LC-MS/MS determination and pharmacokinetic study of albiflorin and paeoniflorin in rat plasma after oral administration of Radix Paeoniae Alba extract and Tang-Min-Ling-Wan

Biomedical Chromatography

Volumn 24, Issue 12, 2010, Pages 1324-1331

  Tong, Ling ^a,b   Wan, Meixu ^b   Zhou, Dandan ^b,c   Gao, Jun ^b   Zhu, Yonghong ^b   Bi, Kaishun ^a  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b Tianjin Tasly Group Co Ltd   (China)

^c SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Albiflorin; LC MS MS; Paeoniflorin; Pharmacokinetics

Indexed keywords

BODY FLUIDS; EXTRACTION; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MEDICINE; PHARMACOKINETICS; PHASE SEPARATION; POSITIVE IONS; RATS;

ALBIFLORIN; LC-MS-MS; LC.MS/MS; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY/TANDEM MASS SPECTROMETRY; ORAL ADMINISTRATION; PAEONIFLORIN; PHARMACOKINETIC STUDIES; RAT PLASMA; SELECTIVE LIQUID CHROMATOGRAPHY;

ELECTROSPRAY IONIZATION;

ACETONITRILE; ALBIFLORIN; CHINESE DRUG; FORMIC ACID; PAEONIA EXTRACT; PAEONIFLORIN; TANG MIN LING WAN; UNCLASSIFIED DRUG;

ACCURACY; ANIMAL EXPERIMENT; AREA UNDER THE CURVE; ARTICLE; CALIBRATION; CHINESE MEDICINE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG DETERMINATION; DRUG ELIMINATION; DRUG HALF LIFE; DRUG STABILITY; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; MALE; MAXIMUM PLASMA CONCENTRATION; NONHUMAN; PAEONIA; QUALITY CONTROL; RAT; SEPARATION TECHNIQUE; SOLID PHASE EXTRACTION; STANDARD; TANDEM MASS SPECTROMETRY; TIME TO MAXIMUM PLASMA CONCENTRATION; VALIDATION STUDY;

RATTUS;

EID: 78449241644     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1443     Document Type: Article

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