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Volumn 69, Issue 6, 2013, Pages 596-607

Management of Women with Recurrent Pregnancy Losses and Antiphospholipid Antibody Syndrome

Author keywords

Heparin treatment; Immunoglobulin G; Implantation; Inflammation; Obstetrical complications; Trophoblast

Indexed keywords

ACETYLSALICYLIC ACID; COMPLEMENT COMPONENT C3; COMPLEMENT COMPONENT C5A; COMPLEMENT COMPONENT C5A RECEPTOR; ENOXAPARIN; GAMMA INTERFERON; GLUCOCORTICOID; HEPARIN; IMMUNOGLOBULIN G; INTERLEUKIN 1BETA; INTERLEUKIN 3; INTERLEUKIN 6; INTERLEUKIN 8; MONOCYTE CHEMOTACTIC PROTEIN 1; PHOSPHOLIPID ANTIBODY; PLACEBO; PLACENTAL GROWTH FACTOR; PROTHROMBIN; STAT3 PROTEIN; STAUROSPORINE; THROMBIN; THROMBOXANE A2; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN RECEPTOR 1;

EID: 84877700397     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/aji.12114     Document Type: Article
Times cited : (45)

References (109)
  • 1
    • 84941817790 scopus 로고
    • Thrombosis, recurrent fetal loss, and thrombocytopenia. Predictive value of the anticardiolipin antibody test
    • Harris EN, Chan JK, Asherson RA, Aber VR, Gharavi AE, Hughes GR: Thrombosis, recurrent fetal loss, and thrombocytopenia. Predictive value of the anticardiolipin antibody test. Arch Intern Med 1986; 146:2153-2156.
    • (1986) Arch Intern Med , vol.146 , pp. 2153-2156
    • Harris, E.N.1    Chan, J.K.2    Asherson, R.A.3    Aber, V.R.4    Gharavi, A.E.5    Hughes, G.R.6
  • 3
    • 77953142772 scopus 로고    scopus 로고
    • Recurrent pregnancy loss: etiology, diagnosis, and therapy
    • Ford HB, Schust DJ: Recurrent pregnancy loss: etiology, diagnosis, and therapy. Rev Obstet Gynecol 2009; 2:76-83.
    • (2009) Rev Obstet Gynecol , vol.2 , pp. 76-83
    • Ford, H.B.1    Schust, D.J.2
  • 4
    • 0021807597 scopus 로고
    • Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus
    • Lockshin MD, Druzin ML, Goei S, Qamar T, Magid MS, Jovanovic L, Ferenc M: Antibody to cardiolipin as a predictor of fetal distress or death in pregnant patients with systemic lupus erythematosus. N Engl J Med 1985; 313:152-156.
    • (1985) N Engl J Med , vol.313 , pp. 152-156
    • Lockshin, M.D.1    Druzin, M.L.2    Goei, S.3    Qamar, T.4    Magid, M.S.5    Jovanovic, L.6    Ferenc, M.7
  • 5
    • 0022385505 scopus 로고
    • Obstetric complications associated with the lupus anticoagulant
    • Branch DW, Scott JR, Kochenour NK, Hershgold E: Obstetric complications associated with the lupus anticoagulant. N Engl J Med 1985; 313:1322-1326.
    • (1985) N Engl J Med , vol.313 , pp. 1322-1326
    • Branch, D.W.1    Scott, J.R.2    Kochenour, N.K.3    Hershgold, E.4
  • 6
    • 0029078582 scopus 로고
    • Antiphospholipid antibodies and beta 2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach
    • Rai RS, Regan L, Clifford K, Pickering W, Dave M, Mackie I, McNally T, Cohen H: Antiphospholipid antibodies and beta 2-glycoprotein-I in 500 women with recurrent miscarriage: results of a comprehensive screening approach. Hum Reprod 1995; 10:2001-2005.
    • (1995) Hum Reprod , vol.10 , pp. 2001-2005
    • Rai, R.S.1    Regan, L.2    Clifford, K.3    Pickering, W.4    Dave, M.5    Mackie, I.6    McNally, T.7    Cohen, H.8
  • 7
    • 0026727718 scopus 로고
    • Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience
    • Branch DW, Silver RM, Blackwell JL, Reading JC, Scott JR: Outcome of treated pregnancies in women with antiphospholipid syndrome: an update of the Utah experience. Obstet Gynecol 1992; 80:614-620.
    • (1992) Obstet Gynecol , vol.80 , pp. 614-620
    • Branch, D.W.1    Silver, R.M.2    Blackwell, J.L.3    Reading, J.C.4    Scott, J.R.5
  • 8
    • 0029619074 scopus 로고
    • High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies
    • Rai RS, Clifford K, Cohen H, Regan L: High prospective fetal loss rate in untreated pregnancies of women with recurrent miscarriage and antiphospholipid antibodies. Hum Reprod 1995; 10:3301-3304.
    • (1995) Hum Reprod , vol.10 , pp. 3301-3304
    • Rai, R.S.1    Clifford, K.2    Cohen, H.3    Regan, L.4
  • 9
    • 49749118657 scopus 로고    scopus 로고
    • Some concerns about the Sydney criteria for antiphospholipid syndrome
    • Carvalho JF: Some concerns about the Sydney criteria for antiphospholipid syndrome. Lupus 2008; 17:770.
    • (2008) Lupus , vol.17 , pp. 770
    • Carvalho, J.F.1
  • 11
    • 34948903311 scopus 로고    scopus 로고
    • Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury
    • Redecha P, Tilley R, Tencati M, Salmon JE, Kirchhofer D, Mackman N, Girardi G: Tissue factor: a link between C5a and neutrophil activation in antiphospholipid antibody induced fetal injury. Blood 2007; 110:2423-2431.
    • (2007) Blood , vol.110 , pp. 2423-2431
    • Redecha, P.1    Tilley, R.2    Tencati, M.3    Salmon, J.E.4    Kirchhofer, D.5    Mackman, N.6    Girardi, G.7
  • 14
    • 11844251124 scopus 로고    scopus 로고
    • Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages
    • Bizzaro N, Tonutti E, Villalta D, Tampoia M, Tozzoli R: Prevalence and clinical correlation of anti-phospholipid-binding protein antibodies in anticardiolipin-negative patients with systemic lupus erythematosus and women with unexplained recurrent miscarriages. Arch Pathol Lab Med 2005; 129:61-68.
    • (2005) Arch Pathol Lab Med , vol.129 , pp. 61-68
    • Bizzaro, N.1    Tonutti, E.2    Villalta, D.3    Tampoia, M.4    Tozzoli, R.5
  • 16
    • 0026590971 scopus 로고
    • Autoantibodies in women with primary recurrent spontaneous abortion of unknown etiology
    • Kwak JY, Gilman-Sachs A, Beaman KD, Beer AE: Autoantibodies in women with primary recurrent spontaneous abortion of unknown etiology. J Reprod Immunol 1992; 22:15-31.
    • (1992) J Reprod Immunol , vol.22 , pp. 15-31
    • Kwak, J.Y.1    Gilman-Sachs, A.2    Beaman, K.D.3    Beer, A.E.4
  • 17
    • 0036851150 scopus 로고    scopus 로고
    • Antiphospholipid antibodies (APA) and recurrent pregnancy loss: treating a unique APA positive population
    • Franklin RD, Kutteh WH: Antiphospholipid antibodies (APA) and recurrent pregnancy loss: treating a unique APA positive population. Hum Reprod 2002; 17:2981-2985.
    • (2002) Hum Reprod , vol.17 , pp. 2981-2985
    • Franklin, R.D.1    Kutteh, W.H.2
  • 18
    • 0028821506 scopus 로고
    • Autoantibodies to phospholipids and nuclear antigens in non-pregnant and pregnant Colombian women with recurrent spontaneous abortions
    • Ruiz JE, Cubillos J, Mendoza JC, Espinel FJ, Kwak JY, Beer AE: Autoantibodies to phospholipids and nuclear antigens in non-pregnant and pregnant Colombian women with recurrent spontaneous abortions. J Reprod Immunol 1995; 28:41-51.
    • (1995) J Reprod Immunol , vol.28 , pp. 41-51
    • Ruiz, J.E.1    Cubillos, J.2    Mendoza, J.C.3    Espinel, F.J.4    Kwak, J.Y.5    Beer, A.E.6
  • 19
    • 79953309488 scopus 로고    scopus 로고
    • Report of the Obstetric APS Task Force: 13th International Congress on Antiphospholipid Antibodies, 13th April 2010
    • Branch W: Report of the Obstetric APS Task Force: 13th International Congress on Antiphospholipid Antibodies, 13th April 2010. Lupus 2011; 20:158-164.
    • (2011) Lupus , vol.20 , pp. 158-164
    • Branch, W.1
  • 20
    • 37649002483 scopus 로고    scopus 로고
    • Microvascular and microangiopathic antiphospholipid-associated syndromes ("MAPS"): semantic or antisemantic
    • Asherson RA, Cervera R: Microvascular and microangiopathic antiphospholipid-associated syndromes ("MAPS"): semantic or antisemantic? Autoimmun Rev 2008; 7:164-167.
    • (2008) Autoimmun Rev , vol.7 , pp. 164-167
    • Asherson, R.A.1    Cervera, R.2
  • 21
    • 84857531966 scopus 로고    scopus 로고
    • Effects of antiphospholipid antibodies on in vitro platelet aggregation
    • Palatinus AA, Ahuja KD, Adams MJ: Effects of antiphospholipid antibodies on in vitro platelet aggregation. Clin Appl Thromb Hemost 2012; 18:59-65.
    • (2012) Clin Appl Thromb Hemost , vol.18 , pp. 59-65
    • Palatinus, A.A.1    Ahuja, K.D.2    Adams, M.J.3
  • 22
    • 84866275320 scopus 로고    scopus 로고
    • Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome
    • Oku K, Amengual O, Atsumi T: Pathophysiology of thrombosis and pregnancy morbidity in the antiphospholipid syndrome. Eur J Clin Invest 2012; 42:1126-1135.
    • (2012) Eur J Clin Invest , vol.42 , pp. 1126-1135
    • Oku, K.1    Amengual, O.2    Atsumi, T.3
  • 23
    • 84866089024 scopus 로고    scopus 로고
    • Antiphospholipid antibodies prolong the activation of endothelial cells induced by necrotic trophoblastic debris: implications for the pathogenesis of preeclampsia
    • Chen Q, Guo F, Hensby-Bennett S, Stone P, Chamley L: Antiphospholipid antibodies prolong the activation of endothelial cells induced by necrotic trophoblastic debris: implications for the pathogenesis of preeclampsia. Placenta 2012; 33:810-815.
    • (2012) Placenta , vol.33 , pp. 810-815
    • Chen, Q.1    Guo, F.2    Hensby-Bennett, S.3    Stone, P.4    Chamley, L.5
  • 24
    • 0033197971 scopus 로고    scopus 로고
    • GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro
    • Gharavi AE, Pierangeli SS, Colden-Stanfield M, Liu XW, Espinola RG, Harris EN: GDKV-induced antiphospholipid antibodies enhance thrombosis and activate endothelial cells in vivo and in vitro. J Immunol 1999; 163:2922-2927.
    • (1999) J Immunol , vol.163 , pp. 2922-2927
    • Gharavi, A.E.1    Pierangeli, S.S.2    Colden-Stanfield, M.3    Liu, X.W.4    Espinola, R.G.5    Harris, E.N.6
  • 27
    • 0034085616 scopus 로고    scopus 로고
    • Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with the severity of thrombosis
    • Kaplanski G, Cacoub P, Farnarier C, Marin V, Grégoire R, Gatel A, Durand JM, Harlé JR, Bongrand P, Piette JC: Increased soluble vascular cell adhesion molecule 1 concentrations in patients with primary or systemic lupus erythematosus-related antiphospholipid syndrome: correlations with the severity of thrombosis. Arthritis Rheum 2000; 43:55-64.
    • (2000) Arthritis Rheum , vol.43 , pp. 55-64
    • Kaplanski, G.1    Cacoub, P.2    Farnarier, C.3    Marin, V.4    Grégoire, R.5    Gatel, A.6    Durand, J.M.7    Harlé, J.R.8    Bongrand, P.9    Piette, J.C.10
  • 28
    • 0035793334 scopus 로고    scopus 로고
    • Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin
    • Pierangeli SS, Espinola RG, Liu X, Harris EN: Thrombogenic effects of antiphospholipid antibodies are mediated by intercellular cell adhesion molecule-1, vascular cell adhesion molecule-1, and P-selectin. Circ Res 2001; 88:245-250.
    • (2001) Circ Res , vol.88 , pp. 245-250
    • Pierangeli, S.S.1    Espinola, R.G.2    Liu, X.3    Harris, E.N.4
  • 29
    • 0030857363 scopus 로고    scopus 로고
    • Tissue factor in health and disease
    • Semeraro N, Colucci M: Tissue factor in health and disease. Thromb Haemost 1997; 78:759-764.
    • (1997) Thromb Haemost , vol.78 , pp. 759-764
    • Semeraro, N.1    Colucci, M.2
  • 31
    • 0033586656 scopus 로고    scopus 로고
    • Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo
    • Pierangeli SS, Colden-Stanfield M, Liu X, Barker JH, Anderson GL, Harris EN: Antiphospholipid antibodies from antiphospholipid syndrome patients activate endothelial cells in vitro and in vivo. Circulation 1999; 99:1997-2002.
    • (1999) Circulation , vol.99 , pp. 1997-2002
    • Pierangeli, S.S.1    Colden-Stanfield, M.2    Liu, X.3    Barker, J.H.4    Anderson, G.L.5    Harris, E.N.6
  • 32
    • 25444450310 scopus 로고    scopus 로고
    • Research around beta 2-glycoprotein I: a major target for antiphospholipid antibodies
    • Atsumi T, Amengual O, Yasuda S, Matsuura E, Koike T: Research around beta 2-glycoprotein I: a major target for antiphospholipid antibodies. Autoimmunity 2005; 38:377-381.
    • (2005) Autoimmunity , vol.38 , pp. 377-381
    • Atsumi, T.1    Amengual, O.2    Yasuda, S.3    Matsuura, E.4    Koike, T.5
  • 33
    • 7044239118 scopus 로고    scopus 로고
    • Antibody-mediated interference with annexins in the antiphospholipid syndrome
    • Rand JH, Wu XX: Antibody-mediated interference with annexins in the antiphospholipid syndrome. Thromb Res 2004; 114:383-389.
    • (2004) Thromb Res , vol.114 , pp. 383-389
    • Rand, J.H.1    Wu, X.X.2
  • 35
    • 0036117498 scopus 로고    scopus 로고
    • Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure
    • Sebire NJ, Fox H, Backos M, Rai R, Paterson C, Regan L: Defective endovascular trophoblast invasion in primary antiphospholipid antibody syndrome-associated early pregnancy failure. Hum Reprod 2002; 17:1067-1071.
    • (2002) Hum Reprod , vol.17 , pp. 1067-1071
    • Sebire, N.J.1    Fox, H.2    Backos, M.3    Rai, R.4    Paterson, C.5    Regan, L.6
  • 40
    • 22244485396 scopus 로고    scopus 로고
    • Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia
    • Pierangeli SS, Girardi G, Vega-Ostertag M, Liu X, Espinola RG, Salmon J: Requirement of activation of complement C3 and C5 for antiphospholipid antibody-mediated thrombophilia. Arthritis Rheum 2005; 52:2120-2124.
    • (2005) Arthritis Rheum , vol.52 , pp. 2120-2124
    • Pierangeli, S.S.1    Girardi, G.2    Vega-Ostertag, M.3    Liu, X.4    Espinola, R.G.5    Salmon, J.6
  • 41
    • 0033009663 scopus 로고    scopus 로고
    • Immunopathology of the implantation site utilizing monoclonal antibodies to natural killer cells in women with recurrent pregnancy losses
    • Kwak JY, Beer AE, Kim SH, Mantouvalos HP: Immunopathology of the implantation site utilizing monoclonal antibodies to natural killer cells in women with recurrent pregnancy losses. Am J Reprod Immunol 1999; 41:91-98.
    • (1999) Am J Reprod Immunol , vol.41 , pp. 91-98
    • Kwak, J.Y.1    Beer, A.E.2    Kim, S.H.3    Mantouvalos, H.P.4
  • 42
    • 0030761057 scopus 로고    scopus 로고
    • Placental pathology and antiphospholipid antibodies: a descriptive study
    • Salafia CM, Cowchock FS: Placental pathology and antiphospholipid antibodies: a descriptive study. Am J Perinatol 1997; 14:435-441.
    • (1997) Am J Perinatol , vol.14 , pp. 435-441
    • Salafia, C.M.1    Cowchock, F.S.2
  • 43
    • 59649114623 scopus 로고    scopus 로고
    • Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule
    • Girardi G, Mackman N: Tissue factor in antiphospholipid antibody-induced pregnancy loss: a pro-inflammatory molecule. Lupus 2008; 17:931-936.
    • (2008) Lupus , vol.17 , pp. 931-936
    • Girardi, G.1    Mackman, N.2
  • 44
    • 33748450585 scopus 로고    scopus 로고
    • Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction
    • Girardi G, Yarilin D, Thurman JM, Holers VM, Salmon JE: Complement activation induces dysregulation of angiogenic factors and causes fetal rejection and growth restriction. J Exp Med 2006; 203:2165-2175.
    • (2006) J Exp Med , vol.203 , pp. 2165-2175
    • Girardi, G.1    Yarilin, D.2    Thurman, J.M.3    Holers, V.M.4    Salmon, J.E.5
  • 45
    • 84870344297 scopus 로고    scopus 로고
    • Decreased endometrial vascularity in patients with antiphospholipid antibodies-associated recurrent miscarriage during midluteal phase
    • e1491
    • Chen L, Quan S, Ou XH, Kong L: Decreased endometrial vascularity in patients with antiphospholipid antibodies-associated recurrent miscarriage during midluteal phase. Fertil Steril 2012; 98:1495-1502 e1491.
    • (2012) Fertil Steril , vol.98 , pp. 1495-1502
    • Chen, L.1    Quan, S.2    Ou, X.H.3    Kong, L.4
  • 46
    • 84921705962 scopus 로고    scopus 로고
    • Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant
    • Empson M, Lassere M, Craig J, Scott J: Prevention of recurrent miscarriage for women with antiphospholipid antibody or lupus anticoagulant. Cochrane Database Syst Rev 2005; CD002859.
    • (2005) Cochrane Database Syst Rev
    • Empson, M.1    Lassere, M.2    Craig, J.3    Scott, J.4
  • 47
    • 7044274078 scopus 로고    scopus 로고
    • Treatment of antiphospholipid syndrome in pregnancy-a systematic review of randomized therapeutic trials
    • Lassere M, Empson M: Treatment of antiphospholipid syndrome in pregnancy-a systematic review of randomized therapeutic trials. Thromb Res 2004; 114:419-426.
    • (2004) Thromb Res , vol.114 , pp. 419-426
    • Lassere, M.1    Empson, M.2
  • 48
    • 0025652559 scopus 로고
    • Effect of low-dose aspirin therapy on utero-placental blood flow and malondialdehyde (MDA) as an indicator of its therapeutic effect
    • Nishino E, Takagi T, Mitsuda N, Masuhiro K, Iwata I, Iwata M, Tanizawa O: Effect of low-dose aspirin therapy on utero-placental blood flow and malondialdehyde (MDA) as an indicator of its therapeutic effect. Nihon Sanka Fujinka Gakkai Zasshi 1990; 42:1641-1647.
    • (1990) Nihon Sanka Fujinka Gakkai Zasshi , vol.42 , pp. 1641-1647
    • Nishino, E.1    Takagi, T.2    Mitsuda, N.3    Masuhiro, K.4    Iwata, I.5    Iwata, M.6    Tanizawa, O.7
  • 49
    • 0027159105 scopus 로고
    • Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3
    • Fishman P, Falach-Vaknine E, Zigelman R, Bakimer R, Sredni B, Djaldetti M, Shoenfeld Y: Prevention of fetal loss in experimental antiphospholipid syndrome by in vivo administration of recombinant interleukin-3. J Clin Invest 1993; 91:1834-1837.
    • (1993) J Clin Invest , vol.91 , pp. 1834-1837
    • Fishman, P.1    Falach-Vaknine, E.2    Zigelman, R.3    Bakimer, R.4    Sredni, B.5    Djaldetti, M.6    Shoenfeld, Y.7
  • 50
    • 0031022366 scopus 로고    scopus 로고
    • Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies)
    • Rai R, Cohen H, Dave M, Regan L: Randomised controlled trial of aspirin and aspirin plus heparin in pregnant women with recurrent miscarriage associated with phospholipid antibodies (or antiphospholipid antibodies). BMJ 1997; 314:253-257.
    • (1997) BMJ , vol.314 , pp. 253-257
    • Rai, R.1    Cohen, H.2    Dave, M.3    Regan, L.4
  • 51
    • 0033784643 scopus 로고    scopus 로고
    • Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome A randomized controlled trial
    • Pattison NS, Chamley LW, Birdsall M, Zanderigo AM, Liddell HS, McDougall J: Does aspirin have a role in improving pregnancy outcome for women with the antiphospholipid syndrome? A randomized controlled trial. Am J Obstet Gynecol 2000; 183:1008-1012.
    • (2000) Am J Obstet Gynecol , vol.183 , pp. 1008-1012
    • Pattison, N.S.1    Chamley, L.W.2    Birdsall, M.3    Zanderigo, A.M.4    Liddell, H.S.5    McDougall, J.6
  • 52
    • 0026600163 scopus 로고
    • Monoclonal antiphospholipid antibody reactivity against human placental trophoblast
    • Lyden TW, Vogt E, Ng AK, Johnson PM, Rote NS: Monoclonal antiphospholipid antibody reactivity against human placental trophoblast. J Reprod Immunol 1992; 22:1-14.
    • (1992) J Reprod Immunol , vol.22 , pp. 1-14
    • Lyden, T.W.1    Vogt, E.2    Ng, A.K.3    Johnson, P.M.4    Rote, N.S.5
  • 53
    • 0027199779 scopus 로고
    • Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation
    • Sthoeger ZM, Mozes E, Tartakovsky B: Anti-cardiolipin antibodies induce pregnancy failure by impairing embryonic implantation. Proc Natl Acad Sci USA 1993; 90:6464-6467.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6464-6467
    • Sthoeger, Z.M.1    Mozes, E.2    Tartakovsky, B.3
  • 54
    • 0037169563 scopus 로고    scopus 로고
    • Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome
    • Guerin J, Sheng Y, Reddel S, Iverson GM, Chapman MG, Krilis SA: Heparin inhibits the binding of beta 2-glycoprotein I to phospholipids and promotes the plasmin-mediated inactivation of this blood protein. Elucidation of the consequences of the two biological events in patients with the anti-phospholipid syndrome. J Biol Chem 2002; 277:2644-2649.
    • (2002) J Biol Chem , vol.277 , pp. 2644-2649
    • Guerin, J.1    Sheng, Y.2    Reddel, S.3    Iverson, G.M.4    Chapman, M.G.5    Krilis, S.A.6
  • 55
    • 0032977127 scopus 로고    scopus 로고
    • Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome
    • Di Simone N, Caliandro D, Castellani R, Ferrazzani S, De Carolis S, Caruso A: Low-molecular weight heparin restores in-vitro trophoblast invasiveness and differentiation in presence of immunoglobulin G fractions obtained from patients with antiphospholipid syndrome. Hum Reprod 1999; 14:489-495.
    • (1999) Hum Reprod , vol.14 , pp. 489-495
    • Di Simone, N.1    Caliandro, D.2    Castellani, R.3    Ferrazzani, S.4    De Carolis, S.5    Caruso, A.6
  • 56
    • 0030730450 scopus 로고    scopus 로고
    • Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera
    • Di Simone N, Ferrazzani S, Castellani R, De Carolis S, Mancuso S, Caruso A: Heparin and low-dose aspirin restore placental human chorionic gonadotrophin secretion abolished by antiphospholipid antibody-containing sera. Hum Reprod 1997; 12:2061-2065.
    • (1997) Hum Reprod , vol.12 , pp. 2061-2065
    • Di Simone, N.1    Ferrazzani, S.2    Castellani, R.3    De Carolis, S.4    Mancuso, S.5    Caruso, A.6
  • 57
    • 9144243607 scopus 로고    scopus 로고
    • Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation
    • Girardi G, Redecha P, Salmon JE: Heparin prevents antiphospholipid antibody-induced fetal loss by inhibiting complement activation. Nat Med 2004; 10:1222-1226.
    • (2004) Nat Med , vol.10 , pp. 1222-1226
    • Girardi, G.1    Redecha, P.2    Salmon, J.E.3
  • 60
    • 0028060072 scopus 로고
    • Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart
    • Friedrichs GS, Kilgore KS, Manley PJ, Gralinski MR, Lucchesi BR: Effects of heparin and N-acetyl heparin on ischemia/reperfusion-induced alterations in myocardial function in the rabbit isolated heart. Circ Res 1994; 75:701-710.
    • (1994) Circ Res , vol.75 , pp. 701-710
    • Friedrichs, G.S.1    Kilgore, K.S.2    Manley, P.J.3    Gralinski, M.R.4    Lucchesi, B.R.5
  • 62
    • 0036308072 scopus 로고    scopus 로고
    • Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins
    • Wang L, Brown JR, Varki A, Esko JD: Heparin's anti-inflammatory effects require glucosamine 6-O-sulfation and are mediated by blockade of L- and P-selectins. J Clin Invest 2002; 110:127-136.
    • (2002) J Clin Invest , vol.110 , pp. 127-136
    • Wang, L.1    Brown, J.R.2    Varki, A.3    Esko, J.D.4
  • 63
    • 33644649240 scopus 로고    scopus 로고
    • Low-molecular weight and unfractionated heparins induce a downregulation of inflammation: decreased levels of proinflammatory cytokines and nuclear factor-kappaB in LPS-stimulated human monocytes
    • Hochart H, Jenkins PV, Smith OP, White B: Low-molecular weight and unfractionated heparins induce a downregulation of inflammation: decreased levels of proinflammatory cytokines and nuclear factor-kappaB in LPS-stimulated human monocytes. Br J Haematol 2006; 133:62-67.
    • (2006) Br J Haematol , vol.133 , pp. 62-67
    • Hochart, H.1    Jenkins, P.V.2    Smith, O.P.3    White, B.4
  • 64
    • 85027952258 scopus 로고    scopus 로고
    • Do dose-related mechanisms exist for the angiogenic behaviours of heparin derivatives
    • Yavuz C, Karahan O: Do dose-related mechanisms exist for the angiogenic behaviours of heparin derivatives Am J Reprod Immunol 2012; 68:185-186.
    • (2012) Am J Reprod Immunol , vol.68 , pp. 185-186
    • Yavuz, C.1    Karahan, O.2
  • 69
    • 0028242369 scopus 로고
    • Low molecular weight heparins and their use in obstetrics and gynecology
    • Fejgin MD, Lourwood DL: Low molecular weight heparins and their use in obstetrics and gynecology. Obstet Gynecol Surv 1994; 49:424-431.
    • (1994) Obstet Gynecol Surv , vol.49 , pp. 424-431
    • Fejgin, M.D.1    Lourwood, D.L.2
  • 70
    • 0036166519 scopus 로고    scopus 로고
    • Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin
    • Pettila V, Leinonen P, Markkola A, Hiilesmaa V, Kaaja R: Postpartum bone mineral density in women treated for thromboprophylaxis with unfractionated heparin or LMW heparin. Thromb Haemost 2002; 87:182-186.
    • (2002) Thromb Haemost , vol.87 , pp. 182-186
    • Pettila, V.1    Leinonen, P.2    Markkola, A.3    Hiilesmaa, V.4    Kaaja, R.5
  • 71
    • 0037334440 scopus 로고    scopus 로고
    • Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies
    • Triolo G, Ferrante A, Ciccia F, Accardo-Palumbo A, Perino A, Castelli A, Giarratano A, Licata G: Randomized study of subcutaneous low molecular weight heparin plus aspirin versus intravenous immunoglobulin in the treatment of recurrent fetal loss associated with antiphospholipid antibodies. Arthritis Rheum 2003; 48:728-731.
    • (2003) Arthritis Rheum , vol.48 , pp. 728-731
    • Triolo, G.1    Ferrante, A.2    Ciccia, F.3    Accardo-Palumbo, A.4    Perino, A.5    Castelli, A.6    Giarratano, A.7    Licata, G.8
  • 72
    • 0029934389 scopus 로고    scopus 로고
    • Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone
    • Kutteh WH: Antiphospholipid antibody-associated recurrent pregnancy loss: treatment with heparin and low-dose aspirin is superior to low-dose aspirin alone. Am J Obstet Gynecol 1996; 174:1584-1589.
    • (1996) Am J Obstet Gynecol , vol.174 , pp. 1584-1589
    • Kutteh, W.H.1
  • 73
    • 77952981639 scopus 로고    scopus 로고
    • Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysis
    • Ziakas PD, Pavlou M, Voulgarelis M: Heparin treatment in antiphospholipid syndrome with recurrent pregnancy loss: a systematic review and meta-analysis. Obstet Gynecol 2010; 115:1256-1262.
    • (2010) Obstet Gynecol , vol.115 , pp. 1256-1262
    • Ziakas, P.D.1    Pavlou, M.2    Voulgarelis, M.3
  • 74
    • 14844286167 scopus 로고    scopus 로고
    • Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin
    • Noble LS, Kutteh WH, Lashey N, Franklin RD, Herrada J: Antiphospholipid antibodies associated with recurrent pregnancy loss: prospective, multicenter, controlled pilot study comparing treatment with low-molecular-weight heparin versus unfractionated heparin. Fertil Steril 2005; 83:684-690.
    • (2005) Fertil Steril , vol.83 , pp. 684-690
    • Noble, L.S.1    Kutteh, W.H.2    Lashey, N.3    Franklin, R.D.4    Herrada, J.5
  • 75
    • 7944225659 scopus 로고    scopus 로고
    • Treatment of antiphospholipid antibody syndrome (APS) in pregnancy: a randomized pilot trial comparing low molecular weight heparin to unfractionated heparin
    • Stephenson MD, Ballem PJ, Tsang P, Purkiss S, Ensworth S, Houlihan E, Ensom MH: Treatment of antiphospholipid antibody syndrome (APS) in pregnancy: a randomized pilot trial comparing low molecular weight heparin to unfractionated heparin. J Obstet Gynaecol Can 2004; 26:729-734.
    • (2004) J Obstet Gynaecol Can , vol.26 , pp. 729-734
    • Stephenson, M.D.1    Ballem, P.J.2    Tsang, P.3    Purkiss, S.4    Ensworth, S.5    Houlihan, E.6    Ensom, M.H.7
  • 76
    • 0029928051 scopus 로고    scopus 로고
    • Low-molecular-weight heparin during pregnancy and delivery: preliminary experience with 41 pregnancies
    • Dulitzki M, Pauzner R, Langevitz P, Pras M, Many A, Schiff E: Low-molecular-weight heparin during pregnancy and delivery: preliminary experience with 41 pregnancies. Obstet Gynecol 1996; 87:380-383.
    • (1996) Obstet Gynecol , vol.87 , pp. 380-383
    • Dulitzki, M.1    Pauzner, R.2    Langevitz, P.3    Pras, M.4    Many, A.5    Schiff, E.6
  • 77
    • 0030957087 scopus 로고    scopus 로고
    • Low-molecular-weight heparin for obstetric thromboprophylaxis: experience of sixty-nine pregnancies in sixty-one women at high risk
    • Nelson-Piercy C, Letsky EA, de Swiet M: Low-molecular-weight heparin for obstetric thromboprophylaxis: experience of sixty-nine pregnancies in sixty-one women at high risk. Am J Obstet Gynecol 1997; 176:1062-1068.
    • (1997) Am J Obstet Gynecol , vol.176 , pp. 1062-1068
    • Nelson-Piercy, C.1    Letsky, E.A.2    de Swiet, M.3
  • 79
    • 24944472305 scopus 로고    scopus 로고
    • Do patients followed in anticoagulation clinics for antiphospholipid syndrome meet criteria for the disorder
    • Dunn AS, Kaboli P, Halfdanarson T, Chan H, Hubert R, Rosen S, White RH: Do patients followed in anticoagulation clinics for antiphospholipid syndrome meet criteria for the disorder? Thromb Haemost 2005; 94:548-554.
    • (2005) Thromb Haemost , vol.94 , pp. 548-554
    • Dunn, A.S.1    Kaboli, P.2    Halfdanarson, T.3    Chan, H.4    Hubert, R.5    Rosen, S.6    White, R.H.7
  • 80
    • 68249099717 scopus 로고    scopus 로고
    • Management of antiphospholipid syndrome
    • Tuthill JI, Khamashta MA: Management of antiphospholipid syndrome. J Autoimmun 2009; 33:92-98.
    • (2009) J Autoimmun , vol.33 , pp. 92-98
    • Tuthill, J.I.1    Khamashta, M.A.2
  • 81
    • 83455162249 scopus 로고    scopus 로고
    • Obstetric antiphospholipid syndrome: an update on pathophysiology and management
    • Ernest JM, Marshburn PB, Kutteh WH: Obstetric antiphospholipid syndrome: an update on pathophysiology and management. Semin Reprod Med 2011; 29:522-539.
    • (2011) Semin Reprod Med , vol.29 , pp. 522-539
    • Ernest, J.M.1    Marshburn, P.B.2    Kutteh, W.H.3
  • 86
    • 84886952261 scopus 로고    scopus 로고
    • The incidence of various antiphospholipid antibodies, measured by commercial-based laboratory, with recurrent spontaneous abortion and the impact of their profiles on reproductive outcome with active anticoagulant therapy
    • Umehara N, Tanaka T: The incidence of various antiphospholipid antibodies, measured by commercial-based laboratory, with recurrent spontaneous abortion and the impact of their profiles on reproductive outcome with active anticoagulant therapy. ISRN Obstet Gynecol 2012; 2012:819356.
    • (2012) ISRN Obstet Gynecol , vol.2012 , pp. 819356
    • Umehara, N.1    Tanaka, T.2
  • 87
    • 84860009240 scopus 로고    scopus 로고
    • Antiphospholipid syndrome: laboratory testing and diagnostic strategies
    • Ortel TL: Antiphospholipid syndrome: laboratory testing and diagnostic strategies. Am J Hematol 2012; 87(Suppl 1):S75-S81.
    • (2012) Am J Hematol , vol.87 , Issue.SUPPL 1
    • Ortel, T.L.1
  • 88
    • 13544276197 scopus 로고    scopus 로고
    • IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis
    • de Laat B, Derksen RH, Urbanus RT, de Groot PG: IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta 2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood 2005; 105:1540-1545.
    • (2005) Blood , vol.105 , pp. 1540-1545
    • de Laat, B.1    Derksen, R.H.2    Urbanus, R.T.3    de Groot, P.G.4
  • 90
    • 82355182716 scopus 로고    scopus 로고
    • Antibodies to Domain I of beta(2)Glycoprotein I are in close relation to patients risk categories in Antiphospholipid Syndrome (APS)
    • Banzato A, Pozzi N, Frasson R, De Filippis V, Ruffatti A, Bison E, Padayattil SJ, Denas G, Pengo V: Antibodies to Domain I of beta(2)Glycoprotein I are in close relation to patients risk categories in Antiphospholipid Syndrome (APS). Thromb Res 2011; 128:583-586.
    • (2011) Thromb Res , vol.128 , pp. 583-586
    • Banzato, A.1    Pozzi, N.2    Frasson, R.3    De Filippis, V.4    Ruffatti, A.5    Bison, E.6    Padayattil, S.J.7    Denas, G.8    Pengo, V.9
  • 91
    • 84861558865 scopus 로고    scopus 로고
    • Antibodies against domain I of beta2-glycoprotein I: the one and only
    • Pelkmans L, de Laat B: Antibodies against domain I of beta2-glycoprotein I: the one and only? Lupus 2012; 21:769-772.
    • (2012) Lupus , vol.21 , pp. 769-772
    • Pelkmans, L.1    de Laat, B.2
  • 93
    • 0031761162 scopus 로고    scopus 로고
    • Treatment of antiphospholipid syndrome in pregnancy
    • Cowchock S: Treatment of antiphospholipid syndrome in pregnancy. Lupus 1998; 7(Suppl 2):S95-S97.
    • (1998) Lupus , vol.7 , Issue.SUPPL 2
    • Cowchock, S.1
  • 94
    • 0035133651 scopus 로고    scopus 로고
    • Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin
    • Vaquero E, Lazzarin N, Valensise H, Menghini S, Di Pierro G, Cesa F, Romanini C: Pregnancy outcome in recurrent spontaneous abortion associated with antiphospholipid antibodies: a comparative study of intravenous immunoglobulin versus prednisone plus low-dose aspirin. Am J Reprod Immunol 2001; 45:174-179.
    • (2001) Am J Reprod Immunol , vol.45 , pp. 174-179
    • Vaquero, E.1    Lazzarin, N.2    Valensise, H.3    Menghini, S.4    Di Pierro, G.5    Cesa, F.6    Romanini, C.7
  • 97
    • 79959504067 scopus 로고    scopus 로고
    • First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss
    • Bramham K, Thomas M, Nelson-Piercy C, Khamashta M, Hunt BJ: First-trimester low-dose prednisolone in refractory antiphospholipid antibody-related pregnancy loss. Blood 2011; 117:6948-6951.
    • (2011) Blood , vol.117 , pp. 6948-6951
    • Bramham, K.1    Thomas, M.2    Nelson-Piercy, C.3    Khamashta, M.4    Hunt, B.J.5
  • 98
    • 33846123728 scopus 로고    scopus 로고
    • Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review
    • Hutton B, Sharma R, Fergusson D, Tinmouth A, Hebert P, Jamieson J, Walker M: Use of intravenous immunoglobulin for treatment of recurrent miscarriage: a systematic review. BJOG 2007; 114:134-142.
    • (2007) BJOG , vol.114 , pp. 134-142
    • Hutton, B.1    Sharma, R.2    Fergusson, D.3    Tinmouth, A.4    Hebert, P.5    Jamieson, J.6    Walker, M.7
  • 99
    • 0029054959 scopus 로고
    • Intravenous immunoglobulin infusion therapy in women with recurrent spontaneous abortions of immune etiologies
    • Kwak JY, Quilty EA, Gilman-Sachs A, Beaman KD, Beer AE: Intravenous immunoglobulin infusion therapy in women with recurrent spontaneous abortions of immune etiologies. J Reprod Immunol 1995; 28:175-188.
    • (1995) J Reprod Immunol , vol.28 , pp. 175-188
    • Kwak, J.Y.1    Quilty, E.A.2    Gilman-Sachs, A.3    Beaman, K.D.4    Beer, A.E.5
  • 100
    • 0030010390 scopus 로고    scopus 로고
    • Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin G infusion in women with recurrent spontaneous abortions
    • Kwak JY, Kwak FM, Ainbinder SW, Ruiz AM, Beer AE: Elevated peripheral blood natural killer cells are effectively downregulated by immunoglobulin G infusion in women with recurrent spontaneous abortions. Am J Reprod Immunol 1996; 35:363-369.
    • (1996) Am J Reprod Immunol , vol.35 , pp. 363-369
    • Kwak, J.Y.1    Kwak, F.M.2    Ainbinder, S.W.3    Ruiz, A.M.4    Beer, A.E.5
  • 101
    • 0343962582 scopus 로고    scopus 로고
    • [Therapeutic use of intravenous immunoglobulins in the antiphospholipid syndrome]
    • Piette JC, Le Thi Huong D, Wechsler B: [Therapeutic use of intravenous immunoglobulins in the antiphospholipid syndrome]. Ann Med Interne (Paris) 2000; 151(Suppl 1):1S51-1S54.
    • (2000) Ann Med Interne (Paris) , vol.151 , Issue.SUPPL 1
    • Piette, J.C.1    Le Thi Huong, D.2    Wechsler, B.3
  • 102
    • 0033979270 scopus 로고    scopus 로고
    • A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group
    • Branch DW, Peaceman AM, Druzin M, Silver RK, El-Sayed Y, Silver RM, Esplin MS, Spinnato J, Harger J: A multicenter, placebo-controlled pilot study of intravenous immune globulin treatment of antiphospholipid syndrome during pregnancy. The Pregnancy Loss Study Group. Am J Obstet Gynecol 2000; 182:122-127.
    • (2000) Am J Obstet Gynecol , vol.182 , pp. 122-127
    • Branch, D.W.1    Peaceman, A.M.2    Druzin, M.3    Silver, R.K.4    El-Sayed, Y.5    Silver, R.M.6    Esplin, M.S.7    Spinnato, J.8    Harger, J.9
  • 103
    • 84869414418 scopus 로고    scopus 로고
    • Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome
    • Xiao J, Xiong J, Zhu F, He L: Effect of prednisone, aspirin, low molecular weight heparin and intravenous immunoglobulin on outcome of pregnancy in women with antiphospholipid syndrome. Exp Ther Med 2013; 5:287-291.
    • (2013) Exp Ther Med , vol.5 , pp. 287-291
    • Xiao, J.1    Xiong, J.2    Zhu, F.3    He, L.4
  • 104
    • 0035673283 scopus 로고    scopus 로고
    • Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype
    • Meroni PL, Raschi E, Testoni C, Tincani A, Balestrieri G, Molteni R, Khamashta MA, Tremoli E, Camera M: Statins prevent endothelial cell activation induced by antiphospholipid (anti-beta2-glycoprotein I) antibodies: effect on the proadhesive and proinflammatory phenotype. Arthritis Rheum 2001; 44:2870-2878.
    • (2001) Arthritis Rheum , vol.44 , pp. 2870-2878
    • Meroni, P.L.1    Raschi, E.2    Testoni, C.3    Tincani, A.4    Balestrieri, G.5    Molteni, R.6    Khamashta, M.A.7    Tremoli, E.8    Camera, M.9
  • 105
    • 0242721975 scopus 로고    scopus 로고
    • Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model
    • Ferrara DE, Liu X, Espinola RG, Meroni PL, Abukhalaf I, Harris EN, Pierangeli SS: Inhibition of the thrombogenic and inflammatory properties of antiphospholipid antibodies by fluvastatin in an in vivo animal model. Arthritis Rheum 2003; 48:3272-3279.
    • (2003) Arthritis Rheum , vol.48 , pp. 3272-3279
    • Ferrara, D.E.1    Liu, X.2    Espinola, R.G.3    Meroni, P.L.4    Abukhalaf, I.5    Harris, E.N.6    Pierangeli, S.S.7
  • 107
    • 0028885044 scopus 로고
    • Sulfated polysaccharide anticoagulants suppress natural killer cell activity in vitro
    • Johann S, Zoller C, Haas S, Blumel G, Lipp M, Forster R: Sulfated polysaccharide anticoagulants suppress natural killer cell activity in vitro. Thromb Haemost 1995; 74:998-1002.
    • (1995) Thromb Haemost , vol.74 , pp. 998-1002
    • Johann, S.1    Zoller, C.2    Haas, S.3    Blumel, G.4    Lipp, M.5    Forster, R.6
  • 109
    • 0034026312 scopus 로고    scopus 로고
    • The antagonism of interferon-gamma (IFN-gamma) by heparin: examination of the blockade of class II MHC antigen and heat shock protein-70 expression
    • Fritchley SJ, Kirby JA, Ali S: The antagonism of interferon-gamma (IFN-gamma) by heparin: examination of the blockade of class II MHC antigen and heat shock protein-70 expression. Clin Exp Immunol 2000; 120:247-252.
    • (2000) Clin Exp Immunol , vol.120 , pp. 247-252
    • Fritchley, S.J.1    Kirby, J.A.2    Ali, S.3


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