Confirmation of initial antiphospholipid antibody positivity depends on the antiphospholipid antibody profile

Journal of Thrombosis and Haemostasis

Volumn 11, Issue 8, 2013, Pages 1527-1531

  Pengo, V ^a   Ruffatti, A ^a   Del Ross, T ^a   Tonello, M ^a   Cuffaro, S ^a   Hoxha, A ^a   Banzato, A ^a   Bison, E ^a   Denas, G ^a   Bracco, A ^a   Padayattil Jose, S ^a  

^a UNIVERSITY OF PADOVA   (Italy)

Author keywords

2; Cardiolipin; Glycoprotein I; Lupus anticoagulant; Phospholipid; Thrombosis

Indexed keywords

CARDIOLIPIN ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY;

ADULT; ANTIBODY DETECTION; ANTIPHOSPHOLIPID SYNDROME; ARTICLE; AUTOIMMUNE DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INCIDENCE; LABORATORY DIAGNOSIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; PARTIAL THROMBOPLASTIN TIME; PREGNANCY; PREVALENCE; PRIORITY JOURNAL; SEX DIFFERENCE; SYSTEMIC LUPUS ERYTHEMATOSUS; THROMBOEMBOLISM; THROMBOSIS;

CARDIOLIPIN; GLYCOPROTEIN I; LUPUS ANTICOAGULANT; PHOSPHOLIPID; THROMBOSIS; Β2;

ADULT; ANTIBODIES, ANTICARDIOLIPIN; ANTIBODIES, ANTIPHOSPHOLIPID; ANTIPHOSPHOLIPID SYNDROME; BETA 2-GLYCOPROTEIN I; COHORT STUDIES; FEMALE; HUMANS; LUPUS COAGULATION INHIBITOR; MALE; MIDDLE AGED; PREDICTIVE VALUE OF TESTS; REPRODUCIBILITY OF RESULTS; RISK; THROMBOSIS; TIME FACTORS;

EID: 84881591707     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/jth.12264     Document Type: Article

References (20)

1. Miyakis S, Lockshin MD, Atsumi T, Branch DW, Brey RL, Cervera R, Derksen RH, De Groot PG, Koike T, Meroni PL, Reber G, Shoenfeld Y, Tincani A, Vlachoyiannopoulos PG, Krilis SA. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006; 4: 295-306.
2. Uthman IW, Gharavi AE. Viral infections and antiphospholipid antibodies. Semin Arthritis Rheum 2002; 31: 256-63.
3. Crowther MA, Ginsberg JS, Julian J, Denburg J, Hirsh J, Douketis J, Laskin C, Fortin P, Anderson D, Kearon C, Clarke A, Geerts W, Forgie M, Green D, Costantini L, Yacura W, Wilson S, Gent M, Kovacs MJ. A comparison of two intensities of warfarin for the prevention of recurrent thrombosis in patients with the antiphospholipid antibody syndrome. N Engl J Med 2003; 349: 1133-8.
4. Nash MJ, Camilleri RS, Kunka S, Mackie IJ, Machin SJ, Cohen H. The anticardiolipin assay is required for sensitive screening for antiphospholipid antibodies. J Thromb Haemost 2004; 2: 1077-81.
5. Brandt JT, Triplett DA, Alving B, Scharrer I. Criteria for the diagnosis of lupus anticoagulants: an update. On behalf of the Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardisation Committee of the ISTH. Thromb Haemost 1995; 74: 1185-90.
6. Pengo V, Tripodi A, Reber G, Rand JH, Ortel TL, Galli M, de Groot PG; Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. Update of the guidelines for lupus anticoagulant detection. Subcommittee on Lupus Anticoagulant/Antiphospholipid Antibody of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis. J Thromb Haemost 2009; 7: 1737-40.
7. Pengo V, Biasiolo A, Fior MG. Autoimmune antiphospholipid antibodies are directed against a cryptic epitope expressed when b2-glycoprotein-I is bound to a suitable surface. Thromb Haemost 1995; 73: 29-34.
8. Tincani A, Allegri F, Balestrieri G, Reber G, Sanmarco M, Meroni P, Boffa MC. Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies. Thromb Res 2004; 114: 553-8.
9. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC. Proposal for the measurements of anti-b2-glycoprotein I antibodies. Standardization group of the European forum on antiphospholipid antibodies. J Thromb Haemost 2004; 2: 1860-2.
10. Pierangeli SS, de Groot PG, Dlott J, Favaloro R, Harris EN, Lakos G, Ortel T, Meroni PL, Otomo K, Pengo V, Tincani A, Wong R, Roubey R. 'Criteria' aPL tests: report of a task force and preconference workshop at the 13th International Congress on Antiphospholipid Antibodies, Galveston, Texas, April 2010. Lupus 2011; 20: 182-90.
11. Giannakopoulos B, Passam F, Ioannou Y, Krilis SA. How we diagnose the antiphospholipid syndrome. Blood 2009; 113: 985-94.
12. Pengo V, Biasiolo A, Rampazzo P, Brocco T. dRVVT is more sensitive than KCT or TTI for detecting lupus anticoagulant activity of anti-b2-glycoprotein I autoantibodies. Thromb Haemost 1999; 81: 256-8.
13. Pengo V, Ruffatti A, Legnani C, Testa S, Fierro T, Marongiu F, Demicheli V, Gresele P, Tonello M, Ghirarduzzi A, Bison E, Denas G, Banzato A, Padayattil Jose S, Iliceto S. Incidence of a first thromboembolic event in asymptomatic carriers of high-risk antiphospholipid antibody profile: a multicenter prospective study. Blood 2011; 118: 4714-18.
14. Pengo V, Ruffatti A, Legnani C, Gresele P, Barcellona D, Erba N, Testa S, Marongiu F, Bison E, Denas G, Banzato A, Padayattil Jose S, Iliceto S. Clinical course of high-risk patients diagnosed with antiphospholipid syndrome. J Thromb Haemost 2010; 8: 237-42.
15. Pengo V, Biasiolo A, Pegoraro C, Cucchini U, Noventa F, Iliceto S. Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost 2005; 93: 147-52.
16. Wahl D, Devignes J, Mohamed S, Zuily S, Lecompte T. Definition and significance of high positivity aCL ELISA. Lupus 2012; 21: 725-6.
17. Ruffatti A, Olivieri S, Tonello M, Bortolati M, Bison E, Salvan E, Facchinetti M, Pengo V. Influence of different IgG anticardiolipin antibody cut-off values on antiphospholipid syndrome classification. J Thromb Haemost 2008; 6: 1693-6.
18. Gardiner C, Hills J, Machin S, Cohen H. Diagnosis of antiphospholipid syndrome in routine clinical practice. Lupus 2013; 22: 18-25.
19. Pengo V, Biasiolo A, Bison E, Chantarangkul V, Tripodi A. Antiphospholipid antibody ELISAs: survey on the performance of clinical laboratories assessed by using lyophilized affinity-purified IgG with anticardiolipin and anti-β2-glycoprotein I activity. Thromb Res 2007; 120: 127-33.
20. Pengo V, Banzato A, Bison E, Bracco A, Denas G, Ruffatti A. What have we learned about antiphospholipid syndrome from patients and antiphospholipid carrier cohorts? Semin Thromb Hemost 2012; 38: 322-7.