β2-glycoprotein I: A novel component of innate immunity

Blood

Volumn 117, Issue 25, 2011, Pages 6939-6947

  Aǧar, Çetin ^a,b   De Groot, Philip G ^b   Mörgelin, Matthias ^c   Monk, Stephanie D D C ^a   Van Os, Gwendolyn ^a,b   Levels, Johannes H M ^a   De Laat, Bas ^b,d   Urbanus, Rolf T ^b   Herwald, Heiko ^c   Van Der Poll, Tom ^a   Meijers, Joost C M ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^c LUND UNIVERSITY   (Sweden)

^d SANQUIN RESEARCH   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA2 GLYCOPROTEIN 1; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; THROMBOPLASTIN;

ADULT; ARTICLE; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; INNATE IMMUNITY; MALE; MONOCYTE; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; SEPSIS; BLOOD; CELL CULTURE; CELL LINE; ESCHERICHIA COLI; IMMUNOLOGY;

BETA 2-GLYCOPROTEIN I; CELL LINE; CELLS, CULTURED; ENDOTHELIAL CELLS; ESCHERICHIA COLI; HUMANS; IMMUNITY, INNATE; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; MONOCYTES; SEPSIS; THROMBOPLASTIN;

EID: 79959532387     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2010-12-325951     Document Type: Article

References (39)

1. van der Poll T, Opal S. Host-pathogen interactions in sepsis. Lancet Infect Dis. 2008;8(1):32-43.
2. Ulevitch RJ, Johnston AR, Weinstein DB. New function for high density lipoproteins. Isolation and characterization of a bacterial lipopolysaccharide- high density lipoprotein complex formed in rabbit plasma. J Clin Invest. 1981;67(3):827-837. (Pubitemid 11142375)
3. Pajkrt D, Doran JE, Koster F, et al. Antiinflammatory effects of reconstituted high-density lipoprotein during human endotoxemia. J Exp Med. 1996;184(5):1601-1608. (Pubitemid 26404453)
4. Schultz H, Hume J, Zhang de S, Gioannini TL, Weiss JP. A novel role for the bactericidal/permeability increasing protein in interactions of gram-negative bacterial outer membrane blebs with dendritic cells. J Immunol. 2007;179(4):2477-2484.
5. Schumann RR, Leong SR, Flaggs GW, et al. Structure and function of lipopolysaccharide binding protein. Science. 1990;249(4975):1429-1431. (Pubitemid 120034117)
6. Schütt C, Schilling T, Grunwald U, Schönfeld W, Krüger C. Krüger. Endotoxin-neutralizing capacity of soluble CD14. Res Immunol. 1992;143(1):71-78.
7. Lozier J, Takahashi N, Putnam FW. Complete amino acid sequence of human plasma beta 2-glycoprotein I. Proc Natl Acad Sci U S A. 1984;81(12):3640-3644. (Pubitemid 14087780)
8. Bouma B, de Groot PG, van den Elsen JM, et al. Adhesion mechanism of human beta(2)-glycoprotein I to phospholipids based on its crystal structure. EMBO J. 1999;18(19):5166-5174. (Pubitemid 29465567)
9. Brier AM, Snyderman R, Mergenhagen SE, Notkins AL. Inflammation and herpes simplex virus: release of a chemotaxis-generating factor from infected cells. Science. 1970;170(962):1104-1106.
10. Pangburn MK, Rawal N. Structure and function of complement C5 convertase enzymes. Biochem Soc Trans. 2002;30(pt 6):1006-1010. (Pubitemid 36002396)
11. Aǧar Ç, van Os GM, Mörgelin M, et al. Beta2-Glycoprotein I can exist in two conformations: implications for our understanding of the antiphospholipid syndrome. Blood. 2010;116(8):1336-1343.
12. Galli M, Comfurius P, Maassen C, et al. Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet. 1990;335(8705):1544-1547. (Pubitemid 20189625)
13. McNeil HP, Simpson RJ, Chesterman CN, Krilis SA. Anti-phospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: beta 2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci U S A. 1990;87(11):4120-4124.
14. Giannakopoulos B, Passam F, Ioannou Y, Krilis SA. How we diagnose the antiphospholipid syndrome. Blood. 2009;113(5):985-994.
15. Schousboe I. Beta 2-Glycoprotein I: a plasma inhibitor of the contact activation of the intrinsic blood coagulation pathway. Blood. 1985;66(5):1086-1091. (Pubitemid 16250272)
16. Brighton TA, Hogg PJ, Dai YP, et al. Beta 2-glycoprotein I in thrombosis: evidence for a role as a natural anticoagulant. Br J Haematol. 1996;93(1):185-194. (Pubitemid 26132396)
17. Shi T, Giannakopoulos B, Iverson GM, et al. Domain V of beta2-glycoprotein I binds factor XI/XIa and is cleaved at Lys317-Thr318. J Biol Chem. 2005;280(2):907-912.
18. Nimpf J, Wurm H, Kostner GM. Interaction of b2-glycoprotein-I with human blood platelets: influence upon the ADP-induced aggregation. Thromb Haemost. 1985;54(2):397-401. (Pubitemid 16252457)
19. Nimpf J, Bevers EM, Bomans PH, et al. Prothrombinase activity of human platelets is inhibited by b2-glycoprotein-I. Biochim Biophys Acta. 1986;884(1):142-149. (Pubitemid 16007960)
20. Nomura S, Komiyama Y, Matsuura E, et al. Binding of beta 2-glycoprotein I to platelet-derived microparticles. Br J Haematol. 1993;85(3):639-640. (Pubitemid 23349081)
21. Chonn A, Semple SC, Cullis PR. Beta 2 glycoprotein I is a major protein associated with very rapidly cleared liposomes in vivo, suggesting a significant role in the immune clearance of "non-self" particles. J Biol Chem. 1995;270(43):25845-25849.
22. Balasubramanian K, Chandra J, Schroit AJ. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem. 1997;272(49):31113-31117. (Pubitemid 27527561)
23. Hulstein JJ, Lenting PJ, de Laat B, Derksen RHWM, Fijnheer R, de Groot PG. Beta2-Glycoprotein I inhibits von Willebrand factor-dependent platelet adhesion and aggregation. Blood. 2007;110(5):1483-1491. (Pubitemid 47443963)
24. Passam FH, Rahgozar S, Qi M, et al. Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1. J Thromb Haemost. 2010;8(8):1754-1762.
25. Takeuchi R, Atsumi T, Ieko M, et al. Coagulation and fibrinolytic activities in 2 siblings with beta(2)-glycoprotein I deficiency. Blood. 2000;96(4):1594-1595. (Pubitemid 30658498)
26. van Zoelen MA, Bakhtiari K, Dessing MC, et al. Ethyl pyruvate exerts combined anti-inflammatory and anticoagulant effects on human monocytic cells. Thromb Haemost. 2006;96(6):789-793. (Pubitemid 44883820)
27. de Kruif MD, Lemaire LC, Giebelen IA, et al. Prednisolone dose-dependently influences inflammation and coagulation during human endotoxemia. J Immunol. 2007;178(3):1845-1851. (Pubitemid 46154657)
28. Bone RC, Balk RA, Cerra FB, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. 1992. Chest. 2009;136(5 suppl):e28.
29. Pennings MT, van Lummel M, Derksen RH, et al. Interaction of b2-glycoprotein I with members of the low density lipoprotein receptor family. J Thromb Haemost. 2006;4(8):1680-1690. (Pubitemid 44144793)
30. Lutters BC, Derksen RH, Tekelenburg WL, et al. Dimers of b2-glycoprotein I increase platelet deposition to collagen via interaction with phospholipids and the apolipoprotein E receptor 2′. J Biol Chem. 2003;278(36):33831- 33838. (Pubitemid 37553217)
31. Urbanus RT, Pennings MT, Derksen RH, de Groot PG. Platelet activation by dimeric beta2-glycoprotein I requires signalling via both glycoprotein Ib alpha and apolipoprotein E receptor 2′. J Thromb Haemost. 2008;6(8):1405-1412. (Pubitemid 352016322)
32. Reitsma PH, Branger J, Van Den Blink B, et al. Procoagulant protein levels are differentially increased during human endotoxemia. J Thromb Haemost. 2003;1(5):1019-1023.
33. Renckens R, Weijer S, de Vos AF, et al. Inhibition of plasmin activity by tranexamic acid does not influence inflammatory pathways during human endotoxemia. Arterioscler Thromb Vasc Biol. 2004;24(3):483-488. (Pubitemid 38326142)
34. de Laat B, Derksen RH, van Lummel M, Pennings MT, de Groot PG. Pathogenic anti-beta2-glycoprotein I antibodies recognize domain I of beta2-glycoprotein I only after a conformational change. Blood. 2006;107(5):1916-1924. (Pubitemid 43289372)
35. Rauch J, Dieudé M, Subang R, Levine JS. The dual role of innate immunity in the antiphospholipid syndrome. Lupus. 2010;19(4):347-353.
36. Watanabe Y, Inaba T, Shimano H, et al. Induction of LDL receptor-related protein during the differentiation of monocyte-macrophages: possible involvement in the atherosclerotic process. Arterioscler Thromb. 1994;14(6):1000-1006.
37. Raschi E, Testoni C, Bosisio D, et al. Role of the MyD88 transduction signaling pathway in endothelial activation by antiphospholipid antibodies. Blood. 2003;101(9):3495-3500. (Pubitemid 36857933)
38. Alard JE, Gaillard F, Daridon C, et al. TLR2 is one of the endothelial receptors for beta 2-glycoprotein I. J Immunol. 2010;185(3):1550-1557.
39. Satta N, Dunoyer-Geindre S, Reber G, et al. The role of TLR2 in the inflammatory activation of mouse fibroblasts by human antiphospholipid antibodies. Blood. 2007;109(4):1507-1514. (Pubitemid 46239583)