Identification of multiple ingredients for a Traditional Chinese Medicine preparation (bu-yang-huan-wu-tang) by liquid chromatography coupled with tandem mass spectrometry

Molecules

Volumn 18, Issue 9, 2013, Pages 11281-11298

  Shaw, Lee Hsin ^a   Chen, Wei Ming ^b,c   Tsai, Tung Hu ^a,d,e  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b CHANG GUNG MEMORIAL HOSPITAL   (Taiwan)

^c CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

^d CHINA MEDICAL UNIVERSITY   (Taiwan)

^e TAIPEI CITY HOSPITAL   (Taiwan)

Author keywords

Bu yang huan wu tang; Herbal analysis; LC MS MS; Traditional Chinese Medicine

Indexed keywords

7,3' DIHYDROXY 4' METHOXYISOFLAVONE; 7,3'-DIHYDROXY-4'-METHOXYISOFLAVONE; ASTRAGALOSIDE A; ASTRAGALOSIDE II; BENZOIC ACID DERIVATIVE; BRIDGED COMPOUND; BU YANG HUAN WU TANG; BU-YANG-HUAN-WU-TANG; CALYCOSIN 7 O BETA D GLUCOSIDE; CALYCOSIN-7-O-BETA-D-GLUCOSIDE; DIGOXIN; DRUG DERIVATIVE; FORMONONETIN; GAMMA BUTYROLACTONE; GLUCOSIDE; ISOFLAVONE DERIVATIVE; LIGUSTILIDE; PAEONIFLORIN; SAPONIN; TRITERPENE; TERPENE;

ARTICLE; CHEMISTRY; CHINESE MEDICINE; ELECTROSPRAY MASS SPECTROMETRY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; ISOLATION AND PURIFICATION; LIMIT OF DETECTION; REPRODUCIBILITY; TANDEM MASS SPECTROMETRY; ANALOGS AND DERIVATIVES;

4-BUTYROLACTONE; BENZOATES; BRIDGED COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DIGOXIN; GLUCOSIDES; HUMANS; ISOFLAVONES; LIMIT OF DETECTION; MEDICINE, CHINESE TRADITIONAL; REPRODUCIBILITY OF RESULTS; SAPONINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; TANDEM MASS SPECTROMETRY; TRITERPENES; MONOTERPENES;

EID: 84885143520     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules180911281     Document Type: Article

References (28)

1. Chinese Pharmacopoeia, 2005 ed.; Chinese Pharmacopeia Commission: Beijing, China, 2005.
2. Li, T.F.; Zhang, J.; Gulinuer, M.; Cai, S.Q.; Lu, J.F. Inhibitory effects of BYHWD on ROS generation in stroke rat brain tissues. Acta Biophys. Sin. 2003, 19, 441-447.
3. Danesh, J.; Wheeler, J.G.; Hirschfield, G.M.; Eda, S.; Eiriksdottir, G.; Rumley, A.; Lowe, G.D.; Pepys, M.B.; Gudnason, V. C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med. 2004, 350, 1387-1397. (Pubitemid 38419992)
4. Li, X.M.; Bai, X.C.; Qin, L.N.; Huang, H.; Xiao, Z.J.; Gao, T.M. Neuroprotective effects of Buyang Huanwu Decoction on neuronal injury in hippocampus after transient forebrain ischemia in rats. Neurosci. Lett. 2003, 346, 29-32. (Pubitemid 36792186)
5. Wang, H.W.; Liou, K.T.; Wang, Y.H.; Lu, C.K.; Lin, Y.L.; Lee, I.J.; Huang, S.T.; Tsai, Y.H.; Cheng, Y.C.; Lin, H.J.; et al. Deciphering the neuroprotective mechanisms of Bu-yang Huan-wu decoction by an integrative neurofunctional and genomic approach in ischemic stroke mice. J. Ethnopharmacol. 2011, 138, 22-33.
6. Zhang, H.; Wang, W.R.; Lin, R.; Zhang, J.Y.; Ji, Q.L.; Lin, Q.Q.; Yang, L.N. Buyang Huanwu decoction ameliorates coronary heart disease with Qi deficiency and blood stasis syndrome by reducing CRP and CD40 in rats. J. Ethnopharmacol. 2011, 130, 98-102.
7. Wang, W.R.; Lin, R.; Zhang, H.; Lin, Q.Q.; Yang, L.N.; Zhang, K.F.; Ren, F. The effects of Buyang Huanwu Decoction on hemorheological disorders and energy metabolism in rats with coronary heart disease. J. Ethnopharmacol. 2011, 137, 214-220.
8. Wu, L.; Zhang, W.; Li, H.; Chen, B.Y.; Zhang, G.M.; Tang, Y.H.; He, F.Y.; Deng, C.Q. Inhibition of aortic intimal hyperplasia and cell cycle protein and extracellular matrix protein expressions by BuYang HuanWu Decoction. J. Ethnopharmacol. 2009, 125, 423-435.
9. Wu, L.; Zhang, W.; Li, H.; Zhang, G.M.; Chen, B.Y.; Tang, Y.H.; Deng, C.Q. Effects of Buyang Huanwu Decoction and its alkaloids and glycosides on aortic intimal hyperplasia and expression of proliferating cell nuclear antigen in rats with aortic intimal injuries. J. Chin. Integr. Med. 2008, 6, 836-842.
10. Rios, J.L.; Waterman, P.G. Review of the pharmacology and toxicology of astragalus. Phytother. Res. 1997, 11, 411-418.
11. State Administration of Traditional Chinese Medicine. Chinese Materia Medica; Shanghai Science and Technology Publishing House: Shanghai, China, 1999; Volume 3, pp. 521-528; Volume 4, pp. 341-356; Volume 4, pp. 75-80; Volume 5, pp. 976-984.
12. Zhang, C.; Wang, X.H.; Zhong, M.F.; Liu, R.H.; Li, H.L.; Zhang, W.D.; Chen, H. Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings. Clin. Exp. Pharmacol. Physiol. 2007, 34, 387-392. (Pubitemid 46494462)
13. Xiao, H.B.; Krucker, M.; Albert, K.; Liang, X.M. Determination and identification of isoflavonoids in Radix astragali by matrix solid-phase dispersion extraction and high-performance liquid chromatography with photodiode array and mass spectrometric detection. J. Chromatogr. A 2004, 1032, 117-124. (Pubitemid 38270351)
14. Wagner, H.; Bauer, R.; Melchart, D.; Xiao, P.G.; Staudinger, A. Radix Astragali - Huang Qi. Chromatogr. Fingerpr. Anal. Herb. Med. 2011, 1024, 83-98.
15. Qi, L.W.; Yu, Q.T.; Li, P.; Li, S.L.; Wang, Y.X.; Sheng, L.H.; Yi, L. Quality evaluation of Radix Astragali through a simultaneous determination of six major active isoflavonoids and four main saponins by high-performance liquid chromatography coupled with diode array and evaporative light scattering detectors. J. Chromatogr. A 2006, 1134, 162-169. (Pubitemid 44740252)
16. Yan, R.; Ko, N.L.; Li, S.L.; Tam, Y.K.; Lin, G. Pharmacokinetics and metabolism of ligustilide, a major bioactive component in Rhizoma Chuanxiong, in the rat. Drug Metab. Dispos. 2008, 36, 400-408. (Pubitemid 351185754)
17. Lu, Q.; Qiu, T.Q.; Yang, H. Ligustilide inhibits vascular smooth muscle cells proliferation. Eur. J. Pharmacol. 2006, 542, 136-140. (Pubitemid 44066356)
18. Li, C.R.; Zhou, Z.; Zhu, D.; Sun, Y.N.; Dai, J.M.; Wang, S.Q. Protective effect of paeoniflorin on irradiation-induced cell damage involved in modulation of reactive oxygen species and the mitogen-activated protein kinases. Int. J. Biochem. Cell Biol. 2007, 39, 426-438. (Pubitemid 44855661)
19. Ji, B.; Geng, P.; Liu, J.G.; Shi, D.Z.; Wang, Y.Y. Effects of active components extracted from Qixue Bingzhi Recipe on proliferation of vascular smooth muscle cells and expressions of platelet-derived growth factor and its receptor genes. J. Chin. Integr. Med. 2006, 4, 30-34.
20. Yang, D.Z.; An, Y.Q.; Jiang, X.L.; Tang, D.Q.; Gao, Y.Y.; Zhao, H.T.; Wu, X.W. Development of a novel method combining HPLC fingerprint and multi-ingredients quantitative analysis for quality evaluation of traditional Chinese medicine preparation. Talanta 2011, 85, 885-890.
21. Shaw, L.H.; Lin, L.C.; Tsai, T.H. HPLC-MS/MS analysis of a traditional Chinese medical formulation of Bu-Yang-Huan-Wu-Tang and its pharmacokinetics after oral administration to rats. PLoS One 2012, 7, e43848.
22. Lurie, I.S.; Toske, S.G. Applicability of ultra-performance liquid chromatography-tandem mass spectrometry for heroin profiling. J. Chromatogr. A 2008, 1188, 322-326.
23. Zu, Y.; Yan, M.; Fu, Y.; Liu, W.; Zhang, L.; Gu, C.; Efferth, T. Determination and quantification of astragalosides in Radix Astragali and its medicinal products using LC-MS. J. Sep. Sci. 2009, 32, 517-525.
24. Wen, X.D.; Qi, L.W.; Li, B.; Li, P.; Yi, L.; Wang, Y.Q.; Liu, E.H.; Yang, X.L. Microsomal metabolism of calycosin, formononetin and drug-drug interactions by dynamic microdialysis sampling and HPLC-DAD-MS analysis. J. Pharm. Biomed. Anal. 2009, 50, 100-105.
25. Zhang, X.; Xiao, H.B.; Xue, X.Y.; Sun, Y.G.; Liang, X.M. Simultaneous characterization of isoflavonoids and astragalosides in two Astragalus species by high-performance liquid chromatography coupled with atmospheric pressure chemical ionization tandem mass spectrometry. J. Sep. Sci. 2007, 30, 2059-2069. (Pubitemid 47377080)
26. Tong, L.; Wan, M.; Zhou, D.; Gao, J.; Zhu, Y.; Bi, K. LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang-Min-Ling-Wan. Biomed. Chromatogr.: BMC 2010, 24, 1324-1331.
27. Wang, D.; Song, Y.; Li, S.L.; Bian, Y.Y.; Guan, J.; Li, P. Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. J. Sep. Sci. 2006, 29, 2012-2022. (Pubitemid 44355483)
28. Xu, Q.; Ma, X.; Liang, X. Determination of astragalosides in the roots of Astragalus spp. using liquid chromatography tandem atmospheric pressure chemical ionization mass spectrometry. Phytochem. Anal.: PCA 2007, 18, 419-427. (Pubitemid 47422798)