vivo Circulation 99 1999 1997 2002
11. B. de Laat, K. Mertens, and P.G. de Groot Mechanisms of Disease: antiphospholipid antibodies[mdash]from clinical association to pathologic mechanism Nat Clin Pract Rheum 4 2008 192 199
12. S.S. Pierangeli, R.G. Espinola, X. Liu, and E.N. Harris Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin Circ Res 88 2001 245 250
13. R.G. Espinola, X. Liu, M. Colden-Stanfield, J. Hall, E.N. Harris, and S.S. Pierangeli E-Selectin mediates pathogenic effects of antiphospholipid antibodies J Thromb Haemost 1 2003 843 848
14. P.L. Meroni, M.O. Borghi, E. Raschi, D. Ventura, P.C. Sarzi Puttini, and F. Atzeni Inflammatory response and the endothelium Thromb Res 114 2004 329 334
15. S. Dunoyer-Geindre, E.K. Kruithof, B. Galve-de Rochemonteix, C. Rosnoblet, J. Gruenberg, and G. Reber Localization of beta2-glycoprotein 1 in late endosomes of human endothelial cells Thromb Haemost 85 2001 903 907
16. S.S. Pierangeli, and E.N. Harris Probing antiphospholipid-mediated thrombosis: the interplay between anticardiolipin antibodies and endothelial cells Lupus 12 2003 539 545
17. P.L. Meroni, E. Raschi, C. Testoni, and M.O. Borghi Endothelial cell activation by antiphospholipid antibodies Clin Immunol 112 2004 169 174
18. M.J. Cuadrado, C. Lopez-Pedrera, M.A. Khamashta, M.T. Camps, F. Tinahones, and A. Torres Thrombosis in primary antiphospholipid syndrome: a pivotal role for monocyte tissue factor expression Arthritis Rheum 40 1997 834 841
19. J.E. Salmon, G. Girardi, and V.M. Holers Complement activation as a mediator of antiphospholipid antibody induced pregnancy loss and thrombosis Ann Rheum Dis 61 Suppl. 2 2002 ii46 ii50
20. A. Carrera-Marín, Z. Romay-Penabad, E. Papalardo, E. Reyes-Maldonado, E. García-Latorre, and G. Vargas C6 knock-out mice are protected from thrombophilia mediated by antiphospholipid antibodies Lupus 21 2012 1497 1505
21. J. Berman, G. Girardi, and J.E. Salmon TNF-alpha is a critical effector and a target for therapy in antiphospholipid antibody-induced pregnancy loss J Immunol 174 2005 485 490
22. V.M. Abrahams Mechanisms of antiphospholipid antibody-associated pregnancy complications Thromb Res 124 2009 521 525
23. J. Kwak-Kim, M.S.L. Agcaoili, L. Aleta, A. Liao, K. Ota, and S. Dambaeva Management of Women with Recurrent Pregnancy Losses and Antiphospholipid Antibody Syndrome Am J Reprod Immunol 69 2013 596 607
24. B. de Laat, M. van Berkel, R.T. Urbanus, B. Siregar, P.G. de Groot, and M.F. Gebbink Immune responses against domain I of beta(2)-glycoprotein I are driven by conformational changes: domain I of beta(2)-glycoprotein I harbors a cryptic immunogenic epitope Arthritis Rheum 63 2011 3960 3968
25. G.M. Iverson, E.J. Victoria, and D.M. Marquis Anti-beta2 glycoprotein I (beta2GPI) autoantibodies recognize an epitope on the first domain of beta2GPI Proc Natl Acad Sci U S A 95 1998 15542 15546
26. C. Agar, G.M. van Os, M. Morgelin, R.R. Sprenger, J.A. Marquart, and R.T. Urbanus Beta2-glycoprotein I can exist in 2 conformations: implications for our understanding of the antiphospholipid syndrome Blood 116 2010 1336 1343
27. R. Takeuchi, T. Atsumi, M. Ieko, H. Takeya, S. Yasuda, and K. Ichikawa Coagulation and fibrinolytic activities in 2 siblings with β2-glycoprotein I deficiency Blood 96 2000 1594 1595
28. C. Agar, P.G. de Groot, M. Morgelin, S.D. Monk, G. van Os, and J.H. Levels beta-glycoprotein I: a novel component of innate immunity Blood 117 2011 6939 6947
29. S.S. Pierangeli, M.E. Vega-Ostertag, E. Raschi, X. Liu, Z. Romay-Penabad, and V. De Micheli Toll-like receptor and antiphospholipid mediated thrombosis: in vivo studies Ann Rheum Dis 66 2007 1327 1333
30. Z. Romay-Penabad, M.G. Montiel-Manzano, T. Shilagard, E. Papalardo, G. Vargas, and A.B. Deora Annexin A2 is involved in antiphospholipid antibody-mediated pathogenic effects in vitro and in vivo Blood 114 2009 3074 3083
31. Z. Romay-Penabad, R. Aguilar-Valenzuela, R.T. Urbanus, R.H.W.M. Derksen, M.T.T. Pennings, and E. Papalardo Apolipoprotein E receptor 2 is involved in the thrombotic complications in a murine model of the antiphospholipid syndrome Blood 117 2011 1408 1414
32. N. Satta, S. Dunoyer-Geindre, G. Reber, R.J. Fish, F. Boehlen, and E.K. Kruithof The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies Blood 109 2007 1507 1514
33. J.E. Alard, F. Gaillard, C. Daridon, Y. Shoenfeld, C. Jamin, and P. Youinou TLR2 is one of the endothelial receptors for beta 2-glycoprotein I J Immunol 185 2010 1550 1557
34. N. Satta, E.K. Kruithof, C. Fickentscher, S. Dunoyer-Geindre, F. Boehlen, and G. Reber Toll-like receptor 2 mediates the activation of human monocytes and endothelial cells by antiphospholipid antibodies Blood 117 2011 5523 5531
35. T. Shi, B. Giannakopoulos, X. Yan, P. Yu, M.C. Berndt, and R.K. Andrews Anti-beta2-glycoprotein I antibodies in complex with beta2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V Arthritis Rheum 54 2006 2558 2567
36. Y. Döring, J. Hurst, M. Lorenz, N. Prinz, N. Clemens, and M.D. Drechsler Human antiphospholipid antibodies induce TNFα in monocytes via Toll-like receptor 8 Immunobiology 215 2010 230 241
37. T. Kawai, and S. Akira The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors Nat Immunol 11 2010 373 384
38. K.H. Mills TLR-dependent T, cell activation in autoimmunity Nat Rev Immunol 11 2011 807 822
39. J.Y. Kang, X. Nan, M.S. Jin, S.J. Youn, Y.H. Ryu, and S. Mah Recognition of lipopeptide patterns by Toll-like receptor 2-Toll-like receptor 6 heterodimer Immunity 31 2009 873 884
40. M.S. Jin, S.E. Kim, J.Y. Heo, M.E. Lee, H.M. Kim, and S.G. Paik Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide Cell 130 2007 1071 1082
41. M.J. Jimenez-Dalmaroni, N. Xiao, A.L. Corper, P. Verdino, G.D. Ainge, and D.S. Larsen Soluble CD36 Ectodomain Binds Negatively Charged Diacylglycerol Ligands and Acts as a Co-Receptor for TLR2 PLoS One 4 2009 e7411
42. M. Triantafilou, F.G. Gamper, R.M. Haston, M.A. Mouratis, S. Morath, and T. Hartung Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting J Biol Chem 281 2006 31002 31011
43. M.L. Marre, T. Petnicki-Ocwieja, A.S. DeFrancesco, C.T. Darcy, and L.T. Hu Human Integrin a3B1 Regulates TLR2 Recognition of Lipopeptides from Endosomal Compartments PLoS One 5 2010 e12871
44. I. Zanoni, R. Ostuni, L.R. Marek, S. Barresi, R. Barbalat, and G.M. Barton CD14 controls the LPS-induced endocytosis of Toll-like receptor 4 Cell 147 2011 868 880
45. R. Barbalat, L. Lau, R.M. Locksley, and G.M. Barton Toll-like receptor 2 on inflammatory monocytes induces type I interferon in response to viral but not bacterial ligands Nat Immunol 10 2009 1200 1207
46. M. Fischer, and M. Ehlers Toll-like Receptors in Autoimmunity Ann N Y Acad Sci 1143 2008 21 34
47. E. Faure, O. Equils, P.A. Sieling, L. Thomas, F.X. Zhang, and C.J. Kirschning Bacterial lipopolysaccharide activates NF-kappaB through toll-like receptor 4 (TLR-4) in cultured human dermal endothelial cells. Differential expression of TLR-4 and TLR-2 in endothelial cells J Biol Chem 275 2000 11058 11063
48. N. Hijiya, K. Miyake, S. Akashi, K. Matsuura, Y. Higuchi, and S. Yamamoto Possible involvement of toll-like receptor 4 in endothelial cell activation of larger vessels in response to lipopolysaccharide Pathobiology 70 2002 18 25
49. E. Faure, L. Thomas, H. Xu, A. Medvedev, O. Equils, and M. Arditi Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation J Immunol 166 2001 2018 2024
50. S. Ehrentraut, R. Lohner, M. Schwederski, H. Ehrentraut, O. Boehm, and S. Noga In vivo Toll-like receptor 4 antagonism restores cardiac function during endotoxemia Shock 36 2011 613 620
51. J. Talreja, M.B.F. Kabir MH, D.J. Stechschulte, and K.N. Dileepan Histamine induces Toll-like receptor 2 and 4 expression in endothelial cells and enhances sensitivity to Gram-positive and Gram-negative bacterial cell wall components Immunology 113 2004 224 233
52. N. Satta, E.K. Kruithof, G. Reber, and P. de Moerloose Induction of TLR2 expression by inflammatory stimuli is required for endothelial cell responses to lipopeptides Mol Immunol 46 2008 145 157
53. F. Cognasse, H. Hamzeh, P. Chavarin, S. Acquart, C. Genin, and O. Garraud Evidence of Toll-like receptor molecules on human platelets Immunol Cell Biol 83 2005 196 198
54. M.K. Brunialti, and P.S. Martins Barbosa de Carvalho H, Machado FR, Barbosa LM, Salomao R. TLR2, TLR4, CD14, CD11B, and CD11C expressions on monocytes surface and cytokine production in patients with sepsis, severe sepsis, and septic shock Shock 25 2006 351 357
55. M. Sorice, A. Longo, A. Capozzi, T. Garofalo, R. Misasi, and C. Alessandri Anti-beta2-glycoprotein I antibodies induce monocyte release of tumor necrosis factor alpha and tissue factor by signal transduction pathways involving lipid rafts Arthritis Rheum 56 2007 2687 2697
56. N. Prinz, N. Clemens, D. Strand, I. Pütz, M. Lorenz, and A. Daiber Antiphospholipid antibodies induce translocation of TLR7 and TLR8 to the endosome in human monocytes and plasmacytoid dendritic cells Blood 118 2011 2322 2332
57. G. Gladigau, P. Haselmayer, I. Scharrer, M. Munder, N. Prinz, and K. Lackner A Role for Toll-Like Receptor Mediated Signals in Neutrophils in the Pathogenesis of the Anti-Phospholipid Syndrome PLoS One 7 2012 e42176
58. F. Fischetti, P. Durigutto, V. Pellis, A. Debeus, P. Macor, and R. Bulla Thrombus formation induced by antibodies to β2-glycoprotein I is complement dependent and requires a priming factor Blood 106 2005 2340 2346
59. S. Ramesh, C.N. Morrell, C. Tarango, G.D. Thomas, I.S. Yuhanna, and G. Girardi Antiphospholipid antibodies promote leukocyte-endothelial cell adhesion and thrombosis in mice by antagonizing eNOS via β2GPI and apoER2 J Clin Invest 121 2011 120 131
60. H. Amital, M. Govoni, R. Maya, P.L. Meroni, B. Ori, and Y. Shoenfeld Role of infectious agents in systemic rheumatic diseases Clin Exp Rheumatol 26 2008 S27 S32
61. C. Agostinis, S. Biffi, C. Garrovo, P. Durigutto, A. Lorenzon, and A. Bek In vivo distribution of β2 glycoprotein I under various pathophysiologic conditions Blood 118 2011 4231 4238
62. A. Lateef, and M. Petri Hormone replacement and contraceptive therapy in autoimmune diseases J Autoimmun 38 2012 J170 J176
63. B.C. Lutters, R.H. Derksen, W.L. Tekelenburg, P.J. Lenting, J. Arnout, and P.G. de Groot Dimers of beta 2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2' J Biol Chem 278 2003 33831 33838
64. M.T. Pennings, M. van Lummel, R.H. Derksen, R.T. Urbanus, R.A. Romijn, and P.J. Lenting Interaction of beta2-glycoprotein I with members of the low density lipoprotein receptor family J Thromb Haemost 4 2006 1680 1690
65. R.T. Urbanus, M.T. Pennings, R.H. Derksen, and P.G. de Groot Platelet activation by dimeric beta2-glycoprotein I requires signaling via both glycoprotein Ibalpha and apolipoprotein E receptor 2' J Thromb Haemost 6 2008 1405 1412
66. P. de Groot, R. Derksen, and R. Urbanus The role of LRP8 (ApoER2') in the pathophysiology of the antiphospholipid syndrome Lupus 19 2010 389 393
67. K. Ma, R. Simantov, J.C. Zhang, R. Silverstein, K.A. Hajjar, and K.R. McCrae High affinity binding of beta 2-glycoprotein I to human endothelial cells is mediated by annexin II J Biol Chem 275 2000 15541 15548
68. J. Zhang, and K.R. McCrae Annexin A2 mediates endothelial cell activation by antiphospholipid/anti-beta2 glycoprotein I antibodies Blood 105 2005 1964 1969
69. G. Cesarman-Maus, N.P. Rios-Luna, A.B. Deora, B. Huang, R. Villa, and C. Cravioto Mdel Autoantibodies against the fibrinolytic receptor, annexin 2, in antiphospholipid syndrome Blood 107 2006 4375 4382
70. N. Prinz, N. Clemens, A. Canisius, and K.J. Lackner Endosomal NADPH-oxidase is critical for induction of the tissue factor gene in monocytes and endothelial cells. Lessons from the antiphospholipid syndrome Thromb Haemost 109 2013 525 531
71. E. Turpin, F. Russo-Marie, T. Dubois, C. de Paillerets, A. Alfsen, and M. Bomsel In adrenocortical tissue, annexins II and VI are attached to clathrin coated vesicles in a calcium-independent manner Biochim Biophys Acta 1402 1998 115 130
72. M.J. Hayes, D. Shao, M. Bailly, and S.E. Moss Regulation of actin dynamics by annexin 2 EMBO J 25 2006 1816 1826
73. F.J. Martin, and A.S. Prince TLR2 Regulates Gap Junction Intercellular Communication in Airway Cells J Immunol 180 2008 4986 4993
74. J.C. Kagan, T. Su, T. Horng, A. Chow, S. Akira, and R. Medzhitov TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta Nat Immunol 9 2008 361 368
75. M. Yamamoto, S. Sato, H. Hemmi, S. Uematsu, K. Hoshino, and T. Kaisho TRAM is specifically involved in the Toll-like receptor 4-mediated MyD88-independent signaling pathway Nat Immunol 4 2003 1144 1150
76. J.H. Spitzer, A. Visintin, A. Mazzoni, M.N. Kennedy, and D.M. Segal Toll-like receptor 1 inhibits Toll-like receptor 4 signaling in endothelial cells Eur J Immunol 32 2002 1182 1187
77. H. Itoh, M. Tatematsu, A. Watanabe, K. Iwano, K. Funami, and T. Seya UNC93B1 Physically Associates with Human TLR8 and Regulates TLR8-Mediated Signaling PLoS One 6 2011 e28500
78. C.L. Baumann, I.M. Aspalter, O. Sharif, A. Pichlmair, S. Blüml, and F. Grebien CD14 is a coreceptor of Toll-like receptors 7 and 9 J Exp Med 207 2010 2689 2701
79. M. Manukyan, K. Triantafilou, M. Triantafilou, A. Mackie, N. Nilsen, and T. Espevik Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1 Eur J Immunol 35 2005 911 921
80. P.L. Meroni, E. Raschi, C. Testoni, A. Tincani, G. Balestrieri, and R. Molteni Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype Arthritis Rheum 44 2001 2870 2878
81. L. Xia, H. Zhou, L. Hu, H. Xie, T. Wang, and Y. Xu Both NF-kappaB and c-Jun/AP-1 involved in anti-beta2GPI/beta2GPI-induced tissue factor expression in monocytes Thromb Haemost 2013 109
82. S. Dunoyer-Geindre, P. de Moerloose, B. Galve-de Rochemonteix, G. Reber, and E.K. Kruithof NFkappaB is an essential intermediate in the activation of endothelial cells by anti-beta(2)-glycoprotein 1 antibodies Thromb Haemost 88 2002 851 857
83. M. Vega-Ostertag, K. Casper, R. Swerlick, D. Ferrara, E.N. Harris, and S.S. Pierangeli Involvement of p38 MAPK in the up-regulation of tissue factor on endothelial cells by antiphospholipid antibodies Arthritis Rheum 52 2005 1545 1554
84. S. Simoncini, C. Sapet, L. Camoin-Jau, N. Bardin, J.R. Harle, and J. Sampol Role of reactive oxygen species and p38 MAPK in the induction of the pro-adhesive endothelial state mediated by IgG from patients with anti-phospholipid syndrome Int Immunol 17 2005 489 500
85. R. Aronovich, D. Gurwitz, Y. Kloog, and J. Chapman Antiphospholipid antibodies, thrombin and LPS activate brain endothelial cells and Ras-dependent pathways through distinct mechanisms Immunobiology 210 2005 781 788
86. E. Raschi, C. Testoni, D. Bosisio, M.O. Borghi, T. Koike, and A. Mantovani Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies Blood 101 2003 3495 3500
87. T. Shi, B. Giannakopoulos, X. Yan, P. Yu, M.C. Berndt, and R.K. Andrews Anti-β2-glycoprotein I antibodies in complex with β2-glycoprotein I can activate platelets in a dysregulated manner via glycoprotein Ib-IX-V Arthritis Rheum 54 2006 2558 2567
88. P. Lichte, J.S. Grigoleit, E.M. Steiner, J.S. Kullmann, M. Schedlowski, and R. Oberbeck Low dose LPS does not increase TLR4 expression on monocytes in a human in vivo model Cytokine 63 2013 74 80
89. V. Hornung, S. Rothenfusser, S. Britsch, A. Krug, B. Jahrsdorfer, and T. Giese Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides J Immunol 168 2002 4531 4537
90. D.H. Kim, H. Iijima, K. Goto, J. Sakai, H. Ishii, and H.J. Kim Human apolipoprotein E receptor 2. A novel lipoprotein receptor of the low density lipoprotein receptor family predominantly expressed in brain J Biol Chem 271 1996 8373 8380
91. X. Mo, L. Liu, J.A. Lopez, and R. Li Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex J Thromb Haemost 10 2012 1875 1886
92. B.A. Badlou, G. Spierenburg, H. Ulrichts, H. Deckmyn, W.M. Smid, and J.-W.N. Akkerman Role of glycoprotein Ibα in phagocytosis of platelets by macrophages Transfusion 46 2006 2090 2099
93. B. Schaaf, K. Luitjens, T. Goldmann, T. van Bremen, F. Sayk, and C. Dodt Mortality in human sepsis is associated with downregulation of Toll-like receptor 2 and CD14 expression on blood monocytes Diagn Pathol 4 2009 12
94. B. Liu, Y. Xu, C. Voss, F.-h. Qiu, M.-z. Zhao, and Y.-d. Liu Altered Protein Expression in Gestational Diabetes Mellitus Placentas Provides Insight into Insulin Resistance and Coagulation/Fibrinolysis Pathways PLoS One 7 2012 e44701