메뉴 건너뛰기




Volumn 4, Issue 4, 2008, Pages 192-199

Mechanisms of disease: Antiphospholipid antibodies - From clinical association to pathologic mechanism

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATED PROTEIN C; BETA2 GLYCOPROTEIN 1 ANTIBODY; CARDIOLIPIN ANTIBODY; LIPOCORTIN 5; LUPUS ANTICOAGULANT; PHOSPHOLIPID ANTIBODY; VON WILLEBRAND FACTOR; ANTICOAGULANT AGENT; BETA2 GLYCOPROTEIN 1;

EID: 45549086562     PISSN: 17458382     EISSN: 17458390     Source Type: Journal    
DOI: 10.1038/ncprheum0740     Document Type: Review
Times cited : (75)

References (47)
  • 1
    • 0037035113 scopus 로고    scopus 로고
    • The antiphospholipid syndrome
    • Levine JS et al. (2002) The antiphospholipid syndrome. N Engl J Med 346: 752-763
    • (2002) N Engl J Med , vol.346 , pp. 752-763
    • Levine, J.S.1
  • 2
    • 0141958839 scopus 로고    scopus 로고
    • Anti-β2-glycoprotein I and antiprothrombin antibodies and the risk of thrombosis in the antiphospholipid syndrome
    • Galli M et al. (2003) Anti-β2-glycoprotein I and antiprothrombin antibodies and the risk of thrombosis in the antiphospholipid syndrome. Blood 102: 2717-2723
    • (2003) Blood , vol.102 , pp. 2717-2723
    • Galli, M.1
  • 3
    • 0037370733 scopus 로고    scopus 로고
    • Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: A systematic review of the literature
    • Galli M et al. (2003) Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: A systematic review of the literature. Blood 101: 1827-1832
    • (2003) Blood , vol.101 , pp. 1827-1832
    • Galli, M.1
  • 4
    • 84936566564 scopus 로고
    • Eine serodiagnostiche reaction bei syphilis [German].
    • Wasserman A et al. (1906) Eine serodiagnostiche reaction bei syphilis [German]. Dtsch Med Wochenschr 32: 745
    • (1906) Dtsch Med Wochenschr , vol.32 , pp. 745
    • Wasserman, A.1
  • 5
    • 84904027913 scopus 로고
    • A new serologically active phospholipid from beef heart
    • Pangborn MC (1941) A new serologically active phospholipid from beef heart. Proc Soc Exp Biol Med 48: 484-486
    • (1941) Proc Soc Exp Biol Med , vol.48 , pp. 484-486
    • Pangborn, M.C.1
  • 6
    • 76949112144 scopus 로고
    • Biologically false positive tests for syphilis: Type, incidence, and cause
    • Moore JE and Mohr GF (1952) Biologically false positive tests for syphilis: Type, incidence, and cause. J Am Med Association 150 467-473
    • (1952) J Am Med Association , vol.150 , pp. 467-473
    • Moore, J.E.1    Mohr, G.F.2
  • 7
    • 0000398625 scopus 로고
    • Natural history of systemic lupus erythematosus: Approach to its study through chromic biological false positive reactors
    • Moore JE and Lutz WB (1955) Natural history of systemic lupus erythematosus: Approach to its study through chromic biological false positive reactors. J Chronic Dis 1: 297-316
    • (1955) J Chronic Dis , vol.1 , pp. 297-316
    • Moore, J.E.1    Lutz, W.B.2
  • 8
    • 0001145459 scopus 로고
    • A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus
    • Conley CL and Hartman RCA (1952) A hemorrhagic disorder caused by circulating anticoagulant in patients with disseminated lupus erythematosus. J Clin Invest 31: 621-622
    • (1952) J Clin Invest , vol.31 , pp. 621-622
    • Conley, C.L.1    Hartman, R.C.A.2
  • 9
    • 0039827760 scopus 로고
    • Syndrome hemorrhagic acquis du a un anticoagulant [French]
    • Beaumont JL (1954) Syndrome hemorrhagic acquis du a un anticoagulant [French]. Sang 25: 1-5
    • (1954) Sang , vol.25 , pp. 1-5
    • Beaumont, J.L.1
  • 10
    • 50549207211 scopus 로고
    • Thrombosis in systemic lupus erythematosus despite circulating anticoagulants
    • Bowie EJW et al. (1963) Thrombosis in systemic lupus erythematosus despite circulating anticoagulants. J Lab Clin Med 62: 416-430
    • (1963) J Lab Clin Med , vol.62 , pp. 416-430
    • Bowie, E.J.W.1
  • 11
    • 0025302635 scopus 로고
    • Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor
    • Galli M et al. (1990) Anticardiolipin antibodies (ACA) directed not to cardiolipin but to a plasma protein cofactor. Lancet 335 1544-1547
    • (1990) Lancet , vol.335 , pp. 1544-1547
    • Galli, M.1
  • 12
    • 0025195938 scopus 로고
    • Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease
    • Matsuura H et al. (1990) Anticardiolipin cofactor(s) and differential diagnosis of autoimmune disease. Lancet 336: 117-118
    • (1990) Lancet , vol.336 , pp. 117-118
    • Matsuura, H.1
  • 13
    • 0025332717 scopus 로고
    • Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: β2-glycoprotein I (apolipoprotein H)
    • McNeil HD et al. (1990) Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation: β2-glycoprotein I (apolipoprotein H). Proc Natl Acad Sci USA 87: 4120-4124
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 4120-4124
    • McNeil, H.D.1
  • 14
    • 0025951058 scopus 로고
    • Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin
    • Bevers EM et al. (1991) Lupus anticoagulant IgG's (LA) are not directed to phospholipids only, but to a complex of lipid-bound human prothrombin. Thromb Haemost 66: 629-632
    • (1991) Thromb Haemost , vol.66 , pp. 629-632
    • Bevers, E.M.1
  • 15
    • 3042706029 scopus 로고    scopus 로고
    • β2-glycoprotein I, playmaker in the antiphospholipid syndrome
    • De Laat B et al. (2004) β2-glycoprotein I, playmaker in the antiphospholipid syndrome. Clin Immunol 112: 161-168
    • (2004) Clin Immunol , vol.112 , pp. 161-168
    • De Laat, B.1
  • 16
    • 0033512274 scopus 로고    scopus 로고
    • International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop
    • Wilson WA et al. (1999) International consensus statement on preliminary classification criteria for definite antiphospholipid syndrome: Report of an international workshop. Arthritis Rheum 42: 1309-1311
    • (1999) Arthritis Rheum , vol.42 , pp. 1309-1311
    • Wilson, W.A.1
  • 17
    • 33344458573 scopus 로고    scopus 로고
    • International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)
    • Miyakis S et al. (2006) International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 4: 295-306
    • (2006) J Thromb Haemost , vol.4 , pp. 295-306
    • Miyakis, S.1
  • 18
    • 0036180724 scopus 로고    scopus 로고
    • High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals
    • Consigny PH et al. (2002) High prevalence of co-factor independent anticardiolipin antibodies in malaria exposed individuals. Clin Exp Immunol 127: 158-164
    • (2002) Clin Exp Immunol , vol.127 , pp. 158-164
    • Consigny, P.H.1
  • 19
    • 17544395726 scopus 로고    scopus 로고
    • Autoantibodies to phospholipids and to the coagulation proteins in AIDS
    • Abuaf N et al. (1997) Autoantibodies to phospholipids and to the coagulation proteins in AIDS. Thromb Haemost 77: 856-861
    • (1997) Thromb Haemost , vol.77 , pp. 856-861
    • Abuaf, N.1
  • 20
    • 0036175471 scopus 로고    scopus 로고
    • Viral infections and antiphospholipid antibodies
    • Uhtman IW et al. (2002) Viral infections and antiphospholipid antibodies. Semin Arthritis Rheum 31: 256-263
    • (2002) Semin Arthritis Rheum , vol.31 , pp. 256-263
    • Uhtman, I.W.1
  • 21
    • 13544276197 scopus 로고    scopus 로고
    • IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2-glycoprotein I cause LAC and their presence correlates strongly with thrombosis
    • De Laat B et al. (2005) IgG antibodies that recognize epitope Gly40-Arg43 in domain I of β2-glycoprotein I cause LAC and their presence correlates strongly with thrombosis. Blood 105: 1540-1545
    • (2005) Blood , vol.105 , pp. 1540-1545
    • De Laat, B.1
  • 22
    • 33750993762 scopus 로고    scopus 로고
    • Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: A metaanalysis
    • Opatrny L et al. (2006) Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a metaanalysis. J Rheumatol 33: 2214-2221
    • (2006) J Rheumatol , vol.33 , pp. 2214-2221
    • Opatrny, L.1
  • 23
    • 7044223470 scopus 로고    scopus 로고
    • β2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome
    • De Laat HB et al. (2004) β2-glycoprotein I-dependent lupus anticoagulant highly correlates with thrombosis in the antiphospholipid syndrome. Blood 104: 3598-3602
    • (2004) Blood , vol.104 , pp. 3598-3602
    • De Laat, H.B.1
  • 24
    • 20444446334 scopus 로고    scopus 로고
    • Antibody profiles for the diagnosis of antiphospholipid syndrome
    • Pengo V et al. (2005) Antibody profiles for the diagnosis of antiphospholipid syndrome. Thromb Haemost 93: 1147-1152
    • (2005) Thromb Haemost , vol.93 , pp. 1147-1152
    • Pengo, V.1
  • 25
    • 33947307174 scopus 로고    scopus 로고
    • A functional coagulation test to identify anti-β2-glycoprotein I dependent lupus anticoagulants
    • Devreese KM (2007) A functional coagulation test to identify anti-β2-glycoprotein I dependent lupus anticoagulants. Thromb Res 119: 753-759
    • (2007) Thromb Res , vol.119 , pp. 753-759
    • Devreese, K.M.1
  • 26
    • 3242741348 scopus 로고    scopus 로고
    • A two-step coagulation test to identify antiβ-glycoprotein I lupus anticoagulants
    • Pengo V (2004) A two-step coagulation test to identify antiβ-glycoprotein I lupus anticoagulants. J Thromb Haemost 2 702-707
    • (2004) J Thromb Haemost , vol.2 , pp. 702-707
    • Pengo, V.1
  • 27
    • 0036228886 scopus 로고    scopus 로고
    • Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients
    • Cervera R et al. (2002) Antiphospholipid syndrome: Clinical and immunologic manifestations and patterns of disease expression in a cohort of 1,000 patients. Arthritis Rheum 46: 1019-1027
    • (2002) Arthritis Rheum , vol.46 , pp. 1019-1027
    • Cervera, R.1
  • 28
    • 0031864287 scopus 로고    scopus 로고
    • Detection of anti-recombinant β2-glycoprotein I fifth-domain antibodies in sera from patients with systemic lupus erythematosus
    • Yang CD et al. (1998) Detection of anti-recombinant β2-glycoprotein I fifth-domain antibodies in sera from patients with systemic lupus erythematosus. Rheumatol Int 18: 5-10
    • (1998) Rheumatol Int , vol.18 , pp. 5-10
    • Yang, C.D.1
  • 29
    • 0030584823 scopus 로고    scopus 로고
    • Human β2-glycoprotein I as an anticardiolipin cofactor determined using mutants expressed by a baculovirus system
    • Igarashi M et al. (1996) Human β2-glycoprotein I as an anticardiolipin cofactor determined using mutants expressed by a baculovirus system. Blood 87: 3262-3270
    • (1996) Blood , vol.87 , pp. 3262-3270
    • Igarashi, M.1
  • 30
    • 0032521680 scopus 로고    scopus 로고
    • Target recognition of β2-glycoprotein I (β2GPI)-dependent anticardiolipin antibodies: Evidence for involvement of the fourth domain of β2GPI in antibody binding
    • George J et al. (1998) Target recognition of β2-glycoprotein I (β2GPI)-dependent anticardiolipin antibodies: Evidence for involvement of the fourth domain of β2GPI in antibody binding. J Immunol 160: 3917-3923
    • (1998) J Immunol , vol.160 , pp. 3917-3923
    • George, J.1
  • 31
    • 0034742562 scopus 로고    scopus 로고
    • β2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of β2-glycoprotein I
    • McNeely PA et al. (2001) β2-glycoprotein I-dependent anticardiolipin antibodies preferentially bind the amino terminal domain of β2-glycoprotein I. Thromb Haemost 86: 590-595
    • (2001) Thromb Haemost , vol.86 , pp. 590-595
    • McNeely, P.A.1
  • 32
    • 0033830410 scopus 로고    scopus 로고
    • Epitope studies with anti-β2-glycoprotein I antibodies from autoantibody and immunized sources
    • Reddel SW et al. (2000) Epitope studies with anti-β2-glycoprotein I antibodies from autoantibody and immunized sources. J Autoimmun 15: 91-96
    • (2000) J Autoimmun , vol.15 , pp. 91-96
    • Reddel, S.W.1
  • 33
    • 0032217240 scopus 로고    scopus 로고
    • Anti-β2-glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI
    • Iverson GM et al. (1998) Anti-β2-glycoprotein I (β2GPI) autoantibodies recognize an epitope on the first domain of β2GPI. Proc Natl Acad Sci USA 95: 15542-15546
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 15542-15546
    • Iverson, G.M.1
  • 34
    • 0037114142 scopus 로고    scopus 로고
    • Use of single point mutations in domain I of β2GPI to determine fine antigenic specificity of antiphospholipid autoantibodies
    • Iverson GM et al. (2002) Use of single point mutations in domain I of β2GPI to determine fine antigenic specificity of antiphospholipid autoantibodies. J Immunol 169: 7097-7103
    • (2002) J Immunol , vol.169 , pp. 7097-7103
    • Iverson, G.M.1
  • 35
    • 0033609058 scopus 로고    scopus 로고
    • Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides
    • Blank M et al. (1999) Prevention of experimental antiphospholipid syndrome and endothelial cell activation by synthetic peptides. Proc Natl Acad Sci USA 96: 5164-5168
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 5164-5168
    • Blank, M.1
  • 36
    • 33846243719 scopus 로고    scopus 로고
    • Current concepts on the pathogenesis of the antiphospholipid syndrome
    • Giannakopoulos B et al. (2007) Current concepts on the pathogenesis of the antiphospholipid syndrome. Blood 109: 422-430
    • (2007) Blood , vol.109 , pp. 422-430
    • Giannakopoulos, B.1
  • 37
    • 0030789659 scopus 로고    scopus 로고
    • Pregnancy loss in the antiphospholipid-antibody syndrome - a possible thrombogenic mechanism
    • Rand JH et al. (1997) Pregnancy loss in the antiphospholipid-antibody syndrome - a possible thrombogenic mechanism. N Engl J Med 337: 154-160
    • (1997) N Engl J Med , vol.337 , pp. 154-160
    • Rand, J.H.1
  • 38
    • 7244254348 scopus 로고    scopus 로고
    • Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
    • Rand JH et al. (2004) Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome. Blood 104: 2783-2790
    • (2004) Blood , vol.104 , pp. 2783-2790
    • Rand, J.H.1
  • 39
    • 33846936761 scopus 로고    scopus 로고
    • Correlation between antiphospholipid antibodies that recognize domain I of β2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5
    • De Laat B et al. (2007) Correlation between antiphospholipid antibodies that recognize domain I of β2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5. Blood 109: 1490-1494
    • (2007) Blood , vol.109 , pp. 1490-1494
    • De Laat, B.1
  • 40
    • 33747160173 scopus 로고    scopus 로고
    • Detection of acquired resistance to activated protein C associated with anti phospholipid antibodies using a novel clotting assay
    • Gardiner C et al. (2006) Detection of acquired resistance to activated protein C associated with anti phospholipid antibodies using a novel clotting assay. Blood Coagul Fibrinolysis 17: 477-483
    • (2006) Blood Coagul Fibrinolysis , vol.17 , pp. 477-483
    • Gardiner, C.1
  • 41
    • 14544295676 scopus 로고    scopus 로고
    • Acquired activated protein C resistance associated with IgG antibodies against β2-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism
    • Nojima J et al. (2005) Acquired activated protein C resistance associated with IgG antibodies against β2-glycoprotein I and prothrombin as a strong risk factor for venous thromboembolism. Clin Chem 51: 545-552
    • (2005) Clin Chem , vol.51 , pp. 545-552
    • Nojima, J.1
  • 42
    • 53049087758 scopus 로고    scopus 로고
    • Correlation between the potency of a β2-glycoprotein I dependent lupus anticoagulant and the level of resistance to activated protein C [abstract]
    • Abstract P-S-539, Geneva
    • De Laat B et al. (2007) Correlation between the potency of a β2-glycoprotein I dependent lupus anticoagulant and the level of resistance to activated protein C [abstract]. Abstract P-S-539, XXIst congress of the ISTH, Geneva
    • (2007) XXIst congress of the ISTH
    • De Laat, B.1
  • 43
    • 27744494859 scopus 로고    scopus 로고
    • The binding site in β2-glycoprotein I for ApoER2' on platelets is located in domain V
    • van Lummel M et al. (2005) The binding site in β2-glycoprotein I for ApoER2' on platelets is located in domain V. J Biol Chem 280: 36729-36736
    • (2005) J Biol Chem , vol.280 , pp. 36729-36736
    • van Lummel, M.1
  • 44
    • 34250757023 scopus 로고    scopus 로고
    • Platelets express three different splice variants of ApoER2 that are all involved in signalling
    • Pennings MT et al. (2007) Platelets express three different splice variants of ApoER2 that are all involved in signalling. J Thromb Haemost 5: 1538-1544
    • (2007) J Thromb Haemost , vol.5 , pp. 1538-1544
    • Pennings, M.T.1
  • 45
    • 39549099464 scopus 로고    scopus 로고
    • Urbanus RT et al. (2007) Current insight into diagnostics and pathophysiology of the antiphospholipid syndrome. Blood Rev [doi:1 0. 1016/j.bire.2007.09.001]
    • Urbanus RT et al. (2007) Current insight into diagnostics and pathophysiology of the antiphospholipid syndrome. Blood Rev [doi:1 0. 1016/j.bire.2007.09.001]
  • 46
    • 34548816709 scopus 로고    scopus 로고
    • β2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation
    • Hulstein JJ et al. (2007) β2-Glycoprotein I inhibits von Willebrand factor dependent platelet adhesion and aggregation. Blood 110: 1483-1491
    • (2007) Blood , vol.110 , pp. 1483-1491
    • Hulstein, J.J.1
  • 47
    • 0242380082 scopus 로고    scopus 로고
    • The clearance of apoptotic cells: Implications for autoimmunity
    • Pittoni V and Valesini G (2002) The clearance of apoptotic cells: implications for autoimmunity. Autoimmun Rev 1: 154-161
    • (2002) Autoimmun Rev , vol.1 , pp. 154-161
    • Pittoni, V.1    Valesini, G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.